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Science 16 June 1995:
Vol. 268. no. 5217, pp. 1584 - 1589
DOI: 10.1126/science.7777857
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Articles

Science, Vol 268, Issue 5217, 1584-1589
Copyright © 1995 by American Association for the Advancement of Science

articles

Extreme discordant sib pairs for mapping quantitative trait loci in humans

N Risch and H Zhang

Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA.

Analysis of differences between siblings (sib pair analysis) is a standard method of genetic linkage analysis for mapping quantitative trait loci, such as those contributing to hypertension and obesity, in humans. In traditional designs, pairs are selected at random or with one sib having an extreme trait value. The majority of such pairs provide little power to detect linkage; only pairs that are concordant for high values, low values, or extremely discordant pairs (for example, one in the top 10 percent and the other in the bottom 10 percent of the distribution) provide substantial power. Focus on discordant pairs can reduce the amount of genotyping necessary over conventional designs by 10- to 40-fold.


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