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Science 9 June 1995:
Vol. 268. no. 5216, pp. 1506 - 1509
DOI: 10.1126/science.7770779
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Articles

Science, Vol 268, Issue 5216, 1506-1509
Copyright © 1995 by American Association for the Advancement of Science

articles

Chemical characterization of a family of brain lipids that induce sleep

BF Cravatt, O Prospero-Garcia, G Siuzdak, NB Gilula, SJ Henriksen, DL Boger, and RA Lerner

Department of Chemistry, Scripps Research Institute, La Jolla, CA 92307, USA.

A molecule isolated from the cerebrospinal fluid of sleep-deprived cats has been chemically characterized and identified as cis-9,10-octadecenoamide. Other fatty acid primary amides in addition to cis-9,10-octadecenoamide were identified as natural constituents of the cerebrospinal fluid of cat, rat, and human, indicating that these compounds compose a distinct family of brain lipids. Synthetic cis-9,10-octadecenoamide induced physiological sleep when injected into rats. Together, these results suggest that fatty acid primary amides may represent a previously unrecognized class of biological signaling molecules.


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