Science 2 June 1995: Vol. 268. no. 5215, pp. 1350 - 1353 DOI: 10.1126/science.7761854

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Articles

Gene Therapy in Heart Failure.

L. E. Vinge, P. W. Raake, and W. J. Koch (2008)
Circ. Res. 102, 1458-1470
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Exercise promotes angiogenesis and improves {beta}-adrenergic receptor signalling in the post-ischaemic failing rat heart.

D. Leosco, G. Rengo, G. Iaccarino, L. Golino, M. Marchese, F. Fortunato, C. Zincarelli, E. Sanzari, M. Ciccarelli, G. Galasso, et al. (2008)
Cardiovasc Res 78, 385-394
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Cardiac-restricted Expression of the Carboxyl-terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth: GRK3 CONTROLS CARDIAC {alpha}1-ADRENERGIC RECEPTOR RESPONSIVENESS.

L. E. Vinge, T. G. von Lueder, E. Aasum, E. Qvigstad, J. A. Gravning, O.-J. How, T. Edvardsen, R. Bjornerheim, M. S. Ahmed, B. W. Mikkelsen, et al. (2008)
J. Biol. Chem. 283, 10601-10610
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Acute beta-blockade prevents myocardial beta-adrenergic receptor desensitization and preserves early ventricular function after brain death..

P. K. Pandalai, K. M. McLean, C. F. Bulcao, J. Y. Duffy, K. M. D'Souza, W. H. Merrill, J. M. Pearl, and S. A. Akhter (2008)
J. Thorac. Cardiovasc. Surg. 135, 792-798
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Endocytosis machinery is required for {beta}1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.

C. Morisco, C. Marrone, J. Galeotti, D. Shao, D. E. Vatner, S. F. Vatner, and J. Sadoshima (2008)
Cardiovasc Res 78, 36-44
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An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro.

G. Mayer, B. Wulffen, C. Huber, J. Brockmann, B. Flicke, L. Neumann, D. Hafenbradl, B. M. Klebl, M. J. Lohse, C. Krasel, et al. (2008)
RNA 14, 524-534
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Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G{alpha}o* protein.

M. Zhu, A. A. Gach, G. Liu, X. Xu, C. C. Lim, J. X. Zhang, L. Mao, K. Chuprun, W. J. Koch, R. Liao, et al. (2008)
Am J Physiol Heart Circ Physiol 294, H1335-H1347
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Norepinephrine- and Epinephrine-induced Distinct 2-Adrenoceptor Signaling Is Dictated by GRK2 Phosphorylation in Cardiomyocytes.

Y. Wang, V. De Arcangelis, X. Gao, B. Ramani, Y.-s. Jung, and Y. Xiang (2008)
J. Biol. Chem. 283, 1799-1807
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Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo.

R. Zennadi, B. J. Moeller, E. J. Whalen, M. Batchvarova, K. Xu, S. Shan, M. Delahunty, M. W. Dewhirst, and M. J. Telen (2007)
Blood 110, 2708-2717
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Substrate Specificities of G Protein-Coupled Receptor Kinase-2 and -3 at Cardiac Myocyte Receptors Provide Basis for Distinct Roles in Regulation of Myocardial Function.

L. E. Vinge, K. W. Andressen, T. Attramadal, G. O. Andersen, M. S. Ahmed, K. Peppel, W. J. Koch, N. J. Freedman, F. O. Levy, T. Skomedal, et al. (2007)
Mol. Pharmacol. 72, 582-591
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Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation.

D. Leosco, G. Rengo, G. Iaccarino, A. Filippelli, A. Lymperopoulos, C. Zincarelli, F. Fortunato, L. Golino, M. Marchese, G. Esposito, et al. (2007)
Am J Physiol Heart Circ Physiol 293, H1596-H1603
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PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation.

D. A. Deshpande, R. M. Pascual, S.-W. Wang, D. M. Eckman, E. C. Riemer, C. D. Funk, and R. B. Penn (2007)
FASEB J 21, 2335-2342
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Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage.

M. H. de Borst, S. H. Diks, J. Bolbrinker, M. W. Schellings, M. B. A. van Dalen, M. P. Peppelenbosch, R. Kreutz, Y. M. Pinto, G. Navis, and H. van Goor (2007)
Am J Physiol Renal Physiol 293, F428-F437
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Increased expression of SERCA in the hearts of transgenic mice results in increased oxidation of glucose.

D. D. Belke, E. Swanson, J. Suarez, B. T. Scott, A. E. Stenbit, and W. H. Dillmann (2007)
Am J Physiol Heart Circ Physiol 292, H1755-H1763
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Principles of Genetic Murine Models for Cardiac Disease.

K. E. Yutzey and J. Robbins (2007)
Circulation 115, 792-799
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Protein Kinase A-Mediated Phosphorylation Contributes to Enhanced Contraction Observed in Mice That Overexpress beta-Adrenergic Receptor Kinase-1.

E. E. Mueller, S. A. Grandy, and S. E. Howlett (2006)
J. Pharmacol. Exp. Ther. 319, 1307-1316
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Cardiac-Specific Ablation of G-Protein Receptor Kinase 2 Redefines Its Roles in Heart Development and {beta}-Adrenergic Signaling.

S. J. Matkovich, A. Diwan, J. L. Klanke, D. J. Hammer, Y. Marreez, A. M. Odley, E. W. Brunskill, W. J. Koch, R. J. Schwartz, and G. W. Dorn II (2006)
Circ. Res. 99, 996-1003
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Cardiac S100A1 Protein Levels Determine Contractile Performance and Propensity Toward Heart Failure After Myocardial Infarction.

P. Most, H. Seifert, E. Gao, H. Funakoshi, M. Volkers, J. Heierhorst, A. Remppis, S. T. Pleger, B. R. DeGeorge Jr, A. D. Eckhart, et al. (2006)
Circulation 114, 1258-1268
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Pleiotropic Phenotype of a Genomic Knock-In of an RGS-Insensitive G184S Gnai2 Allele..

X. Huang, Y. Fu, R. A. Charbeneau, T. L. Saunders, D. K. Taylor, K. D. Hankenson, M. W. Russell, L. G. D'Alecy, and R. R. Neubig (2006)
Mol. Cell. Biol. 26, 6870-6879
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Restoration of myocardial {beta}-adrenergic receptor signaling after left ventricular assist device support.

P. K. Pandalai, C. F. Bulcao, W. H. Merrill, and S. A. Akhter (2006)
J. Thorac. Cardiovasc. Surg. 131, 975-980
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Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease.

P. Penela, C. Murga, C. Ribas, A. S. Tutor, S. Peregrin, and F. Mayor Jr. (2006)
Cardiovasc Res 69, 46-56
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Phospholipase C {epsilon} Modulates {beta}-Adrenergic Receptor- Dependent Cardiac Contraction and Inhibits Cardiac Hypertrophy.

H. Wang, E. A. Oestreich, N. Maekawa, T. A. Bullard, K. L. Vikstrom, R. T. Dirksen, G. G. Kelley, B. C. Blaxall, and A. V. Smrcka (2005)
Circ. Res. 97, 1305-1313
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Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction.

X. Yu, S. Huang, E. Patterson, M. W. Garrett, K. M. Kaufman, J. P. Metcalf, M. Zhu, S. T. Dunn, and D. C. Kem (2005)
Am J Physiol Heart Circ Physiol 289, H1960-H1967
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Role of the {beta}-adrenergic receptor kinase in myocardial dysfunction after brain death.

P. K. Pandalai, J. M. Lyons, J. Y. Duffy, K. M. McLean, C. J. Wagner, W. H. Merrill, J. M. Pearl, and S. A. Akhter (2005)
J. Thorac. Cardiovasc. Surg. 130, 1183-1189
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Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure.

G. Iaccarino, E. Barbato, E. Cipolletta, V. De Amicis, K. B. Margulies, D. Leosco, B. Trimarco, and W. J. Koch (2005)
Eur. Heart J. 26, 1752-1758
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Upregulation of {beta}-adrenergic receptors in heart failure due to volume overload.

X. Wang, E. Sentex, H. K. Saini, D. Chapman, and N. S. Dhalla (2005)
Am J Physiol Heart Circ Physiol 289, H151-H159
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G-protein-coupled receptor kinase activity in human heart failure: Effects of {beta}-adrenoceptor blockade.

K. Leineweber, P. Rohe, A. Beilfuss, C. Wolf, H. Sporkmann, H. Bruck, H.-G. Jakob, G. Heusch, T. Philipp, and O.-E. Brodde (2005)
Cardiovasc Res 66, 512-519
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Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.

L. Wang, S. Liu, L. D. Quarles, and R. F. Spurney (2005)
Am J Physiol Endocrinol Metab 288, E826-E834
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Regulation of Cysteinyl Leukotriene Type 1 Receptor Internalization and Signaling.

S. Naik, C. K. Billington, R. M. Pascual, D. A. Deshpande, F. P. Stefano, T. A. Kohout, D. M. Eckman, J. L. Benovic, and R. B. Penn (2005)
J. Biol. Chem. 280, 8722-8732
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Inhibition of {beta}-adrenergic receptor trafficking in adult cardiocytes by MAP4 decoration of microtubules.

G. Cheng, F. Qiao, T. N. Gallien, D. Kuppuswamy, and G. Cooper IV (2005)
Am J Physiol Heart Circ Physiol 288, H1193-H1202
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Level of {beta}-Adrenergic Receptor Kinase 1 Inhibition Determines Degree of Cardiac Dysfunction After Chronic Pressure Overload-Induced Heart Failure.

H. Tachibana, S. V. Naga Prasad, R. J. Lefkowitz, W. J. Koch, and H. A. Rockman (2005)
Circulation 111, 591-597
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Phosphatidylinositol 3-Kinase Offsets cAMP-Mediated Positive Inotropic Effect via Inhibiting Ca2+ Influx in Cardiomyocytes.

V. Leblais, S.-H. Jo, K. Chakir, V. Maltsev, M. Zheng, M. T. Crow, W. Wang, E. G. Lakatta, and R.-P. Xiao (2004)
Circ. Res. 95, 1183-1190
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{beta}2 Adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery.

J. M. Jones, J. A. Petrofski, K. H. Wilson, C. Steenbergen, W. J. Koch, and C. A. Milano (2004)
Eur. J. Cardiothorac. Surg. 26, 1161-1168
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Network integration of the adrenergic system in cardiac hypertrophy.

L. Barki-Harrington, C. Perrino, and H. A Rockman (2004)
Cardiovasc Res 63, 391-402
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TGF-{beta}1 and angiotensin networking in cardiac remodeling.

S. Rosenkranz (2004)
Cardiovasc Res 63, 423-432
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Altered cAMP-mediated signalling and its role in the pathogenesis of dilated cardiomyopathy.

M. A Movsesian (2004)
Cardiovasc Res 62, 450-459
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Regulation of cardiac contractility by Rab4-modulated {beta}2-adrenergic receptor recycling.

A. Odley, H. S. Hahn, R. A. Lynch, Y. Marreez, H. Osinska, J. Robbins, and G. W. Dorn II (2004)
PNAS 101, 7082-7087
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G Protein-Coupled Receptor Internalization Signaling Is Required for Cardioprotection in Ischemic Preconditioning.

H. Tong, H. A. Rockman, W. J. Koch, C. Steenbergen, and E. Murphy (2004)
Circ. Res. 94, 1133-1141
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Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to {beta}-adrenergic agonists.

U. Kirchhefer, L. R Jones, F. Begrow, P. Boknik, L. Hein, M. J Lohse, B. Riemann, W. Schmitz, J. Stypmann, and J. Neumann (2004)
Cardiovasc Res 62, 122-134
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Right ventricular targeted gene transfer of a {beta}-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding.

S. M. Emani, A. S. Shah, M. K. Bowman, D. C. White, S. Emani, D. D. Glower, and W. J. Koch (2004)
J. Thorac. Cardiovasc. Surg. 127, 787-793
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{beta}2-Adrenoceptor Activation Attenuates Endotoxin-Induced Acute Renal Failure.

A. Nakamura, A. Imaizumi, Y. Yanagawa, T. Kohsaka, and E. J. Johns (2004)
J. Am. Soc. Nephrol. 15, 316-325
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Manipulating Cardiac Contractility in Heart Failure: Data From Mice and Men.

G. W. Dorn II and J. D. Molkentin (2004)
Circulation 109, 150-158
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The Adrenergic Pathway and Heart Failure.

J.R. Keys and W.J. Koch (2004)
Recent Prog. Horm. Res. 59, 13-30
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Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure.

A. El-Armouche, O. Zolk, T. Rau, and T. Eschenhagen (2003)
Cardiovasc Res 60, 478-487
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What Is the Role of {beta}-Adrenergic Signaling in Heart Failure?.

M. J. Lohse, S. Engelhardt, and T. Eschenhagen (2003)
Circ. Res. 93, 896-906
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The Third Intracellular Loop and the Carboxyl Terminus of {beta}2-Adrenergic Receptor Confer Spontaneous Activity of the Receptor.

K. Chakir, Y. Xiang, D. Yang, S.-J. Zhang, H. Cheng, B. K. Kobilka, and R.-P. Xiao (2003)
Mol. Pharmacol. 64, 1048-1058
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Cardiac hypertrophy and altered {beta}-adrenergic signaling in transgenic mice that express the amino terminus of {beta}-ARK1.

J. R. Keys, E. A. Greene, C. J. Cooper, S. V. Naga Prasad, H. A. Rockman, and W. J. Koch (2003)
Am J Physiol Heart Circ Physiol 285, H2201-H2211
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Differential myocardial gene expression in the development and rescue of murine heart failure.

B. C. Blaxall, R. Spang, H. A. Rockman, and W. J. Koch (2003)
Physiol Genomics 15, 105-114
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Enhanced Gi Signaling Selectively Negates {beta}2-Adrenergic Receptor (AR)- but Not {beta}1-AR-Mediated Positive Inotropic Effect in Myocytes From Failing Rat Hearts.

R.-P. Xiao, S.-J. Zhang, K. Chakir, P. Avdonin, W. Zhu, R. A. Bond, C. W. Balke, E. G. Lakatta, and H. Cheng (2003)
Circulation 108, 1633-1639
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Transgenic Overexpression of the Ca2+-binding Protein S100A1 in the Heart Leads to Increased in Vivo Myocardial Contractile Performance.

P. Most, A. Remppis, S. T. Pleger, E. Loffler, P. Ehlermann, J. Bernotat, C. Kleuss, J. Heierhorst, P. Ruiz, H. Witt, et al. (2003)
J. Biol. Chem. 278, 33809-33817
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Phosphorylation of G Protein-Coupled Receptors: GPCR Kinases in Heart Disease.

J. A. Hata and W. J. Koch (2003)
Mol. Interv. 3, 264-272
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Identification and Light-Dependent Translocation of a Cone-Specific Antigen, Cone Arrestin, Recognized by Monoclonal Antibody 7G6.

H. Zhang, N. Cuenca, T. Ivanova, J. Church-Kopish, J. M. Frederick, P. R. MacLeish, and W. Baehr (2003)
Invest. Ophthalmol. Vis. Sci. 44, 2858-2867
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Exercise restores {beta}-adrenergic vasorelaxation in aged rat carotid arteries.

D. Leosco, G. Iaccarino, E. Cipolletta, D. De Santis, E. Pisani, V. Trimarco, N. Ferrara, P. Abete, D. Sorriento, F. Rengo, et al. (2003)
Am J Physiol Heart Circ Physiol 285, H369-H374
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Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy.

D. T. Lucas, P. Aryal, L. I. Szweda, W. J. Koch, and L. A. Leinwand (2003)
Am J Physiol Heart Circ Physiol 284, H575-H583
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Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization.

T. A. Kohout and R. J. Lefkowitz (2003)
Mol. Pharmacol. 63, 9-18
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Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated {beta}-adrenergic signaling modulation.

H. T. Tevaearai, G. B. Walton, A. D. Eckhart, J. R. Keys, and W. J. Koch (2002)
Eur. J. Cardiothorac. Surg. 22, 733-737
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Ischemic Protection and Myofibrillar Cardiomyopathy: Dose-Dependent Effects of In Vivo {delta}PKC Inhibition.

H. S. Hahn, M. G. Yussman, T. Toyokawa, Y. Marreez, T. J. Barrett, K. C. Hilty, H. Osinska, J. Robbins, and G. W. Dorn II (2002)
Circ. Res. 91, 741-748
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Alterations of beta -adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta 1.

S. Rosenkranz, M. Flesch, K. Amann, C. Haeuseler, H. Kilter, U. Seeland, K.-D. Schluter, and M. Bohm (2002)
Am J Physiol Heart Circ Physiol 283, H1253-H1262
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Phosphatidylinositol 3-Kinase Functionally Compartmentalizes the Concurrent Gs Signaling During {beta}2-Adrenergic Stimulation.

S.-H. Jo, V. Leblais, P. H. Wang, M. T. Crow, and R.-P. Xiao (2002)
Circ. Res. 91, 46-53
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Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification.

B. J. A. Janssen and J. F. M. Smits (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R1545-R1564
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Myocyte Redistribution of GRK2 and GRK5 in Hypertensive, Heart-Failure-Prone Rats.

X. P. Yi, A. M. Gerdes, and F. Li (2002)
Hypertension 39, 1058-1063
 |  Abstract »  |  Full Text »  |  PDF »

Adenoviral gene transfer to the heart during cardiopulmonary bypass: effect of myocardial protection technique on transgene expression.

J.M. Jones, K.H. Wilson, W.J. Koch, and C.A. Milano (2002)
Eur. J. Cardiothorac. Surg. 21, 847-852
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Transgenic and knockout mouse models of atrial arrhythmias.

J. E. Olgin and S. Verheule (2002)
Cardiovasc Res 54, 280-286
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Vascular-Targeted Overexpression of G Protein-Coupled Receptor Kinase-2 in Transgenic Mice Attenuates beta -Adrenergic Receptor Signaling and Increases Resting Blood Pressure.

A. D. Eckhart, T. Ozaki, H. Tevaearai, H. A. Rockman, and W. J. Koch (2002)
Mol. Pharmacol. 61, 749-758
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Impaired parasympathetic heart rate control in mice with a reduction of functional G protein beta gamma -subunits.

J. Gehrmann, M. Meister, C. T. Maguire, D. C. Martins, P. E. Hammer, E. J. Neer, C. I. Berul, and U. Mende (2002)
Am J Physiol Heart Circ Physiol 282, H445-H456
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Myocardial distribution and regulation of GRK and beta -arrestin isoforms in congestive heart failure in rats.

L. E. Vinge, E. Oie, Y. Andersson, H. K. Grogaard, G. O. Andersen, and H. Attramadal (2001)
Am J Physiol Heart Circ Physiol 281, H2490-H2499
 |  Abstract »  |  Full Text »  |  PDF »

Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase.

R. S. Ostrom, C. Gregorian, R. M. Drenan, Y. Xiang, J. W. Regan, and P. A. Insel (2001)
J. Biol. Chem. 276, 42063-42069
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Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene Transfer of a {beta}-Adrenergic Receptor Kinase Inhibitor.

H. T. Tevaearai, A. D. Eckhart, K. F. Shotwell, K. Wilson, and W. J. Koch (2001)
Circulation 104, 2069-2074
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic Studies of Cardiac Adrenergic Receptor Regulation.

A. D. Eckhart and W. J. Koch (2001)
J. Pharmacol. Exp. Ther. 299, 1-5
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Prospective crossover comparison of carvedilol and metoprolol in patients with chronic heart failure.

C. Maack, T. Elter, G. Nickenig, K. LaRosee, M. Crivaro, A. Stablein, H. Wuttke, and M. Bohm (2001)
J. Am. Coll. Cardiol. 38, 939-946
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Regulation of myocardial {beta}ARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing {alpha}1B-adrenergic receptors.

G. Iaccarino, J. R. Keys, A. Rapacciuolo, K. F. Shotwell, R. J. Lefkowitz, H. A. Rockman, and W. J. Koch (2001)
J. Am. Coll. Cardiol. 38, 534-540
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Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.

K. S. Kirkwood, N. W. Bunnett, J. Maa, I. Castagliolo, B. Liu, N. Gerard, J. Zacks, C. Pothoulakis, and E. F. Grady (2001)
Am J Physiol Gastrointest Liver Physiol 281, G544-G551
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Cardiac {beta}ARK1 Upregulation Induced by Chronic Salt Deprivation in Rats.

G. Iaccarino, E. Barbato, E. Cipolleta, A. Esposito, A. Fiorillo, W. J. Koch, and B. Trimarco (2001)
Hypertension 38, 255-260
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Cardiac Gene Delivery With Cardiopulmonary Bypass.

M. J. Davidson, J. M. Jones, S. M. Emani, K. H. Wilson, J. Jaggers, W. J. Koch, and C. A. Milano (2001)
Circulation 104, 131-133
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Sympathoadrenergic mechanisms in functional regulation and development of cardiac hypertrophy and failure: findings from genetically engineered mice.

X.-J. Du (2001)
Cardiovasc Res 50, 443-453
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Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice.

M. Palmen, M.J.A.P. Daemen, R. Bronsaer, W.R.M. Dassen, H.R. Zandbergen, M. Kockx, J.F.M. Smits, R. van der Zee, and P.A. Doevendans (2001)
Cardiovasc Res 50, 516-524
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Concomitant Increase of G Protein-Coupled Receptor Kinase Activity and Uncoupling of {beta}-Adrenergic Receptors in Rat Myometrium at Parturition.

V. Simon, S. Mhaouty-Kodja, C. Legrand, and J. Cohen-Tannoudji (2001)
Endocrinology 142, 1899-1905
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Stimulating G Protein-Coupled Receptors : Cure or Cause for Heart Failure?.

D. E. Vatner (2001)
Circ. Res. 88, 645-647
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Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5.

E. P. Chen, H. B. Bittner, S. A. Akhter, W. J. Koch, and R. D. Davis (2001)
Ann. Thorac. Surg. 71, 1320-1324
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To Cre or Not To Cre : The Next Generation of Mouse Models of Human Cardiac Diseases.

K. R. Chien (2001)
Circ. Res. 88, 546-549
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Cardiac Overexpression of a Gq Inhibitor Blocks Induction of Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Activity in In Vivo Pressure Overload.

G. Esposito, S. V. N. Prasad, A. Rapacciuolo, L. Mao, W. J. Koch, and H. A. Rockman (2001)
Circulation 103, 1453-1458
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Effect of Hypothyroidism on G Protein-Coupled Receptor Kinase 2 Expression Levels in Rat Liver, Lung, and Heart.

P. Penela, M. Barradas, M. Alvarez-Dolado, A. Munoz, and F. Mayor Jr. (2001)
Endocrinology 142, 987-991
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Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling.

S. S. G. Ferguson (2001)
Pharmacol. Rev. 53, 1-24
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Upregulation of G protein-linked receptor kinases with advancing age in rat aorta.

W. E. Schutzer, J. F. Reed, M. Bliziotes, and S. L. Mader (2001)