Science 2 June 1995: Vol. 268. no. 5215, pp. 1350 - 1353 DOI: 10.1126/science.7761854

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Articles

Regulation of G-Protein Signaling by RKTG via Sequestration of the G{beta}{gamma} Subunit to the Golgi Apparatus.

Y. Jiang, X. Xie, Y. Zhang, X. Luo, X. Wang, F. Fan, D. Zheng, Z. Wang, and Y. Chen (2010)
Mol. Cell. Biol. 30, 78-90
 |  Abstract »  |  Full Text »  |  PDF »

Protection from sepsis-induced acute renal failure by adenoviral-mediated gene transfer of {beta}2-adrenoceptor.

A. Nakamura, R. Niimi, and Y. Yanagawa (2009)
Nephrol. Dial. Transplant.
 |  Abstract »  |  Full Text »  |  PDF »

Mouse models of altered protein kinase A signaling.

L. S Kirschner, Z. Yin, G. N Jones, and E. Mahoney (2009)
Endocr. Relat. Cancer 16, 773-793
 |  Abstract »  |  Full Text »  |  PDF »

Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway {beta}2-adrenergic receptor physiologic signaling.

W. C. H. Wang, K. A. Mihlbachler, A. C. Brunnett, and S. B. Liggett (2009)
PNAS 106, 15007-15012
 |  Abstract »  |  Full Text »  |  PDF »

Kinase activity-independent regulation of cyclin pathway by GRK2 is essential for zebrafish early development.

X. Jiang, P. Yang, and L. Ma (2009)
PNAS 106, 10183-10188
 |  Abstract »  |  Full Text »  |  PDF »

Myocardial Adeno-Associated Virus Serotype 6-{beta}ARKct Gene Therapy Improves Cardiac Function and Normalizes the Neurohormonal Axis in Chronic Heart Failure.

G. Rengo, A. Lymperopoulos, C. Zincarelli, M. Donniacuo, S. Soltys, J. E. Rabinowitz, and W. J. Koch (2009)
Circulation 119, 89-98
 |  Abstract »  |  Full Text »  |  PDF »

Assembly of High Order G{alpha}q-Effector Complexes with RGS Proteins.

A. Shankaranarayanan, D. M. Thal, V. M. Tesmer, D. L. Roman, R. R. Neubig, T. Kozasa, and J. J. G. Tesmer (2008)
J. Biol. Chem. 283, 34923-34934
 |  Abstract »  |  Full Text »  |  PDF »

Uncoupling of Myocardial {beta}-Adrenergic Receptor Signaling During Coronary Artery Bypass Grafting: The Role of GRK2.

C. F. Bulcao, P. K. Pandalai, K. M. D'Souza, W. H. Merrill, and S. A. Akhter (2008)
Ann. Thorac. Surg. 86, 1189-1194
 |  Abstract »  |  Full Text »  |  PDF »

Designing Heart Performance by Gene Transfer.

J. Davis, M. V. Westfall, D. Townsend, M. Blankinship, T. J. Herron, G. Guerrero-Serna, W. Wang, E. Devaney, and J. M. Metzger (2008)
Physiol Rev 88, 1567-1651
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of vascular smooth muscle G protein-coupled receptor kinase 2 enhances {alpha}1D-adrenergic receptor constriction.

H. I. Cohn, D. M. Harris, S. Pesant, M. Pfeiffer, R.-H. Zhou, W. J. Koch, G. W. Dorn 2nd, and A. D. Eckhart (2008)
Am J Physiol Heart Circ Physiol 295, H1695-H1704
 |  Abstract »  |  Full Text »  |  PDF »

Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes.

J. S. Martini, P. Raake, L. E. Vinge, B. R. DeGeorge Jr., J. K. Chuprun, D. M. Harris, E. Gao, A. D. Eckhart, J. A. Pitcher, and W. J. Koch (2008)
PNAS 105, 12457-12462
 |  Abstract »  |  Full Text »  |  PDF »

Gene Therapy in Heart Failure.

L. E. Vinge, P. W. Raake, and W. J. Koch (2008)
Circ. Res. 102, 1458-1470
 |  Abstract »  |  Full Text »  |  PDF »

Exercise promotes angiogenesis and improves {beta}-adrenergic receptor signalling in the post-ischaemic failing rat heart.

D. Leosco, G. Rengo, G. Iaccarino, L. Golino, M. Marchese, F. Fortunato, C. Zincarelli, E. Sanzari, M. Ciccarelli, G. Galasso, et al. (2008)
Cardiovasc Res 78, 385-394
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac-restricted Expression of the Carboxyl-terminal Fragment of GRK3 Uncovers Distinct Functions of GRK3 in Regulation of Cardiac Contractility and Growth: GRK3 CONTROLS CARDIAC {alpha}1-ADRENERGIC RECEPTOR RESPONSIVENESS.

L. E. Vinge, T. G. von Lueder, E. Aasum, E. Qvigstad, J. A. Gravning, O.-J. How, T. Edvardsen, R. Bjornerheim, M. S. Ahmed, B. W. Mikkelsen, et al. (2008)
J. Biol. Chem. 283, 10601-10610
 |  Abstract »  |  Full Text »  |  PDF »

Acute beta-blockade prevents myocardial beta-adrenergic receptor desensitization and preserves early ventricular function after brain death..

P. K. Pandalai, K. M. McLean, C. F. Bulcao, J. Y. Duffy, K. M. D'Souza, W. H. Merrill, J. M. Pearl, and S. A. Akhter (2008)
J. Thorac. Cardiovasc. Surg. 135, 792-798
 |  Abstract »  |  Full Text »  |  PDF »

Endocytosis machinery is required for {beta}1-adrenergic receptor-induced hypertrophy in neonatal rat cardiac myocytes.

C. Morisco, C. Marrone, J. Galeotti, D. Shao, D. E. Vatner, S. F. Vatner, and J. Sadoshima (2008)
Cardiovasc Res 78, 36-44
 |  Abstract »  |  Full Text »  |  PDF »

An RNA molecule that specifically inhibits G-protein-coupled receptor kinase 2 in vitro.

G. Mayer, B. Wulffen, C. Huber, J. Brockmann, B. Flicke, L. Neumann, D. Hafenbradl, B. M. Klebl, M. J. Lohse, C. Krasel, et al. (2008)
RNA 14, 524-534
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G{alpha}o* protein.

M. Zhu, A. A. Gach, G. Liu, X. Xu, C. C. Lim, J. X. Zhang, L. Mao, K. Chuprun, W. J. Koch, R. Liao, et al. (2008)
Am J Physiol Heart Circ Physiol 294, H1335-H1347
 |  Abstract »  |  Full Text »  |  PDF »

Norepinephrine- and Epinephrine-induced Distinct 2-Adrenoceptor Signaling Is Dictated by GRK2 Phosphorylation in Cardiomyocytes.

Y. Wang, V. De Arcangelis, X. Gao, B. Ramani, Y.-s. Jung, and Y. Xiang (2008)
J. Biol. Chem. 283, 1799-1807
 |  Abstract »  |  Full Text »  |  PDF »

Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo.

R. Zennadi, B. J. Moeller, E. J. Whalen, M. Batchvarova, K. Xu, S. Shan, M. Delahunty, M. W. Dewhirst, and M. J. Telen (2007)
Blood 110, 2708-2717
 |  Abstract »  |  Full Text »  |  PDF »

Substrate Specificities of G Protein-Coupled Receptor Kinase-2 and -3 at Cardiac Myocyte Receptors Provide Basis for Distinct Roles in Regulation of Myocardial Function.

L. E. Vinge, K. W. Andressen, T. Attramadal, G. O. Andersen, M. S. Ahmed, K. Peppel, W. J. Koch, N. J. Freedman, F. O. Levy, T. Skomedal, et al. (2007)
Mol. Pharmacol. 72, 582-591
 |  Abstract »  |  Full Text »  |  PDF »

Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation.

D. Leosco, G. Rengo, G. Iaccarino, A. Filippelli, A. Lymperopoulos, C. Zincarelli, F. Fortunato, L. Golino, M. Marchese, G. Esposito, et al. (2007)
Am J Physiol Heart Circ Physiol 293, H1596-H1603
 |  Abstract »  |  Full Text »  |  PDF »

PKC-dependent regulation of the receptor locus dominates functional consequences of cysteinyl leukotriene type 1 receptor activation.

D. A. Deshpande, R. M. Pascual, S.-W. Wang, D. M. Eckman, E. C. Riemer, C. D. Funk, and R. B. Penn (2007)
FASEB J 21, 2335-2342
 |  Abstract »  |  Full Text »  |  PDF »

Profiling of the renal kinome: a novel tool to identify protein kinases involved in angiotensin II-dependent hypertensive renal damage.

M. H. de Borst, S. H. Diks, J. Bolbrinker, M. W. Schellings, M. B. A. van Dalen, M. P. Peppelenbosch, R. Kreutz, Y. M. Pinto, G. Navis, and H. van Goor (2007)
Am J Physiol Renal Physiol 293, F428-F437
 |  Abstract »  |  Full Text »  |  PDF »

Increased expression of SERCA in the hearts of transgenic mice results in increased oxidation of glucose.

D. D. Belke, E. Swanson, J. Suarez, B. T. Scott, A. E. Stenbit, and W. H. Dillmann (2007)
Am J Physiol Heart Circ Physiol 292, H1755-H1763
 |  Abstract »  |  Full Text »  |  PDF »

Principles of Genetic Murine Models for Cardiac Disease.

K. E. Yutzey and J. Robbins (2007)
Circulation 115, 792-799
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase A-Mediated Phosphorylation Contributes to Enhanced Contraction Observed in Mice That Overexpress beta-Adrenergic Receptor Kinase-1.

E. E. Mueller, S. A. Grandy, and S. E. Howlett (2006)
J. Pharmacol. Exp. Ther. 319, 1307-1316
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac-Specific Ablation of G-Protein Receptor Kinase 2 Redefines Its Roles in Heart Development and {beta}-Adrenergic Signaling.

S. J. Matkovich, A. Diwan, J. L. Klanke, D. J. Hammer, Y. Marreez, A. M. Odley, E. W. Brunskill, W. J. Koch, R. J. Schwartz, and G. W. Dorn II (2006)
Circ. Res. 99, 996-1003
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac S100A1 Protein Levels Determine Contractile Performance and Propensity Toward Heart Failure After Myocardial Infarction.

P. Most, H. Seifert, E. Gao, H. Funakoshi, M. Volkers, J. Heierhorst, A. Remppis, S. T. Pleger, B. R. DeGeorge Jr, A. D. Eckhart, et al. (2006)
Circulation 114, 1258-1268
 |  Abstract »  |  Full Text »  |  PDF »

Pleiotropic Phenotype of a Genomic Knock-In of an RGS-Insensitive G184S Gnai2 Allele..

X. Huang, Y. Fu, R. A. Charbeneau, T. L. Saunders, D. K. Taylor, K. D. Hankenson, M. W. Russell, L. G. D'Alecy, and R. R. Neubig (2006)
Mol. Cell. Biol. 26, 6870-6879
 |  Abstract »  |  Full Text »  |  PDF »

Restoration of myocardial {beta}-adrenergic receptor signaling after left ventricular assist device support.

P. K. Pandalai, C. F. Bulcao, W. H. Merrill, and S. A. Akhter (2006)
J. Thorac. Cardiovasc. Surg. 131, 975-980
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of regulation of G protein-coupled receptor kinases (GRKs) and cardiovascular disease.

P. Penela, C. Murga, C. Ribas, A. S. Tutor, S. Peregrin, and F. Mayor Jr. (2006)
Cardiovasc Res 69, 46-56
 |  Abstract »  |  Full Text »  |  PDF »

Phospholipase C {epsilon} Modulates {beta}-Adrenergic Receptor- Dependent Cardiac Contraction and Inhibits Cardiac Hypertrophy.

H. Wang, E. A. Oestreich, N. Maekawa, T. A. Bullard, K. L. Vikstrom, R. T. Dirksen, G. G. Kelley, B. C. Blaxall, and A. V. Smrcka (2005)
Circ. Res. 97, 1305-1313
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome degradation of GRK2 during ischemia and ventricular tachyarrhythmias in a canine model of myocardial infarction.

X. Yu, S. Huang, E. Patterson, M. W. Garrett, K. M. Kaufman, J. P. Metcalf, M. Zhu, S. T. Dunn, and D. C. Kem (2005)
Am J Physiol Heart Circ Physiol 289, H1960-H1967
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Role of the {beta}-adrenergic receptor kinase in myocardial dysfunction after brain death.

P. K. Pandalai, J. M. Lyons, J. Y. Duffy, K. M. McLean, C. J. Wagner, W. H. Merrill, J. M. Pearl, and S. A. Akhter (2005)
J. Thorac. Cardiovasc. Surg. 130, 1183-1189
 |  Abstract »  |  Full Text »  |  PDF »

Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure.

G. Iaccarino, E. Barbato, E. Cipolletta, V. De Amicis, K. B. Margulies, D. Leosco, B. Trimarco, and W. J. Koch (2005)
Eur. Heart J. 26, 1752-1758
 |  Abstract »  |  Full Text »  |  PDF »

Upregulation of {beta}-adrenergic receptors in heart failure due to volume overload.

X. Wang, E. Sentex, H. K. Saini, D. Chapman, and N. S. Dhalla (2005)
Am J Physiol Heart Circ Physiol 289, H151-H159
 |  Abstract »  |  Full Text »  |  PDF »

G-protein-coupled receptor kinase activity in human heart failure: Effects of {beta}-adrenoceptor blockade.

K. Leineweber, P. Rohe, A. Beilfuss, C. Wolf, H. Sporkmann, H. Bruck, H.-G. Jakob, G. Heusch, T. Philipp, and O.-E. Brodde (2005)
Cardiovasc Res 66, 512-519
 |  Abstract »  |  Full Text »  |  PDF »

Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss.

L. Wang, S. Liu, L. D. Quarles, and R. F. Spurney (2005)
Am J Physiol Endocrinol Metab 288, E826-E834
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Cysteinyl Leukotriene Type 1 Receptor Internalization and Signaling.

S. Naik, C. K. Billington, R. M. Pascual, D. A. Deshpande, F. P. Stefano, T. A. Kohout, D. M. Eckman, J. L. Benovic, and R. B. Penn (2005)
J. Biol. Chem. 280, 8722-8732
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of {beta}-adrenergic receptor trafficking in adult cardiocytes by MAP4 decoration of microtubules.

G. Cheng, F. Qiao, T. N. Gallien, D. Kuppuswamy, and G. Cooper IV (2005)
Am J Physiol Heart Circ Physiol 288, H1193-H1202
 |  Abstract »  |  Full Text »  |  PDF »

Level of {beta}-Adrenergic Receptor Kinase 1 Inhibition Determines Degree of Cardiac Dysfunction After Chronic Pressure Overload-Induced Heart Failure.

H. Tachibana, S. V. Naga Prasad, R. J. Lefkowitz, W. J. Koch, and H. A. Rockman (2005)
Circulation 111, 591-597
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-Kinase Offsets cAMP-Mediated Positive Inotropic Effect via Inhibiting Ca2+ Influx in Cardiomyocytes.

V. Leblais, S.-H. Jo, K. Chakir, V. Maltsev, M. Zheng, M. T. Crow, W. Wang, E. G. Lakatta, and R.-P. Xiao (2004)
Circ. Res. 95, 1183-1190
 |  Abstract »  |  Full Text »  |  PDF »

{beta}2 Adrenoceptor gene therapy ameliorates left ventricular dysfunction following cardiac surgery.

J. M. Jones, J. A. Petrofski, K. H. Wilson, C. Steenbergen, W. J. Koch, and C. A. Milano (2004)
Eur. J. Cardiothorac. Surg. 26, 1161-1168
 |  Abstract »  |  Full Text »  |  PDF »

Network integration of the adrenergic system in cardiac hypertrophy.

L. Barki-Harrington, C. Perrino, and H. A Rockman (2004)
Cardiovasc Res 63, 391-402
 |  Abstract »  |  Full Text »  |  PDF »

TGF-{beta}1 and angiotensin networking in cardiac remodeling.

S. Rosenkranz (2004)
Cardiovasc Res 63, 423-432
 |  Abstract »  |  Full Text »  |  PDF »

Altered cAMP-mediated signalling and its role in the pathogenesis of dilated cardiomyopathy.

M. A Movsesian (2004)
Cardiovasc Res 62, 450-459
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of cardiac contractility by Rab4-modulated {beta}2-adrenergic receptor recycling.

A. Odley, H. S. Hahn, R. A. Lynch, Y. Marreez, H. Osinska, J. Robbins, and G. W. Dorn II (2004)
PNAS 101, 7082-7087
 |  Abstract »  |  Full Text »  |  PDF »

G Protein-Coupled Receptor Internalization Signaling Is Required for Cardioprotection in Ischemic Preconditioning.

H. Tong, H. A. Rockman, W. J. Koch, C. Steenbergen, and E. Murphy (2004)
Circ. Res. 94, 1133-1141
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic triadin 1 overexpression alters SR Ca2+ handling and leads to a blunted contractile response to {beta}-adrenergic agonists.

U. Kirchhefer, L. R Jones, F. Begrow, P. Boknik, L. Hein, M. J Lohse, B. Riemann, W. Schmitz, J. Stypmann, and J. Neumann (2004)
Cardiovasc Res 62, 122-134
 |  Abstract »  |  Full Text »  |  PDF »

Right ventricular targeted gene transfer of a {beta}-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding.

S. M. Emani, A. S. Shah, M. K. Bowman, D. C. White, S. Emani, D. D. Glower, and W. J. Koch (2004)
J. Thorac. Cardiovasc. Surg. 127, 787-793
 |  Abstract »  |  Full Text »  |  PDF »

{beta}2-Adrenoceptor Activation Attenuates Endotoxin-Induced Acute Renal Failure.

A. Nakamura, A. Imaizumi, Y. Yanagawa, T. Kohsaka, and E. J. Johns (2004)
J. Am. Soc. Nephrol. 15, 316-325
 |  Abstract »  |  Full Text »  |  PDF »

Manipulating Cardiac Contractility in Heart Failure: Data From Mice and Men.

G. W. Dorn II and J. D. Molkentin (2004)
Circulation 109, 150-158
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The Adrenergic Pathway and Heart Failure.

J.R. Keys and W.J. Koch (2004)
Recent Prog. Horm. Res. 59, 13-30
 |  Abstract »  |  Full Text »

Inhibitory G-proteins and their role in desensitization of the adenylyl cyclase pathway in heart failure.

A. El-Armouche, O. Zolk, T. Rau, and T. Eschenhagen (2003)
Cardiovasc Res 60, 478-487
 |  Abstract »  |  Full Text »  |  PDF »

What Is the Role of {beta}-Adrenergic Signaling in Heart Failure?.

M. J. Lohse, S. Engelhardt, and T. Eschenhagen (2003)
Circ. Res. 93, 896-906
 |  Abstract »  |  Full Text »  |  PDF »

The Third Intracellular Loop and the Carboxyl Terminus of {beta}2-Adrenergic Receptor Confer Spontaneous Activity of the Receptor.

K. Chakir, Y. Xiang, D. Yang, S.-J. Zhang, H. Cheng, B. K. Kobilka, and R.-P. Xiao (2003)
Mol. Pharmacol. 64, 1048-1058
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac hypertrophy and altered {beta}-adrenergic signaling in transgenic mice that express the amino terminus of {beta}-ARK1.

J. R. Keys, E. A. Greene, C. J. Cooper, S. V. Naga Prasad, H. A. Rockman, and W. J. Koch (2003)
Am J Physiol Heart Circ Physiol 285, H2201-H2211
 |  Abstract »  |  Full Text »  |  PDF »

Differential myocardial gene expression in the development and rescue of murine heart failure.

B. C. Blaxall, R. Spang, H. A. Rockman, and W. J. Koch (2003)
Physiol Genomics 15, 105-114
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Gi Signaling Selectively Negates {beta}2-Adrenergic Receptor (AR)- but Not {beta}1-AR-Mediated Positive Inotropic Effect in Myocytes From Failing Rat Hearts.

R.-P. Xiao, S.-J. Zhang, K. Chakir, P. Avdonin, W. Zhu, R. A. Bond, C. W. Balke, E. G. Lakatta, and H. Cheng (2003)
Circulation 108, 1633-1639
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic Overexpression of the Ca2+-binding Protein S100A1 in the Heart Leads to Increased in Vivo Myocardial Contractile Performance.

P. Most, A. Remppis, S. T. Pleger, E. Loffler, P. Ehlermann, J. Bernotat, C. Kleuss, J. Heierhorst, P. Ruiz, H. Witt, et al. (2003)
J. Biol. Chem. 278, 33809-33817
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of G Protein-Coupled Receptors: GPCR Kinases in Heart Disease.

J. A. Hata and W. J. Koch (2003)
Mol. Interv. 3, 264-272
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Light-Dependent Translocation of a Cone-Specific Antigen, Cone Arrestin, Recognized by Monoclonal Antibody 7G6.

H. Zhang, N. Cuenca, T. Ivanova, J. Church-Kopish, J. M. Frederick, P. R. MacLeish, and W. Baehr (2003)
Invest. Ophthalmol. Vis. Sci. 44, 2858-2867
 |  Abstract »  |  Full Text »  |  PDF »

Exercise restores {beta}-adrenergic vasorelaxation in aged rat carotid arteries.

D. Leosco, G. Iaccarino, E. Cipolletta, D. De Santis, E. Pisani, V. Trimarco, N. Ferrara, P. Abete, D. Sorriento, F. Rengo, et al. (2003)
Am J Physiol Heart Circ Physiol 285, H369-H374
 |  Abstract »  |  Full Text »  |  PDF »

Alterations in mitochondrial function in a mouse model of hypertrophic cardiomyopathy.

D. T. Lucas, P. Aryal, L. I. Szweda, W. J. Koch, and L. A. Leinwand (2003)
Am J Physiol Heart Circ Physiol 284, H575-H583
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of G Protein-Coupled Receptor Kinases and Arrestins During Receptor Desensitization.

T. A. Kohout and R. J. Lefkowitz (2003)
Mol. Pharmacol. 63, 9-18
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Donor heart contractile dysfunction following prolonged ex vivo preservation can be prevented by gene-mediated {beta}-adrenergic signaling modulation.

H. T. Tevaearai, G. B. Walton, A. D. Eckhart, J. R. Keys, and W. J. Koch (2002)
Eur. J. Cardiothorac. Surg. 22, 733-737
 |  Abstract »  |  Full Text »  |  PDF »

Ischemic Protection and Myofibrillar Cardiomyopathy: Dose-Dependent Effects of In Vivo {delta}PKC Inhibition.

H. S. Hahn, M. G. Yussman, T. Toyokawa, Y. Marreez, T. J. Barrett, K. C. Hilty, H. Osinska, J. Robbins, and G. W. Dorn II (2002)
Circ. Res. 91, 741-748
 |  Abstract »  |  Full Text »  |  PDF »

Alterations of beta -adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta 1.

S. Rosenkranz, M. Flesch, K. Amann, C. Haeuseler, H. Kilter, U. Seeland, K.-D. Schluter, and M. Bohm (2002)
Am J Physiol Heart Circ Physiol 283, H1253-H1262
 |  Abstract »  |  Full Text »  |  PDF »

Autonomic function in mice lacking {alpha}5 neuronal nicotinic acetylcholine receptor subunit.

N. Wang, A. Orr-Urtreger, J. Chapman, R. Rabinowitz, R. Nachman, and A. D Korczyn (2002)
J. Physiol. 542, 347-354
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol 3-Kinase Functionally Compartmentalizes the Concurrent Gs Signaling During {beta}2-Adrenergic Stimulation.

S.-H. Jo, V. Leblais, P. H. Wang, M. T. Crow, and R.-P. Xiao (2002)
Circ. Res. 91, 46-53
 |  Abstract »  |  Full Text »  |  PDF »

Autonomic control of blood pressure in mice: basic physiology and effects of genetic modification.

B. J. A. Janssen and J. F. M. Smits (2002)
Am J Physiol Regulatory Integrative Comp Physiol 282, R1545-R1564
 |  Abstract »  |  Full Text »  |  PDF »

Myocyte Redistribution of GRK2 and GRK5 in Hypertensive, Heart-Failure-Prone Rats.

X. P. Yi, A. M. Gerdes, and F. Li (2002)
Hypertension 39, 1058-1063
 |  Abstract »  |  Full Text »  |  PDF »

Adenoviral gene transfer to the heart during cardiopulmonary bypass: effect of myocardial protection technique on transgene expression.

J.M. Jones, K.H. Wilson, W.J. Koch, and C.A. Milano (2002)
Eur. J. Cardiothorac. Surg. 21, 847-852
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic and knockout mouse models of atrial arrhythmias.

J. E. Olgin and S. Verheule (2002)
Cardiovasc Res 54, 280-286
 |  Abstract »  |  Full Text »  |  PDF »

Vascular-Targeted Overexpression of G Protein-Coupled Receptor Kinase-2 in Transgenic Mice Attenuates beta -Adrenergic Receptor Signaling and Increases Resting Blood Pressure.

A. D. Eckhart, T. Ozaki, H. Tevaearai, H. A. Rockman, and W. J. Koch (2002)
Mol. Pharmacol. 61, 749-758
 |  Abstract »  |  Full Text »  |  PDF »

Impaired parasympathetic heart rate control in mice with a reduction of functional G protein beta gamma -subunits.

J. Gehrmann, M. Meister, C. T. Maguire, D. C. Martins, P. E. Hammer, E. J. Neer, C. I. Berul, and U. Mende (2002)
Am J Physiol Heart Circ Physiol 282, H445-H456
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G-Protein-coupled Receptor Function in Heart Failure.

S.V. NAGA PRASAD, J. NIENABER, and H.A. ROCKMAN (2002)
Cold Spring Harb Symp Quant Biol 67, 439-444
 |  Abstract »  |  PDF »

Myocardial distribution and regulation of GRK and beta -arrestin isoforms in congestive heart failure in rats.

L. E. Vinge, E. Oie, Y. Andersson, H. K. Grogaard, G. O. Andersen, and H. Attramadal (2001)
Am J Physiol Heart Circ Physiol 281, H2490-H2499
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Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase.

R. S. Ostrom, C. Gregorian, R. M. Drenan, Y. Xiang, J. W. Regan, and P. A. Insel (2001)
J. Biol. Chem. 276, 42063-42069
 |  Abstract »  |  Full Text »  |  PDF »

Ventricular Dysfunction After Cardioplegic Arrest Is Improved After Myocardial Gene Transfer of a {beta}-Adrenergic Receptor Kinase Inhibitor.

H. T. Tevaearai, A. D. Eckhart, K. F. Shotwell, K. Wilson, and W. J. Koch (2001)
Circulation 104, 2069-2074
 |  Abstract »  |  Full Text »  |  PDF »

Transgenic Studies of Cardiac Adrenergic Receptor Regulation.

A. D. Eckhart and W. J. Koch (2001)
J. Pharmacol. Exp. Ther. 299, 1-5
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Prospective crossover comparison of carvedilol and metoprolol in patients with chronic heart failure.

C. Maack, T. Elter, G. Nickenig, K. LaRosee, M. Crivaro, A. Stablein, H. Wuttke, and M. Bohm (2001)
J. Am. Coll. Cardiol. 38, 939-946
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of myocardial {beta}ARK1 expression in catecholamine-induced cardiac hypertrophy in transgenic mice overexpressing {alpha}1B-adrenergic receptors.

G. Iaccarino, J. R. Keys, A. Rapacciuolo, K. F. Shotwell, R. J. Lefkowitz, H. A. Rockman, and W. J. Koch (2001)
J. Am. Coll. Cardiol. 38, 534-540
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of neutral endopeptidase exacerbates intestinal inflammation induced by Clostridium difficile toxin A.

K. S. Kirkwood, N. W. Bunnett, J. Maa, I. Castagliolo, B. Liu, N. Gerard, J. Zacks, C. Pothoulakis, and E. F. Grady (2001)
Am J Physiol Gastrointest Liver Physiol 281, G544-G551
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac {beta}ARK1 Upregulation Induced by Chronic Salt Deprivation in Rats.

G. Iaccarino, E. Barbato, E. Cipolleta, A. Esposito, A. Fiorillo, W. J. Koch, and B. Trimarco (2001)
Hypertension 38, 255-260
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac Gene Delivery With Cardiopulmonary Bypass.

M. J. Davidson, J. M. Jones, S. M. Emani, K. H. Wilson, J. Jaggers, W. J. Koch, and C. A. Milano (2001)
Circulation 104, 131-133
 |  Abstract »  |  Full Text »  |  PDF »

Sympathoadrenergic mechanisms in functional regulation and development of cardiac hypertrophy and failure: findings from genetically engineered mice.

X.-J. Du (2001)
Cardiovasc Res 50, 443-453
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Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice.

M. Palmen, M.J.A.P. Daemen, R. Bronsaer, W.R.M. Dassen, H.R. Zandbergen, M. Kockx, J.F.M. Smits, R. van der Zee, and P.A. Doevendans (2001)
Cardiovasc Res 50, 516-524
 |  Abstract »  |  Full Text »  |  PDF »

Concomitant Increase of G Protein-Coupled Receptor Kinase Activity and Uncoupling of {beta}-Adrenergic Receptors in Rat Myometrium at Parturition.

V. Simon, S. Mhaouty-Kodja, C. Legrand, and J. Cohen-Tannoudji (2001)
Endocrinology 142, 1899-1905
 |  Abstract »  |  Full Text »

Stimulating G Protein-Coupled Receptors : Cure or Cause for Heart Failure?.

D. E. Vatner (2001)
Circ. Res. 88, 645-647
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Myocardial function in hearts with transgenic overexpression of the G protein-coupled receptor kinase 5.

E. P. Chen, H. B. Bittner, S. A. Akhter, W. J. Koch, and R. D. Davis (2001)
Ann. Thorac. Surg. 71, 1320-1324
 |  Abstract »  |  Full Text »  |  PDF »

To Cre or Not To Cre : The Next Generation of Mouse Models of Human Cardiac Diseases.

K. R. Chien (2001)
Circ. Res. 88, 546-549
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Cardiac Overexpression of a Gq Inhibitor Blocks Induction of Extracellular Signal-Regulated Kinase and c-Jun NH2-Terminal Kinase Activity in In Vivo Pressure Overload.

G. Esposito, S. V. N. Prasad, A. Rapacciuolo, L. Mao, W. J. Koch, and H. A. Rockman (2001)
Circulation 103, 1453-1458
 |  Abstract »  |  Full Text »  |  PDF »

Effect of Hypothyroidism on G Protein-Coupled Receptor Kinase 2 Expression Levels in Rat Liver, Lung, and Heart.

P. Penela, M. Barradas, M. Alvarez-Dolado, A. Munoz, and F. Mayor Jr. (2001)
Endocrinology 142, 987-991
 |  Abstract »  |  Full Text »  |  PDF »

Evolving Concepts in G Protein-Coupled Receptor Endocytosis: The Role in Receptor Desensitization and Signaling.

S. S. G. Ferguson (2001)
Pharmacol. Rev. 53, 1-24
 |  Abstract »  |  Full Text »  |  PDF »

Upregulation of G protein-linked receptor kinases with advancing age in rat aorta.

W. E. Schutzer, J. F. Reed, M. Bliziotes, and S. L. Mader (2001)
Am J Physiol Regulatory Integrative Comp Physiol 280, R897-R903
 |  Abstract »  |  Full Text »  |  PDF »

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