Science 2 June 1995: Vol. 268. no. 5215, pp. 1347 - 1349 DOI: 10.1126/science.7539157

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Articles

Membrane-Bound Fas Ligand Requires RIP1 for Efficient Activation of Caspase-8 within the Death-Inducing Signaling Complex.

M. J. Morgan, Y.-S. Kim, and Z.-g. Liu (2009)
J. Immunol. 183, 3278-3284
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon.

S. Saint Fleur, A. Hoshino, K. Kondo, T. Egawa, and H. Fujii (2009)
Blood 114, 1355-1365
 |  Abstract »  |  Full Text »  |  PDF »

The -670G>A polymorphism in the FAS gene promoter region influences the susceptibility to systemic sclerosis.

V Liakouli, M Manetti, A Pacini, B Tolusso, C Fatini, A Toscano, P Cipriani, S Guiducci, L Bazzichi, V Codullo, et al. (2009)
Ann Rheum Dis 68, 584-590
 |  Abstract »  |  Full Text »  |  PDF »

FAS-L, IL-10, and double-negative CD4-CD8- TCR {alpha}/{beta}+ T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function.

A. Magerus-Chatinet, M.-C. Stolzenberg, M. S. Loffredo, B. Neven, C. Schaffner, N. Ducrot, P. D. Arkwright, B. Bader-Meunier, J. Barbot, S. Blanche, et al. (2009)
Blood 113, 3027-3030
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FAS Promoter Polymorphism: Outcome of Childhood Acute Myeloid Leukemia. A Children's Oncology Group Report.

P. A. Mehta, R. B. Gerbing, T. A. Alonzo, J. S. Elliott, T. A. Zamzow, M. Combs, E. Stover, J. A. Ross, J. P. Perentesis, S. Meschinchi, et al. (2008)
Clin. Cancer Res. 14, 7896-7899
 |  Abstract »  |  Full Text »  |  PDF »

Induction of CD4+ T-cell anergy and apoptosis by activated human B cells.

T. Tretter, R. K. C. Venigalla, V. Eckstein, R. Saffrich, S. Sertel, A. D. Ho, and H.-M. Lorenz (2008)
Blood 112, 4555-4564
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Fas Expression on Antigen-Specific T Cells Has Costimulatory, Helper, and Down-Regulatory Functions In Vivo for Cytotoxic T Cell Responses but Not for T Cell-Dependent B Cell Responses.

I. Puliaeva, R. Puliaev, A. Shustov, M. Haas, and C. S. Via (2008)
J. Immunol. 181, 5912-5929
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The role of DC-STAMP in maintenance of immune tolerance through regulation of dendritic cell function.

Y. Sawatani, T. Miyamoto, S. Nagai, M. Maruya, J. Imai, K. Miyamoto, N. Fujita, K. Ninomiya, T. Suzuki, R. Iwasaki, et al. (2008)
Int. Immunol. 20, 1259-1268
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Cell cycle regulation by FasL and Apo2L/TRAIL in human T-cell blasts. Implications for autoimmune lymphoproliferative syndromes.

A. Bosque, J. I. Aguilo, M. del Rey, E. Paz-Artal, L. M. Allende, J. Naval, and A. Anel (2008)
J. Leukoc. Biol. 84, 488-498
 |  Abstract »  |  Full Text »  |  PDF »

Human TCR {alpha}/{beta}+ CD4-CD8- Double-Negative T Cells in Patients with Autoimmune Lymphoproliferative Syndrome Express Restricted V{beta} TCR Diversity and Are Clonally Related to CD8+ T Cells.

A. Bristeau-Leprince, V. Mateo, A. Lim, A. Magerus-Chatinet, E. Solary, A. Fischer, F. Rieux-Laucat, and M.-L. Gougeon (2008)
J. Immunol. 181, 440-448
 |  Abstract »  |  Full Text »  |  PDF »

Stabilized {beta}-Catenin Potentiates Fas-Mediated T Cell Apoptosis.

Z. Huang, R. Wang, H. Xie, W. Shang, S. Manicassamy, and Z. Sun (2008)
J. Immunol. 180, 6586-6592
 |  Abstract »  |  Full Text »  |  PDF »

Resistance to FasL and tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in Sezary syndrome T-cells associated with impaired death receptor and FLICE-inhibitory protein expression.

E. Contassot, K. Kerl, S. Roques, R. Shane, O. Gaide, M. Dupuis, A. H. Rook, and L. E. French (2008)
Blood 111, 4780-4787
 |  Abstract »  |  Full Text »  |  PDF »

Perforin-dependent apoptosis functionally compensates Fas deficiency in activation-induced cell death of human T lymphocytes.

V. Mateo, M. Menager, G. de Saint-Basile, M.-C. Stolzenberg, B. Roquelaure, N. Andre, B. Florkin, F. le Deist, C. Picard, A. Fischer, et al. (2007)
Blood 110, 4285-4292
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Differential activation of the death receptor pathway in human target cells induced by cytotoxic T lymphocytes showing different kinetics of killing.

J. F. de Vries, P. A. von dem Borne, S. A.P. van Luxemburg-Heijs, M. H.M. Heemskerk, R. Willemze, J.H. F. Falkenburg, and R. M.Y. Barge (2007)
Haematologica 92, 1671-1678
 |  Abstract »  |  Full Text »  |  PDF »

CCL2 Inhibits the Apoptosis Program Induced by Growth Factor Deprivation, Rescuing Functional T Cells.

E. Diaz-Guerra, R. Vernal, M. J. del Prete, A. Silva, and J. A. Garcia-Sanz (2007)
J. Immunol. 179, 7352-7357
 |  Abstract »  |  Full Text »  |  PDF »

Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer risk.

K. D. Crew, M. D. Gammon, M. B. Terry, F. F. Zhang, M. Agrawal, S. M. Eng, S. K. Sagiv, S. L. Teitelbaum, A. I. Neugut, and R. M. Santella (2007)
Carcinogenesis 28, 2548-2551
 |  Abstract »  |  Full Text »  |  PDF »

CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance.

M. Herve, I. Isnardi, Y.-s. Ng, J. B. Bussel, H. D. Ochs, C. Cunningham-Rundles, and E. Meffre (2007)
J. Exp. Med. 204, 1583-1593
 |  Abstract »  |  Full Text »  |  PDF »

Crosstalk between RANKL and Fas signaling in dendritic cells controls immune tolerance.

T. Izawa, N. Ishimaru, K. Moriyama, M. Kohashi, R. Arakaki, and Y. Hayashi (2007)
Blood 110, 242-250
 |  Abstract »  |  Full Text »  |  PDF »

PI3K/AKT/mTOR hypersignaling in autoimmune lymphoproliferative disease engendered by the epistatic interplay of Sle1b and FASlpr.

C. Xie, R. Patel, T. Wu, J. Zhu, T. Henry, M. Bhaskarabhatla, R. Samudrala, K. Tus, Y. Gong, H. Zhou, et al. (2007)
Int. Immunol. 19, 509-522
 |  Abstract »  |  Full Text »  |  PDF »

CD95-Mediated control of anti-citrullinated protein/peptides antibodies (ACPA)-producing plasma cells occurring in rheumatoid arthritis inflamed joints.

B. Rodriguez-Bayona, J. J. Perez-Venegas, C. Rodriguez, and J. A. Brieva (2007)
Rheumatology 46, 612-616
 |  Abstract »  |  Full Text »  |  PDF »

The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling.

A. Bosque, J. I. Aguilo, M. A. Alava, E. Paz-Artal, J. Naval, L. M. Allende, and A. Anel (2007)
Blood 109, 1627-1635
 |  Abstract »  |  Full Text »  |  PDF »

Dominant-Negative Fas Mutation Is Reversed by Down-expression of c-FLIP.

M. Beneteau, S. Daburon, J.-F. Moreau, J.-L. Taupin, and P. Legembre (2007)
Cancer Res. 67, 108-115
 |  Abstract »  |  Full Text »  |  PDF »

The Critical Role of Protein Kinase C-{theta} in Fas/Fas Ligand-Mediated Apoptosis.

S. Manicassamy and Z. Sun (2007)
J. Immunol. 178, 312-319
 |  Abstract »  |  Full Text »  |  PDF »

Familial inflammatory dilated cardiomyopathy.

I. Portig, A. Wilke, M. Freyland, M.-J. Wolf, A. Richter, V. Ruppert, S. Pankuweit, and B. Maisch (2006)
Eur J Heart Fail 8, 816-825
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the CD95 ligand gene in 20 children with autoimmune lymphoproliferative syndrome (ALPS)..

E. Pauly, B. Fritzsching, M. Dechant, J. Fellenberg, C. G. Scheuerpflug, K.-M. Debatin, E. Paz-Artal, M. Del-Rey, S. Calleja, P. Morales, et al. (2006)
Blood 108, 3622-3623
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Variations of the perforin gene in patients with autoimmunity/lymphoproliferation and defective Fas function.

R. Clementi, A. Chiocchetti, G. Cappellano, E. Cerutti, M. Ferretti, E. Orilieri, I. Dianzani, M. Ferrarini, M. Bregni, C. Danesino, et al. (2006)
Blood 108, 3079-3084
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Mice, humans and haplotypes--the hunt for disease genes in SLE.

R. J. Rigby, M. M. A. Fernando, and T. J. Vyse (2006)
Rheumatology 45, 1062-1067
 |  Abstract »  |  Full Text »  |  PDF »

A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome.

M. Del-Rey, J. Ruiz-Contreras, A. Bosque, S. Calleja, J. Gomez-Rial, E. Roldan, P. Morales, A. Serrano, A. Anel, E. Paz-Artal, et al. (2006)
Blood 108, 1306-1312
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Autoreactive MZ and B-1 B-cell activation by Faslpr is coincident with an increased frequency of apoptotic lymphocytes and a defect in macrophage clearance.

Y. Qian, K. L. Conway, X. Lu, H. M. Seitz, G. K. Matsushima, and S. H. Clarke (2006)
Blood 108, 974-982
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Active Transcription of the Human FASL/CD95L/TNFSF6 Promoter Region in T Lymphocytes Involves Chromatin Remodeling: ROLE OF DNA METHYLATION AND PROTEIN ACETYLATION SUGGEST DISTINCT MECHANISMS OF TRANSCRIPTIONAL REPRESSION.

R. Castellano, B. Vire, M. Pion, V. Quivy, D. Olive, I. Hirsch, C. Van Lint, and Y. Collette (2006)
J. Biol. Chem. 281, 14719-14728
 |  Abstract »  |  Full Text »  |  PDF »

EBV latency III immortalization program sensitizes B cells to induction of CD95-mediated apoptosis via LMP1: role of NF-{kappa}B, STAT1, and p53.

C. Le Clorennec, I. Youlyouz-Marfak, E. Adriaenssens, J. Coll, G. W. Bornkamm, and J. Feuillard (2006)
Blood 107, 2070-2078
 |  Abstract »  |  Full Text »  |  PDF »

Pyrimethamine (2,4-Diamino-5-p-chlorophenyl-6-ethylpyrimidine) Induces Apoptosis of Freshly Isolated Human T Lymphocytes, Bypassing CD95/Fas Molecule but Involving Its Intrinsic Pathway.

M. Pierdominici, A. M. Giammarioli, L. Gambardella, M. De Felice, I. Quinti, M. Iacobini, M. Carbonari, W. Malorni, and A. Giovannetti (2005)
J. Pharmacol. Exp. Ther. 315, 1046-1057
 |  Abstract »  |  Full Text »  |  PDF »

Death Ligand Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Inhibits Experimental Autoimmune Thyroiditis.

S. H. Wang, Z. Cao, J. M. Wolf, M. Van Antwerp, and J. R. Baker Jr. (2005)
Endocrinology 146, 4721-4726
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B Couples Protein Kinase B/Akt Signaling to Distinct Survival Pathways and the Regulation of Lymphocyte Homeostasis In Vivo.

R. G. Jones, S. D. Saibil, J. M. Pun, A. R. Elford, M. Bonnard, M. Pellegrini, S. Arya, M. E. Parsons, C. M. Krawczyk, S. Gerondakis, et al. (2005)
J. Immunol. 175, 3790-3799
 |  Abstract »  |  Full Text »  |  PDF »

Haploinsufficiency, rather than the effect of an excessive production of soluble CD95 (CD95{Delta}TM), is the basis for ALPS Ia in a family with duplicated 3' splice site AG in CD95 intron 5 on one allele.

J. Roesler, J.-M. Izquierdo, M. Ryser, A. Rosen-Wolff, M. Gahr, J. Valcarcel, M. J. Lenardo, and L. Zheng (2005)
Blood 106, 1652-1659
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Human cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis.

G. Dotti, B. Savoldo, M. Pule, K. C. Straathof, E. Biagi, E. Yvon, S. Vigouroux, M. K. Brenner, and C. M. Rooney (2005)
Blood 105, 4677-4684
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-8 Activity Prevents Type 2 Cytokine Responses and Is Required for Protective T Cell-Mediated Immunity against Trypanosoma cruzi Infection.

E. M. Silva, L. V. C. Guillermo, F. L. Ribeiro-Gomes, J. De Meis, R. M. S. Pereira, Z. Wu, T. C. Calegari-Silva, S. H. Seabra, U. G. Lopes, R. M. Siegel, et al. (2005)
J. Immunol. 174, 6314-6321
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Trans-Activator of Transcription Substitutes for Oxidative Signaling in Activation-Induced T Cell Death.

K. Gulow, M. Kaminski, K. Darvas, D. Suss, M. Li-Weber, and P. H. Krammer (2005)
J. Immunol. 174, 5249-5260
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Unmasking Evans syndrome: T-cell phenotype and apoptotic response reveal autoimmune lymphoproliferative syndrome (ALPS).

D. T. Teachey, C. S. Manno, K. M. Axsom, T. Andrews, J. K. Choi, B. H. Greenbaum, J. M. McMann, K. E. Sullivan, S. F. Travis, and S. A. Grupp (2005)
Blood 105, 2443-2448
 |  Abstract »  |  Full Text »  |  PDF »

Somatic Mutations -- Not Just for Cancer Anymore.

J. M. Puck and S. E. Straus (2004)
N. Engl. J. Med. 351, 1388-1390
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Autoimmune Lymphoproliferative Syndrome with Somatic Fas Mutations.

E. Holzelova, C. Vonarbourg, M.-C. Stolzenberg, P. D. Arkwright, F. Selz, A.-M. Prieur, S. Blanche, J. Bartunkova, E. Vilmer, A. Fischer, et al. (2004)
N. Engl. J. Med. 351, 1409-1418
 |  Abstract »  |  Full Text »  |  PDF »

Inherited Perforin and Fas Mutations in a Patient with Autoimmune Lymphoproliferative Syndrome and Lymphoma.

R. Clementi, L. Dagna, U. Dianzani, L. Dupre, I. Dianzani, M. Ponzoni, A. Cometa, A. Chiocchetti, M. G. Sabbadini, C. Rugarli, et al. (2004)
N. Engl. J. Med. 351, 1419-1424
 |  Abstract »  |  Full Text »  |  PDF »

T Cell-specific Ablation of Fas Leads to Fas Ligand-mediated Lymphocyte Depletion and Inflammatory Pulmonary Fibrosis.

Z. Hao, B. Hampel, H. Yagita, and K. Rajewsky (2004)
J. Exp. Med. 199, 1355-1365
 |  Abstract »  |  Full Text »  |  PDF »

Changes in sensitivity of peripheral lymphocytes of autoimmune gld mice to FasL-mediated apoptosis reveal a mechanism for the preferential deletion of CD4-CD8-B220+ T cells.

S. Xiao, X. Zhang, K. K. Mann, S. Jodo, L. Li, W. N. Jarjour, A. Marshak-Rothstein, D. H. Sherr, and S.-T. Ju (2004)
Int. Immunol. 16, 759-766
 |  Abstract »  |  Full Text »  |  PDF »

Kostmann syndrome: severe congenital neutropenia associated with defective expression of Bcl-2, constitutive mitochondrial release of cytochrome c, and excessive apoptosis of myeloid progenitor cells.

G. Carlsson, A. A. G. Aprikyan, R. Tehranchi, D. C. Dale, A. Porwit, E. Hellstrom-Lindberg, J. Palmblad, J.-I. Henter, and B. Fadeel (2004)
Blood 103, 3355-3361
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Clearance of Apoptotic Cells Promotes Synergy between Atherogenesis and Autoimmune Disease.

T. Aprahamian, I. Rifkin, R. Bonegio, B. Hugel, J.-M. Freyssinet, K. Sato, J. J. Castellot Jr., and K. Walsh (2004)
J. Exp. Med. 199, 1121-1131
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis a relevant therapeutic target in rheumatoid arthritis?.

M. D. Smith and J. G. Walker (2004)
Rheumatology 43, 405-407
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FAS (CD95) Mutations Are Rare in Gastric MALT Lymphoma but Occur More Frequently in Primary Gastric Diffuse Large B-Cell Lymphoma.

S. Wohlfart, D. Sebinger, P. Gruber, J. Buch, D. Polgar, G. Krupitza, M. Rosner, M. Hengstschlager, M. Raderer, A. Chott, et al. (2004)
Am. J. Pathol. 164, 1081-1089
 |  Abstract »  |  Full Text »  |  PDF »

Complete Loss of Fas Ligand Gene Causes Massive Lymphoproliferation and Early Death, Indicating a Residual Activity of gld Allele.

S. Karray, C. Kress, S. Cuvellier, C. Hue-Beauvais, D. Damotte, C. Babinet, and M. Levi-Strauss (2004)
J. Immunol. 172, 2118-2125
 |  Abstract »  |  Full Text »  |  PDF »

High levels of osteopontin associated with polymorphisms in its gene are a risk factor for development of autoimmunity/lymphoproliferation.

A. Chiocchetti, M. Indelicato, T. Bensi, R. Mesturini, M. Giordano, S. Sametti, L. Castelli, F. Bottarel, M. C. Mazzarino, L. Garbarini, et al. (2004)
Blood 103, 1376-1382
 |  Abstract »  |  Full Text »  |  PDF »

Expression, Localization, and Functional Activity of TL1A, a Novel Th1-Polarizing Cytokine in Inflammatory Bowel Disease.

G. Bamias, C. Martin III, M. Marini, S. Hoang, M. Mishina, W. G. Ross, M. A. Sachedina, C. M. Friel, J. Mize, S. J. Bickston, et al. (2003)
J. Immunol. 171, 4868-4874
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms for T-cell selective cytotoxicity of arabinosylguanine.

C. O. Rodriguez Jr, C. M. Stellrecht, and V. Gandhi (2003)
Blood 102, 1842-1848
 |  Abstract »  |  Full Text »  |  PDF »

Functional FAS Promoter Polymorphisms Are Associated with Increased Risk of Acute Myeloid Leukemia.

K. Sibley, S. Rollinson, J. M. Allan, A. G. Smith, G. R. Law, P. L. Roddam, C. F. Skibola, M. T. Smith, and G. J. Morgan (2003)
Cancer Res. 63, 4327-4330
 |  Abstract »  |  Full Text »  |  PDF »

Human reconstituting hematopoietic stem cells up-regulate Fas expression upon active cell cycling but remain resistant to Fas-induced suppression.

I. Dybedal, L. Yang, D. Bryder, I. Aastrand-Grundstrom, K. Leandersson, and S. E. W. Jacobsen (2003)
Blood 102, 118-126
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B Is Required for Surface Ig-Induced Fas Resistance in B Cells.

B. R. Schram and T. L. Rothstein (2003)
J. Immunol. 170, 3118-3124
 |  Abstract »  |  Full Text »  |  PDF »

Compartmentalized megakaryocyte death generates functional platelets committed to caspase-independent death.

M. C.H. Clarke, J. Savill, D. B. Jones, B. S. Noble, and S. B. Brown (2003)
J. Cell Biol. 160, 577-587
 |  Abstract »  |  Full Text »  |  PDF »

Essential Roles of Perforin in Antigen-Specific Cytotoxicity Mediated by Human CD4+ T Lymphocytes: Analysis Using the Combination of Hereditary Perforin-Deficient Effector Cells and Fas-Deficient Target Cells.

F. Yanai, E. Ishii, K. Kojima, A. Hasegawa, T. Azuma, S. Hirose, N. Suga, A. Mitsudome, M. Zaitsu, Y. Ishida, et al. (2003)
J. Immunol. 170, 2205-2213
 |  Abstract »  |  Full Text »  |  PDF »

Pathological lymphocyte activation by defective clearance of self-ligands in systemic lupus erythematosus.

K. Yasutomo (2003)
Rheumatology 42, 214-222
 |  Abstract »  |  Full Text »  |  PDF »

Role of Defective Apoptosis in Type 1 Diabetes and Other Autoimmune Diseases.

T. Hayashi and D. L. Faustman (2003)
Recent Prog. Horm. Res. 58, 131-153
 |  Abstract »  |  Full Text »  |  PDF »

LF 15-0195 immunosuppressive agent enhances activation-induced T-cell death by facilitating caspase-8 and caspase-10 activation at the DISC level.

P. Ducoroy, O. Micheau, S. Perruche, L. Dubrez-Daloz, D. de Fornel, P. Dutartre, P. Saas, and E. Solary (2003)
Blood 101, 194-201
 |  Abstract »  |  Full Text »  |  PDF »

Frequent Deletion of Fas Gene Sequences Encoding Death and Transmembrane Domains in Nasal Natural Killer/T-Cell Lymphoma.

L. Shen, A. C. T. Liang, L. Lu, W. Y. Au, Y.-L. Kwong, R. H. S. Liang, and G. Srivastava (2002)
Am. J. Pathol. 161, 2123-2131
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Dissection of SLE: SLE1 and FAS Impact Alternate Pathways Leading to Lymphoproliferative Autoimmunity.

X. Shi, C. Xie, D. Kreska, J. A. Richardson, and C. Mohan (2002)
J. Exp. Med. 196, 281-292
 |  Abstract »  |  Full Text »  |  PDF »

CD28-dependent Activation of Protein Kinase B/Akt Blocks Fas-mediated Apoptosis by Preventing Death-inducing Signaling Complex Assembly.

R. G. Jones, A. R. Elford, M. J. Parsons, L. Wu, C. M. Krawczyk, W.-C. Yeh, R. Hakem, R. Rottapel, J. R. Woodgett, and P. S. Ohashi (2002)
J. Exp. Med. 196, 335-348
 |  Abstract »  |  Full Text »  |  PDF »

The Caspase 8 Inhibitor c-FLIPL Modulates T-Cell Receptor-Induced Proliferation but Not Activation-Induced Cell Death of Lymphocytes.

S. M. A. Lens, T. Kataoka, K. A. Fortner, A. Tinel, I. Ferrero, R. H. MacDonald, M. Hahne, F. Beermann, A. Attinger, H.-A. Orbea, et al. (2002)
Mol. Cell. Biol. 22, 5419-5433
 |  Abstract »  |  Full Text »  |  PDF »

Blockade of Fas-dependent apoptosis by soluble Fas in LGL leukemia.

J. H. Liu, S. Wei, T. Lamy, Y. Li, P.K. Epling-Burnette, J. Y. Djeu, and T. P. Loughran Jr (2002)
Blood 100, 1449-1453
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Fas/CD95 Surface Expression in Highly Proliferative Leukemic Cell Lines Correlates with Loss of CtBP/BARS and Redirection of the Protein toward Giant Lysosomal Structures.

I. Monleon, M. Iturralde, M. J. Martinez-Lorenzo, L. Monteagudo, P. Lasierra, L. Larrad, A. Pineiro, J. Naval, M. A. Alava, and A. Anel (2002)
Cell Growth Differ. 13, 315-324
 |  Abstract »  |  Full Text »

Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas.

M. S. Shin, H. S. Kim, C. S. Kang, W. S. Park, S. Y. Kim, S. N. Lee, J. H. Lee, J. Y. Park, J. J. Jang, C. W. Kim, et al. (2002)
Blood 99, 4094-4099
 |  Abstract »  |  Full Text »  |  PDF »

The Caenorhabditis elegans mucolipin-like gene cup-5 is essential for viability and regulates lysosomes in multiple cell types.

B. M. Hersh, E. Hartwieg, and H. R. Horvitz (2002)
PNAS 99, 4355-4360
 |  Abstract »  |  Full Text »  |  PDF »

BCR Engagement Induces Fas Resistance in Primary B Cells in the Absence of Functional Bruton's Tyrosine Kinase.

J. R. Tumang, R. S. Negm, L. A. Solt, T. J. Schneider, T. P. Colarusso, W. D. Hastings, R. T. Woodland, and T. L. Rothstein (2002)
J. Immunol. 168, 2712-2719
 |  Abstract »  |  Full Text »  |  PDF »

Defective Fas Ligand Expression and Activation-Induced Cell Death in the Absence of IL-2-Inducible T Cell Kinase.

A. T. Miller and L. J. Berg (2002)
J. Immunol. 168, 2163-2172
 |  Abstract »  |  Full Text »  |  PDF »

Resistance to Fas-Mediated Apoptosis in EBV-Infected B Cell Lymphomas Is Due to Defects in the Proximal Fas Signaling Pathway.

A. L. Snow, L. J. Chen, R. R. Nepomuceno, S. M. Krams, C. O. Esquivel, and O. M. Martinez (2001)
J. Immunol. 167, 5404-5411
 |  Abstract »  |  Full Text »  |  PDF »

Cellular stress response and apoptosis in cancer therapy.

I. Herr and K.-M. Debatin (2001)
Blood 98, 2603-2614
 |  Abstract »  |  Full Text »  |  PDF »

Immunophenotypic profiles in families with autoimmune lymphoproliferative syndrome.

J. J. H. Bleesing, M. R. Brown, S. E. Straus, J. K. Dale, R. M. Siegel, M. Johnson, M. J. Lenardo, J. M. Puck, and T. A. Fleisher (2001)
Blood 98, 2466-2473
 |  Abstract »  |  Full Text »  |  PDF »

Multiwavelength anomalous diffraction analysis at the M absorption edges of uranium.

Y. Liu, C. M. Ogata, and W. A. Hendrickson (2001)
PNAS
 |  Abstract »  |  Full Text »  |  PDF »

Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases.

S.-H. Shiu and A. B. Bleecker (2001)
PNAS
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Receptor Cross-Linking Triggers a Caspase-8- Dependent Apoptotic Pathway That Is Independent of the Death Effector Domain of Fas-Associated Death Domain Protein.

L. Besnault, N. Schrantz, M. T. Auffredou, G. Leca, M. F. Bourgeade, and A. Vazquez (2001)
J. Immunol. 167, 733-740
 |  Abstract »  |  Full Text »  |  PDF »

Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease.

J Itoh, C de la Motte, S A Strong, A D Levine, and C Fiocchi (2001)
Gut 49, 35-41
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Active Protein Kinase B in T Cells Perturbs Both T and B Cell Homeostasis and Promotes Inflammation.

M. J. Parsons, R. G. Jones, M.-S. Tsao, B. Odermatt, P. S. Ohashi, and J. R. Woodgett (2001)
J. Immunol. 167, 42-48
 |  Abstract »  |  Full Text »  |  PDF »

The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis.

S. E. Straus, E. S. Jaffe, J. M. Puck, J. K. Dale, K. B. Elkon, A. Rosen-Wolff, A. M. J. Peters, M. C. Sneller, C. W. Hallahan, J. Wang, et al. (2001)
Blood 98, 194-200
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Coreceptor Allows Survival of Chronically Stimulated Double-Negative {alpha}/{beta} T Cells: Implications for Autoimmunity.

A. R. A. Hamad, A. Srikrishnan, P. Mirmonsef, C. P.M. Broeren, C. H. June, D. Pardoll, and J. P. Schneck (2001)
J. Exp. Med. 193, 1113-1122
 |  Abstract »  |  Full Text »  |  PDF »

Red blood cells inhibit activation-induced cell death and oxidative stress in human peripheral blood T lymphocytes.

A. M. Fonseca, G. Porto, K. Uchida, and F. A. Arosa (2001)
Blood 97, 3152-3160
 |  Abstract »  |  Full Text »  |  PDF »

Increases in circulating and lymphoid tissue interleukin-10 in autoimmune lymphoproliferative syndrome are associated with disease expression.

U. Lopatin, X. Yao, R. K. Williams, J. J. H. Bleesing, J. K. Dale, D. Wong, J. Teruya-Feldstein, S. Fritz, M. R. Morrow, I. Fuss, et al. (2001)
Blood 97, 3161-3170
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Fas Signaling Pathway Is Involved in Defective T Cell Apoptosis in Autoimmune Murine Arthritis.

J. Zhang, T. Bardos, K. Mikecz, A. Finnegan, and T. T. Glant (2001)
J. Immunol. 166, 4981-4986
 |  Abstract »  |  Full Text »  |  PDF »

Future Development of Lymphoproliferative Disorders in Patients with Autoimmune Hemolytic Anemia.

S. Sallah, J. Y. Wan, and L. R. Hanrahan (2001)
Clin. Cancer Res. 7, 791-794
 |  Abstract »  |  Full Text »

Tolerance and Autoimmunity.

T. Kamradt and N. A. Mitchison (2001)
N. Engl. J. Med. 344, 655-664
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Defective Function of Fas in Patients With Type 1 Diabetes Associated With Other Autoimmune Diseases.

S. DeFranco, S. Bonissoni, F. Cerutti, G. Bona, F. Bottarel, F. Cadario, A. Brusco, G. Loffredo, I. Rabbone, A. Corrias, et al. (2001)
Diabetes 50, 483-488
 |  Abstract »  |  Full Text »

Fas/Fas Ligand Pathway, Apoptosis, and Clonal Anergy Involved in Systemic Acetylcholine Receptor T Cell Epitope Tolerance.

C. Deng, E. Goluszko, and P. Christadoss (2001)
J. Immunol. 166, 3458-3467
 |  Abstract »  |  Full Text »  |  PDF »

No constitutive defect in phagocytosis of apoptotic cells by resident peritoneal macrophages from pre-morbid lupus mice.

R Licht, C W. Jacobs, W J. Tax, and J H. Berden (2001)
Lupus 10, 102-107
 |  Abstract »  |  PDF »

Frequent Mutations of Fas Gene in Thyroid Lymphoma.

T. Takakuwa, Z. Dong, H. Takayama, F. Matsuzuka, S. Nagata, and K. Aozasa (2001)
Cancer Res. 61, 1382-1385
 |  Abstract »  |  Full Text »

Identification of Fas-L-Expressing Apoptotic T Lymphocytes in Normal Human Peripheral Blood : In Vivo Suicide.

G. De Panfilis, A. Caruso, P. Sansoni, G. Pasolini, D. Semenza, and C. Torresani (2001)
Am. J. Pathol. 158, 387-391
 |  Abstract »  |  Full Text »  |  PDF »

The pre-ligand binding assembly domain: a potential target of inhibition of tumour necrosis factor receptor function.

F. K.-M. Chan (2000)
Ann Rheum Dis 59, i50-53
 |  Abstract »  |  Full Text »  |  PDF »

Defective T cell Fas function in patients with multiple sclerosis.

C. Comi, M. Leone, S. Bonissoni, S. DeFranco, F. Bottarel, C. Mezzatesta, A. Chiocchetti, F. Perla, F. Monaco, and U. Dianzani (2000)
Neurology 55, 921-927
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Molecular Mechanisms of Fas Resistance in Murine B Lymphoma Cells.

C. M. Mueller and D. W. Scott (2000)
J. Immunol. 165, 1854-1862
 |  Abstract »  |  Full Text »  |  PDF »

Alloreactivity and apoptosis in graft rejection and transplantation tolerance.

N. Zavazava and D. Kabelitz (2000)
J. Leukoc. Biol. 68, 167-174
 |  Abstract »  |  Full Text »

Fas Preassociation Required for Apoptosis Signaling and Dominant Inhibition by Pathogenic Mutations.

R. M. Siegel, J. K. Frederiksen, D. A. Zacharias, F. K.-M. Chan, M. Johnson, D. Lynch, R. Y. Tsien, and M. J. Lenardo (2000)
Science 288, 2354-2357
 |  Abstract »  |  Full Text »

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