Science 2 June 1995: Vol. 268. no. 5215, pp. 1343 - 1347 DOI: 10.1126/science.7761853

Prev | Table of Contents | Next

Articles

Lymph Node-Targeted Immunotherapy Mediates Potent Immunity Resulting in Regression of Isolated or Metastatic Human Papillomavirus-Transformed Tumors.

K. A. Smith, B. L. Meisenburg, V. L. Tam, R. R. Pagarigan, R. Wong, D. K. Joea, L. Lantzy, M. A. Carrillo, T. M. Gross, U. M. Malyankar, et al. (2009)
Clin. Cancer Res. 15, 6167-6176
 |  Abstract »  |  Full Text »  |  PDF »

Intralymphatic allergen administration renders specific immunotherapy faster and safer: A randomized controlled trial.

G. Senti, B. M. Prinz Vavricka, I. Erdmann, M. I. Diaz, R. Markus, S. J. McCormack, J. J. Simard, B. Wuthrich, R. Crameri, N. Graf, et al. (2008)
PNAS 105, 17908-17912
 |  Abstract »  |  Full Text »  |  PDF »

Direct Presentation of a Melanocyte-Associated Antigen in Peripheral Lymph Nodes Induces Cytotoxic CD8+ T Cells.

P. Schuler, E. Contassot, M. Irla, S. Hugues, O. Preynat-Seauve, F. Beermann, A. Donda, L.E. French, and B. Huard (2008)
Cancer Res. 68, 8410-8418
 |  Abstract »  |  Full Text »  |  PDF »

Presentation of Toxoplasma gondii Antigens via the Endogenous Major Histocompatibility Complex Class I Pathway in Nonprofessional and Professional Antigen-Presenting Cells.

F. Dzierszinski, M. Pepper, J. S. Stumhofer, D. F. LaRosa, E. H. Wilson, L. A. Turka, S. K. Halonen, C. A. Hunter, and D. S. Roos (2007)
Infect. Immun. 75, 5200-5209
 |  Abstract »  |  Full Text »  |  PDF »

A lymphocytic choriomeningitis virus glycoprotein variant that is retained in the endoplasmic reticulum efficiently cross-primes CD8+ T cell responses.

S. Freigang, B. Eschli, N. Harris, M. Geuking, K. Quirin, S. Schrempf, R. Zellweger, J. Weber, H. Hengartner, and R. M. Zinkernagel (2007)
PNAS 104, 13426-13431
 |  Abstract »  |  Full Text »  |  PDF »

Decreased Tumor Surveillance after Adoptive T-Cell Therapy.

M. Matter, V. Pavelic, D. D. Pinschewer, S. Mumprecht, B. Eschli, T. Giroglou, D. von Laer, and A. F. Ochsenbein (2007)
Cancer Res. 67, 7467-7476
 |  Abstract »  |  Full Text »  |  PDF »

Adult Human Fibroblasts Are Potent Immunoregulatory Cells and Functionally Equivalent to Mesenchymal Stem Cells.

M. A. Haniffa, X.-N. Wang, U. Holtick, M. Rae, J. D. Isaacs, A. M. Dickinson, C. M. U. Hilkens, and M. P. Collin (2007)
J. Immunol. 179, 1595-1604
 |  Abstract »  |  Full Text »  |  PDF »

Potential of Transfected Muscle Cells to Contribute to DNA Vaccine Immunogenicity.

H. Shirota, L. Petrenko, C. Hong, and D. M. Klinman (2007)
J. Immunol. 179, 329-336
 |  Abstract »  |  Full Text »  |  PDF »

Extralymphatic Tumors Prepare Draining Lymph Nodes to Invasion via a T-Cell Cross-Tolerance Process.

O. Preynat-Seauve, E. Contassot, P. Schuler, V. Piguet, L. E. French, and B. Huard (2007)
Cancer Res. 67, 5009-5016
 |  Abstract »  |  Full Text »  |  PDF »

Antigen Presentation by Nonhemopoietic Cells Amplifies Clonal Expansion of Effector CD8 T Cells in a Pathogen-Specific Manner.

S. Thomas, G. A. Kolumam, and K. Murali-Krishna (2007)
J. Immunol. 178, 5802-5811
 |  Abstract »  |  Full Text »  |  PDF »

Imatinib mesylate selectively impairs expansion of memory cytotoxic T cells without affecting the control of primary viral infections.

S. Mumprecht, M. Matter, V. Pavelic, and A. F. Ochsenbein (2006)
Blood 108, 3406-3413
 |  Abstract »  |  Full Text »  |  PDF »

Dendritic Cells Cross-Dressed with Peptide MHC Class I Complexes Prime CD8+ T Cells.

B. P. Dolan, K. D. Gibbs Jr, and S. Ostrand-Rosenberg (2006)
J. Immunol. 177, 6018-6024
 |  Abstract »  |  Full Text »  |  PDF »

Direct stimulation of T lymphocytes by immunosomes: Virus-like particles decorated with T cell receptor/CD3 ligands plus costimulatory molecules.

S. V. Derdak, H. J. Kueng, V. M. Leb, A. Neunkirchner, K. G. Schmetterer, E. Bielek, O. Majdic, W. Knapp, B. Seed, and W. F. Pickl (2006)
PNAS 103, 13144-13149
 |  Abstract »  |  Full Text »  |  PDF »

Both Dendritic Cells and Macrophages Can Stimulate Naive CD8 T Cells In Vivo to Proliferate, Develop Effector Function, and Differentiate into Memory Cells.

L.-A. M. Pozzi, J. W. Maciaszek, and K. L. Rock (2005)
J. Immunol. 175, 2071-2081
 |  Abstract »  |  Full Text »  |  PDF »

Priming of CTLs by Lymphocytic Choriomeningitis Virus Depends on Dendritic Cells.

H. C. Probst and M. van den Broek (2005)
J. Immunol. 174, 3920-3924
 |  Abstract »  |  Full Text »  |  PDF »

The Role of Intercellular Adhesion Molecule-1/LFA-1 Interactions in the Generation of Tumor-Specific CD8+ T Cell Responses.

S. R. Jenkinson, N. A. Williams, and D. J. Morgan (2005)
J. Immunol. 174, 3401-3407
 |  Abstract »  |  Full Text »  |  PDF »

Hematopoietic Cells Are Required to Initiate a Chlamydia trachomatis-Specific CD8+ T Cell Response.

L. N. Steele, Z. R. Balsara, and M. N. Starnbach (2004)
J. Immunol. 173, 6327-6337
 |  Abstract »  |  Full Text »  |  PDF »

T cell immunity using transgenic B lymphocytes.

M. Gerloni, M. Rizzi, P. Castiglioni, and M. Zanetti (2004)
PNAS 101, 3892-3897
 |  Abstract »  |  Full Text »  |  PDF »

Intranodal injection of semimature monocyte-derived dendritic cells induces T helper type 1 responses to protein neoantigen.

M. Gilliet, M. Kleinhans, E. Lantelme, D. Schadendorf, G. Burg, and F. O. Nestle (2003)
Blood 102, 36-42
 |  Abstract »  |  Full Text »  |  PDF »

Complementary Role of CD4+ T Cells and Secondary Lymphoid Tissues for Cross-presentation of Tumor Antigen to CD8+ T Cells.

P. Yu, M. T. Spiotto, Y. Lee, H. Schreiber, and Y.-X. Fu (2003)
J. Exp. Med. 197, 985-995
 |  Abstract »  |  Full Text »  |  PDF »

Lack of Effector Cell Function and Altered Tetramer Binding of Tumor-Infiltrating Lymphocytes.

U. Blohm, E. Roth, K. Brommer, T. Dumrese, F. M. Rosenthal, and H. Pircher (2002)
J. Immunol. 169, 5522-5530
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Roles of Adenovirus Vector-Transduced Dendritic Cells, Myoblasts, and Endothelial Cells in Mediating an Immune Response against a Transgene Product.

S. Mercier, H. Gahery-Segard, M. Monteil, R. Lengagne, J.-G. Guillet, M. Eloit, and C. Denesvre (2002)
J. Virol. 76, 2899-2911
 |  Abstract »  |  Full Text »  |  PDF »

Local Costimulation Reinvigorates Tumor-Specific Cytolytic T Lymphocytes for Experimental Therapy in Mice with Large Tumor Burdens.

X.-F. Bai, J. Bender, J. Liu, H. Zhang, Y. Wang, O. Li, P. Du, P. Zheng, and Y. Liu (2001)
J. Immunol. 167, 3936-3943
 |  Abstract »  |  Full Text »  |  PDF »

On the Site and Mode of Antigen Presentation for the Initiation of Clonal Expansion of CD8 T Cells Specific for a Natural Tumor Antigen.

X.-F. Bai, J.-X. Gao, J. Liu, J. Wen, P. Zheng, and Y. Liu (2001)
Cancer Res. 61, 6860-6867
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Potent Human Immunodeficiency Virus Type 1-Specific T-Cell-Restricted Immunity by Genetically Modified Dendritic Cells.

J. Lisziewicz, D. I. Gabrilovich, G. Varga, J. Xu, P. D. Greenberg, S. K. Arya, M. Bosch, J.-P. Behr, and F. Lori (2001)
J. Virol. 75, 7621-7628
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Immune Response by Antigen.

R. M. Zinkernagel and H. Hengartner (2001)
Science 293, 251-253
 |  Abstract »  |  Full Text »

Rapid Peptide Turnover and Inefficient Presentation of Exogenous Antigen Critically Limit the Activation of Self-Reactive CTL by Dendritic Cells.

B. Ludewig, K. McCoy, M. Pericin, A. F. Ochsenbein, T. Dumrese, B. Odermatt, R. E. M. Toes, C. J. M. Melief, H. Hengartner, and R. M. Zinkernagel (2001)
J. Immunol. 166, 3678-3687
 |  Abstract »  |  Full Text »  |  PDF »

Recombinant Expression of Lymphocytic Choriomeningitis Virus Strain WE Glycoproteins: a Single Amino Acid Makes the Difference.

W. R. Beyer, H. Miletic, W. Ostertag, and D. von Laer (2001)
J. Virol. 75, 1061-1064
 |  Abstract »  |  Full Text »

Superior Tumor Protection Induced by a Cellular Vaccine Carrying a Tumor-specific T Helper Epitope by Genetic Exchange of the Class II-associated Invariant Chain Peptide.

J. van Bergen, M. Camps, R. Offringa, C. J. M. Melief, F. Ossendorp, and F. Koning (2000)
Cancer Res. 60, 6427-6433
 |  Abstract »  |  Full Text »

Requirements for Bone Marrow-Derived Antigen-Presenting Cells in Priming Cytotoxic T Cell Responses to Intracellular Pathogens.

L. L. Lenz, E. A. Butz, and M. J. Bevan (2000)
J. Exp. Med. 192, 1135-1142
 |  Abstract »  |  Full Text »  |  PDF »

Macrophages Escape Inhibition of Major Histocompatibility Complex Class I-Dependent Antigen Presentation by Cytomegalovirus.

H. Hengel, U. Reusch, G. Geginat, R. Holtappels, T. Ruppert, E. Hellebrand, and U. H. Koszinowski (2000)
J. Virol. 74, 7861-7868
 |  Abstract »  |  Full Text »

Crucial Role of TNF-{alpha} in CD8 T Cell-Mediated Elimination of 3LL-A9 Lewis Lung Carcinoma Cells In Vivo.

A. Prevost-Blondel, E. Roth, F. M. Rosenthal, and H. Pircher (2000)
J. Immunol. 164, 3645-3651
 |  Abstract »  |  Full Text »  |  PDF »

Immunotherapy with Dendritic Cells Directed against Tumor Antigens Shared with Normal Host Cells Results in Severe Autoimmune Disease.

B. Ludewig, A. F. Ochsenbein, B. Odermatt, D. Paulin, H. Hengartner, and R. M. Zinkernagel (2000)
J. Exp. Med. 191, 795-804
 |  Abstract »  |  Full Text »  |  PDF »

Interleukin-7/B7.1-encoding Adenoviruses Induce Rejection of Transplanted but not Nontransplanted Tumors.

G. Willimsky and T. Blankenstein (2000)
Cancer Res. 60, 685-692
 |  Abstract »  |  Full Text »

Naive CD8+ T Cells Do Not Require Costimulation for Proliferation and Differentiation into Cytotoxic Effector Cells.

B. Wang, R. Maile, R. Greenwood, E. J. Collins, and J. A. Frelinger (2000)
J. Immunol. 164, 1216-1222
 |  Abstract »  |  Full Text »  |  PDF »

Role of Inflammatory Infiltrate in Activation and Effector Function of Cloned Islet Reactive Nonobese Diabetic CD8+ T Cells: Involvement of a Nitric Oxide-Dependent Pathway.

T. Gurlo, K. Kawamura, and H. von Grafenstein (1999)
J. Immunol. 163, 5770-5780
 |  Abstract »  |  Full Text »  |  PDF »

Strong Cytotoxic T Lymphocyte Responses to a Macrophage Inflammatory Protein 1{{alpha}}-expressing Tumor: Linkage between Inflammation and Specific Immunity.

M. Maric and Y. Liu (1999)
Cancer Res. 59, 5549-5553
 |  Abstract »  |  Full Text »  |  PDF »

Cytokine Gene Therapy of Mesothelioma . Immune and Antitumor Effects of Transfected Interleukin-12.

I. Caminschi, E. Venetsanakos, C. C. Leong, M. J. Garlepp, B. W. S. Robinson, and B. Scott (1999)
Am. J. Respir. Cell Mol. Biol. 21, 347-356
 |  Abstract »  |  Full Text »

Protective Immunity from Naive CD8+ T Cells Activated In Vitro with MHC Class I Binding Immunogenic Peptides and IL-2 in the Absence of Specialized APCs.

C. Hauser, F. Zipprich, I. Leblond, S. Wirth, and A. W. Hugin (1999)
J. Immunol. 163, 330-336
 |  Abstract »  |  Full Text »  |  PDF »

Treatment of Breast Cancer with Fibroblasts Transfected with DNA from Breast Cancer Cells.

E. de Zoeten, V. Carr-Brendel, D. Markovic, J. Taylor-Papadimitriou, and E. P. Cohen (1999)
J. Immunol. 162, 6934-6941
 |  Abstract »  |  Full Text »  |  PDF »

A Critical Role for the RelA Subunit of Nuclear Factor {kappa}B in Regulation of Multiple Immune-response Genes and in Fas-induced Cell Death.

F. Ouaaz, M. Li, and A. A. Beg (1999)
J. Exp. Med. 189, 999-1004
 |  Abstract »  |  Full Text »  |  PDF »

Immune surveillance against a solid tumor fails because of immunological ignorance.

A. F. Ochsenbein, P. Klenerman, U. Karrer, B. Ludewig, M. Pericin, H. Hengartner, and R. M. Zinkernagel (1999)
PNAS 96, 2233-2238
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Perforin in Activation-Induced T Cell Death In Vivo: Increased Expansion of Allogeneic Perforin-Deficient T Cells in SCID mice.

D. Spaner, K. Raju, B. Rabinovich, and R. G. Miller (1999)
J. Immunol. 162, 1192-1199
 |  Abstract »  |  Full Text »  |  PDF »

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses.

P. Andre, M. Groettrup, P. Klenerman, R. de Giuli, B. L. Booth Jr., V. Cerundolo, M. Bonneville, F. Jotereau, R. M. Zinkernagel, and V. Lotteau (1998)
PNAS 95, 13120-13124
 |  Abstract »  |  Full Text »  |  PDF »

Tumor-Infiltrating Lymphocytes Exhibiting High Ex Vivo Cytolytic Activity Fail to Prevent Murine Melanoma Tumor Growth In Vivo.

A. Prevost-Blondel, C. Zimmermann, C. Stemmer, P. Kulmburg, F. M. Rosenthal, and H. Pircher (1998)
J. Immunol. 161, 2187-2194
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Major Histocompatibility (MHC) Class II Human Leukocyte Antigen-DR{alpha} Gene Expression in Thyrocytes by Single Strand Binding Protein-1, a Transcription Factor That Also Regulates Thyrotropin Receptor and MHC Class I Gene Expression.

P. L. Balducci-Silano, K. Suzuki, M. Ohta, J. Saito, M. Ohmori, V. Montani, G. Napolitano, M. Shong, S.-I. Taniguchi, M. Pietrarelli, et al. (1998)
Endocrinology 139, 2300-2313
 |  Abstract »  |  Full Text »  |  PDF »

Resistance to Melanoma in Mice Immunized with Semiallogeneic Fibroblasts Transfected with DNA from Mouse Melanoma Cells.

E. F. de Zoeten, V. Carr-Brendel, and E. P. Cohen (1998)
J. Immunol. 160, 2915-2922
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Low Avidity CTL Specific for a Self Epitope Results in Tumor Rejection But Not Autoimmunity.

D. J. Morgan, H. T. C. Kreuwel, S. Fleck, H. I. Levitsky, D. M. Pardoll, and L. A. Sherman (1998)
J. Immunol. 160, 643-651
 |  Abstract »  |  Full Text »  |  PDF »

MHC Class II-Transfected Tumor Cells Directly Present Antigen to Tumor-Specific CD4+ T Lymphocytes1.

T. D. Armstrong, V. K. Clements, and S. Ostrand-Rosenberg (1998)
J. Immunol. 160, 661-666
 |  Abstract »  |  Full Text »  |  PDF »

Dendritic Cells as Adjuvants for Immune-mediated Resistance to Tumors.

G. Schuler and R.M. Steinman (1997)
J. Exp. Med. 186, 1183-1187
 |  Full Text »  |  PDF »

CD44 Regulates Hematopoietic Progenitor Distribution, Granuloma Formation, and Tumorigenicity.

R. Schmits, J. Filmus, N. Gerwin, G. Senaldi, F. Kiefer, T. Kundig, A. Wakeham, A. Shahinian, C. Catzavelos, J. Rak, et al. (1997)
Blood 90, 2217-2233
 |  Abstract »  |  Full Text »  |  PDF »

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy.

D. E. Speiser, R. Miranda, A. Zakarian, M. F. Bachmann, K. McKall-Faienza, B. Odermatt, D. Hanahan, R. M. Zinkernagel, and P. S. Ohashi (1997)
J. Exp. Med. 186, 645-653
 |  Abstract »  |  Full Text »  |  PDF »

Major histocompatibility complex class II-transfected tumor cells present endogenous antigen and are potent inducers of tumor-specific immunity.

T. D. Armstrong, V. K. Clements, B. K. Martin, J. P.-Y. Ting, and S. Ostrand-Rosenberg (1997)
PNAS 94, 6886-6891
 |  Abstract »  |  Full Text »  |  PDF »

On the Key Role of Secondary Lymphoid Organs in Antiviral Immune Responses Studied in Alymphoplastic (aly/aly) and Spleenless (Hox11-/-) Mutant Mice.

U. Karrer, A. Althage, B. Odermatt, C. W.M. Roberts, S. J. Korsmeyer, S. Miyawaki, H. Hengartner, and R. M. Zinkernagel (1997)
J. Exp. Med. 185, 2157-2170
 |  Abstract »  |  Full Text »  |  PDF »

Antigen presentation in retroviral vector-mediated gene transfer in vivo.

E. S. Song, V. Lee, C. D. Surh, A. Lynn, D. Brumm, D. J. Jolly, J. F. Warner, and S. Chada (1997)
PNAS 94, 1943-1948
 |  Abstract »  |  Full Text »  |  PDF »

Protection against immunopathological consequences of a viral infection by activated but not resting cytotoxic T cells: T cell memory without "memory T cells"?.

M. F. Bachmann, T. M. Kundig, H. Hengartner, and R. M. Zinkernagel (1997)
PNAS 94, 640-645
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Costimulatory Molecules Are Required for the Induction of Effector and Memory Cytotoxic T Lymphocytes.

Y. Liu, R. H. Wenger, M. Zhao, and P. J. Nielsen (1997)
J. Exp. Med. 185, 251-262
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products