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Science 26 May 1995:
Vol. 268. no. 5214, pp. 1144 - 1149
DOI: 10.1126/science.7761829
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Articles

Science, Vol 268, Issue 5214, 1144-1149
Copyright © 1995 by American Association for the Advancement of Science

articles

Classical electrostatics in biology and chemistry

B Honig and A Nicholls

Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10032, USA.

A major revival in the use of classical electrostatics as an approach to the study of charged and polar molecules in aqueous solution has been made possible through the development of fast numerical and computational methods to solve the Poisson-Boltzmann equation for solute molecules that have complex shapes and charge distributions. Graphical visualization of the calculated electrostatic potentials generated by proteins and nucleic acids has revealed insights into the role of electrostatic interactions in a wide range of biological phenomena. Classical electrostatics has also proved to be successful quantitative tool yielding accurate descriptions of electrical potentials, diffusion limited processes, pH-dependent properties of proteins, ionic strength-dependent phenomena, and the solvation free energies of organic molecules.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)