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Science 19 May 1995:
Vol. 268. no. 5213, pp. 1042 - 1045
DOI: 10.1126/science.7754383
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Articles

Science, Vol 268, Issue 5213, 1042-1045
Copyright © 1995 by American Association for the Advancement of Science

articles

Local calcium transients triggered by single L-type calcium channel currents in cardiac cells

Lopez-Lopez JR, PS Shacklock, CW Balke, and WG Wier

Department of Physiology, University of Maryland, School of Medicine, Baltimore 21201, USA.

Excitation-contraction coupling was studied in mammalian cardiac cells in which the opening probability of L-type calcium (Ca2+) channels was reduced. Confocal microscopy during voltage-clamp depolarization revealed distinct local transients in the concentration of intracellular calcium ions ([Ca2+]i). When voltage was varied, the latency to occurrence and the relative probability of occurrence of local [Ca2+]i transients varied as predicted if Ca2+ release from the sarcoplasmic reticulum (SR) was linked tightly to Ca2+ flux through L-type Ca2+ channels but not to that through the Na-Ca exchanger or to average [Ca2+]i. Voltage had no effect on the amplitude of local [Ca2+]i transients. Thus, the most efficacious "Ca2+ signal" for activating Ca2+ release from the SR may be a transient microdomain of high [Ca2+]i beneath an individual, open L-type Ca2+ channel.


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M. Jiang, A. Xu, S. Tokmakejian, and N. Narayanan (2000)
Am J Physiol Heart Circ Physiol 278, H1429-H1438
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Modulation of focal and global Ca2+ release in calsequestrin-overexpressing mouse cardiomyocytes.
W. Wang, L. Cleemann, L. R Jones, and M. Morad (2000)
J. Physiol. 524, 399-414
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Intracellular Ca2+ release contributes to automaticity in cat atrial pacemaker cells.
J. Huser, L. A Blatter, and S. L Lipsius (2000)
J. Physiol. 524, 415-422
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Voltage-dependent Ca2+ release from the SR of feline ventricular myocytes is explained by Ca2+-induced Ca2+ release.
V. Piacentino III, K. Dipla, J. P Gaughan, and S. R Houser (2000)
J. Physiol. 523, 533-548
   Abstract »    Full Text »    PDF »
Calcium sparks in smooth muscle.
J. H. Jaggar, V. A. Porter, W. J. Lederer, and M. T. Nelson (2000)
Am J Physiol Cell Physiol 278, C235-C256
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Caffeine-induced Ca2+ sparks in mouse ventricular myocytes.
M. Ritter, Z. Su, K. W. Spitzer, H. Ishida, and W. H. Barry (2000)
Am J Physiol Heart Circ Physiol 278, H666-H669
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