Science 28 April 1995: Vol. 268. no. 5210, pp. 533 - 539 DOI: 10.1126/science.7725097

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Articles

The 26 S Proteasome: From Basic Mechanisms to Drug Targeting.

A. Navon and A. Ciechanover (2009)
J. Biol. Chem. 284, 33713-33718
 |  Abstract »  |  Full Text »  |  PDF »

Architecture and Molecular Mechanism of PAN, the Archaeal Proteasome Regulatory ATPase.

N. Medalia, A. Beer, P. Zwickl, O. Mihalache, M. Beck, O. Medalia, and A. Navon (2009)
J. Biol. Chem. 284, 22952-22960
 |  Abstract »  |  Full Text »  |  PDF »

Insights into the molecular architecture of the 26S proteasome.

S. Nickell, F. Beck, S. H. W. Scheres, A. Korinek, F. Forster, K. Lasker, O. Mihalache, N. Sun, I. Nagy, A. Sali, et al. (2009)
PNAS 106, 11943-11947
 |  Abstract »  |  Full Text »  |  PDF »

ATP-dependent Proteases Differ Substantially in Their Ability to Unfold Globular Proteins.

P. Koodathingal, N. E. Jaffe, D. A. Kraut, S. Prakash, S. Fishbain, C. Herman, and A. Matouschek (2009)
J. Biol. Chem. 284, 18674-18684
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The N-Terminal Penultimate Residue of 20S Proteasome {alpha}1 Influences its N{alpha} Acetylation and Protein Levels as Well as Growth Rate and Stress Responses of Haloferax volcanii.

M. A. Humbard, G. Zhou, and J. A. Maupin-Furlow (2009)
J. Bacteriol. 191, 3794-3803
 |  Abstract »  |  Full Text »  |  PDF »

Structure and Function of a Novel Type of ATP-dependent Clp Protease.

F. I. Andersson, A. Tryggvesson, M. Sharon, A. V. Diemand, M. Classen, C. Best, R. Schmidt, J. Schelin, T. M. Stanne, B. Bukau, et al. (2009)
J. Biol. Chem. 284, 13519-13532
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Proteasomal Components Required for Cell Growth and Stress Responses in the Haloarchaeon Haloferax volcanii.

G. Zhou, D. Kowalczyk, M. A. Humbard, S. Rohatgi, and J. A. Maupin-Furlow (2008)
J. Bacteriol. 190, 8096-8105
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Specificities of Mycobacterium tuberculosis and Mammalian Proteasomes for N-Acetyl Tripeptide Substrates.

G. Lin, C. Tsu, L. Dick, X. K. Zhou, and C. Nathan (2008)
J. Biol. Chem. 283, 34423-34431
 |  Abstract »  |  Full Text »  |  PDF »

Structure of the Human 26S Proteasome: SUBUNIT RADIAL DISPLACEMENTS OPEN THE GATE INTO THE PROTEOLYTIC CORE.

P. C. A. da Fonseca and E. P. Morris (2008)
J. Biol. Chem. 283, 23305-23314
 |  Abstract »  |  Full Text »  |  PDF »

Activation of DegP chaperone-protease via formation of large cage-like oligomers upon binding to substrate proteins.

J. Jiang, X. Zhang, Y. Chen, Y. Wu, Z. H. Zhou, Z. Chang, and S.-F. Sui (2008)
PNAS 105, 11939-11944
 |  Abstract »  |  Full Text »  |  PDF »

Point Mutation of the Proteasome {beta}5 Subunit Gene Is an Important Mechanism of Bortezomib Resistance in Bortezomib-Selected Variants of Jurkat T Cell Lymphoblastic Lymphoma/Leukemia Line.

S. Lu, J. Yang, X. Song, S. Gong, H. Zhou, L. Guo, N. Song, X. Bao, P. Chen, and J. Wang (2008)
J. Pharmacol. Exp. Ther. 326, 423-431
 |  Abstract »  |  Full Text »  |  PDF »

Myofibrillar protein turnover: The proteasome and the calpains.

D. E. Goll, G. Neti, S. W. Mares, and V. F. Thompson (2008)
J Anim Sci 86, E19-E35
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome activation during cardiac hypertrophy by the chaperone H11 Kinase/Hsp22.

N. Hedhli, L. Wang, Q. Wang, E. Rashed, Y. Tian, X. Sui, K. Madura, and C. Depre (2008)
Cardiovasc Res 77, 497-505
 |  Abstract »  |  Full Text »  |  PDF »

N-Linked Glycosylation Does Not Impair Proteasomal Degradation but Affects Class I Major Histocompatibility Complex Presentation.

E. Kario, B. Tirosh, H. L. Ploegh, and A. Navon (2008)
J. Biol. Chem. 283, 244-254
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian Proteasome Subpopulations with Distinct Molecular Compositions and Proteolytic Activities.

O. Drews, R. Wildgruber, C. Zong, U. Sukop, M. Nissum, G. Weber, A. V. Gomes, and P. Ping (2007)
Mol. Cell. Proteomics 6, 2021-2031
 |  Abstract »  |  Full Text »  |  PDF »

ATP-induced Structural Transitions in PAN, the Proteasome-regulatory ATPase Complex in Archaea.

A. A. Horwitz, A. Navon, M. Groll, D. M. Smith, C. Reis, and A. L. Goldberg (2007)
J. Biol. Chem. 282, 22921-22929
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular proteasome in the human alveolar space: a new housekeeping enzyme?.

S. U. Sixt, M. Beiderlinden, H. P. Jennissen, and J. Peters (2007)
Am J Physiol Lung Cell Mol Physiol 292, L1280-L1288
 |  Abstract »  |  Full Text »  |  PDF »

Role of the {beta}1 Subunit in the Function and Stability of the 20S Proteasome in the Hyperthermophilic Archaeon Pyrococcus furiosus.

L. S. Madding, J. K. Michel, K. R. Shockley, S. B. Conners, K. L. Epting, M. R. Johnson, and R. M. Kelly (2007)
J. Bacteriol. 189, 583-590
 |  Abstract »  |  Full Text »  |  PDF »

Global Organization and Function of Mammalian Cytosolic Proteasome Pools: Implications for PA28 and 19S Regulatory Complexes.

T. Shibatani, E. J. Carlson, F. Larabee, A. L. McCormack, K. Fruh, and W. R. Skach (2006)
Mol. Biol. Cell 17, 4962-4971
 |  Abstract »  |  Full Text »  |  PDF »

An Archaeal Peptidase Assembles into Two Different Quaternary Structures: A TETRAHEDRON AND A GIANT OCTAHEDRON.

G. Schoehn, F. M. D. Vellieux, M. Asuncion Dura, V. Receveur-Brechot, C. M. S. Fabry, R. W. H. Ruigrok, C. Ebel, A. Roussel, and B. Franzetti (2006)
J. Biol. Chem. 281, 36327-36337
 |  Abstract »  |  Full Text »  |  PDF »

Posttranslational Modification of the 20S Proteasomal Proteins of the Archaeon Haloferax volcanii.

M. A. Humbard, S. M. Stevens Jr., and J. A. Maupin-Furlow (2006)
J. Bacteriol. 188, 7521-7530
 |  Abstract »  |  Full Text »  |  PDF »

Antigen Processing of a Short Viral Antigen by Proteasomes.

D. Lopez, O. Calero, M. Jimenez, M. Garcia-Calvo, and M. Del Val (2006)
J. Biol. Chem. 281, 30315-30318
 |  Abstract »  |  Full Text »  |  PDF »

Archaeal Proteasomes Effectively Degrade Aggregation-prone Proteins and Reduce Cellular Toxicities in Mammalian Cells.

S.-i. Yamada, J.-i. Niwa, S. Ishigaki, M. Takahashi, T. Ito, J. Sone, M. Doyu, and G. Sobue (2006)
J. Biol. Chem. 281, 23842-23851
 |  Abstract »  |  Full Text »  |  PDF »

The nuclear ubiquitin-proteasome system.

A. von Mikecz (2006)
J. Cell Sci. 119, 1977-1984
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20S Proteasomes Have the Potential to Keep Substrates in Store for Continual Degradation.

M. Sharon, S. Witt, K. Felderer, B. Rockel, W. Baumeister, and C. V. Robinson (2006)
J. Biol. Chem. 281, 9569-9575
 |  Abstract »  |  Full Text »  |  PDF »

Proteasomes shape the repertoire of T cells participating in antigen-specific immune responses.

P. Osterloh, K. Linkemann, S. Tenzer, H.-G. Rammensee, M. P. Radsak, D. H. Busch, and H. Schild (2006)
PNAS 103, 5042-5047
 |  Abstract »  |  Full Text »  |  PDF »

Inhibitor-binding mode of homobelactosin C to proteasomes: New insights into class I MHC ligand generation.

M. Groll, O. V. Larionov, R. Huber, and A. de Meijere (2006)
PNAS 103, 4576-4579
 |  Abstract »  |  Full Text »  |  PDF »

Insight into autoproteolytic activation from the structure of cephalosporin acylase: A protein with two proteolytic chemistries.

J. K. Kim, I. S. Yang, H. J. Shin, K. J. Cho, E. K. Ryu, S. H. Kim, S. S. Park, and K. H. Kim (2006)
PNAS 103, 1732-1737
 |  Abstract »  |  Full Text »  |  PDF »

The Impact of Structural Genomics: Expectations and Outcomes.

J.-M. Chandonia and S. E. Brenner (2006)
Science 311, 347-351
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Quantitative NMR spectroscopy of supramolecular complexes: Dynamic side pores in ClpP are important for product release.

R. Sprangers, A. Gribun, P. M. Hwang, W. A. Houry, and L. E. Kay (2005)
PNAS 102, 16678-16683
 |  Abstract »  |  Full Text »  |  PDF »

Protein turnover in cardiac cell growth and survival.

N. Hedhli, M. Pelat, and C. Depre (2005)
Cardiovasc Res 68, 186-196
 |  Abstract »  |  Full Text »  |  PDF »

X-ray Snapshots of Peptide Processing in Mutants of Tricorn-interacting Factor F1 from Thermoplasma acidophilum.

P. Goettig, H. Brandstetter, M. Groll, W. Gohring, P. V. Konarev, D. I. Svergun, R. Huber, and J.-S. Kim (2005)
J. Biol. Chem. 280, 33387-33396
 |  Abstract »  |  Full Text »  |  PDF »

Crystal Structure of Isoaspartyl Aminopeptidase in Complex with L-Aspartate.

K. Michalska, K. Brzezinski, and M. Jaskolski (2005)
J. Biol. Chem. 280, 28484-28491
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitin-Proteasome Pathway and Its Role in Cancer.

A. Mani and E. P. Gelmann (2005)
J. Clin. Oncol. 23, 4776-4789
 |  Abstract »  |  Full Text »  |  PDF »

Lys6-modified Ubiquitin Inhibits Ubiquitin-dependent Protein Degradation.

F. Shang, G. Deng, Q. Liu, W. Guo, A. L. Haas, B. Crosas, D. Finley, and A. Taylor (2005)
J. Biol. Chem. 280, 20365-20374
 |  Abstract »  |  Full Text »  |  PDF »

The ClpP Double Ring Tetradecameric Protease Exhibits Plastic Ring-Ring Interactions, and the N Termini of Its Subunits Form Flexible Loops That Are Essential for ClpXP and ClpAP Complex Formation.

A. Gribun, M. S. Kimber, R. Ching, R. Sprangers, K. M. Fiebig, and W. A. Houry (2005)
J. Biol. Chem. 280, 16185-16196
 |  Abstract »  |  Full Text »  |  PDF »

Proteasome Inhibition As a Novel Therapeutic Target in Human Cancer.

S. V. Rajkumar, P. G. Richardson, T. Hideshima, and K. C. Anderson (2005)
J. Clin. Oncol. 23, 630-639
 |  Abstract »  |  Full Text »  |  PDF »

Crystal Structure of a Dodecameric Tetrahedral-shaped Aminopeptidase.

S. Russo and U. Baumann (2004)
J. Biol. Chem. 279, 51275-51281
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Ubiquitin Signals in the Developing Acrosome during Spermatogenesis of Rat Testis: An Immunoelectron Microscopic Study.

C. M. Haraguchi, T. Mabuchi, S. Hirata, T. Shoda, K. Hoshi, and S. Yokota (2004)
J. Histochem. Cytochem. 52, 1393-1403
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Proteasome Subunits Low Molecular Mass Polypeptide (LMP) 2 and LMP7 in the Endometrium and Placenta of Rhesus Monkey (Macaca mulatta) During Early Pregnancy.

H.-X. Wang, H.-M. Wang, Q.-L. Li, H.-Y. Lin, D. Qian, and C. Zhu (2004)
Biol Reprod 71, 1317-1324
 |  Abstract »  |  Full Text »  |  PDF »

Sulfadoxine Resistance in Plasmodium vivax Is Associated with a Specific Amino Acid in Dihydropteroate Synthase at the Putative Sulfadoxine-Binding Site.

M. Korsinczky, K. Fischer, N. Chen, J. Baker, K. Rieckmann, and Q. Cheng (2004)
Antimicrob. Agents Chemother. 48, 2214-2222
 |  Abstract »  |  Full Text »  |  PDF »

Role of C-terminal Extensions of Subunits {beta}2 and {beta}7 in Assembly and Activity of Eukaryotic Proteasomes.

P. C. Ramos, A. J. Marques, M. K. London, and R. J. Dohmen (2004)
J. Biol. Chem. 279, 14323-14330
 |  Abstract »  |  Full Text »  |  PDF »

Specificity of the Interaction between Ubiquitin-associated Domains and Ubiquitin.

T. D. Mueller, M. Kamionka, and J. Feigon (2004)
J. Biol. Chem. 279, 11926-11936
 |  Abstract »  |  Full Text »  |  PDF »

Immune Defects in 28-kDa Proteasome Activator {gamma}-Deficient Mice.

L. F. Barton, H. A. Runnels, T. D. Schell, Y. Cho, R. Gibbons, S. S. Tevethia, G. S. Deepe Jr., and J. J. Monaco (2004)
J. Immunol. 172, 3948-3954
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Analysis of Prion-Protein Degradation by Constitutive and Immuno-20S Proteasomes Indicates Differences Correlated with Disease Susceptibility.

S. Tenzer, L. Stoltze, B. Schonfisch, J. Dengjel, M. Muller, S. Stevanovic, H.-G. Rammensee, and H. Schild (2004)
J. Immunol. 172, 1083-1091
 |  Abstract »  |  Full Text »  |  PDF »

PepN is the major aminopeptidase in Escherichia coli: insights on substrate specificity and role during sodium-salicylate-induced stress.

D. Chandu and D. Nandi (2003)
Microbiology 149, 3437-3447
 |  Abstract »  |  Full Text »  |  PDF »

Crystal Structures of Human DJ-1 and Escherichia coli Hsp31, Which Share an Evolutionarily Conserved Domain.

S.-J. Lee, S. J. Kim, I.-K. Kim, J. Ko, C.-S. Jeong, G.-H. Kim, C. Park, S.-O. Kang, P.-G. Suh, H.-S. Lee, et al. (2003)
J. Biol. Chem. 278, 44552-44559
 |  Abstract »  |  Full Text »  |  PDF »

The Caspase-like Sites of Proteasomes, Their Substrate Specificity, New Inhibitors and Substrates, and Allosteric Interactions with the Trypsin-like Sites.

A. F. Kisselev, M. Garcia-Calvo, H. S. Overkleeft, E. Peterson, M. W. Pennington, H. L. Ploegh, N. A. Thornberry, and A. L. Goldberg (2003)
J. Biol. Chem. 278, 35869-35877
 |  Abstract »  |  Full Text »  |  PDF »

Use of RNA Interference and Complementation To Study the Function of the Drosophila and Human 26S Proteasome Subunit S13.

J. Lundgren, P. Masson, C. A. Realini, and P. Young (2003)
Mol. Cell. Biol. 23, 5320-5330
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical Analysis of the 20 S Proteasome of Trypanosoma brucei.

C. C. Wang, Z. Bozdech, C.-l. Liu, A. Shipway, B. J. Backes, J. L. Harris, and M. Bogyo (2003)
J. Biol. Chem. 278, 15800-15808
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of proteasomal subunit S5a/Rpn10/p54 causes lethality, multiple mitotic defects and overexpression of proteasomal genes in Drosophila melanogaster.

T. Szlanka, L. Haracska, I. Kiss, P. Deak, E. Kurucz, I. Ando, E. Viragh, and A. Udvardy (2003)
J. Cell Sci. 116, 1023-1033
 |  Abstract »  |  Full Text »  |  PDF »

Rpn6p, a Proteasome Subunit from Saccharomyces cerevisiae, Is Essential for the Assembly and Activity of the 26 S Proteasome.

P. G. Santamaria, D. Finley, J. P. G. Ballesta, and M. Remacha (2003)
J. Biol. Chem. 278, 6687-6695
 |  Abstract »  |  Full Text »  |  PDF »

Endoproteolytic Activity of the Proteasome.

C.-W. Liu, M. J. Corboy, G. N. DeMartino, and P. J. Thomas (2003)
Science 299, 408-411
 |  Abstract »  |  Full Text »  |  PDF »

Subunit Topology of Two 20S Proteasomes from Haloferax volcanii.

S. J. Kaczowka and J. A. Maupin-Furlow (2003)
J. Bacteriol. 185, 165-174
 |  Abstract »  |  Full Text »  |  PDF »

Identification of macromolecular complexes in cryoelectron tomograms of phantom cells.

A. S. Frangakis, J. Bohm, F. Forster, S. Nickell, D. Nicastro, D. Typke, R. Hegerl, and W. Baumeister (2002)
PNAS 99, 14153-14158
 |  Abstract »  |  Full Text »  |  PDF »

Specific Orientation and Two-dimensional Crystallization of the Proteasome at Metal-chelating Lipid Interfaces.

A. Thess, S. Hutschenreiter, M. Hofmann, R. Tampe, W. Baumeister, and R. Guckenberger (2002)
J. Biol. Chem. 277, 36321-36328
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Immunoproteasome Subunit Expression In Vivo Following Pathogenic Fungal Infection.

L. F. Barton, M. Cruz, R. Rangwala, G. S. Deepe Jr., and J. J. Monaco (2002)
J. Immunol. 169, 3046-3052
 |  Abstract »  |  Full Text »  |  PDF »

Concurrent Translocation of Multiple Polypeptide Chains through the Proteasomal Degradation Channel.

C. Lee, S. Prakash, and A. Matouschek (2002)
J. Biol. Chem. 277, 34760-34765
 |  Abstract »  |  Full Text »  |  PDF »

Membrane Protein Degradation by FtsH Can Be Initiated from Either End.

S. Chiba, Y. Akiyama, and K. Ito (2002)
J. Bacteriol. 184, 4775-4782
 |  Abstract »  |  Full Text »  |  PDF »

Mapping and Structural Dissection of Human 20 S Proteasome Using Proteomic Approaches.

S. Claverol, O. Burlet-Schiltz, E. Girbal-Neuhauser, J. E. Gairin, and B. Monsarrat (2002)
Mol. Cell. Proteomics 1, 567-578
 |  Abstract »  |  Full Text »  |  PDF »

Clastosome: A Subtype of Nuclear Body Enriched in 19S and 20S Proteasomes, Ubiquitin, and Protein Substrates of Proteasome.

M. Lafarga, M. T. Berciano, E. Pena, I. Mayo, J. G. Castano, D. Bohmann, J. P. Rodrigues, J. P. Tavanez, and M. Carmo-Fonseca (2002)
Mol. Biol. Cell 13, 2771-2782
 |  Abstract »  |  Full Text »  |  PDF »

Conformational Remodeling of Proteasomal Substrates by PA700, the 19 S Regulatory Complex of the 26 S Proteasome.

C.-w. Liu, L. Millen, T. B. Roman, H. Xiong, H. F. Gilbert, R. Noiva, G. N. DeMartino, and P. J. Thomas (2002)
J. Biol. Chem. 277, 26815-26820
 |  Abstract »  |  Full Text »  |  PDF »

Binding of Hydrophobic Peptides to Several Non-catalytic Sites Promotes Peptide Hydrolysis by All Active Sites of 20 S Proteasomes. EVIDENCE FOR PEPTIDE-INDUCED CHANNEL OPENING IN THE alpha -RINGS.

A. F. Kisselev, D. Kaganovich, and A. L. Goldberg (2002)
J. Biol. Chem. 277, 22260-22270
 |  Abstract »  |  Full Text »  |  PDF »

Presentation of a major histocompatibility complex class 1-binding peptide by monocyte-derived dendritic cells incorporating hydrophobized polysaccharide-truncated HER2 protein complex: implications for a polyvalent immuno-cell therapy.

Y. Ikuta, N. Katayama, L. Wang, T. Okugawa, Y. Takahashi, M. Schmitt, X. Gu, M. Watanabe, K. Akiyoshi, H. Nakamura, et al. (2002)
Blood 99, 3717-3724
 |  Abstract »  |  Full Text »  |  PDF »

An Easily Dissociated 26 S Proteasome Catalyzes an Essential Ubiquitin-mediated Protein Degradation Pathway in Trypanosoma brucei.

Z. Li, C.-B. Zou, Y. Yao, M. A. Hoyt, S. McDonough, Z. B. Mackey, P. Coffino, and C. C. Wang (2002)
J. Biol. Chem. 277, 15486-15498
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitin-Proteasome Proteolytic Pathway: Destruction for the Sake of Construction.

M. H. Glickman and A. Ciechanover (2002)
Physiol Rev 82, 373-428
 |  Abstract »  |  Full Text »  |  PDF »

Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome.

S. Dawson, S. Apcher, M. Mee, H. Higashitsuji, R. Baker, S. Uhle, W. Dubiel, J. Fujita, and R. J. Mayer (2002)
J. Biol. Chem. 277, 10893-10902
 |  Abstract »  |  Full Text »  |  PDF »

Development of the Proteasome Inhibitor PS-341.

J. Adams (2002)
Oncologist 7, 9-16
 |  Abstract »  |  Full Text »  |  PDF »

The Transporter Associated With Antigen Processing: Function and Implications in Human Diseases.

B. Lankat-Buttgereit and R. Tampe (2002)
Physiol Rev 82, 187-204
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Proteasome Activity Strongly Affects Kiwifruit Pollen Germination. Involvement of the Ubiquitin/Proteasome Pathway as a Major Regulator.

A. Speranza, V. Scoccianti, R. Crinelli, G. L. Calzoni, and M. Magnani (2001)
Plant Physiology 126, 1150-1161
 |  Abstract »  |  Full Text »  |  PDF »

Evolution of Proteasomal ATPases.

K. Wollenberg and J. C. Swaffield (2001)
Mol. Biol. Evol. 18, 962-974
 |  Abstract »  |  Full Text »

Aspartic Peptide Hydrolases in Salmonella enterica Serovar Typhimurium.

R. A. Larsen, T. M. Knox, and C. G. Miller (2001)
J. Bacteriol. 183, 3089-3097
 |  Abstract »  |  Full Text »

Mechanism of Specific Nuclear Transport of Adriamycin: The Mode of Nuclear Translocation of Adriamycin-Proteasome Complex.

K.-i. Kiyomiya, S. Matsuo, and M. Kurebe (2001)
Cancer Res. 61, 2467-2471
 |  Abstract »  |  Full Text »

Protein binding and unfolding by the chaperone ClpA and degradation by the protease ClpAP.

J. R. Hoskins, S. K. Singh, M. R. Maurizi, and S. Wickner (2000)
PNAS 97, 8892-8897
 |  Abstract »  |  Full Text »  |  PDF »

Unfolding and internalization of proteins by the ATP-dependent proteases ClpXP and ClpAP.

S. K. Singh, R. Grimaud, J. R. Hoskins, S. Wickner, and M. R. Maurizi (2000)
PNAS 97, 8898-8903
 |  Abstract »  |  Full Text »  |  PDF »

Why Does Threonine, and Not Serine, Function as the Active Site Nucleophile in Proteasomes?.

A. F. Kisselev, Z. Songyang, and A. L. Goldberg (2000)
J. Biol. Chem. 275, 14831-14837
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of a Gene Encoding Rpn10 of the Fission Yeast Proteasome Reveals That the Polyubiquitin-binding Site of This Subunit Is Essential When Rpn12/Mts3 Activity Is Compromised.

C. R. M. Wilkinson, K. Ferrell, M. Penney, M. Wallace, W. Dubiel, and C. Gordon (2000)
J. Biol. Chem. 275, 15182-15192
 |  Abstract »  |  Full Text »  |  PDF »

Increase of Oxidatively Modified Protein Is Associated With a Decrease of Proteasome Activity and Content in Aging Epidermal Cells.

I. Petropoulos, M. Conconi, X. Wang, B. Hoenel, F. Brégégère, Y. Milner, and B. Friguet (2000)
J. Gerontol. A Biol. Sci. Med. Sci. 55, 220B-227
 |  Abstract »  |  Full Text »

The Proteasome Is Involved in the First Metaphase-to-Anaphase Transition of Meiosis in Rat Oocytes.

L. B.-Y. Josefsberg, D. Galiani, A. Dantes, A. Amsterdam, and N. Dekel (2000)
Biol Reprod 62, 1270-1277
 |  Abstract »  |  Full Text »

Biochemical and Physical Properties of the Methanococcus jannaschii 20S Proteasome and PAN, a Homolog of the ATPase (Rpt) Subunits of the Eucaryal 26S Proteasome.

H. L. Wilson, M. S. Ou, H. C. Aldrich, and J. Maupin-Furlow (2000)
J. Bacteriol. 182, 1680-1692
 |  Abstract »  |  Full Text »

Chronic contractile activity upregulates the proteasome system in rabbit skeletal muscle.

G. A. Ordway, P. D. Neufer, E. R. Chin, and G. N. DeMartino (2000)
J Appl Physiol 88, 1134-1141
 |  Abstract »  |  Full Text »  |  PDF »

Proteolytic Processing and Assembly of the C5 Subunit into the Proteasome Complex.

S. Rodriguez-Vilarino, J. Arribas, P. Arizti, and J. G. Castano (2000)
J. Biol. Chem. 275, 6592-6599
 |  Abstract »  |  Full Text »  |  PDF »

The Ubiquitin-related BAG-1 Provides a Link between the Molecular Chaperones Hsc70/Hsp70 and the Proteasome.

J. Luders, J. Demand, and J. Hohfeld (2000)
J. Biol. Chem. 275, 4613-4617
 |  Abstract »  |  Full Text »  |  PDF »

Nalpha -Acetylation and Proteolytic Activity of the Yeast 20 S Proteasome.

Y. Kimura, M. Takaoka, S. Tanaka, H. Sassa, K. Tanaka, B. Polevoda, F. Sherman, and H. Hirano (2000)
J. Biol. Chem. 275, 4635-4639
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Essential Role of Human Leukocyte Antigen-encoded Proteasome Subunits in NF-kappa B Activation and Prevention of Tumor Necrosis Factor-alpha -induced Apoptosis.

T. Hayashi and D. Faustman (2000)
J. Biol. Chem. 275, 5238-5247
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Mapping Subunit Contacts in the Regulatory Complex of the 26 S Proteasome. S2 AND S5b FORM A TETRAMER WITH ATPase SUBUNITS S4 and S7.

C. Gorbea, D. Taillandier, and M. Rechsteiner (2000)
J. Biol. Chem. 275, 875-882
 |  Abstract »  |  Full Text »  |  PDF »

Evidence for a Role of ClpP in the Degradation of the Chloroplast Cytochrome b6f Complex.

W. Majeran, F.-A. Wollman, and O. Vallon (2000)
PLANT CELL 12, 137-150
 |  Abstract »  |  Full Text »  |  PDF »

Structural and Functional Characterizations of the Proteasome-activating Protein PA26 from Trypanosoma brucei.

Y. Yao, L. Huang, A. Krutchinsky, M.-L. Wong, K. G. Standing, A. L. Burlingame, and C. C. Wang (1999)
J. Biol. Chem. 274, 33921-33930
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Intrinsic Nucleoside Diphosphate Kinase-like Activity Is a Novel Function of the 20 S Proteasome.

M. Yano, S. Mori, and H. Kido (1999)
J. Biol. Chem. 274, 34375-34382
 |  Abstract »  |  Full Text »  |  PDF »

The catalytic sites of 20S proteasomes and their role in subunit maturation: A mutational and crystallographic study.

M. Groll, W. Heinemeyer, S. Jager, T. Ullrich, M. Bochtler, D. H. Wolf, and R. Huber (1999)
PNAS 96, 10976-10983
 |  Abstract »  |  Full Text »  |  PDF »

Chaperone rings in protein folding and degradation.

A. L. Horwich, E. U. Weber-Ban, and D. Finley (1999)
PNAS 96, 11033-11040
 |  Abstract »  |  Full Text »  |  PDF »

Halophilic 20S Proteasomes of the Archaeon Haloferax volcanii: Purification, Characterization, and Gene Sequence Analysis.

H. L. Wilson, H. C. Aldrich, and J. Maupin-Furlow (1999)
J. Bacteriol. 181, 5814-5824
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An Archaebacterial ATPase, Homologous to ATPases in the Eukaryotic 26 S Proteasome, Activates Protein Breakdown by 20 S Proteasomes.

P. Zwickl, D. Ng, K. M. Woo, H.-P. Klenk, and A. L. Goldberg (1999)
J. Biol. Chem. 274, 26008-26014
 |  Abstract »  |  Full Text »  |  PDF »

Follicle cell proteasome activity and acid extract from the egg vitelline coat prompt the onset of self-sterility in Ciona intestinalis oocytes.

R. Marino, R. De Santis, P. Giuliano, and M. R. Pinto (1999)
PNAS 96, 9633-9636
 |  Abstract »  |  Full Text »  |  PDF »

The Proteasome, a Novel Protease Regulated by Multiple Mechanisms.

G. N. DeMartino and C. A. Slaughter (1999)
J. Biol. Chem. 274, 22123-22126
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UV Stimulation of Chromosomal Marker Exchange in Sulfolobus acidocaldarius: Implications for DNA Repair, Conjugation and Homologous Recombination at Extremely High Temperatures.

K. J. Schmidt, K. E. Beck, and D. W. Grogan (1999)
Genetics 152, 1407-1415
 |  Abstract »  |  Full Text »

Multiubiquitin Chain Binding Subunit MCB1 (RPN10) of the 26S Proteasome Is Essential for Developmental Progression in Physcomitrella patens.

P.-A. Girod, H. Fu, J.-P. Zryd, and R. D. Vierstra (1999)
PLANT CELL 11, 1457-1472
 |  Abstract »  |  Full Text »

Mitochondrial Lon of Saccharomyces cerevisiae is a ring-shaped protease with seven flexible subunits.

H. Stahlberg, E. Kutejova, K. Suda, B. Wolpensinger, A. Lustig, G. Schatz, A. Engel, and C. K. Suzuki (1999)
PNAS 96, 6787-6790
 |  Abstract »  |  Full Text »  |  PDF »

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