Science 21 April 1995: Vol. 268. no. 5209, pp. 429 - 431 DOI: 10.1126/science.7716549

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Articles

Inhibition of Envelope-Mediated CD4+-T-Cell Depletion by Human Immunodeficiency Virus Attachment Inhibitors.

L. Alexander, S. Zhang, B. McAuliffe, D. Connors, N. Zhou, T. Wang, M. Agler, J. Kadow, and P.-F. Lin (2009)
Antimicrob. Agents Chemother. 53, 4726-4732
 |  Abstract »  |  Full Text »  |  PDF »

Virion-Associated Vpr of Human Immunodeficiency Virus Type 1 Triggers Activation of Apoptotic Events and Enhances Fas-Induced Apoptosis in Human T Cells.

H. Arokium, M. Kamata, and I. Chen (2009)
J. Virol. 83, 11283-11297
 |  Abstract »  |  Full Text »  |  PDF »

Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients.

G. Stary, I. Klein, S. Kohlhofer, F. Koszik, T. Scherzer, L. Mullauer, H. Quendler, N. Kohrgruber, and G. Stingl (2009)
Blood 114, 3854-3863
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of Nonneutralizing Vaccine-Elicited Antibody Activities to Improved Protective Efficacy in Rhesus Macaques Immunized with Tat/Env Compared with Multigenic Vaccines.

R. H. Florese, T. Demberg, P. Xiao, L. Kuller, K. Larsen, L. E. Summers, D. Venzon, A. Cafaro, B. Ensoli, and M. Robert-Guroff (2009)
J. Immunol. 182, 3718-3727
 |  Abstract »  |  Full Text »  |  PDF »

Tat-Induced FOXO3a Is a Key Mediator of Apoptosis in HIV-1-Infected Human CD4+ T Lymphocytes.

A. Dabrowska, N. Kim, and A. Aldovini (2008)
J. Immunol. 181, 8460-8477
 |  Abstract »  |  Full Text »  |  PDF »

Preferential Cytolysis of Peripheral Memory CD4+ T Cells by In Vitro X4-Tropic Human Immunodeficiency Virus Type 1 Infection before the Completion of Reverse Transcription.

Y. Zhou, L. Shen, H.-C. Yang, and R. F. Siliciano (2008)
J. Virol. 82, 9154-9163
 |  Abstract »  |  Full Text »  |  PDF »

Increased Loss of CCR5+ CD45RA- CD4+ T Cells in CD8+ Lymphocyte-Depleted Simian Immunodeficiency Virus-Infected Rhesus Monkeys.

R. S. Veazey, P. M. Acierno, K. J. McEvers, S. H. C. Baumeister, G. J. Foster, M. D. Rett, M. H. Newberg, M. J. Kuroda, K. Williams, E.-Y. Kim, et al. (2008)
J. Virol. 82, 5618-5630
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis: A Review of Programmed Cell Death.

S. Elmore (2007)
Toxicol Pathol 35, 495-516
 |  Abstract »  |  Full Text »  |  PDF »

A Replication-Competent Adenovirus-Human Immunodeficiency Virus (Ad-HIV) tat and Ad-HIV env Priming/Tat and Envelope Protein Boosting Regimen Elicits Enhanced Protective Efficacy against Simian/Human Immunodeficiency Virus SHIV89.6P Challenge in Rhesus Macaques.

T. Demberg, R. H. Florese, M. J. Heath, K. Larsen, I. Kalisz, V. S. Kalyanaraman, E. M. Lee, R. Pal, D. Venzon, R. Grant, et al. (2007)
J. Virol. 81, 3414-3427
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Human Immunodeficiency Virus Envelope Glycoprotein- Mediated Single Cell Lysis by Low-Molecular-Weight Antagonists of Viral Entry.

N. Madani, A. M. Hubicki, A. L. Perdigoto, M. Springer, and J. Sodroski (2007)
J. Virol. 81, 532-538
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical and NMR Study on the Competition between Proteins SC35, SRp40, and Heterogeneous Nuclear Ribonucleoprotein A1 at the HIV-1 Tat Exon 2 Splicing Site.

H. Hallay, N. Locker, L. Ayadi, D. Ropers, E. Guittet, and C. Branlant (2006)
J. Biol. Chem. 281, 37159-37174
 |  Abstract »  |  Full Text »  |  PDF »

HIV gp41-induced apoptosis is mediated by caspase-3-dependent mitochondrial depolarization, which is inhibited by HIV protease inhibitor nelfinavir.

H. Garg and R. Blumenthal (2006)
J. Leukoc. Biol. 79, 351-362
 |  Abstract »  |  Full Text »  |  PDF »

Severe Acute Respiratory Syndrome Coronavirus 3a Protein Is Released in Membranous Structures from 3a Protein-Expressing Cells and Infected Cells.

C. Huang, K. Narayanan, N. Ito, C. J. Peters, and S. Makino (2006)
J. Virol. 80, 210-217
 |  Abstract »  |  Full Text »  |  PDF »

Viral strategies for evading antiviral cellular immune responses of the host.

A. Iannello, O. Debbeche, E. Martin, L. H. Attalah, S. Samarani, and A. Ahmad (2006)
J. Leukoc. Biol. 79, 16-35
 |  Abstract »  |  Full Text »  |  PDF »

The C Terminus of HIV-1 Tat Modulates the Extent of CD178-mediated Apoptosis of T Cells.

G. R. Campbell, J. D. Watkins, D. Esquieu, E. Pasquier, E. P. Loret, and S. A. Spector (2005)
J. Biol. Chem. 280, 38376-38382
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Mechanisms of CD4+ and CD8+ T-Cell Activation and Bystander Apoptosis Induced by Human Immunodeficiency Virus Type 1 Virions.

G. H. Holm and D. Gabuzda (2005)
J. Virol. 79, 6299-6311
 |  Abstract »  |  Full Text »  |  PDF »

Pertussis Toxin (PTX) B Subunit and the Nontoxic PTX Mutant PT9K/129G Inhibit Tat-Induced TGF-{beta} Production by NK Cells and TGF-{beta}-Mediated NK Cell Apoptosis.

M. R. Zocchi, P. Contini, M. Alfano, and A. Poggi (2005)
J. Immunol. 174, 6054-6061
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Trans-Activator of Transcription Substitutes for Oxidative Signaling in Activation-Induced T Cell Death.

K. Gulow, M. Kaminski, K. Darvas, D. Suss, M. Li-Weber, and P. H. Krammer (2005)
J. Immunol. 174, 5249-5260
 |  Abstract »  |  Full Text »  |  PDF »

Construction of a Minimal HIV-1 Variant that Selectively Replicates in Leukemic Derived T-Cell Lines: Towards a New Virotherapy Approach.

R. E. Jeeninga, B. Jan, B. van der Linden, H. van den Berg, and B. Berkhout (2005)
Cancer Res. 65, 3347-3355
 |  Abstract »  |  Full Text »  |  PDF »

Cell surface-associated Tat modulates HIV-1 infection and spreading through a specific interaction with gp120 viral envelope protein.

S. Marchio, M. Alfano, L. Primo, D. Gramaglia, L. Butini, L. Gennero, E. De Vivo, W. Arap, M. Giacca, R. Pasqualini, et al. (2005)
Blood 105, 2802-2811
 |  Abstract »  |  Full Text »  |  PDF »

Sequence Variation within the Dominant Amino Terminus Epitope Affects Antibody Binding and Neutralization of Human Immunodeficiency Virus Type 1 Tat Protein.

T. J. Ruckwardt, I. Tikhonov, S. Berg, G. S. Hatfield, A. Chandra, P. Chandra, B. Gilliam, R. R. Redfield, R. C. Gallo, and C. D. Pauza (2004)
J. Virol. 78, 13190-13196
 |  Abstract »  |  Full Text »  |  PDF »

The Glutamine-rich Region of the HIV-1 Tat Protein Is Involved in T-cell Apoptosis.

G. R. Campbell, E. Pasquier, J. Watkins, V. Bourgarel-Rey, V. Peyrot, D. Esquieu, P. Barbier, J. de Mareuil, D. Braguer, P. Kaleebu, et al. (2004)
J. Biol. Chem. 279, 48197-48204
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis of Bystander T Cells Induced by Human Immunodeficiency Virus Type 1 with Increased Envelope/Receptor Affinity and Coreceptor Binding Site Exposure.

G. H. Holm, C. Zhang, P. R. Gorry, K. Peden, D. Schols, E. De Clercq, and D. Gabuzda (2004)
J. Virol. 78, 4541-4551
 |  Abstract »  |  Full Text »  |  PDF »

Infection with Oncolytic Herpes Simplex Virus-1 Induces Apoptosis in Neighboring Human Cancer Cells: A Potential Target to Increase Anticancer Activity.

S. F. Stanziale, H. Petrowsky, P. S. Adusumilli, L. Ben-Porat, M. Gonen, and Y. Fong (2004)
Clin. Cancer Res. 10, 3225-3232
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Tat Enters T Cells Using Coated Pits before Translocating from Acidified Endosomes and Eliciting Biological Responses.

A. Vendeville, F. Rayne, A. Bonhoure, N. Bettache, P. Montcourrier, and B. Beaumelle (2004)
Mol. Biol. Cell 15, 2347-2360
 |  Abstract »  |  Full Text »  |  PDF »

Varicella-Zoster Virus-Infected Human Sensory Neurons Are Resistant to Apoptosis, yet Human Foreskin Fibroblasts Are Susceptible: Evidence for a Cell-Type-Specific Apoptotic Response.

C. Hood, A. L. Cunningham, B. Slobedman, R. A. Boadle, and A. Abendroth (2003)
J. Virol. 77, 12852-12864
 |  Abstract »  |  Full Text »  |  PDF »

The Vpu Protein of Human Immunodeficiency Virus Type 1 Plays a Protective Role against Virus-Induced Apoptosis in Primary CD4+ T Lymphocytes.

S. Komoto, S. Tsuji, M. S. Ibrahim, Y.-G. Li, J. Warachit, K. Taniguchi, and K. Ikuta (2003)
J. Virol. 77, 10304-10313
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Profiles of Latent Human Immunodeficiency Virus in Infected Individuals: Effects of Tat on the Host and Reservoir.

X. Lin, D. Irwin, S. Kanazawa, L. Huang, J. Romeo, T. S. B. Yen, and B. M. Peterlin (2003)
J. Virol. 77, 8227-8236
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of CD4+ T lymphocyte cell death in human immunodeficiency virus infection and AIDS.

J. B. Alimonti, T. B. Ball, and K. R. Fowke (2003)
J. Gen. Virol. 84, 1649-1661
 |  Abstract »  |  Full Text »  |  PDF »

Cytolysis by CCR5-Using Human Immunodeficiency Virus Type 1 Envelope Glycoproteins Is Dependent on Membrane Fusion and Can Be Inhibited by High Levels of CD4 Expression.

J. A. LaBonte, N. Madani, and J. Sodroski (2003)
J. Virol. 77, 6645-6659
 |  Abstract »  |  Full Text »  |  PDF »

Monocytes Treated with Human Immunodeficiency Virus Tat Kill Uninfected CD4+ Cells by a Tumor Necrosis Factor-Related Apoptosis-Induced Ligand-Mediated Mechanism.

Y. Yang, I. Tikhonov, T. J. Ruckwardt, M. Djavani, J. C. Zapata, C. D. Pauza, and M. S. Salvato (2003)
J. Virol. 77, 6700-6708
 |  Abstract »  |  Full Text »  |  PDF »

Selective killing of cancer cells by beta -lapachone: Direct checkpoint activation as a strategy against cancer.

Y. Li, X. Sun, J. T. LaMont, A. B. Pardee, and C. J. Li (2003)
PNAS 100, 2674-2678
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Tat-Mediated Apoptosis in Human Brain Microvascular Endothelial Cells.

T.-A. Kim, H. K. Avraham, Y.-H. Koh, S. Jiang, I.-W. Park, and S. Avraham (2003)
J. Immunol. 170, 2629-2637
 |  Abstract »  |  Full Text »  |  PDF »

Cell Killing by HIV-1 Protease.

R. Blanco, L. Carrasco, and I. Ventoso (2003)
J. Biol. Chem. 278, 1086-1093
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of Disease Induced by a Partially Heterologous AIDS Virus in Rhesus Monkeys by Using an Adjuvanted Multicomponent Protein Vaccine.

G. Voss, K. Manson, D. Montefiori, D. I. Watkins, J. Heeney, M. Wyand, J. Cohen, and C. Bruck (2002)
J. Virol. 77, 1049-1058
 |  Abstract »  |  Full Text »  |  PDF »

Cardiomyocytes undergo apoptosis in human immunodeficiency virus cardiomyopathy through mitochondrion- and death receptor-controlled pathways.

C. Twu, N. Q. Liu, W. Popik, M. Bukrinsky, J. Sayre, J. Roberts, S. Rania, V. Bramhandam, K. P. Roos, W. R. MacLellan, et al. (2002)
PNAS 99, 14386-14391
 |  Abstract »  |  Full Text »  |  PDF »

Tat HIV-1 Primary and Tertiary Structures Critical to Immune Response Against Non-homologous Variants.

S. Opi, J.-M. Peloponese Jr., D. Esquieu, G. Campbell, J. de Mareuil, A. Walburger, M. Solomiac, C. Gregoire, E. Bouveret, D. L. Yirrell, et al. (2002)
J. Biol. Chem. 277, 35915-35919
 |  Abstract »  |  Full Text »  |  PDF »

Physical and Functional Interaction of HIV-1 Tat with E2F-4, a Transcriptional Regulator of Mammalian Cell Cycle.

C. Ambrosino, C. Palmieri, A. Puca, F. Trimboli, M. Schiavone, F. Olimpico, M. R. Ruocco, F. di Leva, M. Toriello, I. Quinto, et al. (2002)
J. Biol. Chem. 277, 31448-31458
 |  Abstract »  |  Full Text »  |  PDF »

A Tat subunit vaccine confers protective immunity against the immune-modulating activity of the human immunodeficiency virus type-1 Tat protein in mice.

S. M. Agwale, M. T. Shata, M. S. Reitz Jr., V. S. Kalyanaraman, R. C. Gallo, M. Popovic, and D. M. Hone (2002)
PNAS 99, 10037-10041
 |  Abstract »  |  Full Text »  |  PDF »

Human Immunodeficiency Virus-1 Tat Induces Hyperproliferation and Dysregulation of Renal Glomerular Epithelial Cells.

P. G. Conaldi, A. Bottelli, A. Baj, C. Serra, L. Fiore, G. Federico, B. Bussolati, and G. Camussi (2002)
Am. J. Pathol. 161, 53-61
 |  Abstract »  |  Full Text »  |  PDF »

Tat Acetyl-acceptor Lysines Are Important for Human Immunodeficiency Virus Type-1 Replication.

V. Bres, R. Kiernan, S. Emiliani, and M. Benkirane (2002)
J. Biol. Chem. 277, 22215-22221
 |  Abstract »  |  Full Text »  |  PDF »

A time to kill: viral manipulation of the cell death program.

S. Hay and G. Kannourakis (2002)
J. Gen. Virol. 83, 1547-1564
 |  Abstract »  |  Full Text »  |  PDF »

HIV Tat Binds Egr Proteins and Enhances Egr-dependent Transactivation of the Fas Ligand Promoter.

Y. Yang, B. Dong, P. R. Mittelstadt, H. Xiao, and J. D. Ashwell (2002)
J. Biol. Chem. 277, 19482-19487
 |  Abstract »  |  Full Text »  |  PDF »

Cytopathic Killing of Peripheral Blood CD4+ T Lymphocytes by Human Immunodeficiency Virus Type 1 Appears Necrotic rather than Apoptotic and Does Not Require env.

M. J. Lenardo, S. B. Angleman, V. Bounkeua, J. Dimas, M. G. Duvall, M. B. Graubard, F. Hornung, M. C. Selkirk, C. K. Speirs, C. Trageser, et al. (2002)
J. Virol. 76, 5082-5093
 |  Abstract »  |  Full Text »  |  PDF »

Death of CD4+ T-Cell Lines Caused by Human Immunodeficiency Virus Type 1 Does Not Depend on Caspases or Apoptosis.

D. L. Bolton, B.-I. Hahn, E. A. Park, L. L. Lehnhoff, F. Hornung, and M. J. Lenardo (2002)
J. Virol. 76, 5094-5107
 |  Abstract »  |  Full Text »  |  PDF »

Angiogenic Effects of Extracellular Human Immunodeficiency Virus Type 1 Tat Protein and Its Role in the Pathogenesis of AIDS-Associated Kaposi's Sarcoma.

G. Barillari and B. Ensoli (2002)
Clin. Microbiol. Rev. 15, 310-326
 |  Abstract »  |  Full Text »  |  PDF »

Outcome of Simian-Human Immunodeficiency Virus Strain 89.6p Challenge following Vaccination of Rhesus Macaques with Human Immunodeficiency Virus Tat Protein.

P. Silvera, M. W. Richardson, J. Greenhouse, J. Yalley-Ogunro, N. Shaw, J. Mirchandani, K. Khalili, J.-F. Zagury, M. G. Lewis, and J. Rappaport (2002)
J. Virol. 76, 3800-3809
 |  Abstract »  |  Full Text »  |  PDF »

Why is apoptosis important to clinicians?.

C. Haslett and J. Savill (2001)
BMJ 322, 1499-1500
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Membrane-Fusing Capacity of the Human Immunodeficiency Virus Envelope Proteins Determines the Efficiency of CD4+ T-Cell Depletion in Macaques Infected by a Simian-Human Immunodeficiency Virus.

B. Etemad-Moghadam, D. Rhone, T. Steenbeke, Y. Sun, J. Manola, R. Gelman, J. W. Fanton, P. Racz, K. Tenner-Racz, M. K. Axthelm, et al. (2001)
J. Virol. 75, 5646-5655
 |  Abstract »  |  Full Text »

HIV-1 Tat Inhibits IL-2 Gene Transcription Through Qualitative and Quantitative Alterations of the Cooperative Rel/AP1 Complex Bound to the CD28RE/AP1 Composite Element of the IL-2 Promoter.

E. Gonzalez, C. Punzon, M. Gonzalez, and M. Fresno (2001)
J. Immunol. 166, 4560-4569
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Tat Protein Stimulates In Vivo Vascular Permeability and Lymphomononuclear Cell Recruitment.

M. Arese, C. Ferrandi, L. Primo, G. Camussi, and F. Bussolino (2001)
J. Immunol. 166, 1380-1388
 |  Abstract »  |  Full Text »  |  PDF »

Positive and Negative Aspects of the Human Immunodeficiency Virus Protease: Development of Inhibitors versus Its Role in AIDS Pathogenesis.

K. Ikuta, S. Suzuki, H. Horikoshi, T. Mukai, and R. B. Luftig (2000)
Microbiol. Mol. Biol. Rev. 64, 725-745
 |  Abstract »  |  Full Text »  |  PDF »

Tat Protein of Human Immunodeficiency Virus Type 1 Induces Interleukin-10 in Human Peripheral Blood Monocytes: Implication of Protein Kinase C-Dependent Pathway.

A. Badou, Y. Bennasser, M. Moreau, C. Leclerc, M. Benkirane, and E. Bahraoui (2000)
J. Virol. 74, 10551-10562
 |  Abstract »  |  Full Text »

Importance of Membrane Fusion Mediated by Human Immunodeficiency Virus Envelope Glycoproteins for Lysis of Primary CD4-Positive T Cells.

J. A. LaBonte, T. Patel, W. Hofmann, and J. Sodroski (2000)
J. Virol. 74, 10690-10698
 |  Abstract »  |  Full Text »

Mechanisms of HIV-associated lymphocyte apoptosis.

A. D. Badley, A. A. Pilon, A. Landay, and D. H. Lynch (2000)
Blood 96, 2951-2964
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis Control in Syncytia Induced by the HIV Type 1-Envelope Glycoprotein Complex: Role of Mitochondria and Caspases.

K. F. Ferri, E. Jacotot, J. Blanco, J. A. Este, N. Zamzami, S. A. Susin, Z. Xie, G. Brothers, J. C. Reed, J. M. Penninger, et al. (2000)
J. Exp. Med. 192, 1081-1092
 |  Abstract »  |  Full Text »  |  PDF »

Induction of the Chemokines Interleukin-8 and IP-10 by Human Immunodeficiency Virus Type 1 Tat in Astrocytes.

O. Kutsch, J.-W. Oh, A. Nath, and E. N. Benveniste (2000)
J. Virol. 74, 9214-9221
 |  Abstract »  |  Full Text »

Permissive factors for HIV-1 infection of macrophages.

S. M. Wahl, T. Greenwell-Wild, H. Hale-Donze, N. Moutsopoulos, and J. M. Orenstein (2000)
J. Leukoc. Biol. 68, 303-310
 |  Abstract »  |  Full Text »  |  PDF »

Differential Patterns of Apoptosis in Resolving and Nonresolving Bacterial Pneumonia.

J. A. KAZZAZ, S. HOROWITZ, J. XU, P. KHULLAR, M. S. NIEDERMAN, A. M. FEIN, Z. ZAKERI, L. LIN, and G. C. RHODES (2000)
Am. J. Respir. Crit. Care Med. 161, 2043-2050
 |  Abstract »  |  Full Text »

Spontaneously proliferating lymphocytes from bovine leukaemia virus-infected, lymphocytotic cattle are not the virus-expressing lymphocytes, as these cells are delayed in G0/G1 of the cell cycle and are spared from apoptosis.

D. M. Stone, L. K. Norton, and W. C. Davis (2000)
J. Gen. Virol. 81, 971-981
 |  Abstract »  |  Full Text »

Jembrana Disease Virus Tat Can Regulate Human Immunodeficiency Virus (HIV) Long Terminal Repeat-Directed Gene Expression and Can Substitute for HIV Tat in Viral Replication.

H. Chen, J. He, S. Fong, G. Wilcox, and C. Wood (2000)
J. Virol. 74, 2703-2713
 |  Abstract »  |  Full Text »

Alternatively Spliced Products CC3 and TC3 Have Opposing Effects on Apoptosis.

S. Whitman, X. Wang, R. Shalaby, and E. Shtivelman (2000)
Mol. Cell. Biol. 20, 583-593
 |  Abstract »  |  Full Text »

Identification of Specific Molecular Structures of Human Immunodeficiency Virus Type 1 Tat Relevant for Its Biological Effects on Vascular Endothelial Cells.

S. Mitola, R. Soldi, I. Zanon, L. Barra, M. I. Gutierrez, B. Berkhout, M. Giacca, and F. Bussolino (2000)
J. Virol. 74, 344-353
 |  Abstract »  |  Full Text »

In vitro infection of cells of the monocytic/macrophage lineage with bovine leukaemia virus.

A. Doménech, J. Goyache, L. Llames, M. Jesús Payá, G. Suárez, and E. Gómez-Lucía (2000)
J. Gen. Virol. 81, 109-118
 |  Abstract »  |  Full Text »

Lymphocyte Activation during Acute Simian/Human Immunodeficiency Virus SHIV89.6PD Infection in Macaques.

M. Wallace, P. M. Waterman, J. L. Mitchen, M. Djavani, C. Brown, P. Trivedi, D. Horejsh, M. Dykhuizen, M. Kitabwalla, and C. D. Pauza (1999)
J. Virol. 73, 10236-10244
 |  Abstract »  |  Full Text »

Potent inhibition of tumor survival in vivo by beta -lapachone plus taxol: Combining drugs imposes different artificial checkpoints.

C. J. Li, Y.-Z. Li, A. V. Pinto, and A. B. Pardee (1999)
PNAS 96, 13369-13374
 |  Abstract »  |  Full Text »  |  PDF »

Multifaceted Activities of the HIV-1 Transactivator of Transcription, Tat.

K.-T. Jeang, H. Xiao, and E. A. Rich (1999)
J. Biol. Chem. 274, 28837-28840
 |  Full Text »  |  PDF »

Multiple Interactions of HIV-I Tat Protein with Size-defined Heparin Oligosaccharides.

M. Rusnati, G. Tulipano, D. Spillmann, E. Tanghetti, P. Oreste, G. Zoppetti, M. Giacca, and M. Presta (1999)
J. Biol. Chem. 274, 28198-28205
 |  Abstract »  |  Full Text »  |  PDF »

The potential importance of HIV-induction of lymphocyte homing to lymph nodes.

J. J.-Y. Chen and M. W. Cloyd (1999)
Int. Immunol. 11, 1591-1594
 |  Abstract »  |  Full Text »  |  PDF »

Pronounced acute immunosuppression in vivo mediated by HIV Tat challenge.

S. S. Cohen, C. Li, L. Ding, Y. Cao, A. B. Pardee, E. M. Shevach, and D. I. Cohen (1999)
PNAS 96, 10842-10847
 |  Abstract »  |  Full Text »  |  PDF »

An Inducible Human Immunodeficiency Virus Type 1 (HIV-1) Vector Which Effectively Suppresses HIV-1 Replication.

D. S. An, K. Morizono, Q.-X. Li, S. H. Mao, S. Lu, and I. S. Y. Chen (1999)
J. Virol. 73, 7671-7677
 |  Abstract »  |  Full Text »

Deficient Cellular Immunity--Finding and Fixing the Defects.

P. D. Greenberg and S. R. Riddell (1999)
Science 285, 546-551
 |  Abstract »  |  Full Text »

Tat as one key to HIV-induced immune pathogenesis and Pat toxoid as an important component of a vaccine.

R. C. Gallo (1999)
PNAS 96, 8324-8326
 |  Full Text »  |  PDF »

Poliovirus Induces Apoptosis in the Mouse Central Nervous System.

S. Girard, T. Couderc, J. Destombes, D. Thiesson, F. Delpeyroux, and B. Blondel (1999)
J. Virol. 73, 6066-6072
 |  Abstract »  |  Full Text »

Induction of MHC Class I Expression on Immature Thymocytes in HIV-1-Infected SCID-hu Thy/Liv Mice: Evidence of Indirect Mechanisms.

G. Kovalev, K. Duus, L. Wang, R. Lee, M. Bonyhadi, D. Ho, J. M. McCune, H. Kaneshima, and L. Su (1999)
J. Immunol. 162, 7555-7562
 |  Abstract »  |  Full Text »  |  PDF »

DNA Immunization with HIV-1 tat Mutated in the trans Activation Domain Induces Humoral and Cellular Immune Responses Against Wild-Type Tat.

E. Caselli, M. Betti, M. P. Grossi, P. G. Balboni, C. Rossi, C. Boarini, A. Cafaro, G. Barbanti-Brodano, B. Ensoli, and A. Caputo (1999)
J. Immunol. 162, 5631-5638
 |  Abstract »  |  Full Text »  |  PDF »

Full Peptide Synthesis, Purification, and Characterization of Six Tat Variants. DIFFERENCES OBSERVED BETWEEN HIV-1 ISOLATES FROM AFRICA AND OTHER CONTINENTS.

J.-M. Peloponese Jr., Y. Collette, C. Gregoire, C. Bailly, D. Campese, E. F. Meurs, D. Olive, and E. P. Loret (1999)
J. Biol. Chem. 274, 11473-11478
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Human Immunodeficiency Virus Type 1 Tat Induces Apoptosis and Increases Sensitivity to Apoptotic Signals by Up-Regulating FLICE/Caspase-8.

S. R. Bartz and M. Emerman (1999)
J. Virol. 73, 1956-1963
 |  Abstract »  |  Full Text »

Functional Domains of Tat Required for Efficient Human Immunodeficiency Virus Type 1 Reverse Transcription.

C. Ulich, A. Dunne, E. Parry, C. W. Hooker, R. B. Gaynor, and D. Harrich (1999)
J. Virol. 73, 2499-2508
 |  Abstract »  |  Full Text »

RNA Antisense Abrogation of MAT1 Induces G1 Phase Arrest and Triggers Apoptosis in Aortic Smooth Muscle Cells.

L. Wu, P. Chen, J.-J. Hwang, L. W. Barsky, K. I. Weinberg, A. Jong, and V. A. Starnes (1999)
J. Biol. Chem. 274, 5564-5572
 |  Abstract »  |  Full Text »  |  PDF »

Levels of major selenoproteins in T cells decrease during HIV infection and low molecular mass selenium compounds increase.

V. N. Gladyshev, T. C. Stadtman, D. L. Hatfield, and K.-T. Jeang (1999)
PNAS 96, 835-839
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Mechanism of CD4 Lymphocyte Depletion Involves Effects of HIV on Resting Lymphocytes: Induction of Lymph Node Homing and Apoptosis Upon Secondary Signaling Through Homing Receptors.

L. Wang, J. J. Y. Chen, B. B. Gelman, R. Konig, and M. W. Cloyd (1999)
J. Immunol. 162, 268-276
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Tat Protein Induces Human Immunodeficiency Virus Type 1 (HIV-1) Coreceptors and Promotes Infection with both Macrophage-Tropic and T-Lymphotropic HIV-1 Strains.

L. Huang, I. Bosch, W. Hofmann, J. Sodroski, and A. B. Pardee (1998)
J. Virol. 72, 8952-8960
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Chromatin Condensation Is Not Associated with Apoptosis.

M. J. Hendzel, W. K. Nishioka, Y. Raymond, C. D. Allis, D. P. Bazett-Jones, and J. P. H. Th'ng (1998)
J. Biol. Chem. 273, 24470-24478
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Tat Inhibits Human Natural Killer Cell Function by Blocking L-Type Calcium Channels.

M. R. Zocchi, A. Rubartelli, P. Morgavi, and A. Poggi (1998)
J. Immunol. 161, 2938-2943
 |  Abstract »  |  Full Text »  |  PDF »

A Matter of Life and Cell Death.

G. Evan and T. Littlewood (1998)
Science 281, 1317-1322
 |  Abstract »  |  Full Text »

Role of the Fas/Fas Ligand Apoptotic Pathway in Human Immunodeficiency Virus Type 1 Disease.

D. Kaplan and S. Sieg (1998)
J. Virol. 72, 6279-6282
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HIV-1 Tat Induces Neuronal Death via Tumor Necrosis Factor-alpha and Activation of Non-N-methyl-D-aspartate Receptors by a NFkappa B-Independent Mechanism.

D. R. New, S. B. Maggirwar, L. G. Epstein, S. Dewhurst, and H. A. Gelbard (1998)
J. Biol. Chem. 273, 17852-17858
 |  Abstract »  |  Full Text »  |  PDF »

Human Immunodeficiency Virus Type 1 Vectors Efficiently Transduce Human Hematopoietic Stem Cells.

R. E. Sutton, H. T. M. Wu, R. Rigg, E. Bohnlein, and P. O. Brown (1998)
J. Virol. 72, 5781-5788
 |  Abstract »  |  Full Text »  |  PDF »

The Basic Domain in HIV-1 Tat Protein as a Target for Polysulfonated Heparin-mimicking Extracellular Tat Antagonists.

M. Rusnati, G. Tulipano, C. Urbinati, E. Tanghetti, R. Giuliani, M. Giacca, M. Ciomei, A. Corallini, and M. Presta (1998)
J. Biol. Chem. 273, 16027-16037
 |  Abstract »  |  Full Text »  |  PDF »

Loss of CD4+ T Cells in Human Immunodeficiency Virus Type 1-Infected Chimpanzees Is Associated with Increased Lymphocyte Apoptosis.

I. C. Davis, M. Girard, and P. N. Fultz (1998)
J. Virol. 72, 4623-4632
 |  Abstract »  |  Full Text »  |  PDF »

The Transmembrane Domains of Sindbis Virus Envelope Glycoproteins Induce Cell Death.

A. K. Joe, H. H. Foo, L. Kleeman, and B. Levine (1998)
J. Virol. 72, 3935-3943
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Directly Kills CD4+ T Cells by a Fas-independent Mechanism.

R. T. Gandhi, B. K. Chen, S. E. Straus, J. K. Dale, M. J. Lenardo, and D. Baltimore (1998)
J. Exp. Med. 187, 1113-1122
 |  Abstract »  |  Full Text »  |  PDF »

HIV-1 Tat Elongates the G1 Phase and Indirectly Promotes HIV-1 Gene Expression in Cells of Glial Origin.

M. Kundu, S. Sharma, A. De Luca, A. Giordano, J. Rappaport, K. Khalili, and S. Amini (1998)
J. Biol. Chem. 273, 8130-8136
 |  Abstract »  |  Full Text »  |  PDF »

Human Parvovirus B19 Nonstructural (NS1) Protein Induces Apoptosis in Erythroid Lineage Cells.

S. Moffatt, N. Yaegashi, K. Tada, N. Tanaka, and K. Sugamura (1998)
J. Virol. 72, 3018-3028
 |  Abstract »  |  Full Text »  |  PDF »

Interferon alpha  and Tat involvement in the immunosuppression of uninfected T cells and C-C chemokine decline in AIDS.

D. Zagury, A. Lachgar, V. Chams, L. S. Fall, J. Bernard, J.-F. Zagury, B. Bizzini, A. Gringeri, E. Santagostino, J. Rappaport, et al. (1998)
PNAS 95, 3851-3856
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of Dihydropyridine-sensitive Calcium Channels in Human Dendritic Cell Function. COMPETITION BY HIV-1 TAT.

A. Poggi, A. Rubartelli, and M. R. Zocchi (1998)
J. Biol. Chem. 273, 7205-7209
 |  Abstract »  |  Full Text »  |  PDF »

Adenovirus-Mediated Human Immunodeficiency Virus-1 Nef Expression in Human Monocytes/Macrophages and Effect of Nef on Downmodulation of Fcgamma Receptors and Expression of Monokines.

S. K. De, C. N.S. Venkateshan, P. Seth, D. Carleton Gajdusek, and C. J. Gibbs Jr (1998)
Blood 91, 2108-2117
 |  Abstract »  |  Full Text »  |  PDF »

Productive Human Immunodeficiency Virus-1 Infection of Purified Megakaryocytic Progenitors/Precursors and Maturing Megakaryocytes.

C. Chelucci, M. Federico, R. Guerriero, G. Mattia, I. Casella, E. Pelosi, U. Testa, G. Mariani, H.J. Hassan, and C. Peschle (1998)
Blood 91, 1225-1234
 |  Abstract »  |  Full Text »  |  PDF »

The HIV-1 vpr Protein Acts as a Negative Regulator of Apoptosis in a Human Lymphoblastoid T Cell Line: Possible Implications for the Pathogenesis of AIDS.

L. Conti, G. Rainaldi, P. Matarrese, B. Varano, R. Rivabene, S. Columba, A. Sato, F. Belardelli, W. Malorni, and S. Gessani (1998)
J. Exp. Med. 187, 403-413
 |  Abstract »  |  Full Text »  |  PDF »

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