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Science 21 April 1995:
Vol. 268. no. 5209, pp. 411 - 415
DOI: 10.1126/science.7536343

Articles

Science, Vol 268, Issue 5209, 411-415
Copyright © 1995 by American Association for the Advancement of Science


articles

FAP-1: a protein tyrosine phosphatase that associates with Fas

T Sato, S Irie, S Kitada, and JC Reed

La Jolla Cancer Research Foundation, Oncogene and Tumor Suppressor Gene Program, CA 92037, USA.

Fas is a cell surface receptor that controls a poorly understood signal transduction pathway that leads to cell death by means of apoptosis. A protein tyrosine phosphatase, FAP-1, capable of interacting with the cytosolic domain of Fas, was identified. The carboxyl terminal 15 amino acids of Fas are necessary and sufficient for interaction with FAP-1. FAP-1 expression is highest in tissues and cell lines that are relatively resistant to Fas-mediated cytotoxicity. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line. These findings are consistent with an inhibitory effect of FAP-1 on Fas signal transduction.


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   Abstract »    Full Text »    PDF »
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Differential Regulation and Function of Fas Expression on Glial Cells.
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Expression and Activity of the Fas Antigen in Bovine Ovarian Follicle Cells.
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P. L. Arscott, T. Stokes, A. Myc, T. J. Giordano, N. W. Thompson, and J. R. Baker Jr. (1999)
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Protein Kinase C Inhibits CD95 (Fas/APO-1)-Mediated Apoptosis by at Least Two Different Mechanisms in Jurkat T Cells.
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J. Immunol. 163, 4737-4746
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TRAIL Death Pathway Expression and Induction in Thyroid Follicular Cells.
J. D. Bretz, M. Rymaszewski, P. L. Arscott, A. Myc, K. B. Ain, N. W. Thompson, and J. R. Baker Jr. (1999)
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K. K. Murthy, K. Clark, Y. Fortin, S.-H. Shen, and D. Banville (1999)
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M. Ogata, T. Takada, Y. Mori, Y. Uchida, T. Miki, A. Okuyama, A. Kosugi, M. Sawada, M. Oh-hora, and T. Hamaoka (1999)
J. Biol. Chem. 274, 20717-20724
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S. H. Lee, M. S. Shin, W. S. Park, S. Y. Kim, S. M. Dong, J. H. Pi, H. K. Lee, H. S. Kim, J. J. Jang, C. S. Kim, et al. (1999)
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The Insulin-like Growth Factor 1 Receptor Induces Transformation and Tumorigenicity of Ovarian Mesothelial Cells and Down-Regulates Their Fas-Receptor Expression.
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Myeloma Cells Selected for Resistance to CD95-Mediated Apoptosis Are Not Cross-Resistant to Cytotoxic Drugs: Evidence for Independent Mechanisms of Caspase Activation.
T. H. Landowski, K. H. Shain, M. M. Oshiro, I. Buyuksal, J. S. Painter, and W. S. Dalton (1999)
Blood 94, 265-274
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Identification of the Cell Cycle Regulator VCP (p97/CDC48) as a Substrate of the Band 4.1-related Protein-tyrosine Phosphatase PTPH1.
S.-H. Zhang, J. Liu, R. Kobayashi, and N. K. Tonks (1999)
J. Biol. Chem. 274, 17806-17812
   Abstract »    Full Text »    PDF »
Alterations of Fas (Apo-1/CD95) Gene in Cutaneous Malignant Melanoma.
M. S. Shin, W. S. Park, S. Y. Kim, H. S. Kim, S. J. Kang, K. Y. Song, J. Y. Park, S. M. Dong, J. H. Pi, R. R. Oh, et al. (1999)
Am. J. Pathol. 154, 1785-1791
   Abstract »    Full Text »    PDF »
Unexpected Modes of PDZ Domain Scaffolding Revealed by Structure of nNOS-Syntrophin Complex.
B. J. Hillier, K. S. Christopherson, K. E. Prehoda, D. S. Bredt, and W. A. Lim (1999)
Science 284, 812-815
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Functional Fas Expression in Human Thymic Epithelial Cells.
N. Moulian, C. Renvoize, C. Desodt, A. Serraf, and S. Berrih-Aknin (1999)
Blood 93, 2660-2670
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Activation-Dependent Transcriptional Regulation of the Human fas Promoter Requires NF-kappa B p50-p65 Recruitment.
H. Chan, D. P. Bartos, and L. B. Owen-Schaub (1999)
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A Tailless Fas-FADD Death-Effector Domain Chimera Is Sufficient to Execute Fas Function in T Cells But Not B Cells of MRL-lpr/lpr Mice.
N. H. Kabra, D. Cado, and A. Winoto (1999)
J. Immunol. 162, 2766-2774
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CD95 (Fas/Apo-1) as a Receptor Governing Astrocyte Apoptotic or Inflammatory Responses: A Key Role in Brain Inflammation?.
P. Saas, J. Boucraut, A.-L. Quiquerez, V. Schnuriger, G. Perrin, S. Desplat-Jego, D. Bernard, P. R. Walker, and P.-Y. Dietrich (1999)
J. Immunol. 162, 2326-2333
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The Carboxyl Terminus of B Class Ephrins Constitutes a PDZ Domain Binding Motif.
D. Lin, G. D. Gish, Z. Songyang, and T. Pawson (1999)
J. Biol. Chem. 274, 3726-3733
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Bax Is Frequently Compromised in Burkitt's Lymphomas with Irreversible Resistance to Fas-induced Apoptosis.
M. I. Gutierrez, B. Cherney, A. Hussain, H. Mostowski, G. Tosato, I. Magrath, and K. Bhatia (1999)
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Resistance to Fas-Mediated T Cell Apoptosis in Asthma.
S. Jayaraman, M. Castro, M. O'Sullivan, M. J. Bragdon, and M. J. Holtzman (1999)
J. Immunol. 162, 1717-1722
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A FERM domain governs apical confinement of PTP-BL in epithelial cells.
E Cuppen, M Wijers, J Schepens, J Fransen, B Wieringa, and W Hendriks (1999)
J. Cell Sci. 112, 3299-3308
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Potentiation of Fas-Mediated Apoptosis of Murine Granulosa Cells by Interferon-{gamma}, Tumor Necrosis Factor-{alpha}, and Cycloheximide.
S. M. Quirk, D. A. Porter, S. C. Huber, and R. G. Cowan (1998)
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L. P. Perera and T. A. Waldmann (1998)
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Fas and Fas Ligand Interactions Suppress Melanoma Lung Metastasis.
L. B. Owen-Schaub, K. L. van Golen, L. L. Hill, and J. E. Price (1998)
J. Exp. Med. 188, 1717-1723
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Phosphorylated Forms of Activated Caspases Are Present in Cytosol From HL-60 Cells During Etoposide-Induced Apoptosis.
L. M. Martins, T. J. Kottke, S. H. Kaufmann, and W. C. Earnshaw (1998)
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   Abstract »    Full Text »    PDF »
Apoptosis and expression of soluble Fas mRNA in systemic lupus erythematosus.
T Papo, C Parizot, M Ortova, J-C Piette, C Frances, P Debre, P Godeau, and G Gorochov (1998)
Lupus 7, 455-461
   Abstract »    PDF »
X11 Interaction with beta -Amyloid Precursor Protein Modulates Its Cellular Stabilization and Reduces Amyloid beta -Protein Secretion.
M. Sastre, R. S. Turner, and E. Levy (1998)
J. Biol. Chem. 273, 22351-22357
   Abstract »    Full Text »    PDF »
Two Signaling Pathways Can Increase Fas Expression in Human Thymocytes.
N. Moulian, J. Bidault, C. Planche, and S. Berrih-Aknin (1998)
Blood 92, 1297-1307
   Abstract »    Full Text »    PDF »
Role for Tyrosine Phosphorylation and Lyn Tyrosine Kinase in Fas Receptor-Mediated Apoptosis in Eosinophils.
H.-U. Simon, S. Yousefi, B. Dibbert, H. Hebestreit, M. Weber, D. R. Branch, K. Blaser, F. Levi-Schaffer, and G. P. Anderson (1998)
Blood 92, 547-557
   Abstract »    Full Text »    PDF »
GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain.
B. E. Snow, R. A. Hall, A. M. Krumins, G. M. Brothers, D. Bouchard, C. A. Brothers, S. Chung, J. Mangion, A. G. Gilman, R. J. Lefkowitz, et al. (1998)
J. Biol. Chem. 273, 17749-17755
   Abstract »    Full Text »    PDF »
Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes.
I. Szabo, A. Lepple-Wienhues, K. N. Kaba, M. Zoratti, E. Gulbins, and F. Lang (1998)
PNAS 95, 6169-6174
   Abstract »    Full Text »    PDF »
Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes.
T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Hori, and M. Tada (1998)
J. Biol. Chem. 273, 12725-12731
   Abstract »    Full Text »    PDF »
Phosphorylation of FADD/MORT1 and Fas by Kinases That Associate with the Membrane-Proximal Cytoplasmic Domain of Fas.
N. J. Kennedy and R. C. Budd (1998)
J. Immunol. 160, 4881-4888
   Abstract »    Full Text »    PDF »
Induction of Fas Ligand in Murine Bone Marrow NK Cells by Bacterial Polysaccharides.
O. Halaas, R. Vik, and T. Espevik (1998)
J. Immunol. 160, 4330-4336
   Abstract »    Full Text »    PDF »
Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses.
S. Kitada, J. Andersen, S. Akar, J. M. Zapata, S. Takayama, S. Krajewski, H.-G. Wang, X. Zhang, F. Bullrich, C. M. Croce, et al. (1998)
Blood 91, 3379-3389
   Abstract »    Full Text »    PDF »
The Mammalian Numb Phosphotyrosine-binding Domain. CHARACTERIZATION OF BINDING SPECIFICITY AND IDENTIFICATION OF A NOVEL PDZ DOMAIN-CONTAINING NUMB BINDING PROTEIN, LNX.
S. E. Dho, S. Jacob, C. D. Wolting, M. B. French, L. R. Rohrschneider, and C. J. McGlade (1998)
J. Biol. Chem. 273, 9179-9187
   Abstract »    Full Text »    PDF »
A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases.
R. Takahashi, Q. Deveraux, I. Tamm, K. Welsh, N. Assa-Munt, G. S. Salvesen, and J. C. Reed (1998)
J. Biol. Chem. 273, 7787-7790
   Abstract »    Full Text »    PDF »
Extinction of Insulin-Like Growth Factor-I Mitogenic Signaling by Antiestrogen-Stimulated Fas-Associated Protein Tyrosine Phosphatase-1 in Human Breast Cancer Cells.
G. Freiss, C. Puech, and F. Vignon (1998)
Mol. Endocrinol. 12, 568-579
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Suppression of Fas/APO-1-Mediated Apoptosis by Mitogen-Activated Kinase Signaling.
T. H. Holmstrom, S. C. Chow, I. Elo, E. T. Coffey, S. Orrenius, L. Sistonen, and J. E. Eriksson (1998)
J. Immunol. 160, 2626-2636
   Abstract »    Full Text »    PDF »
PDZ Motifs in PTP-BL and RIL Bind to Internal Protein Segments in the LIM Domain Protein RIL.
E. Cuppen, H. Gerrits, B. Pepers, B. Wieringa, and W. Hendriks (1998)
Mol. Biol. Cell 9, 671-683
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Interaction of Muscle and Brain Sodium Channels with Multiple Members of the Syntrophin Family of Dystrophin-Associated Proteins.
S. H. Gee, R. Madhavan, S. R. Levinson, J. H. Caldwell, R. Sealock, and S. C. Froehner (1998)
J. Neurosci. 18, 128-137
   Abstract »    Full Text »    PDF »
Cutting Edge: Lymphocyte Inhibitor of TRAIL (TNF-Related Apoptosis-Inducing Ligand): A New Receptor Protecting Lymphocytes from the Death Ligand TRAIL.
J. Mongkolsapaya, A. E. Cowper, X.-N. Xu, G. Morris, A. J. McMichael, J. I. Bell, and G. R. Screaton (1998)
J. Immunol. 160, 3-6
   Abstract »    Full Text »    PDF »



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