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Science 21 April 1995: Vol. 268. no. 5209, pp. 411 - 415 DOI: 10.1126/science.7536343
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Articles
Science, Vol 268, Issue 5209, 411-415
Copyright © 1995 by American Association for the Advancement of Science
FAP-1: a protein tyrosine phosphatase that associates with Fas
T Sato,
S Irie,
S Kitada,
and
JC Reed
La Jolla Cancer Research Foundation, Oncogene and Tumor Suppressor Gene Program, CA 92037, USA.
Fas is a cell surface receptor that controls a poorly understood signal transduction pathway that leads to cell death by means of apoptosis. A protein tyrosine phosphatase, FAP-1, capable of interacting with the cytosolic domain of Fas, was identified. The carboxyl terminal 15 amino acids of Fas are necessary and sufficient for interaction with FAP-1. FAP-1 expression is highest in tissues and cell lines that are relatively resistant to Fas-mediated cytotoxicity. Gene transfer-mediated elevations in FAP-1 partially abolished Fas-induced apoptosis in a T cell line. These findings are consistent with an inhibitory effect of FAP-1 on Fas signal transduction.
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- Resistance to Fas-Mediated T Cell Apoptosis in Asthma.
- S. Jayaraman, M. Castro, M. O'Sullivan, M. J. Bragdon, and M. J. Holtzman (1999)
J. Immunol.
162, 1717-1722
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- A FERM domain governs apical confinement of PTP-BL in epithelial cells.
- E Cuppen, M Wijers, J Schepens, J Fransen, B Wieringa, and W Hendriks (1999)
J. Cell Sci.
112, 3299-3308
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- Potentiation of Fas-Mediated Apoptosis of Murine Granulosa Cells by Interferon-{gamma}, Tumor Necrosis Factor-{alpha}, and Cycloheximide.
- S. M. Quirk, D. A. Porter, S. C. Huber, and R. G. Cowan (1998)
Endocrinology
139, 4860-4869
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- Activation of human monocytes induces differential resistance to apoptosis with rapid down regulation of caspase-8/FLICE.
- L. P. Perera and T. A. Waldmann (1998)
PNAS
95, 14308-14313
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- Fas and Fas Ligand Interactions Suppress Melanoma Lung Metastasis.
- L. B. Owen-Schaub, K. L. van Golen, L. L. Hill, and J. E. Price (1998)
J. Exp. Med.
188, 1717-1723
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- Phosphorylated Forms of Activated Caspases Are Present in Cytosol From HL-60 Cells During Etoposide-Induced Apoptosis.
- L. M. Martins, T. J. Kottke, S. H. Kaufmann, and W. C. Earnshaw (1998)
Blood
92, 3042-3049
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- Apoptosis and expression of soluble Fas mRNA in systemic lupus erythematosus.
- T Papo, C Parizot, M Ortova, J-C Piette, C Frances, P Debre, P Godeau, and G Gorochov (1998)
Lupus
7, 455-461
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- X11 Interaction with beta -Amyloid Precursor Protein Modulates Its Cellular Stabilization and Reduces Amyloid beta -Protein Secretion.
- M. Sastre, R. S. Turner, and E. Levy (1998)
J. Biol. Chem.
273, 22351-22357
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- Two Signaling Pathways Can Increase Fas Expression in Human Thymocytes.
- N. Moulian, J. Bidault, C. Planche, and S. Berrih-Aknin (1998)
Blood
92, 1297-1307
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- Role for Tyrosine Phosphorylation and Lyn Tyrosine Kinase in Fas Receptor-Mediated Apoptosis in Eosinophils.
- H.-U. Simon, S. Yousefi, B. Dibbert, H. Hebestreit, M. Weber, D. R. Branch, K. Blaser, F. Levi-Schaffer, and G. P. Anderson (1998)
Blood
92, 547-557
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- GTPase Activating Specificity of RGS12 and Binding Specificity of an Alternatively Spliced PDZ (PSD-95/Dlg/ZO-1) Domain.
- B. E. Snow, R. A. Hall, A. M. Krumins, G. M. Brothers, D. Bouchard, C. A. Brothers, S. Chung, J. Mangion, A. G. Gilman, R. J. Lefkowitz, et al. (1998)
J. Biol. Chem.
273, 17749-17755
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- Tyrosine kinase-dependent activation of a chloride channel in CD95-induced apoptosis in T lymphocytes.
- I. Szabo, A. Lepple-Wienhues, K. N. Kaba, M. Zoratti, E. Gulbins, and F. Lang (1998)
PNAS
95, 6169-6174
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- Direct Association of the Gap Junction Protein Connexin-43 with ZO-1 in Cardiac Myocytes.
- T. Toyofuku, M. Yabuki, K. Otsu, T. Kuzuya, M. Hori, and M. Tada (1998)
J. Biol. Chem.
273, 12725-12731
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- Phosphorylation of FADD/MORT1 and Fas by Kinases That Associate with the Membrane-Proximal Cytoplasmic Domain of Fas.
- N. J. Kennedy and R. C. Budd (1998)
J. Immunol.
160, 4881-4888
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- Induction of Fas Ligand in Murine Bone Marrow NK Cells by Bacterial Polysaccharides.
- O. Halaas, R. Vik, and T. Espevik (1998)
J. Immunol.
160, 4330-4336
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- Expression of Apoptosis-Regulating Proteins in Chronic Lymphocytic Leukemia: Correlations With In Vitro and In Vivo Chemoresponses.
- S. Kitada, J. Andersen, S. Akar, J. M. Zapata, S. Takayama, S. Krajewski, H.-G. Wang, X. Zhang, F. Bullrich, C. M. Croce, et al. (1998)
Blood
91, 3379-3389
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- The Mammalian Numb Phosphotyrosine-binding Domain. CHARACTERIZATION OF BINDING SPECIFICITY AND IDENTIFICATION OF A NOVEL PDZ DOMAIN-CONTAINING NUMB BINDING PROTEIN, LNX.
- S. E. Dho, S. Jacob, C. D. Wolting, M. B. French, L. R. Rohrschneider, and C. J. McGlade (1998)
J. Biol. Chem.
273, 9179-9187
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- A Single BIR Domain of XIAP Sufficient for Inhibiting Caspases.
- R. Takahashi, Q. Deveraux, I. Tamm, K. Welsh, N. Assa-Munt, G. S. Salvesen, and J. C. Reed (1998)
J. Biol. Chem.
273, 7787-7790
| Abstract »
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- Extinction of Insulin-Like Growth Factor-I Mitogenic Signaling by Antiestrogen-Stimulated Fas-Associated Protein Tyrosine Phosphatase-1 in Human Breast Cancer Cells.
- G. Freiss, C. Puech, and F. Vignon (1998)
Mol. Endocrinol.
12, 568-579
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- Suppression of Fas/APO-1-Mediated Apoptosis by Mitogen-Activated Kinase Signaling.
- T. H. Holmstrom, S. C. Chow, I. Elo, E. T. Coffey, S. Orrenius, L. Sistonen, and J. E. Eriksson (1998)
J. Immunol.
160, 2626-2636
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- PDZ Motifs in PTP-BL and RIL Bind to Internal Protein Segments in the LIM Domain Protein RIL.
- E. Cuppen, H. Gerrits, B. Pepers, B. Wieringa, and W. Hendriks (1998)
Mol. Biol. Cell
9, 671-683
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- Interaction of Muscle and Brain Sodium Channels with Multiple Members of the Syntrophin Family of Dystrophin-Associated Proteins.
- S. H. Gee, R. Madhavan, S. R. Levinson, J. H. Caldwell, R. Sealock, and S. C. Froehner (1998)
J. Neurosci.
18, 128-137
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- Cutting Edge: Lymphocyte Inhibitor of TRAIL (TNF-Related Apoptosis-Inducing Ligand): A New Receptor Protecting Lymphocytes from the Death Ligand TRAIL.
- J. Mongkolsapaya, A. E. Cowper, X.-N. Xu, G. Morris, A. J. McMichael, J. I. Bell, and G. R. Screaton (1998)
J. Immunol.
160, 3-6
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