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Science 21 April 1995:
Vol. 268. no. 5209, pp. 408 - 411
DOI: 10.1126/science.7716544
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Articles

Science, Vol 268, Issue 5209, 408-411
Copyright © 1995 by American Association for the Advancement of Science

articles

The role of Ig beta in precursor B cell transition and allelic exclusion

F Papavasiliou, Z Misulovin, H Suh, and MC Nussenzweig

Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10021, USA.

Lymphocytes express multicomponent receptor complexes that mediate diverse antigen-dependent and antigen-independent responses. Despite the central role of antigen-independent events in B cell development, little is known about the mechanisms by which they are initiated. The association between the membrane immunoglobulin (Ig) M heavy chair (micron) and the Ig alpha-Ig beta heterodimer is now shown to be essential in inducing both the transition from progenitor to precursor B cells and subsequent allelic exclusion in transgenic mice. The cytoplasmic domain of Ig beta is sufficient to induce these early antigen-independent events by a mechanism that requires conserved tyrosine residues in this protein.


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