Science 14 April 1995: Vol. 268. no. 5208, pp. 286 - 290 DOI: 10.1126/science.7716521

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Articles

Androgen via p21 Inhibits Tumor Necrosis Factor {alpha}-induced JNK Activation and Apoptosis.

F. Tang, J. Kokontis, Y. Lin, S. Liao, A. Lin, and J. Xiang (2009)
J. Biol. Chem. 284, 32353-32358
 |  Abstract »  |  Full Text »  |  PDF »

Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-{alpha}-induced JNK1 activation.

J. Liu, Y. Zhao, M. Eilers, and A. Lin (2009)
PNAS 106, 18279-18284
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Wip1 Sensitizes Cells to Stress- and DNA Damage-induced Apoptosis.

Y. Xia, P. Ongusaha, S. W. Lee, and Y.-C. Liou (2009)
J. Biol. Chem. 284, 17428-17437
 |  Abstract »  |  Full Text »  |  PDF »

Selectivity of Docking Sites in MAPK Kinases.

A. J. Bardwell, E. Frankson, and L. Bardwell (2009)
J. Biol. Chem. 284, 13165-13173
 |  Abstract »  |  Full Text »  |  PDF »

Activator Protein-1 Has an Essential Role in Pancreatic Cancer Cells and Is Regulated by a Novel Akt-Mediated Mechanism.

S. Shin, T. Asano, Y. Yao, R. Zhang, F.-X. Claret, M. Korc, K. Sabapathy, D. G. Menter, J. L. Abbruzzese, and S. A.G. Reddy (2009)
Mol. Cancer Res. 7, 745-754
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Bad at Thr-201 by JNK1 Promotes Glycolysis through Activation of Phosphofructokinase-1.

H. Deng, F. Yu, J. Chen, Y. Zhao, J. Xiang, and A. Lin (2008)
J. Biol. Chem. 283, 20754-20760
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein Kinase Kinase 4/c-Jun NH2-Terminal Kinase Kinase 1 Protein Expression Is Subject to Translational Regulation in Prostate Cancer Cell Lines.

V. L. Robinson, O. Shalhav, K. Otto, T. Kawai, M. Gorospe, and C. W. Rinker-Schaeffer (2008)
Mol. Cancer Res. 6, 501-508
 |  Abstract »  |  Full Text »  |  PDF »

Required Roles of Bax and JNKs in Central and Peripheral Nervous System Death of Retinoblastoma-deficient Mice.

E. Keramaris, V. A. Ruzhynsky, S. M. Callaghan, E. Wong, R. J. Davis, R. Flavell, R. S. Slack, and D. S. Park (2008)
J. Biol. Chem. 283, 405-415
 |  Abstract »  |  Full Text »  |  PDF »

Retinoic Acid Receptor beta Silences Human Papillomavirus-18 Oncogene Expression by Induction of de Novo Methylation and Heterochromatinization of the Viral Control Region.

J. De-Castro Arce, E. Gockel-Krzikalla, and F. Rosl (2007)
J. Biol. Chem. 282, 28520-28529
 |  Abstract »  |  Full Text »  |  PDF »

Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.

W. Breitwieser, S. Lyons, A. M. Flenniken, G. Ashton, G. Bruder, M. Willington, G. Lacaud, V. Kouskoff, and N. Jones (2007)
Genes & Dev. 21, 2069-2082
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Deletion of MKK4 Gene Potentiates TNF-Induced Apoptosis through the Down-Regulation of NF-{kappa}B Activation and NF-{kappa}B-Regulated Antiapoptotic Gene Products.

G. Sethi, K. S. Ahn, D. Xia, J. M. Kurie, and B. B. Aggarwal (2007)
J. Immunol. 179, 1926-1933
 |  Abstract »  |  Full Text »  |  PDF »

PKC-{alpha} and TAK-1 are intermediates in the activation of c-Jun NH2-terminal kinase by hypoxia-reoxygenation.

D. P. Frazier, A. Wilson, C. J. Dougherty, H. Li, N. H. Bishopric, and K. A. Webster (2007)
Am J Physiol Heart Circ Physiol 292, H1675-H1684
 |  Abstract »  |  Full Text »  |  PDF »

Palytoxin: exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis.

E. V. Wattenberg (2007)
Am J Physiol Cell Physiol 292, C24-C32
 |  Abstract »  |  Full Text »  |  PDF »

K-ras Asp12 mutant neither interacts with Raf, nor signals through Erk and is less tumorigenic than K-ras Val12.

M. V. Cespedes, F. J. Sancho, S. Guerrero, M. Parreno, I. Casanova, M. A. Pavon, E. Marcuello, M. Trias, M. Cascante, G. Capella, et al. (2006)
Carcinogenesis 27, 2190-2200
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Inhibition of T Cell Activation by TIM-2.

J. E. Knickelbein, A. J. de Souza, R. Tosti, P. Narayan, and L. P. Kane (2006)
J. Immunol. 177, 4966-4970
 |  Abstract »  |  Full Text »  |  PDF »

Profile of Michael Karin.

T. H. Davis (2006)
PNAS 103, 12665-12667
 |  Full Text »  |  PDF »

Synaptogenesis regulates axotomy-induced activation of c-Jun-activator protein-1 transcription..

Y.-J. Sung, F. Wu, S. Schacher, and R. T. Ambron (2006)
J. Neurosci. 26, 6439-6449
 |  Abstract »  |  Full Text »  |  PDF »

Cyclic AMP Inhibits p38 Activation via CREB-Induced Dynein Light Chain.

J. Zhang, T. N. Bui, J. Xiang, and A. Lin (2006)
Mol. Cell. Biol. 26, 1223-1234
 |  Abstract »  |  Full Text »  |  PDF »

The p38 Kinases MKK4 and MKK6 Suppress Metastatic Colonization in Human Ovarian Carcinoma.

J. A. Hickson, D. Huo, D. J. Vander Griend, A. Lin, C. W. Rinker-Schaeffer, and S. D. Yamada (2006)
Cancer Res. 66, 2264-2270
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Metastatic Colonization by the Context-Dependent Activation of the c-Jun NH2-Terminal Kinase Kinases JNKK1/MKK4 and MKK7.

D. J. Vander Griend, M. Kocherginsky, J. A. Hickson, W. M. Stadler, A. Lin, and C. W. Rinker-Schaeffer (2005)
Cancer Res. 65, 10984-10991
 |  Abstract »  |  Full Text »  |  PDF »

BAD Ser128 Is Not Phosphorylated by c-Jun NH2-Terminal Kinase for Promoting Apoptosis.

J. Zhang, J. Liu, C. Yu, and A. Lin (2005)
Cancer Res. 65, 8372-8378
 |  Abstract »  |  Full Text »  |  PDF »

Pellino3 Is a Novel Upstream Regulator of p38 MAPK and Activates CREB in a p38-dependent Manner.

M. P. Butler, J. A. Hanly, and P. N. Moynagh (2005)
J. Biol. Chem. 280, 27759-27768
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of Double-stranded RNA-induced Apoptosis Pathways Using Interferon-response Noninducible Small Interfering RNA Expression Vector Library.

S. Matsumoto, M. Miyagishi, H. Akashi, R. Nagai, and K. Taira (2005)
J. Biol. Chem. 280, 25687-25696
 |  Abstract »  |  Full Text »  |  PDF »

Selective Activation of Mitogen-Activated Protein (MAP) Kinase Kinase 3 and p38{alpha} MAP Kinase Is Essential for Cyclic AMP-Dependent UCP1 Expression in Adipocytes.

J. Robidoux, W. Cao, H. Quan, K. W. Daniel, F. Moukdar, X. Bai, L. M. Floering, and S. Collins (2005)
Mol. Cell. Biol. 25, 5466-5479
 |  Abstract »  |  Full Text »  |  PDF »

p38 MAPK Autophosphorylation Drives Macrophage IL-12 Production during Intracellular Infection.

L. Kim, L. D. Rio, B. A. Butcher, T. H. Mogensen, S. R. Paludan, R. A. Flavell, and E. Y. Denkers (2005)
J. Immunol. 174, 4178-4184
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons.

Y. Li, S. Batra, A. Sassano, B. Majchrzak, D. E. Levy, M. Gaestel, E. N. Fish, R. J. Davis, and L. C. Platanias (2005)
J. Biol. Chem. 280, 10001-10010
 |  Abstract »  |  Full Text »  |  PDF »

c-Jun N-Terminal Kinase Contributes to Aberrant Retinoid Signaling in Lung Cancer Cells by Phosphorylating and Inducing Proteasomal Degradation of Retinoic Acid Receptor {alpha}.

H. Srinivas, D. M. Juroske, S. Kalyankrishna, D. D. Cody, R. E. Price, X.-C. Xu, R. Narayanan, N. L. Weigel, and J. M. Kurie (2005)
Mol. Cell. Biol. 25, 1054-1069
 |  Abstract »  |  Full Text »  |  PDF »

MAPK p38{alpha} Is Dispensable for Lymphocyte Development and Proliferation.

J. M. Kim, J. M. White, A. S. Shaw, and B. P. Sleckman (2005)
J. Immunol. 174, 1239-1244
 |  Abstract »  |  Full Text »  |  PDF »

MKK3 and -6-dependent activation of p38{alpha} MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation.

Q. Wang, M. Yerukhimovich, W. A. Gaarde, I. J. Popoff, and C. M. Doerschuk (2005)
Am J Physiol Lung Cell Mol Physiol 288, L359-L369
 |  Abstract »  |  Full Text »  |  PDF »

c-Jun N-terminal Kinase 3 Deficiency Protects Neurons from Axotomy-induced Death in Vivo through Mechanisms Independent of c-Jun Phosphorylation.

E. Keramaris, J. L. Vanderluit, M. Bahadori, K. Mousavi, R. J. Davis, R. Flavell, R. S. Slack, and D. S. Park (2005)
J. Biol. Chem. 280, 1132-1141
 |  Abstract »  |  Full Text »  |  PDF »

c-Jun N-Terminal Protein Kinase 1 (JNK1), but Not JNK2, Is Essential for Tumor Necrosis Factor Alpha-Induced c-Jun Kinase Activation and Apoptosis.

J. Liu, Y. Minemoto, and A. Lin (2004)
Mol. Cell. Biol. 24, 10844-10856
 |  Abstract »  |  Full Text »  |  PDF »

MAP2K4/MKK4 Expression in Pancreatic Cancer: Genetic Validation of Immunohistochemistry and Relationship to Disease Course.

W. Xin, K. J. Yun, F. Ricci, M. Zahurak, W. Qiu, G. H. Su, C. J. Yeo, R. H. Hruban, S. E. Kern, and C. A. Iacobuzio-Donahue (2004)
Clin. Cancer Res. 10, 8516-8520
 |  Abstract »  |  Full Text »  |  PDF »

Ectopic Expression of Nonliganded Retinoic Acid Receptor {beta} Abrogates AP-1 Activity by Selective Degradation of c-Jun in Cervical Carcinoma Cells.

J. D.-C. Arce, U. Soto, J. van Riggelen, E. Schwarz, H. z. Hausen, and F. Rosl (2004)
J. Biol. Chem. 279, 45408-45416
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of APOBEC3G, a Cytidine Deaminase That Hypermutates Human Immunodeficiency Virus.

K. M. Rose, M. Marin, S. L. Kozak, and D. Kabat (2004)
J. Biol. Chem. 279, 41744-41749
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial signals initiate the activation of c-Jun N-terminal kinase (JNK) by hypoxia-reoxygenation.

C. J. DOUGHERTY, L. A. KUBASIAK, D. P. FRAZIER, H. LI, W.-CHENG. XIONG, N. H. BISHOPRIC, and K. A. WEBSTER (2004)
FASEB J 18, 1060-1070
 |  Abstract »  |  Full Text »  |  PDF »

Anti-Inflammatory Effects of Moxifloxacin on Activated Human Monocytic Cells: Inhibition of NF-{kappa}B and Mitogen-Activated Protein Kinase Activation and of Synthesis of Proinflammatory Cytokines.

T. Weiss, I. Shalit, H. Blau, S. Werber, D. Halperin, A. Levitov, and I. Fabian (2004)
Antimicrob. Agents Chemother. 48, 1974-1982
 |  Abstract »  |  Full Text »  |  PDF »

The Significance of Vasoactive Intestinal Peptide in Immunomodulation.

M. Delgado, D. Pozo, and D. Ganea (2004)
Pharmacol. Rev. 56, 249-290
 |  Abstract »  |  Full Text »  |  PDF »

Toxoplasma gondii Interferes with Lipopolysaccharide-Induced Mitogen-Activated Protein Kinase Activation by Mechanisms Distinct from Endotoxin Tolerance.

L. Kim, B. A. Butcher, and E. Y. Denkers (2004)
J. Immunol. 172, 3003-3010
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of c-Jun N-Terminal Kinase by MEKK-2 and Mitogen-Activated Protein Kinase Kinase Kinases in Rheumatoid Arthritis.

D. R. Hammaker, D. L. Boyle, M. Chabaud-Riou, and G. S. Firestein (2004)
J. Immunol. 172, 1612-1618
 |  Abstract »  |  Full Text »  |  PDF »

RhoA Binds to the Amino Terminus of MEKK1 and Regulates Its Kinase Activity.

E. D. Gallagher, S. Gutowski, P. C. Sternweis, and M. H. Cobb (2004)
J. Biol. Chem. 279, 1872-1877
 |  Abstract »  |  Full Text »  |  PDF »

Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms.

D.-X. Hou, K. Kai, J.-J. Li, S. Lin, N. Terahara, M. Wakamatsu, M. Fujii, M. R. Young, and N. Colburn (2004)
Carcinogenesis 25, 29-36
 |  Abstract »  |  Full Text »  |  PDF »

Expression and Activation of Mitogen-Activated Protein Kinase Kinases-3 and -6 in Rheumatoid Arthritis.

M. Chabaud-Riou and G. S. Firestein (2004)
Am. J. Pathol. 164, 177-184
 |  Abstract »  |  Full Text »  |  PDF »

Serine/Threonine Kinase Mirk/Dyrk1B Is an Inhibitor of Epithelial Cell Migration and Is Negatively Regulated by the Met Adaptor Ran-binding Protein M.

Y. Zou, S. Lim, K. Lee, X. Deng, and E. Friedman (2003)
J. Biol. Chem. 278, 49573-49581
 |  Abstract »  |  Full Text »  |  PDF »

Mirk/dyrk1B Is a Rho-induced Kinase Active in Skeletal Muscle Differentiation.

X. Deng, D. Z. Ewton, B. Pawlikowski, M. Maimone, and E. Friedman (2003)
J. Biol. Chem. 278, 41347-41354
 |  Abstract »  |  Full Text »  |  PDF »

PEA3 Transactivates the Muc4/Sialomucin Complex Promoter in Mammary Epithelial and Tumor Cells.

A. Perez, R. Barco, I. Fernandez, S. A. Price-Schiavi, and K. L. Carraway (2003)
J. Biol. Chem. 278, 36942-36952
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of p38 MAP kinase activation in vivo.

D. Brancho, N. Tanaka, A. Jaeschke, J.-J. Ventura, N. Kelkar, Y. Tanaka, M. Kyuuma, T. Takeshita, R. A. Flavell, and R. J. Davis (2003)
Genes & Dev. 17, 1969-1978
 |  Abstract »  |  Full Text »  |  PDF »

Regulatory volume increase is associated with p38 kinase-dependent actin cytoskeleton remodeling in rat kidney MTAL.

M. Bustamante, F. Roger, M.-L. Bochaton-Piallat, G. Gabbiani, P.-Y. Martin, and E. Feraille (2003)
Am J Physiol Renal Physiol 285, F336-F347
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Selective Transcription Factors and Cytokines by Water-Soluble Extract from Lentinus lepideus.

M. Jin, H. J. Jung, J. J. Choi, H. Jeon, J. H. Oh, B. Kim, S. S. Shin, J. K. Lee, K. Yoon, and S. Kim (2003)
Experimental Biology and Medicine 228, 749-758
 |  Abstract »  |  Full Text »  |  PDF »

Ras and Mitogen-Activated Protein Kinase Kinase Kinase-1 Coregulate Activator Protein-1- and Nuclear Factor-{kappa}B-Mediated Gene Expression in Airway Epithelial Cells.

L. Zhou, A. Tan, S. Iasvovskaia, J. Li, A. Lin, and M. B. Hershenson (2003)
Am. J. Respir. Cell Mol. Biol. 28, 762-769
 |  Abstract »  |  Full Text »  |  PDF »

p38{alpha} Isoform Mxi2 Binds to Extracellular Signal-Regulated Kinase 1 and 2 Mitogen-Activated Protein Kinase and Regulates Its Nuclear Activity by Sustaining Its Phosphorylation Levels.

V. Sanz-Moreno, B. Casar, and P. Crespo (2003)
Mol. Cell. Biol. 23, 3079-3090
 |  Abstract »  |  Full Text »  |  PDF »

The lectin jacalin induces phosphorylation of ERK and JNK in CD4+ T cells.

S. M. L. Tamma, V. S. Kalyanaraman, S. Pahwa, P. Dominguez, and R. R. Modesto (2003)
J. Leukoc. Biol. 73, 682-688
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of the Atm Protein to Maintaining Cellular Homeostasis Evidenced by Continuous Activation of the AP-1 Pathway in Atm-deficient Brains.

N. Weizman, Y. Shiloh, and A. Barzilai (2003)
J. Biol. Chem. 278, 6741-6747
 |  Abstract »  |  Full Text »  |  PDF »

Negative Feedback Regulation of MKK6 mRNA Stability by p38{alpha} Mitogen-Activated Protein Kinase.

C. Ambrosino, G. Mace, S. Galban, C. Fritsch, K. Vintersten, E. Black, M. Gorospe, and A. R. Nebreda (2003)
Mol. Cell. Biol. 23, 370-381
 |  Abstract »  |  Full Text »  |  PDF »

Overexpression of Phospholipid Hydroperoxide Glutathione Peroxidase Modulates Acetyl-CoA, 1-O-Alkyl-2-lyso-sn-glycero-3-phosphocholine Acetyltransferase Activity.

H. Sakamoto, T. Tosaki, and Y. Nakagawa (2002)
J. Biol. Chem. 277, 50431-50438
 |  Abstract »  |  Full Text »  |  PDF »

The Absence of NF-{kappa}B-Mediated Inhibition of c-Jun N-Terminal Kinase Activation Contributes to Tumor Necrosis Factor Alpha-Induced Apoptosis.

F. Tang, G. Tang, J. Xiang, Q. Dai, M. R. Rosner, and A. Lin (2002)
Mol. Cell. Biol. 22, 8571-8579
 |  Abstract »  |  Full Text »  |  PDF »

Stimulus-specific Requirements for MAP3 Kinases in Activating the JNK Pathway.

W. Chen, M. A. White, and M. H. Cobb (2002)
J. Biol. Chem. 277, 49105-49110
 |  Abstract »  |  Full Text »  |  PDF »

The Transcriptional Activator Mirk/Dyrk1B Is Sequestered by p38alpha /beta MAP Kinase.

S. Lim, Y. Zou, and E. Friedman (2002)
J. Biol. Chem. 277, 49438-49445
 |  Abstract »  |  Full Text »  |  PDF »

Requirement of Mitogen-activated Protein Kinase Kinase 3 (MKK3) for Activation of p38alpha and p38delta MAPK Isoforms by TGF-beta 1 in Murine Mesangial Cells.

L. Wang, R. Ma, R. A. Flavell, and M. E. Choi (2002)
J. Biol. Chem. 277, 47257-47262
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant Tau Phosphorylation by Glycogen Synthase Kinase-3beta and JNK3 Induces Oligomeric Tau Fibrils in COS-7 Cells.

S. Sato, Y. Tatebayashi, T. Akagi, D.-H. Chui, M. Murayama, T. Miyasaka, E. Planel, K. Tanemura, X. Sun, T. Hashikawa, et al. (2002)
J. Biol. Chem. 277, 42060-42065
 |  Abstract »  |  Full Text »  |  PDF »

Development of a 1-{micro}l Scale Assay for Mitogen-Activated Kinase Kinase 7 Using 2-D Fluorescence Intensity Distribution Analysis Anisotropy.

P. A. Wright, H. F. Boyd, R. C. Bethell, M. Busch, P. Gribbon, J. Kraemer, E. Lopez-Calle, T. H. Mander, D. Winkler, and N. Benson (2002)
J Biomol Screen 7, 419-428
 |  Abstract »  |  PDF »

Raf-independent Deregulation of p38 and JNK Mitogen-activated Protein Kinases Are Critical for Ras Transformation.

K. Pruitt, W. M. Pruitt, G. K. Bilter, J. K. Westwick, and C. J. Der (2002)
J. Biol. Chem. 277, 31808-31817
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Specific Role for Ikappa B Kinase Complex-associated Protein in Cytosolic Stress Signaling.

C. Holmberg, S. Katz, M. Lerdrup, T. Herdegen, M. Jaattela, A. Aronheim, and T. Kallunki (2002)
J. Biol. Chem. 277, 31918-31928
 |  Abstract »  |  Full Text »  |  PDF »

Cell Stress and MEKK1-mediated c-Jun Activation Modulate NFkappa B Activity and Cell Viability.

I. Sanchez-Perez, S. A. Benitah, M. Martinez-Gomariz, J. C. Lacal, and R. Perona (2002)
Mol. Biol. Cell 13, 2933-2945
 |  Abstract »  |  Full Text »  |  PDF »

Mirk Protein Kinase Is Activated by MKK3 and Functions as a Transcriptional Activator of HNF1alpha.

S. Lim, K. Jin, and E. Friedman (2002)
J. Biol. Chem. 277, 25040-25046
 |  Abstract »  |  Full Text »  |  PDF »

The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH2-Terminal Kinase.

K. Lei, A. Nimnual, W.-X. Zong, N. J. Kennedy, R. A. Flavell, C. B. Thompson, D. Bar-Sagi, and R. J. Davis (2002)
Mol. Cell. Biol. 22, 4929-4942
 |  Abstract »  |  Full Text »  |  PDF »

Evaluation of Candidate Genes MAP2K4, MADH4, ACVR1B, and BRCA2 in Familial Pancreatic Cancer: Deleterious BRCA2 Mutations in 17%.

K. M. Murphy, K. A. Brune, C. Griffin, J. E. Sollenberger, G. M. Petersen, R. Bansal, R. H. Hruban, and S. E. Kern (2002)
Cancer Res. 62, 3789-3793
 |  Abstract »  |  Full Text »  |  PDF »

Scaffold Role of a Mitogen-activated Protein Kinase Phosphatase, SKRP1, for the JNK Signaling Pathway.

T. Zama, R. Aoki, T. Kamimoto, K. Inoue, Y. Ikeda, and M. Hagiwara (2002)
J. Biol. Chem. 277, 23919-23926
 |  Abstract »  |  Full Text »  |  PDF »

Parathyroid Hormone Inhibits c-Jun N-Terminal Kinase Activity in Rat Osteoblastic Cells by a Protein Kinase A-Dependent Pathway.

T. A. Doggett, J. T. Swarthout, S. C. Jefcoat Jr., D. Wilhelm, A. Dieckmann, P. Angel, and N. C. Partridge (2002)
Endocrinology 143, 1880-1888
 |  Abstract »  |  Full Text »  |  PDF »

MRK, a Mixed Lineage Kinase-related Molecule That Plays a Role in gamma -Radiation-induced Cell Cycle Arrest.

E. A. Gross, M. G. Callow, L. Waldbaum, S. Thomas, and R. Ruggieri (2002)
J. Biol. Chem. 277, 13873-13882
 |  Abstract »  |  Full Text »  |  PDF »

Cellular N-Ras Promotes Cell Survival by Downregulation of Jun N-Terminal Protein Kinase and p38.

J. C. Wolfman, T. Palmby, C. J. Der, and A. Wolfman (2002)
Mol. Cell. Biol. 22, 1589-1606
 |  Abstract »  |  Full Text »  |  PDF »

Cell adhesion differentially regulates the nucleocytoplasmic distribution of active MAP kinases.

A. E. Aplin, B. P. Hogan, J. Tomeu, and R. L. Juliano (2002)
J. Cell Sci. 115, 2781-2790
 |  Abstract »  |  Full Text »  |  PDF »

Using a Gene-switch Transgenic Approach to Dissect Distinct Roles of MAP Kinases in Heart Failure.

B.G. PETRICH, P. LIAO, and Y. WANG (2002)
Cold Spring Harb Symp Quant Biol 67, 429-438
 |  Abstract »  |  PDF »

The Proto-oncoprotein Brx Activates Estrogen Receptor beta by a p38 Mitogen-activated Protein Kinase Pathway.

P. H. Driggers, J. H. Segars, and D. M. Rubino (2001)
J. Biol. Chem. 276, 46792-46797
 |  Abstract »  |  Full Text »  |  PDF »

Transforming Growth Factor-beta -induced Osteoblast Elongation Regulates Osteoclastic Bone Resorption through a p38 Mitogen-activated Protein Kinase- and Matrix Metalloproteinase-dependent Pathway.

M. A. Karsdal, M. S. Fjording, N. T. Foged, J.-M. Delaisse, and A. Lochter (2001)
J. Biol. Chem. 276, 39350-39358
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Alterations in Activation-Induced Nonresponsive CD8 T Cells.

E. L. Tham and M. F. Mescher (2001)
J. Immunol. 167, 2040-2048
 |  Abstract »  |  Full Text »  |  PDF »

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines.

C. Tournier, C. Dong, T. K. Turner, S. N. Jones, R. A. Flavell, and R. J. Davis (2001)
Genes & Dev. 15, 1419-1426
 |  Abstract »  |  Full Text »  |  PDF »

p38 MAP kinase negatively regulates cyclin D1 expression in airway smooth muscle cells.

K. Page, J. Li, and M. B. Hershenson (2001)
Am J Physiol Lung Cell Mol Physiol 280, L955-L964
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions.

G. Pearson, F. Robinson, T. Beers Gibson, B.-e Xu, M. Karandikar, K. Berman, and M. H. Cobb (2001)
Endocr. Rev. 22, 153-183
 |  Abstract »  |  Full Text »

Induction of Inducible Nitric Oxide Synthase-NO{middle dot} by Lipoarabinomannan of Mycobacterium tuberculosis Is Mediated by MEK1-ERK, MKK7-JNK, and NF-{kappa}B Signaling Pathways.

E. D. Chan, K. R. Morris, J. T. Belisle, P. Hill, L. K. Remigio, P. J. Brennan, and D. W. H. Riches (2001)
Infect. Immun. 69, 2001-2010
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Activation of NF-{kappa}B by hepatitis B virus X protein through an I{kappa}B kinase-independent mechanism.

N. H. Purcell, C. Yu, D. He, J. Xiang, N. Paran, J. A. DiDonato, S. Yamaoka, Y. Shaul, and A. Lin (2001)
Am J Physiol Gastrointest Liver Physiol 280, G669-G677
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IFN-{gamma} + LPS induction of iNOS is modulated by ERK, JNK/SAPK, and p38mapk in a mouse macrophage cell line.

E. D. Chan and D. W. H. Riches (2001)
Am J Physiol Cell Physiol 280, C441-C450
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Cytoprotection by Jun Kinase During Nitric Oxide-Induced Cardiac Myocyte Apoptosis.

P. Andreka, J. Zang, C. Dougherty, T. I. Slepak, K. A. Webster, and N. H. Bishopric (2001)
Circ. Res. 88, 305-312
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Regulation of the Urokinase-type Plasminogen Activator Receptor Gene in Different Grades of Human Glioma Cell Lines.

A. Bhattacharya, S. S. Lakka, S. Mohanam, D. Boyd, and J. S. Rao (2001)
Clin. Cancer Res. 7, 267-276
 |  Abstract »  |  Full Text »

Potentiation of Estrogen Receptor Activation Function 1 (AF-1) by Src/JNK through a Serine 118-Independent Pathway.

W. Feng, P. Webb, P. Nguyen, X. Liu, J. Li, M. Karin, and P. J. Kushner (2001)
Mol. Endocrinol. 15, 32-45
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Heregulin Regulation of Urokinase Plasminogen Activator and its Receptor: Human Breast Epithelial Cell Invasion.

A. Mazumdar, L. Adam, D. Boyd, and R. Kumar (2001)
Cancer Res. 61, 400-405
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SIMKK, a Mitogen-Activated Protein Kinase (MAPK) Kinase, Is a Specific Activator of the Salt Stress-Induced MAPK, SIMK.

S. Kiegerl, F. Cardinale, C. Siligan, A. Gross, E. Baudouin, A. Liwosz, S. Eklöf, S. Till, L. Bögre, H. Hirt, et al. (2000)
PLANT CELL 12, 2247-2258
 |  Abstract »  |  Full Text »

Accumulation of RXR{alpha} During Activation of Cycling Human T Lymphocytes: Modulation of RXRE Transactivation Function by Mitogen-Activated Protein Kinase Pathways.

M. Ishaq, M. Fan, and V. Natarajan (2000)
J. Immunol. 165, 4217-4225
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Cyclic GMP Mediates Apoptosis Induced by Sulindac Derivatives via Activation of c-Jun NH2-Terminal Kinase 1.

J.-W. Soh, Y. Mao, M.-G. Kim, R. Pamukcu, H. Li, G. A. Piazza, W. J. Thompson, and I. B. Weinstein (2000)
Clin. Cancer Res. 6, 4136-4141
 |  Abstract »  |  Full Text »

The Kaposi's Sarcoma-associated Herpes Virus G Protein-coupled Receptor Up-Regulates Vascular Endothelial Growth Factor Expression and Secretion through Mitogen-activated Protein Kinase and p38 Pathways Acting on Hypoxia-inducible Factor 1{{alpha}}.

A. Sodhi, S. Montaner, V. Patel, M. Zohar, C. Bais, E. A. Mesri, and J. S. Gutkind (2000)
Cancer Res. 60, 4873-4880
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Differential Activation of c-Jun NH2-terminal Kinase and p38 Mitogen-activated Protein Kinases by Methyl Methanesulfonate in the Liver and Brain of Rats: Implication for Organ-specific Carcinogenesis.

Y. Suh, U. G. Kang, Y. S. Kim, W.-H. Kim, S.-C. Park, and J.-B. Park (2000)
Cancer Res. 60, 5067-5073
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Immune Cell Activation by Bacterial Cpg-DNA through Myeloid Differentiation Marker 88 and Tumor Necrosis Factor Receptor-Associated Factor (Traf)6.

H. Hacker, R. M. Vabulas, O. Takeuchi, K. Hoshino, S. Akira, and H. Wagner (2000)
J. Exp. Med. 192, 595-600
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The cJun N-terminal kinase (JNK) signaling pathway mediates induction of urokinase-type plasminogen activator (uPA) by the alkylating agent MNNG.

M. Parra, F. Lluis, F. Miralles, C. Caelles, and P. Munoz-Canoves (2000)
Blood 96, 1415-1424
 |  Abstract »  |  Full Text »  |  PDF »

Activation of JNK, p38 and ERK mitogen-activated protein kinases by chromium(VI) is mediated through oxidative stress but does not affect cytotoxicity.

S.-M. Chuang, G.-Y. Liou, and J.-L. Yang (2000)
Carcinogenesis 21, 1491-1500
 |  Abstract »  |  Full Text »  |  PDF »

Activation of MEK Kinase 1 by the c-Abl Protein Tyrosine Kinase in Response to DNA Damage.

S. Kharbanda, P. Pandey, T. Yamauchi, S. Kumar, M. Kaneki, V. Kumar, A. Bharti, Z.-M. Yuan, L. Ghanem, A. Rana, et al. (2000)
Mol. Cell. Biol. 20, 4979-4989
 |  Abstract »  |  Full Text »  |  PDF »

Roles of JNK, p38 and ERK mitogen-activated protein kinases in the growth inhibition and apoptosis induced by cadmium.

S.-M. Chuang, I-C. Wang, and J.-L. Yang (2000)
Carcinogenesis 21, 1423-1432
 |  Abstract »  |  Full Text »  |  PDF »

p38 and Extracellular Signal-Regulated Kinases Regulate the Myogenic Program at Multiple Steps.

Z. Wu, P. J. Woodring, K. S. Bhakta, K. Tamura, F. Wen, J. R. Feramisco, M. Karin, J. Y. J. Wang, and P. L. Puri (2000)
Mol. Cell. Biol. 20, 3951-3964
 |  Abstract »  |  Full Text »  |  PDF »

Human Gastric Cancer Kinase Profile and Prognostic Significance of MKK4 Kinase.

C.-W. Wu, A. F.-Y. Li, C.-W. Chi, C. L. Huang, K.-H. Shen, W.-Y. Liu, and W.-c. Lin (2000)
Am. J. Pathol. 156, 2007-2015
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WNK1, a Novel Mammalian Serine/Threonine Protein Kinase Lacking the Catalytic Lysine in Subdomain II.

B.-e Xu, J. M. English, J. L. Wilsbacher, S. Stippec, E. J. Goldsmith, and M. H. Cobb (2000)
J. Biol. Chem. 275, 16795-16801
 |  Abstract »  |  Full Text »  |  PDF »

MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration.

Y. Xia, C. Makris, B. Su, E. Li, J. Yang, G. R. Nemerow, and M. Karin (2000)
PNAS 97, 5243-5248
 |  Abstract »  |  Full Text »  |  PDF »

Rb Protein Down-regulates the Stress-activated Signals through Inhibiting c-Jun N-terminal Kinase/Stress-activated Protein Kinase.

J. Shim, H.-S. Park, M. J. Kim, J. Park, E. Park, S.-G. Cho, S.-J. Eom, H.-W. Lee, C. O. Joe, and E.-J. Choi (2000)
J. Biol. Chem. 275, 14107-14111
 |  Abstract »  |  Full Text »  |  PDF »

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