Science 14 April 1995: Vol. 268. no. 5208, pp. 251 - 255 DOI: 10.1126/science.7716517

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Articles

Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon.

S. Saint Fleur, A. Hoshino, K. Kondo, T. Egawa, and H. Fujii (2009)
Blood 114, 1355-1365
 |  Abstract »  |  Full Text »  |  PDF »

Embryonic temperature affects muscle fibre recruitment in adult zebrafish: genome-wide changes in gene and microRNA expression associated with the transition from hyperplastic to hypertrophic growth phenotypes.

I. A. Johnston, H.-T. Lee, D. J. Macqueen, K. Paranthaman, C. Kawashima, A. Anwar, J. R. Kinghorn, and T. Dalmay (2009)
J. Exp. Biol. 212, 1781-1793
 |  Abstract »  |  Full Text »  |  PDF »

Pathogen-dependent induction of cytokines and other soluble inflammatory mediators during intramammary infection of dairy cows.

D. D. Bannerman (2009)
J Anim Sci 87, 10-25
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Cell Proliferation by Interleukin-3-induced Nuclear Translocation of Pyruvate Kinase.

A. Hoshino, J. A. Hirst, and H. Fujii (2007)
J. Biol. Chem. 282, 17706-17711
 |  Abstract »  |  Full Text »  |  PDF »

Src family kinases play multiple roles in differentiation of trophoblasts from human term placenta.

G. Daoud, E. Rassart, A. Masse, and J. Lafond (2006)
J. Physiol. 571, 537-553
 |  Abstract »  |  Full Text »  |  PDF »

Unique structural determinants for stat3 recruitment and activation by the granulocyte colony-stimulating factor receptor at phosphotyrosine ligands 704 and 744..

H. Shao, X. Xu, N. Jing, and D. J. Tweardy (2006)
J. Immunol. 176, 2933-2941
 |  Abstract »  |  Full Text »  |  PDF »

Human Bronchial Epithelium Controls TH2 Responses by TH1-Induced, Nitric Oxide-Mediated STAT5 Dephosphorylation: Implications for the Pathogenesis of Asthma.

U. Eriksson, U. Egermann, M. P. Bihl, F. Gambazzi, M. Tamm, P. G. Holt, and R. M. Bingisser (2005)
J. Immunol. 175, 2715-2720
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the Cytoplasmic Domains of CXCR4 Involved in Jak2 and STAT3 Phosphorylation.

B. Ahr, M. Denizot, V. Robert-Hebmann, A. Brelot, and M. Biard-Piechaczyk (2005)
J. Biol. Chem. 280, 6692-6700
 |  Abstract »  |  Full Text »  |  PDF »

LRb-STAT3 Signaling Is Required for the Neuroendocrine Regulation of Energy Expenditure by Leptin.

S. H. Bates, T. A. Dundon, M. Seifert, M. Carlson, E. Maratos-Flier, and M. G. Myers Jr (2004)
Diabetes 53, 3067-3073
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-activated protein kinase pathways and cardiac surgery.

T. A. Khan, C. Bianchi, M. Ruel, P. Voisine, and F. W. Sellke (2004)
J. Thorac. Cardiovasc. Surg. 127, 806-811
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Diacylglycerol Kinase {alpha} by Phosphoinositide 3-Kinase Lipid Products.

A. Cipres, S. Carrasco, E. Merino, E. Diaz, U. M. Krishna, J. R. Falck, C. Martinez-A, and I. Merida (2003)
J. Biol. Chem. 278, 35629-35635
 |  Abstract »  |  Full Text »  |  PDF »

Identification of p21-Activated Kinase Specificity Determinants in Budding Yeast: a Single Amino Acid Substitution Imparts Ste20 Specificity to Cla4.

M. E. Keniry and G. F. Sprague Jr. (2003)
Mol. Cell. Biol. 23, 1569-1580
 |  Abstract »  |  Full Text »  |  PDF »

Inducible Nitric Oxide Synthase Mediates Bone Loss in Ovariectomized Mice.

S. Cuzzocrea, E. Mazzon, L. Dugo, T. Genovese, R. Di Paola, Z. Ruggeri, E. Vegeto, A. P. Caputi, F. A. J. Van de Loo, D. Puzzolo, et al. (2003)
Endocrinology 144, 1098-1107
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Cellular Signaling Pathways: Prospects for Targeted Therapy in Hematological Malignancies.

F. Ravandi, M. Talpaz, and Z. Estrov (2003)
Clin. Cancer Res. 9, 535-550
 |  Abstract »  |  Full Text »  |  PDF »

JAK/STAT but Not ERK1/ERK2 Pathway Mediates Interleukin (IL)-6/Soluble IL-6R Down-regulation of Type II Collagen, Aggrecan Core, and Link Protein Transcription in Articular Chondrocytes. ASSOCIATION WITH A DOWN-REGULATION OF SOX9 EXPRESSION.

F. Legendre, J. Dudhia, J.-P. Pujol, and P. Bogdanowicz (2003)
J. Biol. Chem. 278, 2903-2912
 |  Abstract »  |  Full Text »  |  PDF »

Identification of IFN Regulatory Factor-1 Binding Site in IL-12 p40 Gene Promoter.

S. Maruyama, K. Sumita, H. Shen, M. Kanoh, X. Xu, M. Sato, M. Matsumoto, H. Shinomiya, and Y. Asano (2003)
J. Immunol. 170, 997-1001
 |  Abstract »  |  Full Text »  |  PDF »

Immunotherapy with a posttranscriptionally modified DNA vaccine induces complete protection against metastatic neuroblastoma.

U. Pertl, H. Wodrich, J. M. Ruehlmann, S. D. Gillies, H. N. Lode, and R. A. Reisfeld (2003)
Blood 101, 649-654
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Akt-dependent cell survival by Syk and Rac.

K. Jiang, B. Zhong, C. Ritchey, D. L. Gilvary, E. Hong-Geller, S. Wei, and J. Y. Djeu (2003)
Blood 101, 236-244
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Human T Cell Activation by Novel Src Kinase Inhibitors Is Dependent upon the Complexity of the Signal Delivered to the Cell.

S. Rapecki and R. Allen (2002)
J. Pharmacol. Exp. Ther. 303, 1325-1333
 |  Abstract »  |  Full Text »  |  PDF »

Enforced Expression of Bcl-2 Restores the Number of NK Cells, But Does Not Rescue the Impaired Development of NKT Cells or Intraepithelial Lymphocytes, in IL-2/IL-15 Receptor {beta}-Chain-Deficient Mice.

M. Minagawa, H. Watanabe, C. Miyaji, K. Tomiyama, H. Shimura, A. Ito, M. Ito, J. Domen, I. L. Weissman, and K. Kawai (2002)
J. Immunol. 169, 4153-4160
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 negatively regulates IL-7 receptor alpha chain expression in activated T lymphocytes.

H.-H. Xue, P. E. Kovanen, C. A. Pise-Masison, M. Berg, M. F. Radovich, J. N. Brady, and W. J. Leonard (2002)
PNAS 99, 13759-13764
 |  Abstract »  |  Full Text »  |  PDF »

Prediction of the structure of human Janus kinase 2 (JAK2) comprising JAK homology domains 1 through 7.

F. Giordanetto and R. T. Kroemer (2002)
Protein Eng. Des. Sel. 15, 727-737
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Erythropoietin Receptor through a Novel Extracellular Binding Site.

T. Naranda, R. I. Kaufman, J. Li, K. Wong, A. Boge, D. Hallen, K. Y. C. Fung, M. W. Duncan, N. Andersen, A. Goldstein, et al. (2002)
Endocrinology 143, 2293-2302
 |  Abstract »  |  Full Text »  |  PDF »

Stat3beta Inhibits gamma -Globin Gene Expression in Erythroid Cells.

H. A. Foley, S. F. Ofori-Acquah, A. Yoshimura, S. Critz, B. S. Baliga, and B. S. Pace (2002)
J. Biol. Chem. 277, 16211-16219
 |  Abstract »  |  Full Text »  |  PDF »

Identification of the Critical Sequence Elements in the Cytoplasmic Domain of Leptin Receptor Isoforms Required for Janus Kinase/Signal Transducer and Activator of Transcription Activation by Receptor Heterodimers.

G. Bahrenberg, I. Behrmann, A. Barthel, P. Hekerman, P. C. Heinrich, H.-G. Joost, and W. Becker (2002)
Mol. Endocrinol. 16, 859-872
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Identification of the human erythropoietin receptor region required for Stat1 and Stat3 activation.

K. Kirito, K. Nakajima, T. Watanabe, M. Uchida, M. Tanaka, K. Ozawa, and N. Komatsu (2002)
Blood 99, 102-110
 |  Abstract »  |  Full Text »  |  PDF »

Signaling through a Novel Domain of gp130 Mediates Cell Proliferation and Activation of Hck and Erk Kinases.

M. Schaeffer, M. Schneiderbauer, S. Weidler, R. Tavares, M. Warmuth, G. de Vos, and M. Hallek (2001)
Mol. Cell. Biol. 21, 8068-8081
 |  Abstract »  |  Full Text »  |  PDF »

The IL-15R{alpha} Chain Signals Through Association with Syk in Human B Cells.

E. Bulanova, V. Budagian, T. Pohl, H. Krause, H. Durkop, R. Paus, and S. Bulfone-Paus (2001)
J. Immunol. 167, 6292-6302
 |  Abstract »  |  Full Text »  |  PDF »

Src Family Kinases Are Required for Prolactin Induction of Cell Proliferation.

J. A. F. Vara, M. A. D. Caceres, A. Silva, and J. Martin-Perez (2001)
Mol. Biol. Cell 12, 2171-2183
 |  Abstract »  |  Full Text »  |  PDF »

Acute Myeloid Leukemia.

F. R. Appelbaum, J. M. Rowe, J. Radich, and J. E. Dick (2001)
Hematology 2001, 62-86
 |  Abstract »  |  Full Text »  |  PDF »

JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling.

B. Sporri, P. E. Kovanen, A. Sasaki, A. Yoshimura, and W. J. Leonard (2001)
Blood 97, 221-226
 |  Abstract »  |  Full Text »  |  PDF »

IL-2R{beta} Agonist P1-30 Acts in Synergy with IL-2, IL-4, IL-9, and IL-15: Biological and Molecular Effects.

R. Eckenberg, J.-L. Moreau, O. Melnyk, and J. Theze (2000)
J. Immunol. 165, 4312-4318
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Infection with Histoplasma capsulatum by TNFR1 and -2.

R. Allendoerfer and G. S. Deepe Jr. (2000)
J. Immunol. 165, 2657-2664
 |  Abstract »  |  Full Text »  |  PDF »

Redundant and Opposing Functions of Two Tyrosine Kinases, Btk and Lyn, in Mast Cell Activation.

Y. Kawakami, J. Kitaura, A. B. Satterthwaite, R. M. Kato, K. Asai, S. E. Hartman, M. Maeda-Yamamoto, C. A. Lowell, D. J. Rawlings, O. N. Witte, et al. (2000)
J. Immunol. 165, 1210-1219
 |  Abstract »  |  Full Text »  |  PDF »

The Shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3.

L. Velazquez, G. D. Gish, P. van der Geer, L. Taylor, J. Shulman, and T. Pawson (2000)
Blood 96, 132-138
 |  Abstract »  |  Full Text »  |  PDF »

Hierarchy of Protein Tyrosine Kinases in Interleukin-2 (IL-2) Signaling: Activation of Syk Depends on Jak3; However, Neither Syk nor Lck Is Required for IL-2-Mediated STAT Activation.

Y.-J. Zhou, K. S. Magnuson, T. P. Cheng, M. Gadina, D. M. Frucht, J. Galon, F. Candotti, R. L. Geahlen, P. S. Changelian, and J. J. O'Shea (2000)
Mol. Cell. Biol. 20, 4371-4380
 |  Abstract »  |  Full Text »

The First {alpha} Helix of Interleukin (Il)-2 Folds as a Homotetramer, Acts as an Agonist of the IL-2 Receptor {beta} Chain, and Induces Lymphokine-Activated Killer Cells.

R. Eckenberg, T. Rose, J.-L. Moreau, R. Weil, F. Gesbert, S. Dubois, D. Tello, M. Bossus, H. Gras, A. Tartar, et al. (2000)
J. Exp. Med. 191, 529-540
 |  Abstract »  |  Full Text »  |  PDF »

Interferon-gamma Has Dual Potentials in Inhibiting or Promoting Cell Proliferation.

H. Asao and X.-Y. Fu (2000)
J. Biol. Chem. 275, 867-874
 |  Abstract »  |  Full Text »  |  PDF »

Point Mutation of a Tyrosine in the Linker Region of Syk Results in a Gain of Function.

K. Sada, J. Zhang, and R. P. Siraganian (2000)
J. Immunol. 164, 338-344
 |  Abstract »  |  Full Text »  |  PDF »

The Jak-Stat pathway in normal and perturbed hematopoiesis.

A. C. Ward, I. Touw, and A. Yoshimura (2000)
Blood 95, 19-29
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Constitutive Activation of STATs Upon In Vivo Human Immunodeficiency Virus Infection.

C. Bovolenta, L. Camorali, A. L. Lorini, S. Ghezzi, E. Vicenzi, A. Lazzarin, and G. Poli (1999)
Blood 94, 4202-4209
 |  Abstract »  |  Full Text »  |  PDF »

Autoimmunity and Diabetes.

Kukreja (1999)
J. Clin. Endocrinol. Metab. 84, 4371-4378
 |  Abstract »  |  Full Text »

Dissociation of Janus Kinase 2 and Signal Transducer and Activator of Transcription 5 Activation after Treatment of Nb2 Cells with a Molecular Mimic of Phosphorylated Prolactin.

D. Coss, C. B. Kuo, L. Yang, P. Ingleton, R. Luben, and A. M. Walker (1999)
Endocrinology 140, 5087-5094
 |  Abstract »  |  Full Text »

Restoration of Lymphoid Populations in a Murine Model of X-Linked Severe Combined Immunodeficiency by a Gene-Therapy Approach.

M. Lo, M. L. Bloom, K. Imada, M. Berg, J. M. Bollenbacher, E. T. Bloom, B. L. Kelsall, and W. J. Leonard (1999)
Blood 94, 3027-3036
 |  Abstract »  |  Full Text »  |  PDF »

CIS Associates with the Interleukin-2 Receptor beta Chain and Inhibits Interleukin-2-dependent Signaling.

M. J. Aman, T.-S. Migone, A. Sasaki, D. P. Ascherman, M.-h. Zhu, E. Soldaini, K. Imada, A. Miyajima, A. Yoshimura, and W. J. Leonard (1999)
J. Biol. Chem. 274, 30266-30272
 |  Abstract »  |  Full Text »  |  PDF »

A Thrombopoietin Receptor Mutant Deficient in Jak-STAT Activation Mediates Proliferation But Not Differentiation in UT-7 Cells.

M. Dorsch, N. N. Danial, P. B. Rothman, and S. P. Goff (1999)
Blood 94, 2676-2685
 |  Abstract »  |  Full Text »  |  PDF »

Elevated Cyclin E Levels, Inactive Retinoblastoma Protein, and Suppression of the p27KIP1 Inhibitor Characterize Early Development of Promyeloid Cells into Macrophages.

Q. Liu, R. W. VanHoy, J. H. Zhou, R. Dantzer, G. G. Freund, and K. W. Kelley (1999)
Mol. Cell. Biol. 19, 6229-6239
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine Phosphatases as Targets in Metal-Induced Signaling in Human Airway Epithelial Cells.

J. M. Samet, R. Silbajoris, W. Wu, and L. M. Graves (1999)
Am. J. Respir. Cell Mol. Biol. 21, 357-364
 |  Abstract »  |  Full Text »

Interferon-{{alpha}} Inhibits Proliferation in Human T Lymphocytes by Abrogation of Interleukin 2-induced Changes in Cell Cycle-regulatory Proteins.

S. Erickson, O. Sangfelt, J. Castro, M. Heyman, S. Einhorn, and D. Grandér (1999)
Cell Growth Differ. 10, 575-582
 |  Abstract »  |  Full Text »

Fyn and JAK2 Mediate Ras Activation by Reactive Oxygen Species.

J.-i. Abe and B. C. Berk (1999)
J. Biol. Chem. 274, 21003-21010
 |  Abstract »  |  Full Text »  |  PDF »

Diacylglycerol Kinase Inhibition Prevents IL-2-Induced G1 to S Transition Through a Phosphatidylinositol-3 Kinase-Independent Mechanism.

I. Flores, D. R. Jones, A. Cipres, E. Diaz-Flores, M. A. Sanjuan, and I. Merida (1999)
J. Immunol. 163, 708-714
 |  Abstract »  |  Full Text »  |  PDF »

Oxidative Stress Triggers STAT3 Tyrosine Phosphorylation and Nuclear Translocation in Human Lymphocytes.

M. Carballo, M. Conde, R. El Bekay, J. Martin-Nieto, M. J. Camacho, J. Monteseirin, J. Conde, F. J. Bedoya, and F. Sobrino (1999)
J. Biol. Chem. 274, 17580-17586
 |  Abstract »  |  Full Text »  |  PDF »

New Immunosuppressive Drug PNU156804 Blocks IL-2-Dependent Proliferation and NF-{kappa}B and AP-1 Activation.

A. Mortellaro, S. Songia, P. Gnocchi, M. Ferrari, C. Fornasiero, R. D'Alessio, A. Isetta, F. Colotta, and J. Golay (1999)
J. Immunol. 162, 7102-7109
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of T-Cell Activation by Human T-Cell Lymphotropic Virus Type I.

P. Hollsberg (1999)
Microbiol. Mol. Biol. Rev. 63, 308-333
 |  Abstract »  |  Full Text »  |  PDF »

Protein Kinase B (c-Akt), Phosphatidylinositol 3-Kinase, and STAT5 Are Activated by Erythropoietin (EPO) in HCD57 Erythroid Cells But Are Constitutively Active in an EPO-Independent, Apoptosis-Resistant Subclone (HCD57-SREI Cells).

H. Bao, S. M. Jacobs-Helber, A. E. Lawson, K. Penta, A. Wickrema, and S. T. Sawyer (1999)
Blood 93, 3757-3773
 |  Abstract »  |  Full Text »  |  PDF »

Functional Differentiation Signals Mediated by Distinct Regions of the Cytoplasmic Domain of the Granulocyte Colony-Stimulating Factor Receptor.

D. C. Koay and A. C. Sartorelli (1999)
Blood 93, 3774-3784
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Cell Shape Changes through Activation of the Interleukin-3 Common beta  Chain Receptor by the RON Receptor-type Tyrosine Kinase.

A. Mera, M. Suga, M. Ando, T. Suda, and N. Yamaguchi (1999)
J. Biol. Chem. 274, 15766-15774
 |  Abstract »  |  Full Text »  |  PDF »

IL-3 and IL-4 Activate Cyclic Nucleotide Phosphodiesterases 3 (PDE3) and 4 (PDE4) by Different Mechanisms in FDCP2 Myeloid Cells.

F. Ahmad, G. Gao, L. M. Wang, T. R. Landstrom, E. Degerman, J. H. Pierce, and V. C. Manganiello (1999)
J. Immunol. 162, 4864-4875
 |  Abstract »  |  Full Text »  |  PDF »

Optimal Proliferation of a Hematopoietic Progenitor Cell Line Requires Either Costimulation With Stem Cell Factor or Increase of Receptor Expression That Can Be Replaced by Overexpression of Bcl-2.

H.-M. Huang, J.-C. Li, Y.-C. Hsieh, H.-F. Yang-Yen, and J. J.-Y. Yen (1999)
Blood 93, 2569-2577
 |  Abstract »  |  Full Text »  |  PDF »

Retinoic Acid Is Able to Induce Interferon Regulatory Factor 1 in Squamous Carcinoma Cells via a STAT-1 Independent Signalling Pathway.

Z. A. Percario, V. Giandomenico, G. Fiorucci, M. V. Chiantore, S. Vannucchi, J. Hiscott, E. Affabris, and G. Romeo (1999)
Cell Growth Differ. 10, 263-270
 |  Abstract »  |  Full Text »

IL-2-Dependent Expression of Genes Involved in Cytoskeleton Organization, Oncogene Regulation, and Transcriptional Control.

S. Herblot, P. Chastagner, L. Samady, J.-L. Moreau, C. Demaison, P. Froussard, X. Liu, J. Bonnet, and J. Theze (1999)
J. Immunol. 162, 3280-3288
 |  Abstract »  |  Full Text »  |  PDF »

Interferon-alpha Activates Multiple STAT Proteins and Upregulates Proliferation-Associated IL-2Ralpha , c-myc, and pim-1 Genes in Human T Cells.

S. Matikainen, T. Sareneva, T. Ronni, A. Lehtonen, P. J. Koskinen, and I. Julkunen (1999)
Blood 93, 1980-1991
 |  Abstract »  |  Full Text »  |  PDF »

Reconstitution of the Functional Mouse Oncostatin M (OSM) Receptor: Molecular Cloning of the Mouse OSM Receptor beta  Subunit.

M. Tanaka, T. Hara, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, and A. Miyajima (1999)
Blood 93, 804-815
 |  Abstract »  |  Full Text »  |  PDF »

STAT3 Is Required for the gp130-mediated Full Activation of the c-myc Gene.

N. Kiuchi, K. Nakajima, M. Ichiba, T. Fukada, M. Narimatsu, K. Mizuno, M. Hibi, and T. Hirano (1999)
J. Exp. Med. 189, 63-73
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human.

C. WIDMANN, S. GIBSON, M. B. JARPE, and G. L. JOHNSON (1999)
Physiol Rev 79, 143-180
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Induces STAT4 Activation in Primary NK Cells and NK Cell Lines, But Not in T Cells.

K. S. Wang, J. Ritz, and D. A. Frank (1999)
J. Immunol. 162, 299-304
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Stat3 Recruitment and Activation Motif Within the Granulocyte Colony-Stimulating Factor Receptor.

A. Chakraborty, K. F. Dyer, M. Cascio, T. A. Mietzner, and D. J. Tweardy (1999)
Blood 93, 15-24
 |  Abstract »  |  Full Text »  |  PDF »

Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1) deficient mice.

T. Naka, T. Matsumoto, M. Narazaki, M. Fujimoto, Y. Morita, Y. Ohsawa, H. Saito, T. Nagasawa, Y. Uchiyama, and T. Kishimoto (1998)
PNAS 95, 15577-15582
 |  Abstract »  |  Full Text »  |  PDF »

The Box-1 Region of the Leukemia Inhibitory Factor Receptor alpha -Chain Cytoplasmic Domain Is Sufficient for Hemopoietic Cell Proliferation and Differentiation.

Y. Zhang, T. Willson, D. Metcalf, D. Cary, D. J. Hilton, R. Clark, and N. A. Nicola (1998)
J. Biol. Chem. 273, 34370-34383
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Mediators of Asthma: An Update.

P. J. Barnes, K. F. Chung, and C. P. Page (1998)
Pharmacol. Rev. 50, 515-596
 |  Abstract »  |  Full Text »  |  PDF »

Conditional Activation of Janus Kinase (JAK) Confers Factor Independence upon Interleukin-3-dependent Cells. ESSENTIAL ROLE OF Ras IN JAK-TRIGGERED MITOGENESIS.

R. Mizuguchi and M. Hatakeyama (1998)
J. Biol. Chem. 273, 32297-32303
 |  Abstract »  |  Full Text »  |  PDF »

MRG1, the product of a melanocyte-specific gene related gene, is a cytokine-inducible transcription factor with transformation activity.

H. B. Sun, Y. X. Zhu, T. Yin, G. Sledge, and Y.-C. Yang (1998)
PNAS 95, 13555-13560
 |  Abstract »  |  Full Text »  |  PDF »

Functional Cooperation of the Interleukin-2 Receptor beta  Chain and Jak1 in Phosphatidylinositol 3-Kinase Recruitment and Phosphorylation.

T.-S. Migone, S. Rodig, N. A. Cacalano, M. Berg, R. D. Schreiber, and W. J. Leonard (1998)
Mol. Cell. Biol. 18, 6416-6422
 |  Abstract »  |  Full Text »

Transcriptional Regulation of the {beta}-Casein Gene by Cytokines: Cross-Talk between STAT5 and Other Signaling Molecules.

D. Chida, H. Wakao, A. Yoshimura, and A. Miyajima (1998)
Mol. Endocrinol. 12, 1792-1806
 |  Abstract »  |  Full Text »

Activation of E2F-mediated Transcription by Human T-cell Leukemia Virus Type I Tax Protein in a p16INK4A-negative T-cell Line.

I. Lemasson, S. Thebault, C. Sardet, C. Devaux, and J.-M. Mesnard (1998)
J. Biol. Chem. 273, 23598-23604
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Stat1-mediated gene activation by PIAS1.

B. Liu, J. Liao, X. Rao, S. A. Kushner, C. D. Chung, D. D. Chang, and K. Shuai (1998)
PNAS 95, 10626-10631
 |  Abstract »  |  Full Text »  |  PDF »

IL-2 Receptor {alpha}-Chain Expression Is Independently Regulated in Primary and Secondary Lymphoid Organs.

C. Demaison, L. Fiette, V. Blanchetiere, A. Schimpl, J. Theze, and P. Froussard (1998)
J. Immunol. 161, 1977-1982
 |  Abstract »  |  Full Text »  |  PDF »

IFN-{alpha} Priming of Human Monocytes Differentially Regulates Gram-Positive and Gram-Negative Bacteria-Induced IL-10 Release and Selectively Enhances IL-12p70, CD80, and MHC Class I Expression.

P. Hermann, M. Rubio, T. Nakajima, G. Delespesse, and M. Sarfati (1998)
J. Immunol. 161, 2011-2018
 |  Abstract »  |  Full Text »  |  PDF »

Differential Binding Activity of the Transcription Factor LIL-Stat in Immature and Differentiated Normal and Leukemic Myeloid Cells.

L. M.L. Tuyt, K. Bregman, C. Lummen, W. H.A. Dokter, and E. Vellenga (1998)
Blood 92, 1364-1373
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A New Tyrosine-phosphorylated 97-kDa Adaptor Protein Mediates Interleukin-2-induced Association of SHP-2 with p85-Phosphatidylinositol 3-Kinase in Human T Lymphocytes.

F. Gesbert, C. Guenzi, and J. Bertoglio (1998)
J. Biol. Chem. 273, 18273-18281
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Involvement of Ras in Bruton's Tyrosine Kinase-mediated JNK Activation.

J. Deng, Y. Kawakami, S. E. Hartman, T. Satoh, and T. Kawakami (1998)
J. Biol. Chem. 273, 16787-16791
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Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation.

M. Onishi, T. Nosaka, K. Misawa, A. L.-F. Mui, D. Gorman, M. McMahon, A. Miyajima, and T. Kitamura (1998)
Mol. Cell. Biol. 18, 3871-3879
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Differential Regulation of the Janus Kinase-STAT Pathway and Biologic Function of IL-13 in Primary Human NK and T Cells: A Comparative Study with IL-4.

C.-R. Yu, R. A. Kirken, M. G. Malabarba, H. A. Young, and J. R. Ortaldo (1998)
J. Immunol. 161, 218-227
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Induction of Synaptosomal-Associated Protein-23 kD (SNAP-23) by Various Cytokines.

Y. Morikawa, H. Nishida, K. Misawa, T. Nosaka, A. Miyajima, E. Senba, and T. Kitamura (1998)
Blood 92, 129-135
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Macrophage-Derived Nitric Oxide Regulates T Cell Activation via Reversible Disruption of the Jak3/STAT5 Signaling Pathway.

R. M. Bingisser, P. A. Tilbrook, P. G. Holt, and U. R. Kees (1998)
J. Immunol. 160, 5729-5734
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IL-6 Produced by Kupffer Cells Induces STAT Protein Activation in Hepatocytes Early During the Course of Systemic Listerial Infections.

S. H. Gregory, E. J. Wing, K. L. Danowski, N. van Rooijen, K. F. Dyer, and D. J. Tweardy (1998)
J. Immunol. 160, 6056-6061
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Prolactin (PRL) and Its Receptor: Actions, Signal Transduction Pathways and Phenotypes Observed in PRL Receptor Knockout Mice.

C. Bole-Feysot, V. Goffin, M. Edery, N. Binart, and P. A. Kelly (1998)
Endocr. Rev. 19, 225-268
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Human and Simian T-Cell Leukemia Viruses Type 2 (HTLV-2 and STLV-2pan-p) Transform T Cells Independently of Jak/STAT Activation.

J. C. Mulloy, T.-S. Migone, T. M. Ross, N. Ton, P. L. Green, W. J. Leonard, and G. Franchini (1998)
J. Virol. 72, 4408-4412
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Delineation of the Regions of Interleukin-2 (IL-2) Receptor beta  Chain Important for Association of Jak1 and Jak3. Jak1-INDEPENDENT FUNCTIONAL RECRUITMENT OF Jak3 TO IL-2Rbeta.

M.-h. Zhu, J. A. Berry, S. M. Russell, and W. J. Leonard (1998)
J. Biol. Chem. 273, 10719-10725
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Prolonged STAT1 Activation Related to the Growth Arrest of Malignant Lymphoma Cells by Interferon-alpha.

P. M. Grimley, H. Fang, H. Rui, E. F. Petricoin III, S. Ray, F. Dong, K. H. Fields, R. Hu, K. C. Zoon, S. Audet, et al. (1998)
Blood 91, 3017-3027
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Effect of tyrosine kinase inhibition on surfactant protein A gene expression during human lung development.

J. M. Klein, L. J. Dewild, and T. A. McCarthy (1998)
Am J Physiol Lung Cell Mol Physiol 274, L542-L551
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JAK2 and JAK1 Constitutively Associate With an Interleukin-5 (IL-5) Receptor alpha  and beta c Subunit, Respectively, and Are Activated Upon IL-5 Stimulation.

N. Ogata, T. Kouro, A. Yamada, M. Koike, N. Hanai, T. Ishikawa, and K. Takatsu (1998)
Blood 91, 2264-2271
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Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.

Y. Qiu, D. Robinson, T. G. Pretlow, and H.-J. Kung (1998)
PNAS 95, 3644-3649
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Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells.

T.-S. Migone, N. A. Cacalano, N. Taylor, T. Yi, T. A. Waldmann, and J. A. Johnston (1998)
PNAS 95, 3845-3850
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Essential Role of Induced Nitric Oxide in the Initiation of the Inflammatory Response after Hemorrhagic Shock.

C. Hierholzer, B. Harbrecht, J. M. Menezes, J. Kane, J. MacMicking, C. F. Nathan, A. B. Peitzman, T. R. Billiar, and D. J. Tweardy (1998)
J. Exp. Med. 187, 917-928
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Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.

T. Miyazaki, A. Takaoka, L. Nogueira, I. Dikic, H. Fujii, S. Tsujino, Y. Mitani, M. Maeda, J. Schlessinger, and T. Taniguchi (1998)
Genes & Dev. 12, 770-775
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Signal Transduction Pathways Regulating Hematopoietic Differentiation.

T. E. Smithgall (1998)
Pharmacol. Rev. 50, 1-20
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Cutting Edge: Constitutive Activation of TCR Signaling Molecules in IL-2-Independent Herpesvirus saimiri-Transformed T Cells.

N. Noraz, K. Saha, F. Ottones, S. Smith, and N. Taylor (1998)
J. Immunol. 160, 2042-2045
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Impaired Expression of the Thrombopoietin Receptor by Platelets from Patients with Polycythemia Vera.

A. R. Moliterno, W. D. Hankins, and J. L. Spivak (1998)
N. Engl. J. Med. 338, 572-580
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