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Science 14 April 1995:
Vol. 268. no. 5208, pp. 247 - 251
DOI: 10.1126/science.7716516
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Articles

Science, Vol 268, Issue 5208, 247-251
Copyright © 1995 by American Association for the Advancement of Science

articles

Localization of protein kinases by anchoring proteins: a theme in signal transduction

D Mochly-Rosen

Department of Molecular Pharmacology, School of Medicine, Stanford University, CA 94305-5332, USA.

A fundamental question in signal transduction is how stimulation of a specific protein kinase leads to phosphorylation of particular protein substrates throughout the cell. Recent studies indicate that specific anchoring proteins located at various sites in the cell compartmentalize the kinases to their sites of action. Inhibitors of the interactions between kinases and their anchoring proteins inhibit the functions mediated by the kinases. These data indicate that the location of these anchoring proteins provides some of the specificity of the responses mediated by each kinase and suggest that inhibitors of the interaction between the kinases and their anchoring proteins may be useful as therapeutic agents.


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