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Science 14 April 1995:
Vol. 268. no. 5208, pp. 233 - 239
DOI: 10.1126/science.7716514
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Articles

Science, Vol 268, Issue 5208, 233-239
Copyright © 1995 by American Association for the Advancement of Science

articles

Integrins and signal transduction pathways: the road taken

EA Clark and JS Brugge

ARIAD Pharmaceuticals, Cambridge, MA 02139, USA.

Adhesive interactions play critical roles in directing the migration, proliferation, and differentiation of cells; aberrations in such interactions can lead to pathological disorders. These adhesive interactions, mediated by cell surface receptors that bind to ligands on adjacent cells or in the extracellular matrix, also regulate intracellular signal transduction pathways that control adhesion-induced changes in cell physiology. Though the extracellular molecular interactions involving many adhesion receptors have been well characterized, the adhesion-dependent intracellular signaling events that regulate these physiological alterations have only begun to be elucidated. This article will focus on recent advances in our understanding of intracellular signal transduction pathways regulated by the integrin family of adhesion receptors.


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J. Immunol. 172, 3850-3859
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Microbiology 149, 2417-2426
   Abstract »    Full Text »    PDF »
14-3-3{zeta} Mediates Integrin-induced Activation of Cdc42 and Rac: PLATELET GLYCOPROTEIN Ib-IX REGULATES INTEGRIN-INDUCED SIGNALING BY SEQUESTERING 14-3-3{zeta}.
K. Bialkowska, Y. Zaffran, S. C. Meyer, and J. E. B. Fox (2003)
J. Biol. Chem. 278, 33342-33350
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Age-related Changes in the Biomolecular Mechanisms of Clvarial Osteoblast Biology Affect Fibroblast Growth Factor-2 Signaling and Osteogenesis.
C. M. Cowan, N. Quarto, S. M. Warren, A. Salim, and M. T. Longaker (2003)
J. Biol. Chem. 278, 32005-32013
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A role for Syk-kinase in the control of the binding cycle of the {beta}2 integrins (CD11/CD18) in human polymorphonuclear neutrophils.
T. Willeke, J. Schymeinsky, P. Prange, S. Zahler, and B. Walzog (2003)
J. Leukoc. Biol. 74, 260-269
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Overexpression of Platelet-type 12-Lipoxygenase Promotes Tumor Cell Survival by Enhancing {alpha}v{beta}3 and {alpha}v{beta}5 Integrin Expression.
G. P. Pidgeon, K. Tang, Y. L. Cai, E. Piasentin, and K. V. Honn (2003)
Cancer Res. 63, 4258-4267
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Neutrophil-activating potential of antineutrophil cytoplasm autoantibodies.
A. A. Rarok, P. C. Limburg, and C. G. M. Kallenberg (2003)
J. Leukoc. Biol. 74, 3-15
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Functions of Pulmonary Epithelial Integrins: From Development to Disease.
D. SHEPPARD (2003)
Physiol Rev 83, 673-686
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The F-actin Cross-linking and Focal Adhesion Protein Filamin A Is a Ligand and in Vivo Substrate for Protein Kinase C{alpha}.
U. Tigges, B. Koch, J. Wissing, B. M. Jockusch, and W. H. Ziegler (2003)
J. Biol. Chem. 278, 23561-23569
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T helper (Th) 2 predominance in atopic diseases is due to pre