Science 7 April 1995: Vol. 268. no. 5207, pp. 98 - 100 DOI: 10.1126/science.7701349

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Articles

TIP39/parathyroid hormone type 2 receptor signaling is a potent inhibitor of chondrocyte proliferation and differentiation.

D. Panda, D. Goltzman, H. Juppner, and A. C. Karaplis (2009)
Am J Physiol Endocrinol Metab 297, E1125-E1136
 |  Abstract »  |  Full Text »  |  PDF »

Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells.

J.-P. Vilardaga, M. Bunemann, T. N. Feinstein, N. Lambert, V. O. Nikolaev, S. Engelhardt, M. J. Lohse, and C. Hoffmann (2009)
Mol. Endocrinol. 23, 590-599
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Bone Resorption and Mineral Homeostasis by Osteocytes.

P. D. Pajevic (2009)
IBMS BoneKEy 6, 63-70
 |  Abstract »  |  Full Text »  |  PDF »

Severe growth retardation and early lethality in mice lacking the nuclear localization sequence and C-terminus of PTH-related protein.

D. Miao, H. Su, B. He, J. Gao, Q. Xia, M. Zhu, Z. Gu, D. Goltzman, and A. C. Karaplis (2008)
PNAS 105, 20309-20314
 |  Abstract »  |  Full Text »  |  PDF »

Osteoblastic regulation of B lymphopoiesis is mediated by Gs{alpha}-dependent signaling pathways.

J. Y. Wu, L. E. Purton, S. J. Rodda, M. Chen, L. S. Weinstein, A. P. McMahon, D. T. Scadden, and H. M. Kronenberg (2008)
PNAS 105, 16976-16981
 |  Abstract »  |  Full Text »  |  PDF »

PTHR1 mutations associated with Ollier disease result in receptor loss of function.

A. Couvineau, V. Wouters, G. Bertrand, C. Rouyer, B. Gerard, L. M. Boon, B. Grandchamp, M. Vikkula, and C. Silve (2008)
Hum. Mol. Genet. 17, 2766-2775
 |  Abstract »  |  Full Text »  |  PDF »

NHERF1 Mutations and Responsiveness of Renal Parathyroid Hormone.

Z. Karim, B. Gerard, N. Bakouh, R. Alili, C. Leroy, L. Beck, C. Silve, G. Planelles, P. Urena-Torres, B. Grandchamp, et al. (2008)
N. Engl. J. Med. 359, 1128-1135
 |  Abstract »  |  Full Text »  |  PDF »

Variable number of tandem repeats polymorphism in parathyroid hormone-related protein as predictor of peak bone mass in young healthy Finnish males.

A. Gupta, V.-V. Valimaki, M. J Valimaki, E. Loyttyniemi, M. Richard, P. L Bukka, D. Goltzman, and A. C Karaplis (2008)
Eur. J. Endocrinol. 158, 755-764
 |  Abstract »  |  Full Text »  |  PDF »

Wnt and Hedgehog Signaling Pathways in Bone Development.

T. F. Day and Y. Yang (2008)
J. Bone Joint Surg. Am. 90, 19-24
 |  Abstract »  |  Full Text »  |  PDF »

Tibial Dyschondroplasia 40 Years Later.

R. M. Leach Jr. and E. Monsonego-Ornan (2007)
Poult. Sci. 86, 2053-2058
 |  Abstract »  |  Full Text »  |  PDF »

Novel Mutations in the Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Type 1 Causing Blomstrand Osteochondrodysplasia Types I and II.

J. Hoogendam, H. Farih-Sips, L. C. Wynaendts, C. W. G. M. Lowik, J. M. Wit, and M. Karperien (2007)
J. Clin. Endocrinol. Metab. 92, 1088-1095
 |  Abstract »  |  Full Text »  |  PDF »

Proline-rich Motifs in the Parathyroid Hormone (PTH)/PTH-related Protein Receptor C Terminus Mediate Scaffolding of c-Src with beta-Arrestin2 for ERK1/2 Activation.

A. Rey, D. Manen, R. Rizzoli, J. Caverzasio, and S. L. Ferrari (2006)
J. Biol. Chem. 281, 38181-38188
 |  Abstract »  |  Full Text »  |  PDF »

Hematopoietic-Osteoblastic Interactions in the Hematopoietic Stem Cell Niche.

L. M. Calvi (2006)
IBMS BoneKEy 3, 10-18
 |  Abstract »  |  Full Text »  |  PDF »

The AT1A receptor "gain-of-function" mutant N111S/{Delta}329 is both constitutively active and hyperreactive to angiotensin II.

S. Billet, S. Bardin, R. Tacine, E. Clauser, and S. Conchon (2006)
Am J Physiol Endocrinol Metab 290, E840-E848
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Ligand Binding to the Parathyroid Hormone (PTH)/PTH-Related Protein Receptor: Selectivity of a Modified PTH(1-15) Radioligand for G{alpha}S-Coupled Receptor Conformations.

T. Dean, A. Linglart, M. J. Mahon, M. Bastepe, H. Juppner, J. T. Potts Jr., and T. J. Gardella (2006)
Mol. Endocrinol. 20, 931-943
 |  Abstract »  |  Full Text »  |  PDF »

How PTHrP Controls Growth Plate Chondrocytes.

H. M. Kronenberg (2005)
IBMS BoneKEy 2, 7-15
 |  Full Text »  |  PDF »

Rare Causes of Hypercalcemia.

T. P. Jacobs and J. P. Bilezikian (2005)
J. Clin. Endocrinol. Metab. 90, 6316-6322
 |  Abstract »  |  Full Text »  |  PDF »

Reduced Affinity to and Inhibition by DKK1 Form a Common Mechanism by Which High Bone Mass-Associated Missense Mutations in LRP5 Affect Canonical Wnt Signaling.

M. Ai, S. L. Holmen, W. Van Hul, B. O. Williams, and M. L. Warman (2005)
Mol. Cell. Biol. 25, 4946-4955
 |  Abstract »  |  Full Text »  |  PDF »

Isogenic Human Cell Lines for Drug Discovery: Regulation of Target Gene Expression by Engineered Zinc-Finger Protein Transcription Factors.

P.-Q. Liu, S. Tan, M. C. Mendel, R. J. Murrills, B. M. Bhat, B. Schlag, R. Samuel, J. J. Matteo, R. de la Rosa, K. Howes, et al. (2005)
J Biomol Screen 10, 304-313
 |  Abstract »  |  PDF »

PTHrP and PTH/PTHrP Receptor 1 Expression in Odontogenic Cells of Normal and HHM Model Rat Incisors.

A. Kato, M. Suzuki, Y. Karasawa, T. Sugimoto, and K. Doi (2005)
Toxicol Pathol 33, 456-464
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Chicken ccn2 Gene by Interaction between RNA cis-Element and Putative trans-Factor during Differentiation of Chondrocytes.

Y. Mukudai, S. Kubota, T. Eguchi, S. Kondo, K. Nakao, and M. Takigawa (2005)
J. Biol. Chem. 280, 3166-3177
 |  Abstract »  |  Full Text »  |  PDF »

Histopathological Study of Time Course Changes in PTHrP-Induced Incisor Lesions of Rats.

A. Kato, M. Suzuki, Y. Karasawa, T. Sugimoto, and K. Doi (2005)
Toxicol Pathol 33, 230-238
 |  Abstract »  |  Full Text »  |  PDF »

Novel Parathyroid Hormone (PTH) Antagonists That Bind to the Juxtamembrane Portion of the PTH/PTH-related Protein Receptor.

N. Shimizu, T. Dean, J. C. Tsang, A. Khatri, J. T Potts Jr, and T. J. Gardella (2005)
J. Biol. Chem. 280, 1797-1807
 |  Abstract »  |  Full Text »  |  PDF »

Recessive mutations in PTHR1 cause contrasting skeletal dysplasias in Eiken and Blomstrand syndromes.

S. Duchatelet, E. Ostergaard, D. Cortes, A. Lemainque, and C. Julier (2005)
Hum. Mol. Genet. 14, 1-5
 |  Abstract »  |  Full Text »  |  PDF »

The interplay of osteogenesis and hematopoiesis: expression of a constitutively active PTH/PTHrP receptor in osteogenic cells perturbs the establishment of hematopoiesis in bone and of skeletal stem cells in the bone marrow.

S. A. Kuznetsov, M. Riminucci, N. Ziran, T. W. Tsutsui, A. Corsi, L. Calvi, H. M. Kronenberg, E. Schipani, P. G. Robey, and P. Bianco (2004)
J. Cell Biol. 167, 1113-1122
 |  Abstract »  |  Full Text »  |  PDF »

Stimulatory G protein directly regulates hypertrophic differentiation of growth plate cartilage in vivo.

M. Bastepe, L. S. Weinstein, N. Ogata, H. Kawaguchi, H. Juppner, H. M. Kronenberg, and U.-i. Chung (2004)
PNAS 101, 14794-14799
 |  Abstract »  |  Full Text »  |  PDF »

The Short Stature Homeodomain Protein SHOX Induces Cellular Growth Arrest and Apoptosis and Is Expressed in Human Growth Plate Chondrocytes.

A. Marchini, T. Marttila, A. Winter, S. Caldeira, I. Malanchi, R. J. Blaschke, B. Hacker, E. Rao, M. Karperien, J. M. Wit, et al. (2004)
J. Biol. Chem. 279, 37103-37114
 |  Abstract »  |  Full Text »  |  PDF »

A Form of Jansen's Metaphyseal Chondrodysplasia with Limited Metabolic and Skeletal Abnormalities Is Caused by a Novel Activating Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Mutation.

M. Bastepe, A. Raas-Rothschild, J. Silver, I. Weissman, S. Wientroub, H. Juppner, and D. Gillis (2004)
J. Clin. Endocrinol. Metab. 89, 3595-3600
 |  Abstract »  |  Full Text »  |  PDF »

RhoA/ROCK Signaling Suppresses Hypertrophic Chondrocyte Differentiation.

G. Wang, A. Woods, S. Sabari, L. Pagnotta, L.-A. Stanton, and F. Beier (2004)
J. Biol. Chem. 279, 13205-13214
 |  Abstract »  |  Full Text »  |  PDF »

Efficacy as a Vector: the Relative Prevalence and Paucity of Inverse Agonism.

T. Kenakin (2004)
Mol. Pharmacol. 65, 2-11
 |  Abstract »  |  Full Text »  |  PDF »

Systemic and Local Regulation of the Growth Plate.

B. C. J. van der Eerden, M. Karperien, and J. M. Wit (2003)
Endocr. Rev. 24, 782-801
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Contact Site for Residue 19 of Parathyroid Hormone (PTH) and PTH-Related Protein Analogs in Transmembrane Domain Two of the Type 1 PTH Receptor.

R. C. Gensure, N. Shimizu, J. Tsang, and T. J. Gardella (2003)
Mol. Endocrinol. 17, 2647-2658
 |  Abstract »  |  Full Text »  |  PDF »

Type X collagen gene regulation by Runx2 contributes directly to its hypertrophic chondrocyte-specific expression in vivo.

Q. Zheng, G. Zhou, R. Morello, Y. Chen, X. Garcia-Rojas, and B. Lee (2003)
J. Cell Biol. 162, 833-842
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Cytoplasmic Domains of hVPAC1 Receptor Required for Activation of Adenylyl Cyclase: CRUCIAL ROLE OF TWO CHARGED AMINO ACIDS STRICTLY CONSERVED IN CLASS II G PROTEIN-COUPLED RECEPTORS.

A. Couvineau, J.-J. Lacapere, Y.-V. Tan, C. Rouyer-Fessard, P. Nicole, and M. Laburthe (2003)
J. Biol. Chem. 278, 24759-24766
 |  Abstract »  |  Full Text »  |  PDF »

Basic Helix-loop-helix Protein DEC1 Promotes Chondrocyte Differentiation at the Early and Terminal Stages.

M. Shen, E. Yoshida, W. Yan, T. Kawamoto, K. Suardita, Y. Koyano, K. Fujimoto, M. Noshiro, and Y. Kato (2002)
J. Biol. Chem. 277, 50112-50120
 |  Abstract »  |  Full Text »  |  PDF »

Impaired Desensitization of a Mutant Adrenocorticotropin Receptor Associated with Apparent Constitutive Activity.

F. M. Swords, A. Baig, D. M. Malchoff, C. D. Malchoff, M. O. Thorner, P. J. King, L. Hunyady, and A. J. L. Clark (2002)
Mol. Endocrinol. 16, 2746-2753
 |  Abstract »  |  Full Text »  |  PDF »

Selective Ligand-induced Stabilization of Active and Desensitized Parathyroid Hormone Type 1 Receptor Conformations.

A. Bisello, M. Chorev, M. Rosenblatt, L. Monticelli, D. F. Mierke, and S. L. Ferrari (2002)
J. Biol. Chem. 277, 38524-38530
 |  Abstract »  |  Full Text »  |  PDF »

Anabolic Actions of Parathyroid Hormone during Bone Growth Are Dependent on c-fos.

B. Demiralp, H.-L. Chen, A. J. Koh, E. T. Keller, and L. K. McCauley (2002)
Endocrinology 143, 4038-4047
 |  Abstract »  |  Full Text »  |  PDF »

The Cyclin D1 and Cyclin A Genes Are Targets of Activated PTH/PTHrP Receptors in Jansen's Metaphyseal Chondrodysplasia.

F. Beier and P. LuValle (2002)
Mol. Endocrinol. 16, 2163-2173
 |  Abstract »  |  Full Text »  |  PDF »

Positional cloning of the gene LIMBIN responsible for bovine chondrodysplastic dwarfism.

H. Takeda, M. Takami, T. Oguni, T. Tsuji, K. Yoneda, H. Sato, N. Ihara, T. Itoh, S. R. Kata, Y. Mishina, et al. (2002)
PNAS 99, 10549-10554
 |  Abstract »  |  Full Text »  |  PDF »

Ihh enhances differentiation of CFK-2 chondrocytic cells and antagonizes PTHrP-mediated activation of PKA.

R. A. Deckelbaum, G. Chan, D. Miao, D. Goltzman, and A. C. Karaplis (2002)
J. Cell Sci. 115, 3015-3025
 |  Abstract »  |  Full Text »  |  PDF »

Isoforms of Mammalian Adenylyl Cyclase: Multiplicities of Signaling.

R. K. Sunahara and R. Taussig (2002)
Mol. Interv. 2, 168-184
 |  Abstract »  |  Full Text »  |  PDF »

Parathyroid Hormone and Parathyroid Hormone-related Protein Exert Both Pro- and Anti-apoptotic Effects in Mesenchymal Cells.

H.-L. Chen, B. Demiralp, A. Schneider, A. J. Koh, C. Silve, C.-Y. Wang, and L. K. McCauley (2002)
J. Biol. Chem. 277, 19374-19381
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the cAMP Pathway by the TSH Receptor Involves Switching of the Ectodomain from a Tethered Inverse Agonist to an Agonist.

V. Vlaeminck-Guillem, S.-C. Ho, P. Rodien, G. Vassart, and S. Costagliola (2002)
Mol. Endocrinol. 16, 736-746
 |  Abstract »  |  Full Text »  |  PDF »

Homologous Mutations Near the Junction of the Sixth Transmembrane Domain and the Third Extracellular Loop Lead to Constitutive Activity and Enhanced Agonist Affinity at all Muscarinic Receptor Subtypes.

D. J. Ford, A. Essex, T. A. Spalding, E. S. Burstein, and J. Ellis (2002)
J. Pharmacol. Exp. Ther. 300, 810-817
 |  Abstract »  |  Full Text »  |  PDF »

Partial Rescue of PTH/PTHrP Receptor Knockout Mice by Targeted Expression of the Jansen Transgene.

D. W. Soegiarto, S. Kiachopoulos, E. Schipani, H. Juppner, R. G. Erben, and B. Lanske (2001)
Endocrinology 142, 5303-5310
 |  Abstract »  |  Full Text »  |  PDF »

TGFbeta and PTHrP Control Chondrocyte Proliferation by Activating Cyclin D1 Expression.

F. Beier, Z. Ali, D. Mok, A. C. Taylor, T. Leask, C. Albanese, R. G. Pestell, and P. LuValle (2001)
Mol. Biol. Cell 12, 3852-3863
 |  Abstract »  |  Full Text »  |  PDF »

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiation.

E. Minina, H. M. Wenzel, C. Kreschel, S. Karp, W. Gaffield, A. P. McMahon, and A. Vortkamp (2001)
Development 128, 4523-4534
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Determinants of Inverse Agonism in a Constitutively Active Parathyroid Hormone/Parathyroid Hormone-related Peptide Receptor by Photoaffinity Cross-linking and Mutational Analysis.

R. C. Gensure, P. H. Carter, B. D. Petroni, H. Juppner, and T. J. Gardella (2001)
J. Biol. Chem. 276, 42692-42699
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the murine gammaherpesvirus 68 ORF74 product: a novel oncogenic G protein-coupled receptor.

M. N. Wakeling, D. J. Roy, A. A. Nash, and J. P. Stewart (2001)
J. Gen. Virol. 82, 1187-1197
 |  Abstract »  |  Full Text »

Absence of Functional Type 1 Parathyroid Hormone (PTH)/PTH-Related Protein Receptors in Humans Is Associated with Abnormal Breast Development and Tooth Impaction.

J. J. Wysolmerski, S. Cormier, W. M. Philbrick, P. Dann, J.-P. Zhang, J. Roume, A.-L. Delezoide, and C. Silve (2001)
J. Clin. Endocrinol. Metab. 86, 1788-1794
 |  Abstract »  |  Full Text »

Selective and Nonselective Inverse Agonists for Constitutively Active Type-1 Parathyroid Hormone Receptors: Evidence for Altered Receptor Conformations.

P. H. Carter, B. D. Petroni, R. C. Gensure, E. Schipani, J. T. Potts Jr., and T. J. Gardella (2001)
Endocrinology 142, 1534-1545
 |  Abstract »  |  Full Text »

Prospects for Research for Disorders of the Endocrine System.

J. D. Wilson (2001)
JAMA 285, 624-627
 |  Abstract »  |  Full Text »  |  PDF »

Ectopic and Abnormal Hormone Receptors in Adrenal Cushing's Syndrome.

A. Lacroix, N. N'Diaye, J. Tremblay, and P. Hamet (2001)
Endocr. Rev. 22, 75-110
 |  Abstract »  |  Full Text »

Cellular Distribution of Constitutively Active Mutant Parathyroid Hormone (PTH)/PTH-Related Protein Receptors and Regulation of Cyclic Adenosine 3',5'-Monophosphate Signaling by {beta}-Arrestin2.

S. L. Ferrari and A. Bisello (2001)
Mol. Endocrinol. 15, 149-163
 |  Abstract »  |  Full Text »

Constitutive activation of tethered-peptide/ corticotropin-releasing factor receptor chimeras.

S. M. Nielsen, L. Z. Nielsen, S. A. Hjorth, M. H. Perrin, and W. W. Vale (2000)
PNAS 97, 10277-10281
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis Mediated by Activation of the G Protein-Coupled Receptor for Parathyroid Hormone (PTH)/ PTH-Related Protein (PTHrP).

P. R. Turner, S. Mefford, S. Christakos, and R. A. Nissenson (2000)
Mol. Endocrinol. 14, 241-254
 |  Abstract »  |  Full Text »

The Nematode Leucine-Rich Repeat-Containing, G Protein-Coupled Receptor (LGR) Protein Homologous to Vertebrate Gonadotropin and Thyrotropin Receptors is Constitutively Activated in Mammalian Cells.

M. Kudo, T. Chen, K. Nakabayashi, S. Yu Hsu, and A. J. W. Hsueh (2000)
Mol. Endocrinol. 14, 272-284
 |  Abstract »  |  Full Text »

Inhibition of chondrocyte differentiation in vitro by constitutive and inducible overexpression of the c-fos proto-oncogene.

D. Thomas, A Sunters, A Gentry, and A. Grigoriadis (2000)
J. Cell Sci. 113, 439-450
 |  Abstract »  |  PDF »

Indian hedgehog coordinates endochondral bone growth and morphogenesis via parathyroid hormone related-protein-dependent and -independent pathways.

S. Karp, E Schipani, B St-Jacques, J Hunzelman, H Kronenberg, and A. McMahon (2000)
Development 127, 543-548
 |  Abstract »  |  PDF »

Effects of CTGF/Hcs24, a Product of a Hypertrophic Chondrocyte-Specific Gene, on the Proliferation and Differentiation of Chondrocytes in Culture.

T. Nakanishi, T. Nishida, T. Shimo, K. Kobayashi, T. Kubo, T. Tamatani, K. Tezuka, and M. Takigawa (2000)
Endocrinology 141, 264-273
 |  Abstract »  |  Full Text »  |  PDF »

IMAGe, a New Clinical Association of Intrauterine Growth Retardation, Metaphyseal Dysplasia, Adrenal Hypoplasia Congenita, and Genital Anomalies.

(1999)
J. Clin. Endocrinol. Metab. 84, 4335-4340
 |  Abstract »  |  Full Text »

The glutamate receptor antagonist MK801 modulates bone resorption in vitro by a mechanism predominantly involving osteoclast differentiation.

N. M. PEET, P. S. GRABOWSKI, I. LAKETIC-LJUBOJEVIC, and T. M. SKERRY (1999)
FASEB J 13, 2179-2185
 |  Abstract »  |  Full Text »

Receptors for PTH and PTHrP: their biological importance and functional properties.

M. Mannstadt, H. Juppner, and T. J. Gardella (1999)
Am J Physiol Renal Physiol 277, F665-F675
 |  Abstract »  |  Full Text »  |  PDF »

Fibroblast Growth Factor Receptor 3 Gene Transcription Is Suppressed by Cyclic Adenosine 3',5'-Monophosphate. IDENTIFICATION OF A CHONDROCYTIC REGULATORY ELEMENT.

D. G. McEwen, R. P. Green, M. C. Naski, D. A. Towler, and D. M. Ornitz (1999)
J. Biol. Chem. 274, 30934-30942
 |  Abstract »  |  Full Text »  |  PDF »

A Frame-Shift Mutation in the Type I Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Causing Blomstrand Lethal Osteochondrodysplasia.

M. Karperien, H. J. van der Harten, R. van Schooten, H. Farih-Sips, N. S. den Hollander, S. L. J. Kneppers, P. Nijweide, S. E. Papapoulos, and C. W. G. M. Lowik (1999)
J. Clin. Endocrinol. Metab. 84, 3713-3720
 |  Abstract »  |  Full Text »  |  PDF »

Calcitonin Receptor-Mediated Growth Suppression of HEK-293 Cells Is Accompanied by Induction of p21WAF1/CIP1 and G2/M Arrest.

A. Evdokiou, L.-J. Raggatt, G. J. Atkins, and D. M. Findlay (1999)
Mol. Endocrinol. 13, 1738-1750
 |  Abstract »  |  Full Text »

A Novel Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Mutation in Jansen's Metaphyseal Chondrodysplasia.

E. Schipani, C. Langman, J. Hunzelman, M. Le Merrer, K. Y. Loke, M. J. Dillon, C. Silve, and H. Jüppner (1999)
J. Clin. Endocrinol. Metab. 84, 3052-3057
 |  Abstract »  |  Full Text »

The Rat Growth Hormone-Releasing Hormone Receptor Gene: Structure, Regulation, and Generation of Receptor Isoforms with Different Signaling Properties.

T. L. Miller, P. A. Godfrey, V. I. DeAlmeida, and K. E. Mayo (1999)
Endocrinology 140, 4152-4165
 |  Abstract »  |  Full Text »

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.

B. St-Jacques, M. Hammerschmidt, and A. P. McMahon (1999)
Genes & Dev. 13, 2072-2086
 |  Abstract »  |  Full Text »

Point Mutation Causing Constitutive Signaling of CXCR2 Leads to Transforming Activity Similar to Kaposi's Sarcoma Herpesvirus-G Protein-Coupled Receptor.

M. Burger, J. A. Burger, R. C. Hoch, Z. Oades, H. Takamori, and I. U. Schraufstatter (1999)
J. Immunol. 163, 2017-2022
 |  Abstract »  |  Full Text »  |  PDF »

A G Protein-coupled Receptor from Zebrafish Is Activated by Human Parathyroid Hormone and Not by Human or Teleost Parathyroid Hormone-related Peptide. IMPLICATIONS FOR THE EVOLUTIONARY CONSERVATION OF CALCIUM-REGULATING PEPTIDE HORMONES.

D. A. Rubin, P. Hellman, L. I. Zon, C. J. Lobb, C. Bergwitz, and H. Juppner (1999)
J. Biol. Chem. 274, 23035-23042
 |  Abstract »  |  Full Text »  |  PDF »

Two Cytoplasmic Loops of the Glucagon Receptor Are Required to Elevate cAMP or Intracellular Calcium.

A. M. Cypess, C. G. Unson, C.-R. Wu, and T. P. Sakmar (1999)
J. Biol. Chem. 274, 19455-19464
 |  Abstract »  |  Full Text »  |  PDF »

3',5'-Cyclic Adenosine Monophosphate Activation in Osteoblastic Cells: Effects on Parathyroid Hormone-1 Receptors and Osteoblastic Differentiation in Vitro.

A. J. Koh, C. A. Beecher, T. J. Rosol, and L. K. McCauley (1999)
Endocrinology 140, 3154-3162
 |  Abstract »  |  Full Text »

Distribution of the Parathyroid Hormone 2 Receptor in Rat: Immunolocalization Reveals Expression by Several Endocrine Cells.

T. B. Usdin, J. Hilton, T. Vertesi, G. Harta, G. Segre, and E. Mezey (1999)
Endocrinology 140, 3363-3371
 |  Abstract »  |  Full Text »

Measurement of Agonist and Antagonist Ligand-Binding Parameters at the Human Parathyroid Hormone Type 1 Receptor: Evaluation of Receptor States and Modulation by Guanine Nucleotide.

S. R. J. Hoare, G. de Vries, and T. B. Usdin (1999)
J. Pharmacol. Exp. Ther. 289, 1323-1333
 |  Abstract »  |  Full Text »

Parathyroid Hormone-related Peptide (PTHrP)-dependent and -independent Effects of Transforming Growth Factor {beta} (TGF-{beta}) on Endochondral Bone Formation.

R. Serra, A. Karaplis, and P. Sohn (1999)
J. Cell Biol. 145, 783-794
 |  Abstract »  |  Full Text »  |  PDF »

Selective Modulation of Wild Type Receptor Functions by Mutants of G-Protein-coupled Receptors.

C. Le Gouill, J.-L. Parent, C.-A. Caron, R. Gaudreau, L. Volkov, M. Rola-Pleszczynski, and J. Stankova (1999)
J. Biol. Chem. 274, 12548-12554
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Construction of Phosphorylation-independent beta -Arrestin Mutants with Constitutive Activity in Cells.

A. Kovoor, J. Celver, R. I. Abdryashitov, C. Chavkin, and V. V. Gurevich (1999)
J. Biol. Chem. 274, 6831-6834
 |  Abstract »  |  Full Text »  |  PDF »

Editorial: Parathyroid Hormone (PTH)/PTHrP Receptor Mutations in Human Chondrodysplasia.

R. A. Nissenson (1998)
Endocrinology 139, 4753-4755
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Interspecies Polymorphisms Confer Constitutive Activity to the Mastomys Cholecystokinin-B/Gastrin Receptor.

K. Schaffer, E. W. McBride, M. Beinborn, and A. S. Kopin (1998)
J. Biol. Chem. 273, 28779-28784
 |  Abstract »  |  Full Text »  |  PDF »

Parathyroid hormone-related protein is required for tooth eruption.

W. M. Philbrick, B. E. Dreyer, I. A. Nakchbandi, and A. C. Karaplis (1998)
PNAS 95, 11846-11851
 |  Abstract »  |  Full Text »  |  PDF »

High Constitutive Activity of the Human Formyl Peptide Receptor.

K. Wenzel-Seifert, C. M. Hurt, and R. Seifert (1998)
J. Biol. Chem. 273, 24181-24189
 |  Abstract »  |  Full Text »  |  PDF »

Protean Effects of a Natural Peptide Agonist of the G Protein-Coupled Secretin Receptor Demonstrated by Receptor Mutagenesis.

S. C. Ganguli, C.-G. Park, M. H. Holtmann, E. M. Hadac, T. P. Kenakin, and L. J. Miller (1998)
J. Pharmacol. Exp. Ther. 286, 593-598
 |  Abstract »  |  Full Text »

Creation of a Constitutively Activated State of the 5-Hydroxytryptamine2A Receptor by Site-Directed Mutagenesis: Inverse Agonist Activity of Antipsychotic Drugs.

C. T. Egan, K. Herrick-Davis, and M. Teitler (1998)
J. Pharmacol. Exp. Ther. 286, 85-90
 |  Abstract »  |  Full Text »

A Ligand-Mimetic Model for Constitutive Activation of the Melanocortin-1 Receptor.

D. Lu, D. I. Vage, and R. D. Cone (1998)
Mol. Endocrinol. 12, 592-604
 |  Abstract »  |  Full Text »

Effects of Parathyroid Hormone (PTH) and PTH-Related Peptide on Expressions of Matrix Metalloproteinase- 2, -3, and -9 in Growth Plate Chondrocyte Cultures.

Y. Kawashima-Ohya, H. Satakeda, Y. Kuruta, T. Kawamoto, W. Yan, Y. Akagawa, T. Hayakawa, M. Noshiro, Y. Okada, S. Nakamura, et al. (1998)
Endocrinology 139, 2120-2127
 |  Abstract »  |  Full Text »  |  PDF »

Advances in endocrinology.

P. E Clayton and V. Tillmann (1998)
Arch. Dis. Child. 78, 278-284
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Constitutive Activation of the Human Vasoactive Intestinal Peptide 1 Receptor, a Member of the New Class II Family of G Protein-coupled Receptors.

P. Gaudin, J.-J. Maoret, A. Couvineau, C. Rouyer-Fessard, and M. Laburthe (1998)
J. Biol. Chem. 273, 4990-4996
 |  Abstract »  |  Full Text »  |  PDF »

Transmembrane Residues Together with the Amino Terminus Limit the Response of the Parathyroid Hormone (PTH) 2 Receptor to PTH-related Peptide.

P. R. Turner, S. Mefford, T. Bambino, and R. A. Nissenson (1998)
J. Biol. Chem. 273, 3830-3837
 |  Abstract »  |  Full Text »  |  PDF »

Cancer and Bone.

T. A. Guise and G. R. Mundy (1998)
Endocr. Rev. 19, 18-54
 |  Abstract »  |  Full Text »

Multiple Regions of Ligand Discrimination Revealed by Analysis of Chimeric Parathyroid Hormone 2 (PTH2) and PTH/PTH-Related Peptide (PTHrP) Receptors.

J. A. Clark, T. I. Bonner, A. S. Kim, and T. B. Usdin (1998)
Mol. Endocrinol. 12, 193-206
 |  Abstract »  |  Full Text »

Structure and Regulation of the Human Growth Hormone-Releasing Hormone Receptor Gene.

S. Petersenn, A. C. Rasch, M. Heyens, and H. M. Schulte (1998)
Mol. Endocrinol. 12, 233-247
 |  Abstract »  |  Full Text »

Identification, Functional Characterization, and Developmental Expression of Two Nonallelic Parathyroid Hormone (PTH)/PTH-Related Peptide Receptor Isoforms in Xenopus laevis (Daudin).

C. Bergwitz, P. Klein, H. Kohno, S. A. Forman, K. Lee, D. Rubin, and H. Juppner (1998)
Endocrinology 139, 723-732
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Activity of Glucagon Receptor Mutants.

S. A. Hjorth, C. Ørskov, and T. W. Schwartz (1998)
Mol. Endocrinol. 12, 78-86
 |  Abstract »  |  Full Text »

Synthesis and characterization of a novel retinylamine analog inhibitor of constitutively active rhodopsin mutants found in patients with autosomal dominant retinitis pigmentosa.

T. Yang, B. B. Snider, and D. D. Oprian (1997)
PNAS 94, 13559-13564
 |  Abstract »  |  Full Text »  |  PDF »

Targeted expression of constitutively active receptors for parathyroid hormone and parathyroid hormone-related peptide delays endochondral bone formation and rescues mice that lack parathyroid hormone-related peptide.

E. Schipani, B. Lanske, J. Hunzelman, A. Luz, C. S. Kovacs, K. Lee, A. Pirro, H. M. Kronenberg, and H. Juppner (1997)
PNAS 94, 13689-13694
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Cyclic Adenosine Monophosphate Analog Induces Hypercalcemia via Production of 1,25-Dihydroxyvitamin D in Patients with Solid Tumors.

M. P. Saunders, A. J. Salisbury, K. J. O'Byrne, L. Long, R. M. Whitehouse, D. C. Talbot, E. B. Mawer, and A. L. Harris (1997)
J. Clin. Endocrinol. Metab. 82, 4044-4048
 |  Abstract »  |  Full Text »  |  PDF »

Constitutive Activation of the Cyclic Adenosine 3',5'-Monophosphate Signaling Pathway by Parathyroid Hormone (PTH)/PTH-Related Peptide Receptors Mutated at the Two Loci for Jansen's Metaphyseal Chondrodysplasia.

E. Schipani, G. S. Jensen, J. Pincus, R. A. Nissenson, T. J. Gardella, and H. Jüppner (1997)
Mol. Endocrinol. 11, 851-858
 |  Abstract »  |  Full Text »

Somatostatin Acts by Inhibiting the Cyclic 3',5'-Adenosine Monophosphate (cAMP)/Protein Kinase A Pathway, cAMP Response Element-Binding Protein (CREB) Phosphorylation, and CREB Transcription Potency.

J. J. Tentler, J. R. Hadcock, and A. Gutierrez-Hartmann (1997)
Mol. Endocrinol. 11, 859-866
 |  Abstract »  |  Full Text »

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