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Science 7 April 1995:
Vol. 268. no. 5207, pp. 94 - 97
DOI: 10.1126/science.7701348
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Articles

Science, Vol 268, Issue 5207, 94-97
Copyright © 1995 by American Association for the Advancement of Science

articles

A morbillivirus that caused fatal disease in horses and humans

K Murray, P Selleck, P Hooper, A Hyatt, A Gould, L Gleeson, H Westbury, L Hiley, L Selvey, B Rodwell, and al. et

CSIRO Australian Animal Health Laboratory, East Geelong, Victoria.

A morbillivirus has been isolated and added to an increasing list of emerging viral diseases. This virus caused an outbreak of fatal respiratory disease in horses and humans. Genetic analyses show it to be only distantly related to the classic morbilliviruses rinderpest, measles, and canine distemper. When seen by electron microscopy, viruses had 10- and 18-nanometer surface projections that gave them a "double-fringed" appearance. The virus induced syncytia that developed in the endothelium of blood vessels, particularly the lungs.


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