Science 31 March 1995: Vol. 267. no. 5206, pp. 2000 - 2003 DOI: 10.1126/science.7535475

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Articles

Critical Role for Interleukin-1{beta} (IL-1{beta}) during Chlamydia muridarum Genital Infection and Bacterial Replication-Independent Secretion of IL-1{beta} in Mouse Macrophages.

D. Prantner, T. Darville, J. D. Sikes, C. W. Andrews Jr., H. Brade, R. G. Rank, and U. M. Nagarajan (2009)
Infect. Immun. 77, 5334-5346
 |  Abstract »  |  Full Text »  |  PDF »

Thalidomide Inhibits Activation of Caspase-1.

M. Keller, G. Sollberger, and H.-D. Beer (2009)
J. Immunol. 183, 5593-5599
 |  Abstract »  |  Full Text »  |  PDF »

9E,11E-Conjugated Linoleic Acid Increases Expression of the Endogenous Antiinflammatory Factor, Interleukin-1 Receptor Antagonist, in RAW 264.7 Cells.

Y. Lee, J. T. Thompson, and J. P. Vanden Heuvel (2009)
J. Nutr. 139, 1861-1866
 |  Abstract »  |  Full Text »  |  PDF »

Inflammatory Role of ASC in Antigen-Induced Arthritis Is Independent of Caspase-1, NALP-3, and IPAF.

L. Kolly, M. Karababa, L. A. B. Joosten, S. Narayan, R. Salvi, V. Petrilli, J. Tschopp, W. B. van den Berg, A. K.-L. So, and N. Busso (2009)
J. Immunol. 183, 4003-4012
 |  Abstract »  |  Full Text »  |  PDF »

NOD2 contributes to cutaneous defense against Staphylococcus aureus through {alpha}-toxin-dependent innate immune activation.

P. Hruz, A. S. Zinkernagel, G. Jenikova, G. J. Botwin, J.-P. Hugot, M. Karin, V. Nizet, and L. Eckmann (2009)
PNAS 106, 12873-12878
 |  Abstract »  |  Full Text »  |  PDF »

Fungal Zymosan and Mannan Activate the Cryopyrin Inflammasome.

M. Lamkanfi, R. K. S. Malireddi, and T.-D. Kanneganti (2009)
J. Biol. Chem. 284, 20574-20581
 |  Abstract »  |  Full Text »  |  PDF »

Uric Acid Is a Danger Signal Activating NALP3 Inflammasome in Lung Injury Inflammation and Fibrosis.

P. Gasse, N. Riteau, S. Charron, S. Girre, L. Fick, V. Petrilli, J. Tschopp, V. Lagente, V. F. J. Quesniaux, B. Ryffel, et al. (2009)
Am. J. Respir. Crit. Care Med. 179, 903-913
 |  Abstract »  |  Full Text »  |  PDF »

Asc and Ipaf Inflammasomes Direct Distinct Pathways for Caspase-1 Activation in Response to Legionella pneumophila.

C. L. Case, S. Shin, and C. R. Roy (2009)
Infect. Immun. 77, 1981-1991
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-1 Mediates Resistance in Murine Melioidosis.

K. Breitbach, G. W. Sun, J. Kohler, K. Eske, P. Wongprompitak, G. Tan, Y. Liu, Y.-H. Gan, and I. Steinmetz (2009)
Infect. Immun. 77, 1589-1595
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-7 deficiency protects from endotoxin-induced lymphocyte apoptosis and improves survival.

M. Lamkanfi, L. O. Moreira, P. Makena, D. C. J. Spierings, K. Boyd, P. J. Murray, D. R. Green, and T.-D. Kanneganti (2009)
Blood 113, 2742-2745
 |  Abstract »  |  Full Text »  |  PDF »

Crystal Structure of Procaspase-1 Zymogen Domain Reveals Insight into Inflammatory Caspase Autoactivation.

J. M. Elliott, L. Rouge, C. Wiesmann, and J. M. Scheer (2009)
J. Biol. Chem. 284, 6546-6553
 |  Abstract »  |  Full Text »  |  PDF »

Inflammasome recognition of influenza virus is essential for adaptive immune responses.

T. Ichinohe, H. K. Lee, Y. Ogura, R. Flavell, and A. Iwasaki (2009)
J. Exp. Med. 206, 79-87
 |  Abstract »  |  Full Text »  |  PDF »

Paneth cells directly sense gut commensals and maintain homeostasis at the intestinal host-microbial interface.

S. Vaishnava, C. L. Behrendt, A. S. Ismail, L. Eckmann, and L. V. Hooper (2008)
PNAS 105, 20858-20863
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Peptidecentric Proteomics Reveals Caspase-7 as a Substrate of the Caspase-1 Inflammasomes.

M. Lamkanfi, T.-D. Kanneganti, P. Van Damme, T. Vanden Berghe, I. Vanoverberghe, J. Vandekerckhove, P. Vandenabeele, K. Gevaert, and G. Nunez (2008)
Mol. Cell. Proteomics 7, 2350-2363
 |  Abstract »  |  Full Text »  |  PDF »

Active Caspase-1-Mediated Secretion of Retinoic Acid Inducible Gene-I.

M.-J. Kim and J.-Y. Yoo (2008)
J. Immunol. 181, 7324-7331
 |  Abstract »  |  Full Text »  |  PDF »

The Nalp3 inflammasome is essential for the development of silicosis.

S. L. Cassel, S. C. Eisenbarth, S. S. Iyer, J. J. Sadler, O. R. Colegio, L. A. Tephly, A. B. Carter, P. B. Rothman, R. A. Flavell, and F. S. Sutterwala (2008)
PNAS 105, 9035-9040
 |  Abstract »  |  Full Text »  |  PDF »

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1{beta} secretion in response to Bacillus anthracis infection and muramyl dipeptide.

L.-C. Hsu, S. R. Ali, S. McGillivray, P.-H. Tseng, S. Mariathasan, E. W. Humke, L. Eckmann, J. J. Powell, V. Nizet, V. M. Dixit, et al. (2008)
PNAS 105, 7803-7808
 |  Abstract »  |  Full Text »  |  PDF »

P2X7 Receptor Differentially Couples to Distinct Release Pathways for IL-1{beta} in Mouse Macrophage.

P. Pelegrin, C. Barroso-Gutierrez, and A. Surprenant (2008)
J. Immunol. 180, 7147-7157
 |  Abstract »  |  Full Text »  |  PDF »

Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity.

J. Li, H. L. Yin, and J. Yuan (2008)
J. Cell Biol. 181, 321-333
 |  Abstract »  |  Full Text »  |  PDF »

MyD88 Negatively Controls Hypergammaglobulinemia with Autoantibody Production during Bacterial Infection.

A. Woods, P. Soulas-Sprauel, B. Jaulhac, B. Arditi, A.-M. Knapp, J.-L. Pasquali, A.-S. Korganow, and T. Martin (2008)
Infect. Immun. 76, 1657-1667
 |  Abstract »  |  Full Text »  |  PDF »

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury.

J. P. de Rivero Vaccari, G. Lotocki, A. E. Marcillo, W. D. Dietrich, and R. W. Keane (2008)
J. Neurosci. 28, 3404-3414
 |  Abstract »  |  Full Text »  |  PDF »

Pannexin-1-Mediated Intracellular Delivery of Muramyl Dipeptide Induces Caspase-1 Activation via Cryopyrin/NLRP3 Independently of Nod2.

N. Marina-Garcia, L. Franchi, Y.-G. Kim, D. Miller, C. McDonald, G.-J. Boons, and G. Nunez (2008)
J. Immunol. 180, 4050-4057
 |  Abstract »  |  Full Text »  |  PDF »

Pseudomonas aeruginosa activates caspase 1 through Ipaf.

E. A. Miao, R. K. Ernst, M. Dors, D. P. Mao, and A. Aderem (2008)
PNAS 105, 2562-2567
 |  Abstract »  |  Full Text »  |  PDF »

Protective Effect of IL-18 on Kainate- and IL-1{beta}-Induced Cerebellar Ataxia in Mice.

T. Andoh, H. Kishi, K. Motoki, K. Nakanishi, Y. Kuraishi, and A. Muraguchi (2008)
J. Immunol. 180, 2322-2328
 |  Abstract »  |  Full Text »  |  PDF »

Disease-associated CIAS1 mutations induce monocyte death, revealing low-level mosaicism in mutation-negative cryopyrin-associated periodic syndrome patients.

M. Saito, R. Nishikomori, N. Kambe, A. Fujisawa, H. Tanizaki, K. Takeichi, T. Imagawa, T. Iehara, H. Takada, T. Matsubayashi, et al. (2008)
Blood 111, 2132-2141
 |  Abstract »  |  Full Text »  |  PDF »

The Caspase-1 Digestome Identifies the Glycolysis Pathway as a Target during Infection and Septic Shock.

W. Shao, G. Yeretssian, K. Doiron, S. N. Hussain, and M. Saleh (2007)
J. Biol. Chem. 282, 36321-36329
 |  Abstract »  |  Full Text »  |  PDF »

Broad and Specific Caspase Inhibitor-Induced Acute Repression of Apoptosis in Atherosclerotic Lesions Evaluated by Radiolabeled Annexin A5 Imaging.

M. Sarai, D. Hartung, A. Petrov, J. Zhou, N. Narula, L. Hofstra, F. Kolodgie, S. Isobe, S. Fujimoto, J.-L. Vanderheyden, et al. (2007)
J. Am. Coll. Cardiol. 50, 2305-2312
 |  Abstract »  |  Full Text »  |  PDF »

ASC/PYCARD and Caspase-1 Regulate the IL-18/IFN-{gamma} Axis during Anaplasma phagocytophilum Infection.

J. H. F. Pedra, F. S. Sutterwala, B. Sukumaran, Y. Ogura, F. Qian, R. R. Montgomery, R. A. Flavell, and E. Fikrig (2007)
J. Immunol. 179, 4783-4791
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-1 inflammasomes in infection and inflammation.

M. Lamkanfi, T.-D. Kanneganti, L. Franchi, and G. Nunez (2007)
J. Leukoc. Biol. 82, 220-225
 |  Abstract »  |  Full Text »  |  PDF »

Cisplatin-Induced Acute Renal Failure Is Associated with an Increase in the Cytokines Interleukin (IL)-1beta, IL-18, IL-6, and Neutrophil Infiltration in the Kidney.

S. Faubel, E. C. Lewis, L. Reznikov, D. Ljubanovic, T. S. Hoke, H. Somerset, D.-J. Oh, L. Lu, C. L. Klein, C. A. Dinarello, et al. (2007)
J. Pharmacol. Exp. Ther. 322, 8-15
 |  Abstract »  |  Full Text »  |  PDF »

Caspase inhibition reduces cardiac myocyte dyshomeostasis and improves cardiac contractile function after major burn injury.

D. L. Carlson, D. L. Maass, J. White, P. Sikes, and J. W. Horton (2007)
J Appl Physiol 103, 323-330
 |  Abstract »  |  Full Text »  |  PDF »

MDP-induced interleukin-1{beta} processing requires Nod2 and CIAS1/NALP3.

Q. Pan, J. Mathison, C. Fearns, V. V. Kravchenko, J. Da Silva Correia, H. M. Hoffman, K. S. Kobayashi, J. Bertin, E. P. Grant, A. J. Coyle, et al. (2007)
J. Leukoc. Biol. 82, 177-183
 |  Abstract »  |  Full Text »  |  PDF »

Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria.

L. Franchi, T.-D. Kanneganti, G. R. Dubyak, and G. Nunez (2007)
J. Biol. Chem. 282, 18810-18818
 |  Abstract »  |  Full Text »  |  PDF »

Appearances can be deceiving: phenotypes of knockout mice.

I. Barbaric, G. Miller, and T. N. Dear (2007)
Brief Funct Genomic Proteomic
 |  Abstract »  |  Full Text »  |  PDF »

(S)-1-((S)-2-{[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino}-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2R,3S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1beta and IL-18.

W. Wannamaker, R. Davies, M. Namchuk, J. Pollard, P. Ford, G. Ku, C. Decker, P. Charifson, P. Weber, U. A. Germann, et al. (2007)
J. Pharmacol. Exp. Ther. 321, 509-516
 |  Abstract »  |  Full Text »  |  PDF »

Proximal tubules from caspase-1-deficient mice are protected against hypoxia-induced membrane injury.

C. L. Edelstein, T. S. Hoke, H. Somerset, W. Fang, C. L. Klein, C. A. Dinarello, and S. Faubel (2007)
Nephrol. Dial. Transplant. 22, 1052-1061
 |  Abstract »  |  Full Text »  |  PDF »

A Role for Caspase-1 in Heart Failure.

S. Merkle, S. Frantz, M. P. Schon, J. Bauersachs, M. Buitrago, R. J.A. Frost, E. M. Schmitteckert, M. J. Lohse, and S. Engelhardt (2007)
Circ. Res. 100, 645-653
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1.

S. M. Miggin, E. Palsson-McDermott, A. Dunne, C. Jefferies, E. Pinteaux, K. Banahan, C. Murphy, P. Moynagh, M. Yamamoto, S. Akira, et al. (2007)
PNAS 104, 3372-3377
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Legionella Phagosome Maturation and Infection through Flagellin and Host Ipaf.

A. Amer, L. Franchi, T.-D. Kanneganti, M. Body-Malapel, N. Ozoren, G. Brady, S. Meshinchi, R. Jagirdar, A. Gewirtz, S. Akira, et al. (2006)
J. Biol. Chem. 281, 35217-35223
 |  Abstract »  |  Full Text »  |  PDF »

The Inflammatory Caspases: Key Players in the Host Response to Pathogenic Invasion and Sepsis.

A. Nadiri, M. K. Wolinski, and M. Saleh (2006)
J. Immunol. 177, 4239-4245
 |  Abstract »  |  Full Text »  |  PDF »

Haplotypes of the Caspase-1 Gene, Plasma Caspase-1 Levels, and Cardiovascular Risk.

S. Blankenberg, T. Godefroy, O. Poirier, H. J. Rupprecht, S. Barbaux, C. Bickel, V. Nicaud, R. Schnabel, F. Kee, C. Morrison, et al. (2006)
Circ. Res. 99, 102-108
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of caspase-1 in rat brain reduces spontaneous nonrapid eye movement sleep and nonrapid eye movement sleep enhancement induced by lipopolysaccharide.

L. Imeri, S. Bianchi, and M. R. Opp (2006)
Am J Physiol Regulatory Integrative Comp Physiol 291, R197-R204
 |  Abstract »  |  Full Text »  |  PDF »

Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis.

M. Lara-Tejero, F. S. Sutterwala, Y. Ogura, E. P. Grant, J. Bertin, A. J. Coyle, R. A. Flavell, and J. E. Galan (2006)
J. Exp. Med. 203, 1407-1412
 |  Abstract »  |  Full Text »  |  PDF »

ASC Directs NF-{kappa}B Activation by Regulating Receptor Interacting Protein-2 (RIP2) Caspase-1 Interactions..

A. Sarkar, M. Duncan, J. Hart, E. Hertlein, D. C. Guttridge, and M. D. Wewers (2006)
J. Immunol. 176, 4979-4986
 |  Abstract »  |  Full Text »  |  PDF »

Cytokines in Atherosclerosis: Pathogenic and Regulatory Pathways.

A. Tedgui and Z. Mallat (2006)
Physiol Rev 86, 515-581
 |  Abstract »  |  Full Text »  |  PDF »

Necrotic death as a cell fate..

W.-X. Zong and C. B. Thompson (2006)
Genes & Dev. 20, 1-15
 |  Abstract »  |  Full Text »  |  PDF »

Both Hemopoietic and Resident Cells Are Required for MyD88-Dependent Pulmonary Inflammatory Response to Inhaled Endotoxin.

N. Noulin, V. F. J. Quesniaux, S. Schnyder-Candrian, B. Schnyder, I. Maillet, T. Robert, B. B. Vargaftig, B. Ryffel, and I. Couillin (2005)
J. Immunol. 175, 6861-6869
 |  Abstract »  |  Full Text »  |  PDF »

Cardiac Apoptosis in Severe Relapsing Fever Borreliosis.

D. Londono, Y. Bai, W. R. Zuckert, H. Gelderblom, and D. Cadavid (2005)
Infect. Immun. 73, 7669-7676
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-1 Is a Direct Target Gene of ETS1 and Plays a Role in ETS1-Induced Apoptosis.

H. Pei, C. Li, Y. Adereth, T. Hsu, D. K. Watson, and R. Li (2005)
Cancer Res. 65, 7205-7213
 |  Abstract »  |  Full Text »  |  PDF »

The Induction of a Type 1 Immune Response following a Trypanosoma brucei Infection Is MyD88 Dependent.

M. B. Drennan, B. Stijlemans, J. Van Den Abbeele, V. J. Quesniaux, M. Barkhuizen, F. Brombacher, P. De Baetselier, B. Ryffel, and S. Magez (2005)
J. Immunol. 175, 2501-2509
 |  Abstract »  |  Full Text »  |  PDF »

IL-Converting Enzyme/Caspase-1 Inhibitor VX-765 Blocks the Hypersensitive Response to an Inflammatory Stimulus in Monocytes from Familial Cold Autoinflammatory Syndrome Patients.

J. H. Stack, K. Beaumont, P. D. Larsen, K. S. Straley, G. W. Henkel, J. C. R. Randle, and H. M. Hoffman (2005)
J. Immunol. 175, 2630-2634
 |  Abstract »  |  Full Text »  |  PDF »

Proapoptotic Effects of Caspase-1/Interleukin-Converting Enzyme Dominate in Myocardial Ischemia.

F. M. Syed, H. S. Hahn, A. Odley, Y. Guo, J. G. Vallejo, R. A. Lynch, D. L. Mann, R. Bolli, and G. W. Dorn II (2005)
Circ. Res. 96, 1103-1109
 |  Abstract »  |  Full Text »  |  PDF »

The Nef-Mediated AIDS-Like Disease of CD4C/Human Immunodeficiency Virus Transgenic Mice Is Associated with Increased Fas/FasL Expression on T Cells and T-Cell Death but Is Not Prevented in Fas-, FasL-, Tumor Necrosis Factor Receptor 1-, or Interleukin-1{beta}-Converting Enzyme-Deficient or Bcl2-Expressing Transgenic Mice.

E. Priceputu, I. Rodrigue, P. Chrobak, J. Poudrier, T. W. Mak, Z. Hanna, C. Hu, D. G. Kay, and P. Jolicoeur (2005)
J. Virol. 79, 6377-6391
 |  Abstract »  |  Full Text »  |  PDF »

Endotoxemic acute renal failure is attenuated in caspase-1-deficient mice.

W. Wang, S. Faubel, D. Ljubanovic, A. Mitra, S. A. Falk, J. Kim, Y. Tao, A. Soloviev, L. L. Reznikov, C. A. Dinarello, et al. (2005)
Am J Physiol Renal Physiol 288, F997-F1004
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Caspase-1/Toll-like Receptor 4-independent Pathway of Cell Death Induced by Cytosolic Shigella in Infected Macrophages.

T. Suzuki, K. Nakanishi, H. Tsutsui, H. Iwai, S. Akira, N. Inohara, M. Chamaillard, G. Nunez, and C. Sasakawa (2005)
J. Biol. Chem. 280, 14042-14050
 |  Abstract »  |  Full Text »  |  PDF »

INCA, a Novel Human Caspase Recruitment Domain Protein That Inhibits Interleukin-1{beta} Generation.

M. Lamkanfi, G. Denecker, M. Kalai, K. D'hondt, A. Meeus, W. Declercq, X. Saelens, and P. Vandenabeele (2004)
J. Biol. Chem. 279, 51729-51738
 |  Abstract »  |  Full Text »  |  PDF »

ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules.

M. Yamamoto, K. Yaginuma, H. Tsutsui, J. Sagara, X. Guan, E. Seki, K. Yasuda, M. Yamamoto, S. Akira, K. Nakanishi, et al. (2004)
Genes Cells 9, 1055-1067
 |  Abstract »  |  Full Text »  |  PDF »

Internucleosomal DNA cleavage in apoptotic WEHI 231 cells is mediated by a chymotrypsin-like protease.

J. Murn, U. Urleb, and I. Mlinaric-Rascan (2004)
Genes Cells 9, 1103-1111
 |  Abstract »  |  Full Text »  |  PDF »

Increased expression of caspase-1 and interleukin-18 in peripheral blood mononuclear cells in patients with multiple sclerosis.

W.-X. Huang, P. Huang, and J. Hillert (2004)
Multiple Sclerosis 10, 482-487
 |  Abstract »  |  PDF »

Caspase-1 Inhibitor Reduces Severity of Pseudomonas aeruginosa Keratitis in Mice.

A. Thakur, R. P. Barrett, J. A. Hobden, and L. D. Hazlett (2004)
Invest. Ophthalmol. Vis. Sci. 45, 3177-3184
 |  Abstract »  |  Full Text »  |  PDF »

The Domains of Apoptosis: A Genomics Perspective.

J. C. Reed, K. S. Doctor, and A. Godzik (2004)
Sci. STKE 2004, re9
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-1 Activates Nuclear Factor of the {kappa}-Enhancer in B Cells Independently of Its Enzymatic Activity.

M. Lamkanfi, M. Kalai, X. Saelens, W. Declercq, and P. Vandenabeele (2004)
J. Biol. Chem. 279, 24785-24793
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Bacterial Infection-Induced IFN-{gamma} Is Critically but Not Solely Dependent on Toll-Like Receptor 4-Myeloid Differentiation Factor 88-IFN-{alpha}{beta}-STAT1 Signaling.

A. G. Rothfuchs, C. Trumstedt, H. Wigzell, and M. E. Rottenberg (2004)
J. Immunol. 172, 6345-6353
 |  Abstract »  |  Full Text »  |  PDF »

Anthrax Lethal Toxin Rapidly Activates Caspase-1/ICE and Induces Extracellular Release of Interleukin (IL)-1{beta} and IL-18.

R. Cordoba-Rodriguez, H. Fang, C. S. R. Lankford, and D. M. Frucht (2004)
J. Biol. Chem. 279, 20563-20566
 |  Abstract »  |  Full Text »  |  PDF »

Roles of caspase-1 in Listeria infection in mice.

N. M. Tsuji, H. Tsutsui, E. Seki, K. Kuida, H. Okamura, K. Nakanishi, and R. A. Flavell (2004)
Int. Immunol. 16, 335-343
 |  Abstract »  |  Full Text »  |  PDF »

IFN-{alpha} Sensitizes Human Umbilical Vein Endothelial Cells to Apoptosis Induced by Double-Stranded RNA.

W. J. Kaiser, J. L. Kaufman, and M. K. Offermann (2004)
J. Immunol. 172, 1699-1710
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-1 Is Not Required for Type 1 Diabetes in the NOD Mouse.

W. H. Schott, B. D. Haskell, H. M. Tse, M. J. Milton, J. D. Piganelli, C. M. Choisy-Rossi, P. C. Reifsnyder, A. V. Chervonsky, and E. H. Leiter (2004)
Diabetes 53, 99-104
 |  Abstract »  |  Full Text »  |  PDF »

Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death.

W.-H. Zhang, X. Wang, M. Narayanan, Y. Zhang, C. Huo, J. C. Reed, and R. M. Friedlander (2003)
PNAS 100, 16012-16017
 |  Abstract »  |  Full Text »  |  PDF »

Protection against Murine Leukemia Virus-Induced Spongiform Myeloencephalopathy in Mice Overexpressing Bcl-2 but Not in Mice Deficient for Interleukin-6, Inducible Nitric Oxide Synthetase, ICE, Fas, Fas Ligand, or TNF-R1 Genes.

P. Jolicoeur, C. Hu, T. W. Mak, J.-C. Martinou, and D. G. Kay (2003)
J. Virol. 77, 13161-13170
 |  Abstract »  |  Full Text »  |  PDF »

A Salmonella protein causes macrophage cell death by inducing autophagy.

L. D. Hernandez, M. Pypaert, R. A. Flavell, and J. E. Galan (2003)
J. Cell Biol. 163, 1123-1131
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis-Associated Speck-Like Protein Containing a Caspase Recruitment Domain Is a Regulator of Procaspase-1 Activation.

C. Stehlik, S. H. Lee, A. Dorfleutner, A. Stassinopoulos, J. Sagara, and J. C. Reed (2003)
J. Immunol. 171, 6154-6163
 |  Abstract »  |  Full Text »  |  PDF »

Ways of dying: multiple pathways to apoptosis.

J. M. Adams (2003)
Genes & Dev. 17, 2481-2495
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Shigella-induced necrosis and apoptosis of U937 cells and J774 macrophages.

T. Nonaka, T. Kuwabara, H. Mimuro, A. Kuwae, and S. Imajoh-Ohmi (2003)
Microbiology 149, 2513-2527
 |  Abstract »  |  Full Text »  |  PDF »

The Apoptosis-Necrosis Continuum: Insights from Genetically Altered Mice.

C. J. Zeiss (2003)
Vet. Pathol. 40, 481-495
 |  Abstract »  |  Full Text »  |  PDF »

CARD6 Is a Modulator of NF-{kappa}B Activation by Nod1- and Cardiak-mediated Pathways.

C. Stehlik, H. Hayashi, F. Pio, A. Godzik, and J. C. Reed (2003)
J. Biol. Chem. 278, 31941-31949
 |  Abstract »  |  Full Text »  |  PDF »

Dissociation between Neurodegeneration and Caspase-11-Mediated Activation of Caspase-1 and Caspase-3 in a Mouse Model of Amyotrophic Lateral Sclerosis.

S. J. Kang, I. Sanchez, N. Jing, and J. Yuan (2003)
J. Neurosci. 23, 5455-5460
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Comparative Analysis of Apoptosis and Inflammation Genes of Mice and Humans.

J. C. Reed, K. Doctor, A. Rojas, J. M. Zapata, C. Stehlik, L. Fiorentino, J. Damiano, W. Roth, S.-i. Matsuzawa, R. Newman, et al. (2003)
Genome Res. 13, 1376-1388
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Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity.

L. Salmena, B. Lemmers, A. Hakem, E. Matysiak-Zablocki, K. Murakami, P.Y. B. Au, D. M. Berry, L. Tamblyn, A. Shehabeldin, E. Migon, et al. (2003)
Genes & Dev. 17, 883-895
 |  Abstract »  |  Full Text »  |  PDF »

Poly(ADP-ribose) Polymerase Activation and Changes in Bax Protein Expression Associated with Extracellular ATP-Mediated Apoptosis in Human Embryonic Kidney 293-P2X7 Cells.

L. T. Wen, C. C. Caldwell, and A. F. Knowles (2003)
Mol. Pharmacol. 63, 706-713
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-1-Deficient Mice Have Delayed Neutrophil Apoptosis and a Prolonged Inflammatory Response to Lipopolysaccharide-Induced Acute Lung Injury.

S. J. Rowe, L. Allen, V. C. Ridger, P. G. Hellewell, and M. K. B. Whyte (2002)
J. Immunol. 169, 6401-6407
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Caspase-11 Gene Expression in Response to Lipopolysaccharide and Interferon-gamma Requires Nuclear Factor-kappa B and Signal Transducer and Activator of Transcription (STAT) 1.

R. Schauvliege, J. Vanrobaeys, P. Schotte, and R. Beyaert (2002)
J. Biol. Chem. 277, 41624-41630
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Mechanisms of p75-mediated Death of Hippocampal Neurons. ROLE OF CASPASES.

C. M. Troy, J. E. Friedman, and W. J. Friedman (2002)
J. Biol. Chem. 277, 34295-34302
 |  Abstract »  |  Full Text »  |  PDF »

Tissue-Protective Effects of Estrogen Involve Regulation of Caspase Gene Expression.

D. G. Monroe, R. R. Berger, and M. M. Sanders (2002)
Mol. Endocrinol. 16, 1322-1331
 |  Abstract »  |  Full Text »  |  PDF »

Listeria monocytogenes Infection in Caspase-11-Deficient Mice.

N. J. Mueller, R. A. Wilkinson, and J. A. Fishman (2002)
Infect. Immun. 70, 2657-2664
 |  Abstract »  |  Full Text »  |  PDF »

CARD-8 Protein, a New CARD Family Member That Regulates Caspase-1 Activation and Apoptosis.

M. Razmara, S. M. Srinivasula, L. Wang, J.-L. Poyet, B. J. Geddes, P. S. DiStefano, J. Bertin, and E. S. Alnemri (2002)
J. Biol. Chem. 277, 13952-13958
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of Langerhans Cell-Derived IL-18 to Contact Hypersensitivity.

B. Wang, C. Feliciani, B. G. Howell, I. Freed, Q. Cai, H. Watanabe, and D. N. Sauder (2002)
J. Immunol. 168, 3303-3308
 |  Abstract »  |  Full Text »  |  PDF »

IAP Suppression of Apoptosis Involves Distinct Mechanisms: the TAK1/JNK1 Signaling Cascade and Caspase Inhibition.

M. G. Sanna, J. d. S. Correia, O. Ducrey, J. Lee, K. Nomoto, N. Schrantz, Q. L. Deveraux, and R. J. Ulevitch (2002)
Mol. Cell. Biol. 22, 1754-1766
 |  Abstract »  |  Full Text »  |  PDF »

Priming of Macrophages with Lipopolysaccharide Potentiates P2X7-mediated Cell Death via a Caspase-1-dependent Mechanism, Independently of Cytokine Production.

R. A. Le Feuvre, D. Brough, Y. Iwakura, K. Takeda, and N. J. Rothwell (2002)
J. Biol. Chem. 277, 3210-3218
 |  Abstract »  |  Full Text »  |  PDF »

Activation of caspases in intestinal villus epithelial cells of normal and nematode infected rats.

Y Hyoh, S Ishizaka, T Horii, A Fujiwara, T Tegoshi, M Yamada, and N Arizono (2002)
Gut 50, 71-77
 |  Abstract »  |  Full Text »  |  PDF »

Anti-apoptotic role of Sonic hedgehog protein at the early stages of nervous system organogenesis.

J.-B. Charrier, F. Lapointe, N. M. L. Douarin, and M.-A. Teillet (2001)
Development 128, 4011-4020
 |  Abstract »  |  Full Text »  |  PDF »

Identification and Characterization of a Novel Class of Interleukin-1 Post-Translational Processing Inhibitors.

D. G. Perregaux, P. McNiff, R. Laliberte, N. Hawryluk, H. Peurano, E. Stam, J. Eggler, R. Griffiths, M. A. Dombroski, and C. A. Gabel (2001)
J. Pharmacol. Exp. Ther. 299, 187-197
 |  Abstract »  |  Full Text »  |  PDF »

Serpin Protein CrmA Suppresses Hypoxia-Mediated Apoptosis of Ventricular Myocytes.

R. M. Gurevich, K. M. Regula, and L. A. Kirshenbaum (2001)
Circulation 103, 1984-1991
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide-Induced IL-18 Secretion from Murine Kupffer Cells Independently of Myeloid Differentiation Factor 88 That Is Critically Involved in Induction of Production of IL-12 and IL-1{{beta}}.

E. Seki, H. Tsutsui, H. Nakano, N. M. Tsuji, K. Hoshino, O. Adachi, K. Adachi, S. Futatsugi, K. Kuida, O. Takeuchi, et al. (2001)
J. Immunol. 166, 2651-2657
 |  Abstract »  |  Full Text »  |  PDF »

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