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Science 17 March 1995:
Vol. 267. no. 5204, pp. 1645 - 1648
DOI: 10.1126/science.7886453

Articles

Science, Vol 267, Issue 5204, 1645-1648
Copyright © 1995 by American Association for the Advancement of Science


articles

Epithelial antibiotics induced at sites of inflammation

BS Schonwetter, ED Stolzenberg, and MA Zasloff

Magainin Research Institute, Magainin Pharmaceuticals, Inc., Plymouth Meeting, PA 19462.

The role of antimicrobial peptides in epithelial defense is not fully understood. An epithelial beta-defensin, lingual antimicrobial peptide (LAP), was isolated from bovine tongue and the corresponding complementary DNA cloned. LAP showed a broad spectrum of antibacterial and antifungal activities. LAP messenger RNA abundance was markedly increased in the epithelium surrounding naturally occurring tongue lesions. This increase coincided with the cellular hallmarks of acute and chronic inflammation in the underlying lamina propria, supporting a role for epithelial antimicrobial peptides as integral components of the inflammatory response.


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Epithelial antibiotic induced in states of disease.
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The Expression of the Gene Coding for the Antibacterial Peptide LL-37 Is Induced in Human Keratinocytes during Inflammatory Disorders.
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