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Science 10 March 1995:
Vol. 267. no. 5203, pp. 1502 - 1506
DOI: 10.1126/science.7878470
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Articles

Science, Vol 267, Issue 5203, 1502-1506
Copyright © 1995 by American Association for the Advancement of Science

articles

Pineal opsin: a nonvisual opsin expressed in chick pineal

M Max, PJ McKinnon, KJ Seidenman, RK Barrett, ML Applebury, JS Takahashi, and RF Margolskee

Roche Institute of Molecular Biology, Roche Research Center, Nutley, NJ 07110.

Pineal opsin (P-opsin), an opsin from chick that is highly expressed in pineal but is not detectable in retina, was cloned by the polymerase chain reaction. It is likely that the P-opsin lineage diverged from the retinal opsins early in opsin evolution. The amino acid sequence of P-opsin is 42 to 46 percent identical to that of the retinal opsins. P-opsin is a seven-membrane spanning, G protein-linked receptor with a Schiff-base lysine in the seventh membrane span and a Schiff-base counterion in the third membrane span. The primary sequence of P-opsin suggests that it will be maximally sensitive to approximately 500-nanometer light and produce a slow and prolonged phototransduction response consistent with the nonvisual function of pineal photoreception.


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