Science 10 March 1995: Vol. 267. no. 5203, pp. 1494 - 1498 DOI: 10.1126/science.7533327

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Articles

TRAF2 and TRAF3 independently mediate Ig class switching driven by CD40.

H. H. Jabara, Y. Weng, T. Sannikova, and R. S. Geha (2009)
Int. Immunol. 21, 477-488
 |  Abstract »  |  Full Text »  |  PDF »

The in vivo function of a noncanonical TRAF2-binding domain in the C-terminus of CD40 in driving B-cell growth and differentiation.

L.-F. Lu, C. L. Ahonen, E. F. Lind, V. S. Raman, W. J. Cook, L.-L. Lin, and R. J. Noelle (2007)
Blood 110, 193-200
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of the Interferon Antiviral Response by the TBK1/IKKi Adaptor Protein TANK.

B. Guo and G. Cheng (2007)
J. Biol. Chem. 282, 11817-11826
 |  Abstract »  |  Full Text »  |  PDF »

CD30 Activates Both the Canonical and Alternative NF-{kappa}B Pathways in Anaplastic Large Cell Lymphoma Cells.

C. W. Wright, J. M. Rumble, and C. S. Duckett (2007)
J. Biol. Chem. 282, 10252-10262
 |  Abstract »  |  Full Text »  |  PDF »

B Cell Maturation Antigen, the Receptor for a Proliferation-Inducing Ligand and B Cell-Activating Factor of the TNF Family, Induces Antigen Presentation in B Cells.

M. Yang, H. Hase, D. Legarda-Addison, L. Varughese, B. Seed, and A. T. Ting (2005)
J. Immunol. 175, 2814-2824
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TNF receptor (TNFR)-associated factor (TRAF) 3 serves as an inhibitor of TRAF2/5-mediated activation of the noncanonical NF-{kappa}B pathway by TRAF-binding TNFRs.

J. Hauer, S. Puschner, P. Ramakrishnan, U. Simon, M. Bongers, C. Federle, and H. Engelmann (2005)
PNAS 102, 2874-2879
 |  Abstract »  |  Full Text »  |  PDF »

Key Molecular Contacts Promote Recognition of the BAFF Receptor by TNF Receptor-Associated Factor 3: Implications for Intracellular Signaling Regulation.

C.-Z. Ni, G. Oganesyan, K. Welsh, X. Zhu, J. C. Reed, A. C. Satterthwait, G. Cheng, and K. R. Ely (2004)
J. Immunol. 173, 7394-7400
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for TRAF3 in Signaling by LMP1 But Not CD40 in B Lymphocytes.

P. Xie, B. S. Hostager, and G. A. Bishop (2004)
J. Exp. Med. 199, 661-671
 |  Abstract »  |  Full Text »  |  PDF »

CD40/CD40 Homodimers Are Required for CD40-induced Phosphatidylinositol 3-Kinase-dependent Expression of B7.2 by Human B Lymphocytes.

C. Reyes-Moreno, J. Girouard, R. Lapointe, A. Darveau, and W. Mourad (2004)
J. Biol. Chem. 279, 7799-7806
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor Receptor-associated Factor (TRAF) 1 Regulates CD40-induced TRAF2-mediated NF-{kappa}B Activation.

M. Fotin-Mleczek, F. Henkler, A. Hausser, H. Glauner, D. Samel, A. Graness, P. Scheurich, D. Mauri, and H. Wajant (2004)
J. Biol. Chem. 279, 677-685
 |  Abstract »  |  Full Text »  |  PDF »

Structurally Distinct Recognition Motifs in Lymphotoxin-{beta} Receptor and CD40 for Tumor Necrosis Factor Receptor-associated Factor (TRAF)-mediated Signaling.

C. Li, P. S. Norris, C.-Z. Ni, M. L. Havert, E. M. Chiong, B. R. Tran, E. Cabezas, J. C. Reed, A. C. Satterthwait, C. F. Ware, et al. (2003)
J. Biol. Chem. 278, 50523-50529
 |  Abstract »  |  Full Text »  |  PDF »

CD40-dependent Activation of Phosphatidylinositol 3-Kinase/Akt Pathway Mediates Endothelial Cell Survival and in Vitro Angiogenesis.

M. C. Deregibus, S. Buttiglieri, S. Russo, B. Bussolati, and G. Camussi (2003)
J. Biol. Chem. 278, 18008-18014
 |  Abstract »  |  Full Text »  |  PDF »

Enhancement of B-MYB Transcriptional Activity by ZPR9, a Novel Zinc Finger Protein.

H.-A Seong, K.-T. Kim, and H. Ha (2003)
J. Biol. Chem. 278, 9655-9662
 |  Abstract »  |  Full Text »  |  PDF »

TNFR-Associated Factor-3 Is Associated With BAFF-R and Negatively Regulates BAFF-R-Mediated NF-{kappa}B Activation and IL-10 Production.

L.-G. Xu and H.-B. Shu (2002)
J. Immunol. 169, 6883-6889
 |  Abstract »  |  Full Text »  |  PDF »

Prevention of B cell antigen receptor-induced apoptosis by ligation of CD40 occurs downstream of cell cycle regulation.

W. J. M. Mackus, S. M. A. Lens, R. H. Medema, M. J. Kwakkenbos, L. M. Evers, M. H. J. v. Oers, R. A. W. v. Lier, and E. Eldering (2002)
Int. Immunol. 14, 973-982
 |  Abstract »  |  Full Text »  |  PDF »

Nonstructural 5A Protein of Hepatitis C Virus Modulates Tumor Necrosis Factor alpha -stimulated Nuclear Factor kappa B Activation.

K.-J. Park, S.-H. Choi, S. Y. Lee, S. B. Hwang, and M. M. C. Lai (2002)
J. Biol. Chem. 277, 13122-13128
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CD40 activation in epithelial ovarian carcinoma cells modulates growth, apoptosis, and cytokine secretion.

N J Gallagher, A G Eliopoulos, A Agathangelo, J Oates, J Crocker, and L S Young (2002)
Mol. Pathol. 55, 110-120
 |  Abstract »  |  Full Text »  |  PDF »

Dissection of B cell differentiation during primary immune responses in mice with altered CD40 signals.

T. Yasui, M. Muraoka, Y. Takaoka-Shichijo, I. Ishida, N. Takegahara, J. Uchida, A. Kumanogoh, S. Suematsu, M. Suzuki, and H. Kikutani (2002)
Int. Immunol. 14, 319-329
 |  Abstract »  |  Full Text »  |  PDF »

All TRAFs are not created equal: common and distinct molecular mechanisms of TRAF-mediated signal transduction.

J. Y. Chung, Y. C. Park, H. Ye, and H. Wu (2002)
J. Cell Sci. 115, 679-688
 |  Abstract »  |  Full Text »  |  PDF »

Ceramide-Rich Membrane Rafts Mediate CD40 Clustering.

H. Grassme, V. Jendrossek, J. Bock, A. Riehle, and E. Gulbins (2002)
J. Immunol. 168, 298-307
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a CD40-Dominant Inhibitory Receptor Mutant.

A. M. Mehl, M. Jones, M. Rowe, and P. Brennan (2001)
J. Immunol. 167, 6388-6393
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Characterization of CD40 Signaling Intermediates.

B. G. Werneburg, S. J. Zoog, T. T. A. Dang, M. R. Kehry, and J. J. Crute (2001)
J. Biol. Chem. 276, 43334-43342
 |  Abstract »  |  Full Text »  |  PDF »

Activation of TRAF5 and TRAF6 Signal Cascades Negatively Regulates the Latent Replication Origin of Epstein-Barr Virus through p38 Mitogen-Activated Protein Kinase.

M. Shirakata, K.-I. Imadome, K. Okazaki, and K. Hirai (2001)
J. Virol. 75, 5059-5068
 |  Abstract »  |  Full Text »

Differential Signaling and Tumor Necrosis Factor Receptor-Associated Factor (Traf) Degradation Mediated by Cd40 and the Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 (Lmp1).

K. D. Brown, B. S. Hostager, and G. A. Bishop (2001)
J. Exp. Med. 193, 943-954
 |  Abstract »  |  Full Text »  |  PDF »

Caspase-mediated cleavage of TRAF3 in FasL-stimulated Jurkat-T cells.

Z. H. Lee, S. E. Lee, K. Kwack, W. Yeo, T. H. Lee, S. S. Bae, P.-G. Suh, and H.-H. Kim (2001)
J. Leukoc. Biol. 69, 490-496
 |  Abstract »  |  Full Text »

CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways.

L. L. Pearson, B. E. Castle, and M. R. Kehry (2001)
Int. Immunol. 13, 273-283
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Hodgkin disease: pharmacologic intervention of the CD40-NFkappa B pathway by a protease inhibitor.

C. M. Annunziata, Y. J. Safiran, S. G. Irving, U. N. Kasid, and J. Cossman (2000)
Blood 96, 2841-2848
 |  Abstract »  |  Full Text »  |  PDF »

The expression and function of Epstein-Barr virus encoded latent genes.

L S Young, C W Dawson, and A G Eliopoulos (2000)
Mol. Pathol. 53, 238-247
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Molecular basis for CD40 signaling mediated by TRAF3.

C.-Z. Ni, K. Welsh, E. Leo, C.-k. Chiou, H. Wu, J. C. Reed, and K. R. Ely (2000)
PNAS 97, 10395-10399
 |  Abstract »  |  Full Text »  |  PDF »

TRAF4 Deficiency Leads to Tracheal Malformation with Resulting Alterations in Air Flow to the Lungs.

H. Shiels, X. Li, P. T. Schumacker, E. Maltepe, P. A. Padrid, A. Sperling, C. B. Thompson, and T. Lindsten (2000)
Am. J. Pathol. 157, 679-688
 |  Abstract »  |  Full Text »  |  PDF »

The Prodomain of Caspase-1 Enhances Fas-mediated Apoptosis through Facilitation of Caspase-8 Activation.

T. Tatsuta, A. Shiraishi, and J. D. Mountz (2000)
J. Biol. Chem. 275, 14248-14254
 |  Abstract »  |  Full Text »  |  PDF »

Alymphoplasia (aly)-Type Nuclear Factor {kappa}B-Inducing Kinase (Nik) Causes Defects in Secondary Lymphoid Tissue Chemokine Receptor Signaling and Homing of Peritoneal Cells to the Gut-Associated Lymphatic Tissue System.

S. Fagarasan, R. Shinkura, T. Kamata, F. Nogaki, K. Ikuta, K. Tashiro, and T. Honjo (2000)
J. Exp. Med. 191, 1477-1486
 |  Abstract »  |  Full Text »  |  PDF »

NF-kappa B Activation by Camptothecin. A LINKAGE BETWEEN NUCLEAR DNA DAMAGE AND CYTOPLASMIC SIGNALING EVENTS.

T. T. Huang, S. M. Wuerzberger-Davis, B. J. Seufzer, S. D. Shumway, T. Kurama, D. A. Boothman, and S. Miyamoto (2000)
J. Biol. Chem. 275, 9501-9509
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Membrane Localization of TRAF 3 Enables JNK Activation.

H. Dadgostar and G. Cheng (2000)
J. Biol. Chem. 275, 2539-2544
 |  Abstract »  |  Full Text »  |  PDF »

Physical and Functional Interaction of Filamin (Actin-binding Protein-280) and Tumor Necrosis Factor Receptor-associated Factor 2.

A. Leonardi, H. Ellinger-Ziegelbauer, G. Franzoso, K. Brown, and U. Siebenlist (2000)
J. Biol. Chem. 275, 271-278
 |  Abstract »  |  Full Text »  |  PDF »

Th2-Dependent B Cell Responses in the Absence of CD40-CD40 Ligand Interactions.

N. Chirmule, J. Tazelaar, and J. M. Wilson (2000)
J. Immunol. 164, 248-255
 |  Abstract »  |  Full Text »  |  PDF »

Lineage-Specific Modulation of Interleukin 4 Signaling by Interferon Regulatory Factor 4.

S. Gupta, M. Jiang, A. Anthony, and A. B. Pernis (1999)
J. Exp. Med. 190, 1837-1848
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Subcellular Localization and Substrate Specificity of Extracellular Signal-Regulated Kinase in B Cells upon Stimulation with IgM and CD40.

Y. Shirakata, K. Ishii, H. Yagita, K. Okumura, M. Taniguchi, and T. Takemori (1999)
J. Immunol. 163, 6589-6597
 |  Abstract »  |  Full Text »  |  PDF »

Frequent Expression of the Variant CD30 in Human Malignant Myeloid and Lymphoid Neoplasms.

R. Horie, V. Gattei, K. Ito, S. Imajo-Ohmi, T. Tange, J. Miyauchi, A. Pinto, M. Degan, A. De Iuliis, F. Tassan Mazzocco, et al. (1999)
Am. J. Pathol. 155, 2029-2041
 |  Abstract »  |  Full Text »  |  PDF »

Differential Role for p38 Mitogen-Activated Protein Kinase in Regulating CD40-Induced Gene Expression in Dendritic Cells and B Cells.

A. Aicher, G. L. Shu, D. Magaletti, T. Mulvania, A. Pezzutto, A. Craxton, and E. A. Clark (1999)
J. Immunol. 163, 5786-5795
 |  Abstract »  |  Full Text »  |  PDF »

TRAF Family Proteins Interact with the Common Neurotrophin Receptor and Modulate Apoptosis Induction.

X. Ye, P. Mehlen, S. Rabizadeh, T. VanArsdale, H. Zhang, H. Shin, J. J. L. Wang, E. Leo, J. Zapata, C. A. Hauser, et al. (1999)
J. Biol. Chem. 274, 30202-30208
 |  Abstract »  |  Full Text »  |  PDF »

Mimicry of CD40 Signals by Epstein-Barr Virus LMP1 in B Lymphocyte Responses.

J. Uchida, T. Yasui, Y. Takaoka-Shichijo, M. Muraoka, W. Kulwichit, N. Raab-Traub, and H. Kikutani (1999)
Science 286, 300-303
 |  Abstract »  |  Full Text »

TANK Potentiates Tumor Necrosis Factor Receptor-Associated Factor-Mediated c-Jun N-Terminal Kinase/Stress-Activated Protein Kinase Activation through the Germinal Center Kinase Pathway.

A. I-D. Chin, J. Shu, C. Shan Shi, Z. Yao, J. H. Kehrl, and G. Cheng (1999)
Mol. Cell. Biol. 19, 6665-6672
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Stress Kinase Pathway in Signaling Via the T Cell Costimulatory Receptor 4-1BB.

J. L. Cannons, K. P. Hoeflich, J. R. Woodgett, and T. H. Watts (1999)
J. Immunol. 163, 2990-2998
 |  Abstract »  |  Full Text »  |  PDF »

Intracellular Signaling of gp34, the OX40 Ligand: Induction of c-jun and c-fos mRNA Expression Through gp34 upon Binding of Its Receptor, OX40.

Y. Matsumura, T. Hori, S. Kawamata, A. Imura, and T. Uchiyama (1999)
J. Immunol. 163, 3007-3011
 |  Abstract »  |  Full Text »  |  PDF »

TNF-Mediated Activation of the Stress-Activated Protein Kinase Pathway: TNF Receptor-Associated Factor 2 Recruits and Activates Germinal Center Kinase Related.

C.-S. Shi, A. Leonardi, J. Kyriakis, U. Siebenlist, and J. H. Kehrl (1999)
J. Immunol. 163, 3279-3285
 |  Abstract »  |  Full Text »  |  PDF »

Targeted disruption of Traf5 gene causes defects in CD40- and CD27-mediated lymphocyte activation.

H. Nakano, S. Sakon, H. Koseki, T. Takemori, K. Tada, M. Matsumoto, E. Munechika, T. Sakai, T. Shirasawa, H. Akiba, et al. (1999)
PNAS 96, 9803-9808
 |  Abstract »  |  Full Text »  |  PDF »

Differential Requirements for Tumor Necrosis Factor Receptor-associated Factor Family Proteins in CD40-mediated Induction of NF-kappa B and Jun N-terminal Kinase Activation.

E. Leo, K. Welsh, S.-i. Matsuzawa, J. M. Zapata, S. Kitada, R. S. Mitchell, K. R. Ely, and J. C. Reed (1999)
J. Biol. Chem. 274, 22414-22422
 |  Abstract »  |  Full Text »  |  PDF »

The Epstein-Barr Virus Oncoprotein Latent Membrane Protein 1 Engages the Tumor Necrosis Factor Receptor-Associated Proteins TRADD and Receptor-Interacting Protein (RIP) but Does Not Induce Apoptosis or Require RIP for NF-kappa B Activation.

K. M. Izumi, E. C. McFarland, A. T. Ting, E. A. Riley, B. Seed, and E. D. Kieff (1999)
Mol. Cell. Biol. 19, 5759-5767
 |  Abstract »  |  Full Text »  |  PDF »

Crystallographic analysis of CD40 recognition and signaling by human TRAF2.

S. M. McWhirter, S. S. Pullen, J. M. Holton, J. J. Crute, M. R. Kehry, and T. Alber (1999)
PNAS 96, 8408-8413
 |  Abstract »  |  Full Text »  |  PDF »

Activation of the Janus Kinase 3-STAT5a Pathway After CD40 Triggering of Human Monocytes But Not of Resting B Cells.

P. Revy, C. Hivroz, G. Andreu, P. Graber, C. Martinache, A. Fischer, and A. Durandy (1999)
J. Immunol. 163, 787-793
 |  Abstract »  |  Full Text »  |  PDF »

The Human Tumor Necrosis Factor (TNF) Receptor-associated Factor 1 Gene (TRAF1) Is Up-regulated by Cytokines of the TNF Ligand Family and Modulates TNF-induced Activation of NF-kappa B and c-Jun N-terminal Kinase.

R. Schwenzer, K. Siemienski, S. Liptay, G. Schubert, N. Peters, P. Scheurich, R. M. Schmid, and H. Wajant (1999)
J. Biol. Chem. 274, 19368-19374
 |  Abstract »  |  Full Text »  |  PDF »

The Guanine-Nucleotide Exchange Factor Vav Is a Crucial Regulator of B Cell Receptor Activation and B Cell Responses to Nonrepetitive Antigens.

M. F. Bachmann, L. Nitschke, C. Krawczyk, K. Tedford, P. S. Ohashi, K. D. Fischer, and J. M. Penninger (1999)
J. Immunol. 163, 137-142
 |  Abstract »  |  Full Text »  |  PDF »

Cutting Edge: Contrasting Roles of TNF Receptor-Associated Factor 2 (TRAF2) and TRAF3 in CD40-Activated B Lymphocyte Differentiation.

B. S. Hostager and G. A. Bishop (1999)
J. Immunol. 162, 6307-6311
 |  Abstract »  |  Full Text »  |  PDF »

Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain.

V. Baud, Z.-G. Liu, B. Bennett, N. Suzuki, Y. Xia, and M. Karin (1999)
Genes & Dev. 13, 1297-1308
 |  Abstract »  |  Full Text »

CD40 Signaling through Tumor Necrosis Factor Receptor-associated Factors (TRAFs). BINDING SITE SPECIFICITY AND ACTIVATION OF DOWNSTREAM PATHWAYS BY DISTINCT TRAFs.

S. S. Pullen, T. T. A. Dang, J. J. Crute, and M. R. Kehry (1999)
J. Biol. Chem. 274, 14246-14254
 |  Abstract »  |  Full Text »  |  PDF »

Role of Cellular Tumor Necrosis Factor Receptor-Associated Factors in NF-kappa B Activation and Lymphocyte Transformation by Herpesvirus Saimiri STP.

H. Lee, J.-K. Choi, M. Li, K. Kaye, E. Kieff, and J. U. Jung (1999)
J. Virol. 73, 3913-3919
 |  Abstract »  |  Full Text »

CD40- and HLA-DR-mediated cell death pathways share a lot of similarities but differ in their use of ADP-ribosyltransferase activities.

C. Leveille, H. Zekki, R. Al-Daccak, and W. Mourad (1999)
Int. Immunol. 11, 719-730
 |  Abstract »  |  Full Text »  |  PDF »

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.

M. A. Lomaga, W.-C. Yeh, I. Sarosi, G. S. Duncan, C. Furlonger, A. Ho, S. Morony, C. Capparelli, G. Van, S. Kaufman, et al. (1999)
Genes & Dev. 13, 1015-1024
 |  Abstract »  |  Full Text »

Differential Responses to CD40 Ligation Among Burkitt Lymphoma Lines That Are Uniformly Responsive to Epstein-Barr Virus Latent Membrane Protein 1.

N. V. Henriquez, E. Floettmann, M. Salmon, M. Rowe, and A. B. Rickinson (1999)
J. Immunol. 162, 3298-3307
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a Novel Activation-inducible Protein of the Tumor Necrosis Factor Receptor Superfamily and Its Ligand.

B. Kwon, K.-Y. Yu, J. Ni, G.-L. Yu, I.-K. Jang, Y.-J. Kim, L. Xing, D. Liu, S.-X. Wang, and B. S. Kwon (1999)
J. Biol. Chem. 274, 6056-6061
 |  Abstract »  |  Full Text »  |  PDF »

CD40 Signaling of Monocyte Inflammatory Cytokine Synthesis through an ERK1/2-dependent Pathway. A TARGET OF INTERLEUKIN ()-4 AND IL-10 ANTI-INFLAMMATORY ACTION.

J. Suttles, D. M. Milhorn, R. W. Miller, J. C. Poe, L. M. Wahl, and R. D. Stout (1999)
J. Biol. Chem. 274, 5835-5842
 |  Abstract »  |  Full Text »  |  PDF »

Two differently regulated nuclear factor kappa B activation pathways triggered by the cytoplasmic tail of CD40.

N. Tsukamoto, N. Kobayashi, S. Azuma, T. Yamamoto, and J.-i. Inoue (1999)
PNAS 96, 1234-1239
 |  Abstract »  |  Full Text »  |  PDF »

Specificities of CD40 signaling: Involvement of TRAF2 in CD40-induced NF-kappa B activation and intercellular adhesion molecule-1 up-regulation.

H. H. Lee, P. W. Dempsey, T. P. Parks, X. Zhu, D. Baltimore, and G. Cheng (1999)
PNAS 96, 1421-1426
 |  Abstract »  |  Full Text »  |  PDF »

Increased TNF-{alpha}-Induced Apoptosis in Lymphocytes from Aged Humans: Changes in TNF-{alpha} Receptor Expression and Activation of Caspases.

S. Aggarwal, S. Gollapudi, and S. Gupta (1999)
J. Immunol. 162, 2154-2161
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Necrosis Factor Receptor-Associated Factor 1 Is Overexpressed in Reed-Sternberg Cells of Hodgkin's Disease and Epstein-Barr Virus-Transformed Lymphoid Cells.

H. Durkop, H.-D. Foss, G. Demel, H. Klotzbach, C. Hahn, and H. Stein (1999)
Blood 93, 617-623
 |  Abstract »  |  Full Text »  |  PDF »

Genetic Analysis of Apoptotic and Survival Signals.

T. W. MAK and W.-C. YEH (1999)
Cold Spring Harb Symp Quant Biol 64, 335-342
 |  Abstract »  |  PDF »

Structural Studies of Human TRAF2.

H. WU, Y.C. PARK, H. YE, and L. TONG (1999)
Cold Spring Harb Symp Quant Biol 64, 541-550
 |  Abstract »  |  PDF »

Structural and Biochemical Analysis of Signal Transduction by the TRAF Family of Adapter Proteins.

S.M. MCWHIRTER, S.S. PULLEN, B.G. WERNEBURG, M.E. LABADIA, R.H. INGRAHAM, J.J. CRUTE, M.R. KEHRY, and T. ALBER (1999)
Cold Spring Harb Symp Quant Biol 64, 551-562
 |  Abstract »  |  PDF »

Role of the COOH-terminal Domains of Meprin A in Folding, Secretion, and Activity of the Metalloendopeptidase.

T. Tsukuba and J. S. Bond (1998)
J. Biol. Chem. 273, 35260-35267
 |  Abstract »  |  Full Text »  |  PDF »

Role of NF-kappa B in immune and inflammatory responses in the gut.

M F NEURATH, C BECKER, and K BARBULESCU (1998)
Gut 43, 856-860
 |  Abstract »  |  Full Text »  |  PDF »

Signaling Pathways Mediated by the TNF- and Cytokine-Receptor Families Target a Common cis-Element of the IFN Regulatory Factor 1 Promoter.

S. Gupta, D. Xia, M. Jiang, S. Lee, and A. B. Pernis (1998)
J. Immunol. 161, 5997-6004
 |  Abstract »  |  Full Text »  |  PDF »

Activation of human monocytes induces differential resistance to apoptosis with rapid down regulation of caspase-8/FLICE.

L. P. Perera and T. A. Waldmann (1998)
PNAS 95, 14308-14313
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B Activation in CD27 Signaling: Involvement of TNF Receptor-Associated Factors in Its Signaling and Identification of Functional Region of CD27.

H. Yamamoto, T. Kishimoto, and S. Minamoto (1998)
J. Immunol. 161, 4753-4759
 |  Abstract »  |  Full Text »  |  PDF »

The TRAF Family of Signal Transducers Mediates NF-kappa B Activation by the TRANCE Receptor.

B. R. Wong, R. Josien, S. Y. Lee, M. Vologodskaia, R. M. Steinman, and Y. Choi (1998)
J. Biol. Chem. 273, 28355-28359
 |  Abstract »  |  Full Text »  |  PDF »

Role of the TRAF Binding Site and NF-kappa B Activation in Epstein-Barr Virus Latent Membrane Protein 1-Induced Cell Gene Expression.

O. Devergne, E. C. McFarland, G. Mosialos, K. M. Izumi, C. F. Ware, and E. Kieff (1998)
J. Virol. 72, 7900-7908
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Determinants of NF-kappa B-Inducing Kinase Action.

X. Lin, Y. Mu, E. T. Cunningham Jr., K. B. Marcu, R. Geleziunas, and W. C. Greene (1998)
Mol. Cell. Biol. 18, 5899-5907
 |  Abstract »  |  Full Text »

p38 MAPK Is Required for CD40-Induced Gene Expression and Proliferation in B Lymphocytes.

A. Craxton, G. Shu, J. D. Graves, J. Saklatvala, E. G. Krebs, and E. A. Clark (1998)
J. Immunol. 161, 3225-3236
 |  Abstract »  |  Full Text »  |  PDF »

Role of JAK3 in CD40-Mediated Signaling.

H. H. Jabara, R. H. Buckley, J. L. Roberts, G. Lefranc, J. Loiselet, G. Khalil, and R. S. Geha (1998)
Blood 92, 2435-2440
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the Epstein-Barr virus latent membrane protein 1 induces B cell lymphoma in transgenic mice.

W. Kulwichit, R. H. Edwards, E. M. Davenport, J. F. Baskar, V. Godfrey, and N. Raab-Traub (1998)
PNAS 95, 11963-11968
 |  Abstract »  |  Full Text »  |  PDF »

An Intact Zinc Ring Finger Is Required for Tumor Necrosis Factor Receptor-associated Factor-mediated Nuclear Factor-kappa B Activation but Is Dispensable for c-Jun N-terminal Kinase Signaling.

H. Dadgostar and G. Cheng (1998)
J. Biol. Chem. 273, 24775-24780
 |  Abstract »  |  Full Text »  |  PDF »

Tumor necrosis factor receptor-associated factors (TRAFs)---a family of adapter proteins that regulates life and death.

R. H. Arch, R. W. Gedrich, and C. B. Thompson (1998)
Genes & Dev. 12, 2821-2830
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TNFR80-Dependent Enhancement of TNFR60-Induced Cell Death Is Mediated by TNFR-Associated Factor 2 and Is Specific for TNFR60.

T. Weiss, M. Grell, K. Siemienski, F. Muhlenbeck, H. Durkop, K. Pfizenmaier, P. Scheurich, and H. Wajant (1998)
J. Immunol. 161, 3136-3142
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Tumor Necrosis Factor Signaling to Stress-activated Protein Kinase (SAPK)/Jun NH2-terminal Kinase (JNK) and p38. GERMINAL CENTER KINASE COUPLES TRAF2 TO MITOGEN-ACTIVATED PROTEIN KINASE/ERK KINASE KINASE 1 AND SAPK WHILE RECEPTOR INTERACTING PROTEIN ASSOCIATES WITH A MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE UPSTREAM OF MKK6 AND p38.

T. Yuasa, S. Ohno, J. H. Kehrl, and J. M. Kyriakis (1998)
J. Biol. Chem. 273, 22681-22692
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for Dual Signals by Anti-CD40 and IL-4 for the Induction of Nuclear Factor-{kappa}B, IL-6, and IgE in Human B Lymphocytes.

J. D. Jeppson, H. R. Patel, N. Sakata, J. Domenico, N. Terada, and E. W. Gelfand (1998)
J. Immunol. 161, 1738-1742
 |  Abstract »  |  Full Text »  |  PDF »

TNF Receptor-Associated Factor-3 Signaling Mediates Activation of p38 and Jun N-Terminal Kinase, Cytokine Secretion, and Ig Production Following Ligation of CD40 on Human B Cells.

A. C. Grammer, J. L. Swantek, R. D. McFarland, Y. Miura, T. Geppert, and P. E. Lipsky (1998)
J. Immunol. 161, 1183-1193
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RIP2 Is a Novel NF-kappa B-activating and Cell Death-inducing Kinase.

J. V. McCarthy, J. Ni, and V. M. Dixit (1998)
J. Biol. Chem. 273, 16968-16975
 |  Abstract »  |  Full Text »  |  PDF »

The N-Terminal Domains Target TNF Receptor-Associated Factor-2 to the Nucleus and Display Transcriptional Regulatory Activity.

W. Min, J. R. Bradley, J. J. Galbraith, S. J. Jones, E. C. Ledgerwood, and J. S. Pober (1998)
J. Immunol. 161, 319-324
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Cooperation of Both TNF Receptors in Inducing Apoptosis: Involvement of the TNF Receptor-Associated Factor Binding Domain of the TNF Receptor 75.

W. Declercq, G. Denecker, W. Fiers, and P. Vandenabeele (1998)
J. Immunol. 161, 390-399
 |  Abstract »  |  Full Text »  |  PDF »

CD28-independent, TRAF2-dependent Costimulation of Resting T Cells by 4-1BB Ligand.

K. Saoulli, S. Y. Lee, J. L. Cannons, W. C. Yeh, A. Santana, M. D. Goldstein, N. Bangia, M. A. DeBenedette, T. W. Mak, Y. Choi, et al. (1998)
J. Exp. Med. 187, 1849-1862
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CD27, a Member of the Tumor Necrosis Factor Receptor Superfamily, Activates NF-kappa B and Stress-activated Protein Kinase/c-Jun N-terminal Kinase via TRAF2, TRAF5, and NF-kappa B-inducing Kinase.

H. Akiba, H. Nakano, S. Nishinaka, M. Shindo, T. Kobata, M. Atsuta, C. Morimoto, C. F. Ware, N. L. Malinin, D. Wallach, et al. (1998)
J. Biol. Chem. 273, 13353-13358
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Interaction of Tumor Necrosis Factor Receptor-Associated Factor Signaling Proteins with the Latent Membrane Protein 1 PXQXT Motif Is Essential for Induction of Epidermal Growth Factor Receptor Expression.

W. E. Miller, J. L. Cheshire, and N. Raab-Traub (1998)
Mol. Cell. Biol. 18, 2835-2844
 |  Abstract »  |  Full Text »

Dominant Signals Leading to Inhibitor {kappa}B Protein Degradation Mediate CD40 Ligand Rescue of WEHI 231 Immature B Cells from Receptor-Mediated Apoptosis.

S. L. Schauer, R. E. Bellas, and G. E. Sonenshein (1998)
J. Immunol. 160, 4398-4405
 |  Abstract »  |  Full Text »  |  PDF »

Gene Expression by Single Reed-Sternberg Cells: Pathways of Apoptosis and Activation.

C. Messineo, M. H. Jamerson, E. Hunter, R. Braziel, A. Bagg, S. G. Irving, and J. Cossman (1998)
Blood 91, 2443-2451
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Differential regulation of Ikappa B kinase alpha  and beta  by two upstream kinases, NF-kappa B-inducing kinase and mitogen-activated protein kinase/ERK kinase kinase-1.

H. Nakano, M. Shindo, S. Sakon, S. Nishinaka, M. Mihara, H. Yagita, and K. Okumura (1998)
PNAS 95, 3537-3542
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Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2- and TRAF5-mediated NF-kappa B Activation.

S. Kawamata, T. Hori, A. Imura, A. Takaori-Kondo, and T. Uchiyama (1998)
J. Biol. Chem. 273, 5808-5814
 |  Abstract »  |  Full Text »  |  PDF »

Interaction of an Adenovirus E3 14.7-Kilodalton Protein with a Novel Tumor Necrosis Factor Alpha-Inducible Cellular Protein Containing Leucine Zipper Domains.

Y. Li, J. Kang, and M. S. Horwitz (1998)
Mol. Cell. Biol. 18, 1601-1610
 |  Abstract »  |  Full Text »

Differential Coupling of Membrane Ig and CD40 to the Extracellularly Regulated Kinase Signaling Pathway.

J. M. Purkerson and D. C. Parker (1998)
J. Immunol. 160, 2121-2129
 |  Abstract »  |  Full Text »  |  PDF »

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