Science 24 February 1995: Vol. 267. no. 5201, pp. 1178 - 1183 DOI: 10.1126/science.7855601

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Articles

The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells.

B. L. Ruis, K. R. Fattah, and E. A. Hendrickson (2008)
Mol. Cell. Biol. 28, 6182-6195
 |  Abstract »  |  Full Text »  |  PDF »

Cooperative Effect of the Attenuation Determinants Derived from Poliovirus Sabin 1 Strain Is Essential for Attenuation of Enterovirus 71 in the NOD/SCID Mouse Infection Model.

M. Arita, Y. Ami, T. Wakita, and H. Shimizu (2008)
J. Virol. 82, 1787-1797
 |  Abstract »  |  Full Text »  |  PDF »

Homologous Recombination Is the Principal Pathway for the Repair of DNA Damage Induced by Tirapazamine in Mammalian Cells.

J. W. Evans, S. B. Chernikova, L. A. Kachnic, J. P. Banath, O. Sordet, Y. M. Delahoussaye, A. Treszezamsky, B. H. Chon, Z. Feng, Y. Gu, et al. (2008)
Cancer Res. 68, 257-265
 |  Abstract »  |  Full Text »  |  PDF »

The antipsychotic drug trifluoperazine inhibits DNA repair and sensitizes non small cell lung carcinoma cells to DNA double-strand break induced cell death.

A. G. Polischouk, A. Holgersson, D. Zong, B. Stenerlow, H. L. Karlsson, L. Moller, K. Viktorsson, and R. Lewensohn (2007)
Mol. Cancer Ther. 6, 2303-2309
 |  Abstract »  |  Full Text »  |  PDF »

Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice.

Q. L. K. Lam, C. K. C. Lo, B.-J. Zheng, K.-H. Ko, D. G. Osmond, G. E. Wu, R. Rottapel, and L. Lu (2007)
Int. Immunol. 19, 267-276
 |  Abstract »  |  Full Text »  |  PDF »

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.

T. L Blundell, B. L Sibanda, R. W. Montalvao, S. Brewerton, V. Chelliah, C. L Worth, N. J Harmer, O. Davies, and D. Burke (2006)
Phil Trans R Soc B 361, 413-423
 |  Abstract »  |  Full Text »  |  PDF »

Experimental Models to Study Development and Function of the Human Immune System In Vivo.

N. Legrand, K. Weijer, and H. Spits (2006)
J. Immunol. 176, 2053-2058
 |  Abstract »  |  Full Text »  |  PDF »

Chromosomal Radiosensitivity in Two Cell Lineages Derived from Clinically Radiosensitive Cancer Patients.

C. N. Sprung, M. Chao, T. Leong, and M. J. McKay (2005)
Clin. Cancer Res. 11, 6352-6358
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic H-Ras Up-regulates Expression of Ku80 to Protect Cells from {gamma}-Ray Irradiation in NIH3T3 Cells.

I.-Y. Chang, C.-K. Youn, H.-B. Kim, M.-H. Kim, H.-J. Cho, Y. Yoon, Y.-S. Lee, M.-H. Chung, and H. J. You (2005)
Cancer Res. 65, 6811-6819
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of complex apurinic/apyrimidinic-site clustering associated with an authentic site-specific radiation-induced DNA double-strand break.

K. Datta, R. D. Neumann, and T. A. Winters (2005)
PNAS 102, 10569-10574
 |  Abstract »  |  Full Text »  |  PDF »

DNA-Dependent Protein Kinase Is a Molecular Target for the Development of Noncytotoxic Radiation-Sensitizing Drugs.

E. T. Shinohara, L. Geng, J. Tan, H. Chen, Y. Shir, E. Edwards, J. Halbrook, E. A. Kesicki, A. Kashishian, and D. E. Hallahan (2005)
Cancer Res. 65, 4987-4992
 |  Abstract »  |  Full Text »  |  PDF »

More than just strand breaks: the recognition of structural DNA discontinuities by DNA-dependent protein kinase catalytic subunit.

R. Dip and H. Naegeli (2005)
FASEB J 19, 704-715
 |  Abstract »  |  Full Text »  |  PDF »

Effects of a long-term spaceflight on immunoglobulin heavy chains of the urodele amphibian Pleurodeles waltl.

R. Boxio, C. Dournon, and J.-P. Frippiat (2005)
J Appl Physiol 98, 905-910
 |  Abstract »  |  Full Text »  |  PDF »

Deficiency in the Catalytic Subunit of DNA-Dependent Protein Kinase Causes Down-Regulation of ATM.

Y. Peng, R. G. Woods, H. Beamish, R. Ye, S. P. Lees-Miller, M. F. Lavin, and J. S. Bedford (2005)
Cancer Res. 65, 1670-1677
 |  Abstract »  |  Full Text »  |  PDF »

Evidence that Stable Retroviral Transduction and Cell Survival following DNA Integration Depend on Components of the Nonhomologous End Joining Repair Pathway.

R. Daniel, J. G. Greger, R. A. Katz, K. D. Taganov, X. Wu, J. C. Kappes, and A. M. Skalka (2004)
J. Virol. 78, 8573-8581
 |  Abstract »  |  Full Text »  |  PDF »

Cell-interdependent cisplatin killing by Ku/DNA-dependent protein kinase signaling transduced through gap junctions.

R. Jensen and P. M. Glazer (2004)
PNAS 101, 6134-6139
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Pathology of Severe Combined Immunodeficiency in Mice, Horses, and Dogs.

L. E. Perryman (2004)
Vet. Pathol. 41, 95-100
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the Phosphatidylinositol 3-Kinase/Akt Pathway for Enhancing Breast Cancer Cells to Radiotherapy.

K. Liang, W. Jin, C. Knuefermann, M. Schmidt, G. B. Mills, K. K. Ang, L. Milas, and Z. Fan (2003)
Mol. Cancer Ther. 2, 353-360
 |  Abstract »  |  Full Text »  |  PDF »

Threonines 2638/2647 in DNA-PK Are Essential for Cellular Resistance to Ionizing Radiation.

S. Soubeyrand, L. Pope, B. Pakuts, and R. J. G. Hache (2003)
Cancer Res. 63, 1198-1201
 |  Abstract »  |  Full Text »  |  PDF »

Low Activation Threshold As a Mechanism for Ligand-Independent Signaling in Pre-T Cells.

M. C. Haks, S. M. Belkowski, M. Ciofani, M. Rhodes, J. M. Lefebvre, S. Trop, P. Hugo, J. C. Zuniga-Pflucker, and D. L. Wiest (2003)
J. Immunol. 170, 2853-2861
 |  Abstract »  |  Full Text »  |  PDF »

Nonhomologous end joining and V(D)J recombination require an additional factor.

Y. Dai, B. Kysela, L. A. Hanakahi, K. Manolis, E. Riballo, M. Stumm, T. O. Harville, S. C. West, M. A. Oettinger, and P. A. Jeggo (2003)
PNAS 100, 2462-2467
 |  Abstract »  |  Full Text »  |  PDF »

Function of DNA-Protein Kinase Catalytic Subunit During the Early Meiotic Prophase Without Ku70 and Ku86.

G. Hamer, H. L. Roepers-Gajadien, A. van Duyn-Goedhart, I. S. Gademan, H. B. Kal, P. P.W. van Buul, T. Ashley, and D. G. de Rooij (2003)
Biol Reprod 68, 717-721
 |  Abstract »  |  Full Text »  |  PDF »

DNA-dependent Protein Kinase Activity Is Not Required for Immunoglobulin Class Switching.

G. C. Bosma, J. Kim, T. Urich, D. M. Fath, M. G. Cotticelli, N. R. Ruetsch, M. Z. Radic, and M. J. Bosma (2002)
J. Exp. Med. 196, 1483-1495
 |  Abstract »  |  Full Text »  |  PDF »

A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2.

T. Woods, W. Wang, E. Convery, A. Errami, M. Z. Zdzienicka, and K. Meek (2002)
Nucleic Acids Res. 30, 5120-5128
 |  Abstract »  |  Full Text »  |  PDF »

A Targeted Inhibition of DNA-Dependent Protein Kinase Sensitizes Breast Cancer Cells Following Ionizing Radiation.

C.-H. Kim, S.-J. Park, and S.-H. Lee (2002)
J. Pharmacol. Exp. Ther. 303, 753-759
 |  Abstract »  |  Full Text »  |  PDF »

Variable Diversity Joining Recombination: Nonhairpin Coding Ends in Thymocytes of SCID and Wild-Type Mice.

P. B. Nakajima and M. J. Bosma (2002)
J. Immunol. 169, 3094-3104
 |  Abstract »  |  Full Text »  |  PDF »

Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.

J. Huang and W. S. Dynan (2002)
Nucleic Acids Res. 30, 667-674
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative trait loci regulating relative lymphocyte proportions in mouse peripheral blood.

J. Chen and D. E. Harrison (2002)
Blood 99, 561-566
 |  Abstract »  |  Full Text »  |  PDF »

Replication protein A is sequentially phosphorylated during meiosis.

G. S. Brush, D. M. Clifford, S. M. Marinco, and A. J. Bartrand (2001)
Nucleic Acids Res. 29, 4808-4817
 |  Abstract »  |  Full Text »  |  PDF »

Restriction enzymes increase efficiencies of illegitimate DNA integration but decrease homologous integration in mammalian cells.

P. Manivasakam, J. Aubrecht, S. Sidhom, and R. H. Schiestl (2001)
Nucleic Acids Res. 29, 4826-4833
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Retrovirus-Host DNA Junctions in Cells Deficient in Nonhomologous-End Joining.

K. Taganov, R. Daniel, R. A. Katz, O. Favorova, and A. M. Skalka (2001)
J. Virol. 75, 9549-9552
 |  Abstract »  |  Full Text »  |  PDF »

scid Thymocytes with TCR{beta} Gene Rearrangements Are Targets for the Oncogenic Effect of SCL and LMO1 Transgenes.

D. S. Chervinsky, D. H. Lam, M. P. Melman, K. W. Gross, and P. D. Aplan (2001)
Cancer Res. 61, 6382-6387
 |  Abstract »  |  Full Text »  |  PDF »

The Absence of the DNA-Dependent Protein Kinase Catalytic Subunit in Mice Results in Anaphase Bridges and in Increased Telomeric Fusions with Normal Telomere Length and G-Strand Overhang.

F. A. Goytisolo, E. Samper, S. Edmonson, G. E. Taccioli, and M. A. Blasco (2001)
Mol. Cell. Biol. 21, 3642-3651
 |  Abstract »  |  Full Text »  |  PDF »

Humoral Hypercalcemia of Malignancy : Severe Combined Immunodeficient/Beige Mouse Model of Adult T-Cell Lymphoma Independent of Human T-Cell Lymphotropic Virus Type-1 Tax Expression.

V. Richard, M. D. Lairmore, P. L. Green, G. Feuer, R. S. Erbe, B. Albrecht, C. D'Souza, E. T. Keller, J. Dai, and T. J. Rosol (2001)
Am. J. Pathol. 158, 2219-2228
 |  Abstract »  |  Full Text »  |  PDF »

Radiation-induced Genomic Rearrangements Formed by Nonhomologous End-Joining of DNA Double-Strand Breaks.

K. Rothkamm, M. Kühne, P. A. Jeggo, and M. Löbrich (2001)
Cancer Res. 61, 3886-3893
 |  Abstract »  |  Full Text »

The RAG proteins in V(D)J recombination: more than just a nuclease.

M. J. Sadofsky (2001)
Nucleic Acids Res. 29, 1399-1409
 |  Abstract »  |  Full Text »  |  PDF »

Xenotransplantation of immunodeficient mice with mobilized human blood CD34+ cells provides an in vivo model for human megakaryocytopoiesis and platelet production.

L. E. Perez, H. M. Rinder, C. Wang, J. B. Tracey, N. Maun, and D. S. Krause (2001)
Blood 97, 1635-1643
 |  Abstract »  |  Full Text »  |  PDF »

Severe Combined Immunodeficient Cells Expressing Mutant hRAD54 Exhibit a Marked DNA Double-Strand Break Repair and Error-prone Chromosome Repair Defect.

J. M. Pluth, L. M. Fried, and C. U. Kirchgessner (2001)
Cancer Res. 61, 2649-2655
 |  Abstract »  |  Full Text »

DNA-Dependent Protein Kinase Is Not Required for Efficient Lentivirus Integration.

V. Baekelandt, A. Claeys, P. Cherepanov, E. De Clercq, B. De Strooper, B. Nuttin, and Z. Debyser (2000)
J. Virol. 74, 11278-11285
 |  Abstract »  |  Full Text »  |  PDF »

Identification of a novel pre-TCR isoform in which the accessibility of the TCR{beta} subunit is determined by occupancy of the `missing' V domain of pre-T{alpha}.

M. A. Berger, M. Carleton, M. Rhodes, J. M. Sauder, S. Trop, R. L. Dunbrack, P. Hugo, and D. L. Wiest (2000)
Int. Immunol. 12, 1579-1591
 |  Abstract »  |  Full Text »  |  PDF »

Both V(D)J recombination and radioresistance require DNA-PK kinase activity, though minimal levels suffice for V(D)J recombination.

L. J. Kienker, E. K. Shin, and K. Meek (2000)
Nucleic Acids Res. 28, 2752-2761
 |  Abstract »  |  Full Text »  |  PDF »

Unexpected Rearrangement and Expression of the Immunoglobulin {lambda}1 Locus in Scid Mice.

N. R. Ruetsch, G. C. Bosma, and M. J. Bosma (2000)
J. Exp. Med. 191, 1933-1944
 |  Abstract »  |  Full Text »  |  PDF »

The DNA-bending protein, HMG1, is required for correct cleavage of 23 bp recombination signal sequences by recombination activating gene proteins in vitro.

T. Yoshida, A. Tsuboi, K.-i. Ishiguro, F. Nagawa, and H. Sakano (2000)
Int. Immunol. 12, 721-729
 |  Abstract »  |  Full Text »  |  PDF »

The C-terminal conserved domain of DNA-PKcs, missing in the SCID mouse, is required for kinase activity.

H. J. Beamish, R. Jessberger, E. Riballo, A. Priestley, T. Blunt, B. Kysela, and P. A. Jeggo (2000)
Nucleic Acids Res. 28, 1506-1513
 |  Abstract »  |  Full Text »  |  PDF »

The catalytic subunit DNA-dependent protein kinase (DNA-PKcs) facilitates recovery from radiation-induced inhibition of DNA replication.

J. Guan, S. DiBiase, and G. Iliakis (2000)
Nucleic Acids Res. 28, 1183-1192
 |  Abstract »  |  Full Text »  |  PDF »

NOD/LtSz-Rag1null Mice: An Immunodeficient and Radioresistant Model for Engraftment of Human Hematolymphoid Cells, HIV Infection, and Adoptive Transfer of NOD Mouse Diabetogenic T Cells.

L. D. Shultz, P. A. Lang, S. W. Christianson, B. Gott, B. Lyons, S. Umeda, E. Leiter, R. Hesselton, E. J. Wagar, J. H. Leif, et al. (2000)
J. Immunol. 164, 2496-2507
 |  Abstract »  |  Full Text »  |  PDF »

Ionizing Radiation Exposure Results in Up-regulation of Ku70 via a p53/Ataxia-Telangiectasia-mutated Protein-dependent Mechanism.

K. D. Brown, T. A. Lataxes, S. Shangary, J. L. Mannino, J. F. Giardina, J. Chen, and R. Baskaran (2000)
J. Biol. Chem. 275, 6651-6656
 |  Abstract »  |  Full Text »  |  PDF »

Activation of p70 Ribosomal Protein S6 Kinase Is an Essential Step in the DNA Damage-dependent Signaling Pathway Responsible for the Ultraviolet B-mediated Increase in Interstitial Collagenase (MMP-1) and Stromelysin-1 (MMP-3) Protein Levels in Human Dermal Fibroblasts.

P. Brenneisen, J. Wenk, M. Wlaschek, T. Krieg, and K. Scharffetter-Kochanek (2000)
J. Biol. Chem. 275, 4336-4344
 |  Abstract »  |  Full Text »  |  PDF »

Coordinate modulation of Sp1, NF-kappa B, and p53 in confluent human malignant melanoma cells after ionizing radiation.

C.-R. YANG, C. WILSON-VAN PATTEN, S. M. PLANCHON, S. M. WUERZBERGER-DAVIS, T. W. DAVIS, S. CUTHILL, S. MIYAMOTO, and D. A. BOOTHMAN (2000)
FASEB J 14, 379-390
 |  Abstract »  |  Full Text »

Analyses of TCRB Rearrangements Substantiate a Profound Deficit in Recombination Signal Sequence Joining in SCID Foals: Implications for the Role of DNA-Dependent Protein Kinase in V(D)J Recombination.

E. K. Shin, T. Rijkers, A. Pastink, and K. Meek (2000)
J. Immunol. 164, 1416-1424
 |  Abstract »  |  Full Text »  |  PDF »

Re-Evaluating Gadolinium(III) Texaphyrin as a Radiosensitizing Agent.

E. J. Bernhard, J. B. Mitchell, D. Deen, M. Cardell, D. I. Rosenthal, and J. M. Brown (2000)
Cancer Res. 60, 86-91
 |  Abstract »  |  Full Text »

Regulated Genomic Instability and Neoplasia in the Lymphoid Lineage.

G. J. Vanasse, P. Concannon, and D. M. Willerford (1999)
Blood 94, 3997-4010
 |  Full Text »  |  PDF »

Gamma-Irradiation Directly Affects the Formation of Coding Joints in SCID Cell Lines.

A. Binnie, S. Olson, G. E. Wu, and S. M. Lewis (1999)
J. Immunol. 163, 5418-5426
 |  Abstract »  |  Full Text »  |  PDF »

Antifungal Activities of Antineoplastic Agents: Saccharomyces cerevisiae as a Model System To Study Drug Action.

M. E. Cardenas, M. C. Cruz, M. Del Poeta, N. Chung, J. R. Perfect, and J. Heitman (1999)
Clin. Microbiol. Rev. 12, 583-611
 |  Abstract »  |  Full Text »  |  PDF »

Murine Splenocytes Induce Severe Gastritis and Delayed-Type Hypersensitivity and Suppress Bacterial Colonization in Helicobacter pylori-Infected SCID Mice.

K. A. Eaton, S. R. Ringler, and S. J. Danon (1999)
Infect. Immun. 67, 4594-4602
 |  Abstract »  |  Full Text »  |  PDF »

Coordinate Regulation of RAG1 and RAG2 by Cell Type-Specific DNA Elements 5' of RAG2.

W. Yu, Z. Misulovin, H. Suh, R. R. Hardy, M. Jankovic, N. Yannoutsos, and M. C. Nussenzweig (1999)
Science 285, 1080-1084
 |  Abstract »  |  Full Text »

Roles of Replication Protein A and DNA-dependent Protein Kinase in the Regulation of DNA Replication following DNA Damage.

Y. Wang, X.-Y. Zhou, H. Wang, M. S. Huq, and G. Iliakis (1999)
J. Biol. Chem. 274, 22060-22064
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Terminal Deoxynucleotidyltransferase Activity by the DNA-Dependent Protein Kinase.

S. Mickelsen, C. Snyder, K. Trujillo, M. Bogue, D. B. Roth, and K. Meek (1999)
J. Immunol. 163, 834-843
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation.

G. Luo, M. S. Yao, C. F. Bender, M. Mills, A. R. Bladl, A. Bradley, and J. H. J. Petrini (1999)
PNAS 96, 7376-7381
 |  Abstract »  |  Full Text »  |  PDF »

Novel Endogenous Type D Retroviral Particles Expressed at High Levels in a SCID Mouse Thymic Lymphoma.

S. Ristevski, D. F. J. Purcell, J. Marshall, D. Campagna, S. Nouri, S. P. Fenton, D. A. McPhee, and G. Kannourakis (1999)
J. Virol. 73, 4662-4669
 |  Abstract »  |  Full Text »  |  PDF »

Ku Antigen-DNA Conformation Determines the Activation of DNA-Dependent Protein Kinase and DNA Sequence-Directed Repression of Mouse Mammary Tumor Virus Transcription.

W. Giffin, W. Gong, C. Schild-Poulter, and R. J. G. Hache (1999)
Mol. Cell. Biol. 19, 4065-4078
 |  Abstract »  |  Full Text »  |  PDF »

The Ability of p53 to Activate Downstream Genes p21WAF1/cip1 and MDM2, and Cell Cycle Arrest following DNA Damage Is Delayed and Attenuated in scid Cells Deficient in the DNA-dependent Protein Kinase.

L. A. Kachnic, B. Wu, H. Wunsch, K. L. Mekeel, J. S. DeFrank, W. Tang, and S. N. Powell (1999)
J. Biol. Chem. 274, 13111-13117
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for the Kinase Activity of Human DNA-Dependent Protein Kinase Catalytic Subunit in DNA Strand Break Rejoining.

A. Kurimasa, S. Kumano, N. V. Boubnov, M. D. Story, C.-S. Tung, S. R. Peterson, and D. J. Chen (1999)
Mol. Cell. Biol. 19, 3877-3884
 |  Abstract »  |  Full Text »  |  PDF »

A Role for DNA-PK in Retroviral DNA Integration.

R. Daniel, R. A. Katz, and A. M. Skalka (1999)
Science 284, 644-647
 |  Abstract »  |  Full Text »

The DNA-dependent protein kinase.

G. C.M. Smith and S. P. Jackson (1999)
Genes & Dev. 13, 916-934
 |  Full Text »

Ku-Dependent Nonhomologous DNA End Joining in Xenopus Egg Extracts.

P. Labhart (1999)
Mol. Cell. Biol. 19, 2585-2593
 |  Abstract »  |  Full Text »  |  PDF »

OBA/Ku86: DNA Binding Specificity and Involvement in Mammalian DNA Replication.

M. T. Ruiz, D. Matheos, G. B. Price, and M. Zannis-Hadjopoulos (1999)
Mol. Biol. Cell 10, 567-580
 |  Abstract »  |  Full Text »

Catalytic subunit of DNA-dependent protein kinase: Impact on lymphocyte development and tumorigenesis.

A. Kurimasa, H. Ouyang, L.-j. Dong, S. Wang, X. Li, C. Cordon-Cardo, D. J. Chen, and G. C. Li (1999)
PNAS 96, 1403-1408
 |  Abstract »  |  Full Text »  |  PDF »

A Role for RAD51 in the Generation of Immunoglobulin Gene Diversity in Rabbits.

R. A. Barrington, M. Fasullo, and K. L. Knight (1999)
J. Immunol. 162, 911-919
 |  Abstract »  |  Full Text »  |  PDF »

Formation of coding joints in V(D)J recombination-inducible severe combined immune deficient pre-B cell lines.

Y. Chang and M. L. Brown (1999)
PNAS 96, 191-196
 |  Abstract »  |  Full Text »  |  PDF »

The Nuclease Activity of Mre11 Is Required for Meiosis but Not for Mating Type Switching, End Joining, or Telomere Maintenance.

S. Moreau, J. R. Ferguson, and L. S. Symington (1999)
Mol. Cell. Biol. 19, 556-566
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Extracts Lacking DNA-dependent Protein Kinase Are Deficient in Multiple Round Transcription.

R. L. Woodard, M. G. Anderson, and W. S. Dynan (1999)
J. Biol. Chem. 274, 478-485
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of variable (diversity) joining recombination in DNAdependent protein kinase (DNA-PK)-deficient mice reveals DNA-PK-independent pathways for both signal and coding joint formation.

M. A. Bogue, C. Jhappan, and D. B. Roth (1998)
PNAS 95, 15559-15564
 |  Abstract »  |  Full Text »  |  PDF »

Inactivation of DNA-Dependent Protein Kinase by Protein Kinase Cdelta : Implications for Apoptosis.

A. Bharti, S.-K. Kraeft, M. Gounder, P. Pandey, S. Jin, Z.-M. Yuan, S. P. Lees-Miller, R. Weichselbaum, D. Weaver, L. B. Chen, et al. (1998)
Mol. Cell. Biol. 18, 6719-6728
 |  Abstract »  |  Full Text »  |  PDF »

Failure of Hairpin-Ended and Nicked DNA To Activate DNA-Dependent Protein Kinase: Implications for V(D)J Recombination.

V. Smider, W. K. Rathmell, G. Brown, S. Lewis, and G. Chu (1998)
Mol. Cell. Biol. 18, 6853-6858
 |  Abstract »  |  Full Text »  |  PDF »

Productive and Nonproductive Complexes of Ku and DNA-Dependent Protein Kinase at DNA Termini.

R. B. West, M. Yaneva, and M. R. Lieber (1998)
Mol. Cell. Biol. 18, 5908-5920
 |  Abstract »  |  Full Text »  |  PDF »

Requirement for an Interaction of XRCC4 with DNA Ligase IV for Wild-type V(D)J Recombination and DNA Double-strand Break Repair in Vivo.

U. Grawunder, D. Zimmer, P. Kulesza, and M. R. Lieber (1998)
J. Biol. Chem. 273, 24708-24714
 |  Abstract »  |  Full Text »  |  PDF »

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo.

D. K. Bishop, U. Ear, A. Bhattacharyya, C. Calderone, M. Beckett, R. R. Weichselbaum, and A. Shinohara (1998)
J. Biol. Chem. 273, 21482-21488
 |  Abstract »  |  Full Text »  |  PDF »

A Human Severe Combined Immunodeficiency (SCID) Condition with Increased Sensitivity to Ionizing Radiations and Impaired V(D)J Rearrangements Defines a New DNA Recombination/Repair Deficiency.

N. Nicolas, D. Moshous, M. Cavazzana-Calvo, D. Papadopoulo, R. de Chasseval, F. Le Deist, A. Fischer, and J.-P. de Villartay (1998)
J. Exp. Med. 188, 627-634
 |  Abstract »  |  Full Text »  |  PDF »

Sequence-specific Binding of Ku Autoantigen to Single-stranded DNA.

H. Torrance, W. Giffin, D. J. Rodda, L. Pope, and R. J. G. Hache (1998)
J. Biol. Chem. 273, 20810-20819
 |  Abstract »  |  Full Text »  |  PDF »

Molecular analyses of adaptive survival responses (ASRs): role of ASRs in radiotherapy.

D. A Boothman, E. Odegaard, C.-R. Yang, K. Hosley, and M. S Mendonca (1998)
Human and Experimental Toxicology 17, 448-453
 |  Abstract »  |  PDF »

DNA-Dependent Protein Kinase Phosphorylation of Ikappa Balpha and Ikappa Bbeta Regulates NF-kappa B DNA Binding Properties.

L. Liu, Y.-T. Kwak, F. Bex, L. F. Garcia-Martinez, X.-H. Li, K. Meek, W. S. Lane, and R. B. Gaynor (1998)
Mol. Cell. Biol. 18, 4221-4234
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase.

T. Ruscetti, B. E. Lehnert, J. Halbrook, H. Le Trong, M. F. Hoekstra, D. J. Chen, and S. R. Peterson (1998)
J. Biol. Chem. 273, 14461-14467
 |  Abstract »  |  Full Text »  |  PDF »

Functional Analysis of Human Replication Protein A in Nucleotide Excision Repair.

E. Stigger, R. Drissi, and S.-H. Lee (1998)
J. Biol. Chem. 273, 9337-9343
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Sp1 Phosphorylation by Human Immunodeficiency Virus Type 1 Tat.

R. F. Chun, O. J. Semmes, C. Neuveut, and K.-T. Jeang (1998)
J. Virol. 72, 2615-2629
 |  Abstract »  |  Full Text »  |  PDF »

Structure of Nonhairpin Coding-End DNA Breaks in Cells Undergoing V(D)J Recombination.

M. S. Schlissel (1998)
Mol. Cell. Biol. 18, 2029-2037
 |  Abstract »  |  Full Text »  |  PDF »

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139.

E. P. Rogakou, D. R. Pilch, A. H. Orr, V. S. Ivanova, and W. M. Bonner (1998)
J. Biol. Chem. 273, 5858-5868
 |  Abstract »  |  Full Text »  |  PDF »

Radiation-Induced Chromosome Aberrations in Saccharomyces cerevisiae : Influence of DNA Repair Pathways.

A. A. Friedl, M. Kiechle, B. Fellerhoff, and F. Eckardt-Schupp (1998)
Genetics 148, 975-988
 |  Abstract »  |  Full Text »  |  PDF »

Lectin Histochemistry Reveals the Appearance of M-cells in Peyer's Patches of SCID Mice After Syngeneic Normal Bone Marrow Transplantation.

R. Sharma, U. Schumacher, and E. Adam (1998)
J. Histochem. Cytochem. 46, 143-148
 |  Abstract »  |  Full Text »

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku.

O. Hammarsten and G. Chu (1998)
PNAS 95, 525-530
 |  Abstract »  |  Full Text »  |  PDF »

The XRCC4 Gene Product Is a Target for and Interacts with the DNA-dependent Protein Kinase.

R. Leber, T. W. Wise, R. Mizuta, and K. Meek (1998)
J. Biol. Chem. 273, 1794-1801
 |  Abstract »  |  Full Text »  |  PDF »

Footprint Analysis of the RAG Protein Recombination Signal Sequence Complex for V(D)J Type Recombination.

F. Nagawa, K.-i. Ishiguro, A. Tsuboi, T. Yoshida, A. Ishikawa, T. Takemori, A. J. Otsuka, and H. Sakano (1998)
Mol. Cell. Biol. 18, 655-663
 |  Abstract »  |  Full Text »  |  PDF »

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development.

A. Nussenzweig, K. Sokol, P. Burgman, L. Li, and G. C. Li (1997)
PNAS 94, 13588-13593
 |  Abstract »  |  Full Text »  |  PDF »

Minisatellite instability in severe combined immunodeficiency mouse cells.

H. Imai, H. Nakagama, K. Komatsu, T. Shiraishi, H. Fukuda, T. Sugimura, and M. Nagao (1997)
PNAS 94, 10817-10820
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Double Strand Break Repair.

G. Chu (1997)
J. Biol. Chem. 272, 24097-24100
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Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo.

H. Ouyang, A. Nussenzweig, A. Kurimasa, V. d. C. Soares, X. Li, C. Cordon-Cardo, W.-h. Li, N. Cheong, M. Nussenzweig, G. Iliakis, et al. (1997)
J. Exp. Med. 186, 921-929
 |  Abstract »  |  Full Text »  |  PDF »

SV40 Large Tumor Antigen Nuclear Import Is Regulated by the Double-stranded DNA-dependent Protein Kinase Site (Serine 120) Flanking the Nuclear Localization Sequence.

C.-Y. Xiao, S. Hubner, and D. A. Jans (1997)
J. Biol. Chem. 272, 22191-22198
 |  Abstract »  |  Full Text »  |  PDF »

The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.

N. Liu, J. E. Lamerdin, J. D. Tucker, Z.-Q. Zhou, C. A. Walter, J. S. Albala, D. B. Busch, and L. H. Thompson (1997)
PNAS 94, 9232-9237
 |  Abstract »  |  Full Text »  |  PDF »

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