Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 10 February 1995:
Vol. 267. no. 5199, pp. 894 - 897
DOI: 10.1126/science.7846532
Prev | Table of Contents | Next

Articles

Science, Vol 267, Issue 5199, 894-897
Copyright © 1995 by American Association for the Advancement of Science

articles

Casein kinase II alpha transgene-induced murine lymphoma: relation to theileriosis in cattle

DC Seldin and P Leder

Department of Genetics, Harvard Medical School, Howard Hughes Medical Institute, Boston, MA 02115.

Infection of cattle with the protozoan parasite Theileria parva results in a fatal lymphoproliferative syndrome that is associated with the overexpression of casein kinase II. The role of this enzyme in the pathogenesis of lymphoproliferative disorders was investigated by expressing the catalytic subunit in lymphocytes of transgenic mice. Adult transgenic mice displayed a stochastic propensity to develop lymphoma; co-expression of a c-myc transgene in addition to casein kinase II resulted in neonatal leukemia. Thus, the casein kinase II gene can serve as an oncogene, and its dysregulated expression is capable of transforming lymphocytes in a two-step pathway with c-myc.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
CK2{beta} Is Expressed in Endometrial Carcinoma and Has a Role in Apoptosis Resistance and Cell Proliferation.
J. Pallares, D. Llobet, M. Santacana, N. Eritja, A. Velasco, D. Cuevas, S. Lopez, V. Palomar-Asenjo, A. Yeramian, X. Dolcet, et al. (2009)
Am. J. Pathol. 174, 287-296
   Abstract »    Full Text »    PDF »
Recruitment of Ikaros to Pericentromeric Heterochromatin Is Regulated by Phosphorylation.
Z. Gurel, T. Ronni, S. Ho, J. Kuchar, K. J. Payne, C. W. Turk, and S. Dovat (2008)
J. Biol. Chem. 283, 8291-8300
   Abstract »    Full Text »    PDF »
The Alpha Catalytic Subunit of Protein Kinase CK2 Is Required for Mouse Embryonic Development.
D. Y. Lou, I. Dominguez, P. Toselli, E. Landesman-Bollag, C. O'Brien, and D. C. Seldin (2008)
Mol. Cell. Biol. 28, 131-139
   Abstract »    Full Text »    PDF »
Phosphorylation of StarD10 on Serine 284 by Casein Kinase II Modulates Its Lipid Transfer Activity.
M. A. Olayioye, M. Buchholz, S. Schmid, P. Schoffler, P. Hoffmann, and T. Pomorski (2007)
J. Biol. Chem. 282, 22492-22498
   Abstract »    Full Text »    PDF »
Protein Kinase CK2 Is Inhibited by Human Nucleolar Phosphoprotein p140 in an Inositol Hexakisphosphate-dependent Manner.
Y.-K. Kim, K. J. Lee, H. Jeon, and Y. G. Yu (2006)
J. Biol. Chem. 281, 36752-36757
   Abstract »    Full Text »    PDF »
Nuclear Export of S6K1 II Is Regulated by Protein Kinase CK2 Phosphorylation at Ser-17.
G. Panasyuk, I. Nemazanyy, A. Zhyvoloup, M. Bretner, D. W. Litchfield, V. Filonenko, and I. T. Gout (2006)
J. Biol. Chem. 281, 31188-31201
   Abstract »    Full Text »    PDF »
Casein kinase 2 (CK2) increases survivin expression via enhanced beta-catenin-T cell factor/lymphoid enhancer binding factor-dependent transcription.
J. C. Tapia, V. A. Torres, D. A. Rodriguez, L. Leyton, and A. F. G. Quest (2006)
PNAS 103, 15079-15084
   Abstract »    Full Text »    PDF »
The Pleckstrin Homology Domain-Containing Protein CKIP-1 Is Involved in Regulation of Cell Morphology and the Actin Cytoskeleton and Interaction with Actin Capping Protein.
D. A. Canton, M. E. K. Olsten, K. Kim, A. Doherty-Kirby, G. Lajoie, J. A. Cooper, and D. W. Litchfield (2005)
Mol. Cell. Biol. 25, 3519-3534
   Abstract »    Full Text »    PDF »
Inhibition of Human Papillomavirus Type 16 E7 Phosphorylation by the S100 MRP-8/14 Protein Complex.
S. Tugizov, J. Berline, R. Herrera, M. E. Penaranda, M. Nakagawa, and J. Palefsky (2005)
J. Virol. 79, 1099-1112
   Abstract »    Full Text »    PDF »
The Pleckstrin Homology Domain of CK2 Interacting Protein-1 Is Required for Interactions and Recruitment of Protein Kinase CK2 to the Plasma Membrane.
M. E. K. Olsten, D. A. Canton, C. Zhang, P. A. Walton, and D. W. Litchfield (2004)
J. Biol. Chem. 279, 42114-42127
   Abstract »    Full Text »    PDF »
Biochemical and Functional Characterization of Protein Kinase CK2 in Ascidian Ciona intestinalis Oocytes at Fertilization: CLONING AND SEQUENCE ANALYSIS OF cDNA FOR {alpha} AND {beta} SUBUNITS.
G. L. Russo, M. Tosto, A. Mupo, I. Castellano, A. Cuomo, and E. Tosti (2004)
J. Biol. Chem. 279, 33012-33023
   Abstract »    Full Text »    PDF »
CK2 Controls Multiple Protein Kinases by Phosphorylating a Kinase-Targeting Molecular Chaperone, Cdc37.
Y. Miyata and E. Nishida (2004)
Mol. Cell. Biol. 24, 4065-4074
   Abstract »    Full Text »    PDF »
Phosphorylation Controls Ikaros's Ability To Negatively Regulate the G1-S Transition.
P. G.-d. Arco, K. Maki, and K. Georgopoulos (2004)
Mol. Cell. Biol. 24, 2797-2807
   Abstract »    Full Text »    PDF »
Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.
J. R. Carlyle, A. M. Jamieson, S. Gasser, C. S. Clingan, H. Arase, and D. H. Raulet (2004)
PNAS 101, 3527-3532
   Abstract »    Full Text »    PDF »
E{micro}-BRD2 transgenic mice develop B-cell lymphoma and leukemia.
R. J. Greenwald, J. R. Tumang, A. Sinha, N. Currier, R. D. Cardiff, T. L. Rothstein, D. V. Faller, and G. V. Denis (2004)
Blood 103, 1475-1484
   Abstract »    Full Text »    PDF »
Antigen- and/or immune-driven lymphoproliferative disorders.
M. D. Aljurf, T. W. Owaidah, A. Ezzat, E. Ibrahim, and A. Tbakhi (2003)
Ann. Onc. 14, 1595-1606
   Full Text »    PDF »
Phosphorylation of Threonine 10 on CKBBP1/SAG/ROC2/Rbx2 by Protein Kinase CKII Promotes the Degradation of I{kappa}B{alpha} and p27Kip1.
Y.-S. Kim, J.-Y. Lee, M.-Y. Son, W. Park, and Y.-S. Bae (2003)
J. Biol. Chem. 278, 28462-28469
   Abstract »    Full Text »    PDF »
Genome-wide expression screens indicate a global role for protein kinase CK2 in chromatin remodeling.
T. Barz, K. Ackermann, G. Dubois, R. Eils, and W. Pyerin (2003)
J. Cell Sci. 116, 1563-1577
   Abstract »    Full Text »    PDF »
Protein kinase CKII regulates the interaction of {beta}-catenin with {alpha}-catenin and its protein stability.
S. Bek and R. Kemler (2003)
J. Cell Sci. 115, 4743-4753
   Abstract »    Full Text »    PDF »
A Positive Feedback Loop between Protein Kinase CKII and Cdc37 Promotes the Activity of Multiple Protein Kinases.
S. Bandhakavi, R. O. McCann, D. E. Hanna, and C. V. C. Glover (2003)
J. Biol. Chem. 278, 2829-2836
   Abstract »    Full Text »    PDF »
Inhibition of Protein Kinase CK2 by Anthraquinone-related Compounds. A STRUCTURAL INSIGHT.
E. De Moliner, S. Moro, S. Sarno, G. Zagotto, G. Zanotti, L. A. Pinna, and R. Battistutta (2003)
J. Biol. Chem. 278, 1831-1836
   Abstract »    Full Text »    PDF »
Protein Kinase CK2 Promotes Aberrant Activation of Nuclear Factor-{kappa}B, Transformed Phenotype, and Survival of Breast Cancer Cells.
R. Romieu-Mourez, E. Landesman-Bollag, D. C. Seldin, and G. E. Sonenshein (2002)
Cancer Res. 62, 6770-6778
   Abstract »    Full Text »    PDF »
Protein kinase CK2: a challenge to canons.
L. A. Pinna (2002)
J. Cell Sci. 115, 3873-3878
   Abstract »    Full Text »    PDF »
Sensitization of Tumor Cells to Apo2 Ligand/TRAIL-induced Apoptosis by Inhibition of Casein Kinase II.
R. Ravi and A. Bedi (2002)
Cancer Res. 62, 4180-4185
   Abstract »    Full Text »    PDF »
Translated Alu sequence determines nuclear localization of a novel catalytic subunit of casein kinase 2.
P. Hilgard, T. Huang, A. W. Wolkoff, and R. J. Stockert (2002)
Am J Physiol Cell Physiol 283, C472-C483
   Abstract »    Full Text »    PDF »
Unique Activation Mechanism of Protein Kinase CK2. THE N-TERMINAL SEGMENT IS ESSENTIAL FOR CONSTITUTIVE ACTIVITY OF THE CATALYTIC SUBUNIT BUT NOT OF THE HOLOENZYME.
S. Sarno, P. Ghisellini, and L. A. Pinna (2002)
J. Biol. Chem. 277, 22509-22514
   Abstract »    Full Text »    PDF »
Interactions between Protein Kinase CK2 and Pin1. EVIDENCE FOR PHOSPHORYLATION-DEPENDENT INTERACTIONS.
M. M. Messenger, R. B. Saulnier, A. D. Gilchrist, P. Diamond, G. J. Gorbsky, and D. W. Litchfield (2002)
J. Biol. Chem. 277, 23054-23064
   Abstract »    Full Text »    PDF »
CK2 Forms a Stable Complex with TFIIIB and Activates RNA Polymerase III Transcription in Human Cells.
I. M. Johnston, S. J. Allison, J. P. Morton, L. Schramm, P. H. Scott, and R. J. White (2002)
Mol. Cell. Biol. 22, 3757-3768
   Abstract »    Full Text »    PDF »
Phosphorylation by the Protein Kinase CK2 Promotes Calpain-Mediated Degradation of I{kappa}B{alpha}.
J. Shen, P. Channavajhala, D. C. Seldin, and G. E. Sonenshein (2001)
J. Immunol. 167, 4919-4925
   Abstract »    Full Text »    PDF »
Roles of IKK Kinases and Protein Kinase CK2 in Activation of Nuclear Factor-{{kappa}}B in Breast Cancer.
R. Romieu-Mourez, E. Landesman-Bollag, D. C. Seldin, A. M. Traish, F. Mercurio, and G. E. Sonenshein (2001)
Cancer Res. 61, 3810-3818
   Abstract »    Full Text »
Wnt signaling and cancer.
P. Polakis (2000)
Genes & Dev. 14, 1837-1851
   Full Text »
Mutation of recombinant catalytic subunit {alpha} of the protein kinase CK2 that affects catalytic efficiency and specificity.
D. Chaillot, N. Declerck, K. Niefind, D. Schomburg, T. Chardot, and J.C. Meunier (2000)
Protein Eng. Des. Sel. 13, 291-298
   Abstract »    Full Text »    PDF »
The Regulatory beta Subunit of Protein Kinase CK2 Mediates Formation of Tetrameric CK2 Complexes.
K. C. Graham and D. W. Litchfield (2000)
J. Biol. Chem. 275, 5003-5010
   Abstract »    Full Text »    PDF »
Negative Regulation of CD4 Lineage Development and Responses by CD5.
C. Pena-Rossi, L. A. Zuckerman, J. Strong, J. Kwan, W. Ferris, S. Chan, A. Tarakhovsky, A. D. Beyers, and N. Killeen (1999)
J. Immunol. 163, 6494-6501
   Abstract »    Full Text »    PDF »
Expression of the Casein Kinase 2 Subunits in Chinese Hamster Ovary and 3T3 L1 Cells Provides Information on the Role of the Enzyme in Cell Proliferation and the Cell Cycle.
D. Li, G. Dobrowolska, L. D. Aicher, M. Chen, J. H. Wright, P. Drueckes, E. L. Dunphy, E. S. Munar, and E. G. Krebs (1999)
J. Biol. Chem. 274, 32988-32996
   Abstract »    Full Text »    PDF »
The intracellular parasite Theileria parva protects infected T cells from apoptosis.
V. T. Heussler, J. Machado Jr, P. C. Fernandez, C. Botteron, C.-G. Chen, M. J. Pearse, and D. A. E. Dobbelaere (1999)
PNAS 96, 7312-7317
   Abstract »    Full Text »    PDF »
Inducible Expression of Protein Kinase CK2 in Mammalian Cells. EVIDENCE FOR FUNCTIONAL SPECIALIZATION OF CK2 ISOFORMS.
G. Vilk, R. B. Saulnier, R. St. Pierre, and D. W. Litchfield (1999)
J. Biol. Chem. 274, 14406-14414
   Abstract »    Full Text »    PDF »
Phosphorylation of CD45 by Casein Kinase 2. MODULATION OF ACTIVITY AND MUTATIONAL ANALYSIS.
Y. Wang, W. Guo, L. Liang, and W. J. Esselman (1999)
J. Biol. Chem. 274, 7454-7461
   Abstract »    Full Text »    PDF »
Nuclear Matrix Targeting of the Protein Kinase CK2 Signal as a Common Downstream Response to Androgen or Growth Factor Stimulation of Prostate Cancer Cells.
C. Guo, S. Yu, A. T. Davis, and K. Ahmed (1999)
Cancer Res. 59, 1146-1151
   Abstract »    Full Text »    PDF »
Antisense Expression of the CK2 alpha -Subunit Gene in Arabidopsis. Effects on Light-Regulated Gene Expression and Plant Growth.
Y. Lee, A. M. Lloyd, and S. J. Roux (1999)
Plant Physiology 119, 989-1000
   Abstract »    Full Text »
Activation of protein kinase CK2 by LPS is mediated by the MAP kinase pathway.
T. K. Means, T. A. Lodie, and M. J. Fenton (1999)
Innate Immunity 5, 37-40
   Abstract »    PDF »
Structural interpretation of site-directed mutagenesis and specificity of the catalytic subunit of protein kinase CK2 using comparative modelling.
N. Srinivasan, M. Antonelli, G. Jacob, I. Korn, F. Romero, A. Jedlicki, V. Dhanaraj, M. F.-R. Sayed, T. L. Blundell, C. C. Allende, et al. (1999)
Protein Eng. Des. Sel. 12, 119-127
   Abstract »    Full Text »    PDF »
Acceleration of lpr Lymphoproliferative and Autoimmune Disease by Transgenic Protein Kinase CK2{alpha}.
I. R. Rifkin, P. L. Channavajhala, H. L.B. Kiefer, A. J. Carmack, E. Landesman-Bollag, B. C. Beaudette, B. Jersky, D. J. Salant, S.-T. Ju, A. Marshak-Rothstein, et al. (1998)
J. Immunol. 161, 5164-5170
   Abstract »    Full Text »    PDF »
Regulation of Erythroid Kruppel-like Factor (EKLF) Transcriptional Activity by Phosphorylation of a Protein Kinase Casein Kinase II Site within Its Interaction Domain.
L. Ouyang, X. Chen, and J. J. Bieker (1998)
J. Biol. Chem. 273, 23019-23025
   Abstract »    Full Text »    PDF »
Protein Kinase CK2alpha ' Is Induced by Serum as a Delayed Early Gene and Cooperates with Ha-ras in Fibroblast Transformation.
M. Orlandini, F. Semplici, R. Ferruzzi, F. Meggio, L. A. Pinna, and S. Oliviero (1998)
J. Biol. Chem. 273, 21291-21297
   Abstract »    Full Text »    PDF »
Identification and Partial Characterization of Factor Va Heavy Chain Kinase from Human Platelets.
M. Kalafatis (1998)
J. Biol. Chem. 273, 8459-8466
   Abstract »    Full Text »    PDF »
Temperature-sensitive Mutations of the CKA1 Gene Reveal a Role for Casein Kinase II in Maintenance of Cell Polarity in Saccharomyces cerevisiae.
A. Rethinaswamy, M. J. Birnbaum, and C. V. C. Glover (1998)
J. Biol. Chem. 273, 5869-5877
   Abstract »    Full Text »    PDF »
Casein Kinase II-mediated Phosphorylation of the C Terminus of Sp1 Decreases Its DNA Binding Activity.
S. A. Armstrong, D. A. Barry, R. W. Leggett, and C. R. Mueller (1997)
J. Biol. Chem. 272, 13489-13495
   Abstract »    Full Text »    PDF »
Ornithine Decarboxylase Expression Leads to Translocation and Activation of Protein Kinase CK2 in Vivo.
L. J. Shore, A. P. Soler, and S. K. Gilmour (1997)
J. Biol. Chem. 272, 12536-12543
   Abstract »    Full Text »    PDF »
Specific Interaction between Casein Kinase 2and the Nucleolar Protein Nopp140.
D. Li, U.T. Meier, G. Dobrowolska, and EdwinG. Krebs (1997)
J. Biol. Chem. 272, 3773-3779
   Abstract »    Full Text »    PDF »
Protein Kinase CK2 Mutants Defective in Substrate Recognition.
S. Sarno, P. Vaglio, F. Meggio, O.-G. Issinger, and L. A. Pinna (1996)
J. Biol. Chem. 271, 10595-10601
   Abstract »    Full Text »    PDF »
Induced Release of Cell Surface Protein Kinase Yields CK1- and CK2-like Enzymes in Tandem.
J. Walter, M. Schnölzer, W. Pyerin, V. Kinzel, and D. Kübler (1996)
J. Biol. Chem. 271, 111-119
   Abstract »    Full Text »    PDF »
Sp1 Is Phosphorylated and Its DNA Binding Activity Down-regulated upon Terminal Differentiation of the Liver.
R. W. Leggett, S. A. Armstrong, D. Barry, and C. R. Mueller (1995)
J. Biol. Chem. 270, 25879-25884
   Abstract »    Full Text »    PDF »
Casein Kinase II Is Required for Cell Cycle Progression during G(1) and G(2)/M in Saccharomyces cerevisiae.
D. E. Hanna, A. Rethinaswamy, and C. V. C. Glover (1995)
J. Biol. Chem. 270, 25905-25914
   Abstract »    Full Text »    PDF »
Casein kinase II in theileriosis.
O. ole-MoiYoi (1995)
Science 267, 834-836
   PDF »
Stress-induced Activation of Protein Kinase CK2 by Direct Interaction with p38 Mitogen-activated Protein Kinase.
M. Sayed, S. O. Kim, B. S. Salh, O.-G. Issinger, and S. L. Pelech (2000)
J. Biol. Chem. 275, 16569-16573
   Abstract »    Full Text »    PDF »
Tumor Necrosis Factor alpha -induced Phosphorylation of RelA/p65 on Ser529 Is Controlled by Casein Kinase II.
D. Wang, S. D. Westerheide, J. L. Hanson, and A. S. Baldwin Jr. (2000)
J. Biol. Chem. 275, 32592-32597
   Abstract »    Full Text »    PDF »
Cell Cycle-regulated Phosphorylation of the Human SIX1 Homeodomain Protein.
H. L. Ford, E. Landesman-Bollag, C. S. Dacwag, P. T. Stukenberg, A. B. Pardee, and D. C. Seldin (2000)
J. Biol. Chem. 275, 22245-22254
   Abstract »    Full Text »    PDF »
The Replacement of ATP by the Competitive Inhibitor Emodin Induces Conformational Modifications in the Catalytic Site of Protein Kinase CK2.
R. Battistutta, S. Sarno, E. De Moliner, E. Papinutto, G. Zanotti, and L. A. Pinna (2000)
J. Biol. Chem. 275, 29618-29622
   Abstract »    Full Text »    PDF »
The Tumor Suppressor PTEN Is Phosphorylated by the Protein Kinase CK2 at Its C Terminus. IMPLICATIONS FOR PTEN STABILITY TO PROTEASOME-MEDIATED DEGRADATION.
J. Torres and R. Pulido (2001)
J. Biol. Chem. 276, 993-998
   Abstract »    Full Text »    PDF »
Phosphorylation of the Human Ubiquitin-conjugating Enzyme, CDC34, by Casein Kinase 2.
K. Block, T. G. Boyer, and P. R. Yew (2001)
J. Biol. Chem. 276, 41049-41058
   Abstract »    Full Text »    PDF »
Endogenous Protein Kinase CK2 Participates in Wnt Signaling in Mammary Epithelial Cells.
D. H. Song, D. J. Sussman, and D. C. Seldin (2000)
J. Biol. Chem. 275, 23790-23797
   Abstract »    Full Text »    PDF »
Transcription Factors Ets1, NF-kappa B, and Sp1 Are Major Determinants of the Promoter Activity of the Human Protein Kinase CK2alpha Gene.
A. Krehan, H. Ansuini, O. Bocher, S. Grein, U. Wirkner, and W. Pyerin (2000)
J. Biol. Chem. 275, 18327-18336
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)