Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.


Science 3 February 1995:
Vol. 267. no. 5198, pp. 688 - 693
DOI: 10.1126/science.7839146

Articles

Science, Vol 267, Issue 5198, 688-693
Copyright © 1995 by American Association for the Advancement of Science


articles

Requirement of MADS domain transcription factor D-MEF2 for muscle formation in Drosophila

B Lilly, B Zhao, G Ranganayakulu, BM Paterson, RA Schulz, and EN Olson

Department of Biochemistry and Molecular Biology, University of Texas M.D. Anderson Cancer Center, Houston 77030.

Members of the myocyte enhancer binding factor-2 (MEF2) family of MADS (MCM1, agamous, deficiens, and serum response factor) box transcription factors are expressed in the skeletal, cardiac, and smooth muscle lineages of vertebrate and Drosophila embryos. These factors bind an adenine-thymidine-rich DNA sequence associated with muscle-specific genes. The function of MEF2 was determined by generating a loss-of-function of the single mef2 gene in Drosophila (D-mef2). In loss-of-function embryos, somatic, cardiac, and visceral muscle cells did not differentiate, but myoblasts were normally specified and positioned. These results demonstrate that different muscle cell types share a common myogenic differentiation program controlled by MEF2.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Molecular Mechanism of Temperature Sensitivity for Mutations Affecting the Drosophila Muscle Regulator Myocyte Enhancer Factor-2.
T. L. Lovato, M. M. Adams, P. W. Baker, and R. M. Cripps (2009)
Genetics 183, 107-117
   Abstract »    Full Text »    PDF »
Direct Interaction between Myocyte Enhancer Factor 2 (MEF2) and Protein Phosphatase 1{alpha} Represses MEF2-Dependent Gene Expression.
R. L. S. Perry, C. Yang, N. Soora, J. Salma, M. Marback, L. Naghibi, H. Ilyas, J. Chan, J. W. Gordon, and J. C. McDermott (2009)
Mol. Cell. Biol. 29, 3355-3366
   Abstract »    Full Text »    PDF »
Crossveinless and the TGF{beta} pathway regulate fiber number in the Drosophila adult jump muscle.
M. S. Jaramillo, C. V. Lovato, E. M. Baca, and R. M. Cripps (2009)
Development 136, 1105-1113
   Abstract »    Full Text »    PDF »
The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis.
T. Mann, R. Bodmer, and P. Pandur (2009)
Development 136, 317-326
   Abstract »    Full Text »    PDF »
Alternative Requirements for Vestigial, Scalloped, and Dmef2 during Muscle Differentiation in Drosophila melanogaster.
H. Deng, S. C. Hughes, J. B. Bell, and A. J. Simmonds (2009)
Mol. Biol. Cell 20, 256-269
   Abstract »    Full Text »    PDF »
Myocyte Enhancer Factor 2 and Chorion Factor 2 Collaborate in Activation of the Myogenic Program in Drosophila.
K. K. K. Tanaka, A. L. Bryantsev, and R. M. Cripps (2008)
Mol. Cell. Biol. 28, 1616-1629
   Abstract »    Full Text »    PDF »
Differentiation-dependent lysine 4 acetylation enhances MEF2C binding to DNA in skeletal muscle cells.
C. Angelelli, A. Magli, D. Ferrari, M. Ganassi, V. Matafora, F. Parise, G. Razzini, A. Bachi, S. Ferrari, and S. Molinari (2008)
Nucleic Acids Res. 36, 915-928
   Abstract »    Full Text »    PDF »
mef2 activity levels differentially affect gene expression during Drosophila muscle development.
S. J. Elgar, J. Han, and M. V. Taylor (2008)
PNAS 105, 918-923
   Abstract »    Full Text »    PDF »
Regulation of Skeletal Muscle Sarcomere Integrity and Postnatal Muscle Function by Mef2c.
M. J. Potthoff, M. A. Arnold, J. McAnally, J. A. Richardson, R. Bassel-Duby, and E. N. Olson (2007)
Mol. Cell. Biol. 27, 8143-8151
   Abstract »    Full Text »    PDF »
MEF2: a central regulator of diverse developmental programs.
M. J. Potthoff and E. N. Olson (2007)
Development 134, 4131-4140
   Abstract »    Full Text »    PDF »
Mef2s are required for thick filament formation in nascent muscle fibres.
Y. Hinits and S. M. Hughes (2007)
Development 134, 2511-2519
   Abstract »    Full Text »    PDF »
Requirement of the LIM Homeodomain Transcription Factor Tailup for Normal Heart and Hematopoietic Organ Formation in Drosophila melanogaster.
Y. Tao, J. Wang, T. Tokusumi, K. Gajewski, and R. A. Schulz (2007)
Mol. Cell. Biol. 27, 3962-3969
   Abstract »    Full Text »    PDF »
Regulation of HDAC9 Gene Expression by MEF2 Establishes a Negative-Feedback Loop in the Transcriptional Circuitry of Muscle Differentiation.
M. Haberland, M. A. Arnold, J. McAnally, D. Phan, Y. Kim, and E. N. Olson (2007)
Mol. Cell. Biol. 27, 518-525
   Abstract »    Full Text »    PDF »
MyoD, modularity, and myogenesis: conservation of regulators and redundancy in C. elegans.
L. R. Baugh and C. P. Hunter (2006)
Genes & Dev. 20, 3342-3346
   Full Text »    PDF »
Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis.
C. Karamboulas, G. D. Dakubo, J. Liu, Y. De Repentigny, K. Yutzey, V. A. Wallace, R. Kothary, and I. S. Skerjanc (2006)
J. Cell Sci. 119, 4315-4321
   Abstract »    Full Text »    PDF »
Cardioblast-intrinsic Tinman activity controls proper diversification and differentiation of myocardial cells in Drosophila.
S. Zaffran, I. Reim, L. Qian, P. C. Lo, R. Bodmer, and M. Frasch (2006)
Development 133, 4073-4083
   Abstract »    Full Text »    PDF »
A Drosophila model of the rhabdomyosarcoma initiator PAX7-FKHR.
R. L. Galindo, J. A. Allport, and E. N. Olson (2006)
PNAS 103, 13439-13444
   Abstract »    Full Text »    PDF »
Lateral positioning at the dorsal midline: Slit and Roundabout receptors guide Drosophila heart cell migration.
E. Santiago-Martinez, N. H. Soplop, and S. G. Kramer (2006)
PNAS 103, 12441-12446
   Abstract »    Full Text »    PDF »
Myospryn Is a Direct Transcriptional Target for MEF2A That Encodes a Striated Muscle, {alpha}-Actinin-interacting, Costamere-localized Protein.
J. T. Durham, O. M. Brand, M. Arnold, J. G. Reynolds, L. Muthukumar, H. Weiler, J. A. Richardson, and F. J. Naya (2006)
J. Biol. Chem. 281, 6841-6849
   Abstract »    Full Text »    PDF »
Mapping Dmef2-binding regulatory modules by using a ChIP-enriched in silico targets approach.
G. Junion, T. Jagla, S. Duplant, R. Tapin, J.-P. Da Ponte, and K. Jagla (2005)
PNAS 102, 18479-18484
   Abstract »    Full Text »    PDF »
Centronuclear myopathy in mice lacking a novel muscle-specific protein kinase transcriptionally regulated by MEF2.
O. Nakagawa, M. Arnold, M. Nakagawa, H. Hamada, J. M. Shelton, H. Kusano, T. M. Harris, G. Childs, K. P. Campbell, J. A. Richardson, et al. (2005)
Genes & Dev. 19, 2066-2077
   Abstract »    Full Text »    PDF »
Adult Myogenesis in Drosophila melanogaster Can Proceed Independently of Myocyte Enhancer Factor-2.
P. W. Baker, K. K. K. Tanaka, N. Klitgord, and R. M. Cripps (2005)
Genetics 170, 1747-1759
   Abstract »    Full Text »    PDF »
A positive feedback loop between Dumbfounded and Rolling pebbles leads to myotube enlargement in Drosophila.
S. D. Menon, Z. Osman, K. Chenchill, and W. Chia (2005)
J. Cell Biol. 169, 909-920
   Abstract »    Full Text »    PDF »
BOP, a regulator of right ventricular heart development, is a direct transcriptional target of MEF2C in the developing heart.
D. Phan, T. L. Rasmussen, O. Nakagawa, J. McAnally, P. D. Gottlieb, P. W. Tucker, J. A. Richardson, R. Bassel-Duby, and E. N. Olson (2005)
Development 132, 2669-2678
   Abstract »    Full Text »    PDF »
Expression, Regulation, and Requirement of the Toll Transmembrane Protein during Dorsal Vessel Formation in Drosophila melanogaster.
J. Wang, Y. Tao, I. Reim, K. Gajewski, M. Frasch, and R. A. Schulz (2005)
Mol. Cell. Biol. 25, 4200-4210
   Abstract »    Full Text »    PDF »
Identification of Direct Serum-response Factor Gene Targets during Me2SO-induced P19 Cardiac Cell Differentiation.
S. X. Zhang, E. Garcia-Gras, D. R. Wycuff, S. J. Marriot, N. Kadeer, W. Yu, E. N. Olson, D. J. Garry, M. S. Parmacek, and R. J. Schwartz (2005)
J. Biol. Chem. 280, 19115-19126
   Abstract »    Full Text »    PDF »
Myocyte Enhancer Factor 2 Acetylation by p300 Enhances Its DNA Binding Activity, Transcriptional Activity, and Myogenic Differentiation.
K. Ma, J. K. L. Chan, G. Zhu, and Z. Wu (2005)
Mol. Cell. Biol. 25, 3575-3582
   Abstract »    Full Text »    PDF »
PC4 Coactivates MyoD by Relieving the Histone Deacetylase 4-Mediated Inhibition of Myocyte Enhancer Factor 2C.
L. Micheli, L. Leonardi, F. Conti, P. Buanne, N. Canu, M. Caruso, and F. Tirone (2005)
Mol. Cell. Biol. 25, 2242-2259
   Abstract »    Full Text »    PDF »
Epsin potentiates Notch pathway activity in Drosophila and C. elegans.
X. Tian, D. Hansen, T. Schedl, and J. B. Skeath (2004)
Development 131, 5807-5815
   Abstract »    Full Text »    PDF »
A myocardin-related transcription factor regulates activity of serum response factor in Drosophila.
Z. Han, X. Li, J. Wu, and E. N. Olson (2004)
PNAS 101, 12567-12572
   Abstract »    Full Text »    PDF »
Mef2c is a direct transcriptional target of ISL1 and GATA factors in the anterior heart field during mouse embryonic development.
E. Dodou, M. P. Verzi, J. P. Anderson, S.-M. Xu, and B. L. Black (2004)
Development 131, 3931-3942
   Abstract »    Full Text »    PDF »
Mcm1 Promotes Replication Initiation by Binding Specific Elements at Replication Origins.
V. K. Chang, J. J. Donato, C. S. Chan, and B. K. Tye (2004)
Mol. Cell. Biol. 24, 6514-6524
   Abstract »    Full Text »    PDF »
HRC Is a Direct Transcriptional Target of MEF2 during Cardiac, Skeletal, and Arterial Smooth Muscle Development In Vivo.
J. P. Anderson, E. Dodou, A. B. Heidt, S. J. De Val, E. J. Jaehnig, S. B. Greene, E. N. Olson, and B. L. Black (2004)
Mol. Cell. Biol. 24, 3757-3768
   Abstract »    Full Text »    PDF »
pyramus and thisbe: FGF genes that pattern the mesoderm of Drosophila embryos.
A. Stathopoulos, B. Tam, M. Ronshaugen, M. Frasch, and M. Levine (2004)
Genes & Dev. 18, 687-699
   Abstract »    Full Text »    PDF »
Transcription of Drosophila Troponin I Gene Is Regulated by Two Conserved, Functionally Identical, Synergistic Elements.
M.-C. Marin, J.-R. Rodriguez, and A. Ferrus (2004)
Mol. Biol. Cell 15, 1185-1196
   Abstract »    Full Text »    PDF »
Sizing up the heart: development redux in disease.
E. N. Olson and M. D. Schneider (2003)
Genes & Dev. 17, 1937-1956
   Full Text »    PDF »
Evolutionary genomics of inversions in Drosophila pseudoobscura: Evidence for epistasis.
S. W. Schaeffer, M. P. Goetting-Minesky, M. Kovacevic, J. R. Peoples, J. L. Graybill, J. M. Miller, K. Kim, J. G. Nelson, and W. W. Anderson (2003)
PNAS 100, 8319-8324
   Abstract »    Full Text »    PDF »
Mcm7, a Subunit of the Presumptive MCM Helicase, Modulates Its Own Expression in Conjunction with Mcm1.
M. J. Fitch, J. J. Donato, and B. K. Tye (2003)
J. Biol. Chem. 278, 25408-25416
   Abstract »    Full Text »    PDF »
pannier and pointedP2 act sequentially to regulate Drosophila heart development.
A. D. Alvarez, W. Shi, B. A. Wilson, and J. B. Skeath (2003)
Development 130, 3015-3026
   Abstract »    Full Text »    PDF »
Gata factor Pannier is required to establish competence for heart progenitor formation.
S. L. Klinedinst and R. Bodmer (2003)
Development 130, 3027-3038
   Abstract »    Full Text »    PDF »
Myogenic cells fates are antagonized by Notch only in asymmetric lineages of the Drosophila heart, with or without cell division.
Z. Han and R. Bodmer (2003)
Development 130, 3039-3051
   Abstract »    Full Text »    PDF »
Sply regulation of sphingolipid signaling molecules is essential for Drosophila development.
D. R. Herr, H. Fyrst, V. Phan, K. Heinecke, R. Georges, G. L. Harris, and J. D. Saba (2003)
Development 130, 2443-2453
   Abstract »    Full Text »    PDF »
Drosophila paramyosin is important for myoblast fusion and essential for myofibril formation.
H. Liu, M. Mardahl-Dumesnil, S. T. Sweeney, C. J. O'Kane, and S. I. Bernstein (2003)
J. Cell Biol. 160, 899-908
   Abstract »    Full Text »    PDF »
The Hox gene abdominal-A specifies heart cell fate in the Drosophila dorsal vessel.
T. L. Lovato, T. P. Nguyen, M. R. Molina, and R. M. Cripps (2002)
Development 129, 5019-5027
   Abstract »    Full Text »    PDF »
Molecular Mechanisms of Chamber-specific Myocardial Gene Expression: Transgenic Analysis of the ANF Promoter.
E.M. SMALL and P.A. KRIEG (2002)
Cold Spring Harb Symp Quant Biol 67, 71-80
   Abstract »    PDF »
myoblasts incompetent encodes a zinc finger transcription factor required to specify fusion-competent myoblasts in Drosophila.
M. Ruiz-Gomez, N. Coutts, M. L. Suster, M. Landgraf, and M. Bate (2002)
Development 129, 133-141
   Abstract »    Full Text »    PDF »
rolling pebbles (rols) is required in Drosophila muscle precursors for recruitment of myoblasts for fusion.
A. Rau, D. Buttgereit, A. Holz, R. Fetter, S. K. Doberstein, A. Paululat, N. Staudt, J. Skeath, A. M. Michelson, and R. Renkawitz-Pohl (2001)
Development 128, 5061-5073
   Abstract »    Full Text »    PDF »
Mechanism for Nucleocytoplasmic Shuttling of Histone Deacetylase 7.
H.-Y. Kao, A. Verdel, C.-C. Tsai, C. Simon, H. Juguilon, and S. Khochbin (2001)
J. Biol. Chem. 276, 47496-47507
   Abstract »    Full Text »    PDF »
Drosophila Lame duck, a novel member of the Gli superfamily, acts as a key regulator of myogenesis by controlling fusion-competent myoblast development.
H. Duan, J. B. Skeath, and H. T. Nguyen (2001)
Development 128, 4489-4500
   Abstract »    Full Text »    PDF »
The Mef2c gene is a direct transcriptional target of myogenic bHLH and MEF2 proteins during skeletal muscle development.
D.-Z. Wang, M. R. Valdez, J. McAnally, J. Richardson, and E. N. Olson (2001)
Development 128, 4623-4633
   Abstract »    Full Text »    PDF »
Nkx2-5 Activity Is Essential for Cardiomyogenesis.
M. Jamali, P. J. Rogerson, S. Wilton, and I. S. Skerjanc (2001)
J. Biol. Chem. 276, 42252-42258
   Abstract »    Full Text »    PDF »
Characterization of Drosophila hibris, a gene related to human nephrin.
H. A. Dworak, M. A. Charles, L. B. Pellerano, and H. Sink (2001)
Development 128, 4265-4276
   Abstract »    Full Text »    PDF »
Differential localization of HDAC4 orchestrates muscle differentiation.
E. A. Miska, E. Langley, D. Wolf, C. Karlsson, J. Pines, and T. Kouzarides (2001)
Nucleic Acids Res. 29, 3439-3447
   Abstract »    Full Text »    PDF »
Switching Repulsion to Attraction: Changing Responses to Slit During Transition in Mesoderm Migration.
S. G. Kramer, T. Kidd, J. H. Simpson, and C. S. Goodman (2001)
Science 292, 737-740
   Abstract »    Full Text »
Spatially restricted activity of a Drosophila lipid phosphatase guides migrating germ cells.
M Starz-Gaiano, N. Cho, A Forbes, and R Lehmann (2001)
Development 128, 983-991
   Abstract »    PDF »
Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion.
B. A. Bour, M. Chakravarti, J. M. West, and S. M. Abmayr (2000)
Genes & Dev. 14, 1498-1511
   Abstract »    Full Text »
The localized assembly of extracellular matrix integrin ligands requires cell-cell contact.
M. Martin-Bermudo and N. Brown (2000)
J. Cell Sci. 113, 3715-3723
   Abstract »    PDF »
Myocyte Enhancer Factor 2C and Myogenin Up-regulate Each Other's Expression and Induce the Development of Skeletal Muscle in P19 Cells.
A. G. Ridgeway, S. Wilton, and I. S. Skerjanc (2000)
J. Biol. Chem. 275, 41-46
   Abstract »    Full Text »    PDF »
Induction and differentiation of the zebrafish heart requires fibroblast growth factor 8 (fgf8/acerebellar).
F Reifers, E. Walsh, S Leger, D. Stainier, and M Brand (2000)
Development 127, 225-235
   Abstract »    PDF »
Independent Repressor Domains in ZEB Regulate Muscle and T-Cell Differentiation.
A. A. Postigo and D. C. Dean (1999)
Mol. Cell. Biol. 19, 7961-7971
   Abstract »    Full Text »    PDF »
Oogenic function of the myogenic factor D-MEF2: Negative regulation of the Decapentaplegic receptor gene thick veins.
E. Y. Mantrova, R. A. Schulz, and T. Hsu (1999)
PNAS 96, 11889-11894
   Abstract »    Full Text »    PDF »
Bone Morphogenetic Proteins Induce Cardiomyocyte Differentiation through the Mitogen-Activated Protein Kinase Kinase Kinase TAK1 and Cardiac Transcription Factors Csx/Nkx-2.5 and GATA-4.
K. Monzen, I. Shiojima, Y. Hiroi, S. Kudoh, T. Oka, E. Takimoto, D. Hayashi, T. Hosoda, A. Habara-Ohkubo, T. Nakaoka, et al. (1999)
Mol. Cell. Biol. 19, 7096-7105
   Abstract »    Full Text »    PDF »
zfh-1, the Drosophila Homologue of ZEB, Is a Transcriptional Repressor That Regulates Somatic Myogenesis.
A. A. Postigo, E. Ward, J. B. Skeath, and D. C. Dean (1999)
Mol. Cell. Biol. 19, 7255-7263
   Abstract »    Full Text »    PDF »
Genes regulating dendritic outgrowth, branching, and routing in Drosophila.
F.-B. Gao, J. E. Brenman, L. Y. Jan, and Y. N. Jan (1999)
Genes & Dev. 13, 2549-2561
   Abstract »    Full Text »
Muscle LIM Proteins Are Associated with Muscle Sarcomeres and Require dMEF2 for Their Expression during Drosophila Myogenesis.
B. E. Stronach, P. J. Renfranz, B. Lilly, and M. C. Beckerle (1999)
Mol. Biol. Cell 10, 2329-2342
   Abstract »    Full Text »
Activated Notch Inhibits Myogenic Activity of the MADS-Box Transcription Factor Myocyte Enhancer Factor 2C.
J. Wilson-Rawls, J. D. Molkentin, B. L. Black, and E. N. Olson (1999)
Mol. Cell. Biol. 19, 2853-2862
   Abstract »    Full Text »    PDF »
p38 Mitogen-activated Protein Kinase Pathway Promotes Skeletal Muscle Differentiation. PARTICIPATION OF THE MEF2C TRANSCRIPTION FACTOR.
A. Zetser, E. Gredinger, and E. Bengal (1999)
J. Biol. Chem. 274, 5193-5200
   Abstract »    Full Text »    PDF »
Targeted disruption of gene function in Drosophila by RNA interference (RNA-i): A role for nautilus in embryonic somatic muscle formation.
L. Misquitta and B. M. Paterson (1999)
PNAS 96, 1451-1456
   Abstract »    Full Text »    PDF »
Vascular Cell Adhesion Molecule-1 Gene Expression during Human Smooth Muscle Cell Differentiation Is Independent of NF-kappa B Activation.
J. Lavie, F. Dandre, H. Louis, J.-M. D. Lamaziere, and J. Bonnet (1999)
J. Biol. Chem. 274, 2308-2314
   Abstract »    Full Text »    PDF »
p21CIP1 and p57KIP2 control muscle differentiation at the myogenin step.
P. Zhang, C. Wong, D. Liu, M. Finegold, J. W. Harper, and S. J. Elledge (1999)
Genes & Dev. 13, 213-224
   Abstract »    Full Text »
The zinc finger proteins Pannier and GATA4 function as cardiogenic factors in Drosophila.
K Gajewski, N Fossett, J. Molkentin, and R. Schulz (1999)
Development 126, 5679-5688
   Abstract »    PDF »
Functions for Drosophila brachyenteron and forkhead in mesoderm specification and cell signalling.
T Kusch and R Reuter (1999)
Development 126, 3991-4003
   Abstract »    PDF »
The Drosophila homeobox genes zfh-1 and even-skipped are required for cardiac-specific differentiation of a numb-dependent lineage decision.
M. Su, M Fujioka, T Goto, and R Bodmer (1999)
Development 126, 3241-3251
   Abstract »    PDF »
A role for serum response factor in coronary smooth muscle differentiation from proepicardial cells.
T. Landerholm, X. Dong, J Lu, N. Belaguli, R. Schwartz, and M. Majesky (1999)
Development 126, 2053-2062
   Abstract »    PDF »
Regulation of the MEF2 Family of Transcription Factors by p38.
M. Zhao, L. New, V. V. Kravchenko, Y. Kato, H. Gram, F. di Padova, E. N. Olson, R. J. Ulevitch, and J. Han (1999)
Mol. Cell. Biol. 19, 21-30
   Abstract »    Full Text »    PDF »
Myocyte Enhancer Factor 2C and Nkx2-5 Up-regulate Each Other's Expression and Initiate Cardiomyogenesis in P19 Cells.
I. S. Skerjanc, H. Petropoulos, A. G. Ridgeway, and S. Wilton (1998)
J. Biol. Chem. 273, 34904-34910
   Abstract »    Full Text »    PDF »
Transcriptional Regulation of Smooth Muscle Contractile Apparatus Expression.
J. SOLWAY, S. M. FORSYTHE, A. J. HALAYKO, J. E. VIEIRA, M. B. HERSHENSON, and B. CAMORETTI-MERCADO (1998)
Am. J. Respir. Crit. Care Med. 158, S100-S108
   Abstract »    Full Text »    PDF »
Molecular Cloning, Characterization, and Promoter Analysis of the Mouse Crp2/SmLim Gene. PREFERENTIAL EXPRESSION OF ITS PROMOTER IN THE VASCULAR SMOOTH MUSCLE CELLS OF TRANSGENIC MICE.
S.-F. Yet, S. C. Folta, M. K. Jain, C.-M. Hsieh, K. Maemura, M. D. Layne, D. Zhang, P. B. Marria, M. Yoshizumi, M. T. Chin, et al. (1998)
J. Biol. Chem. 273, 10530-10537
   Abstract »    Full Text »    PDF »
The Rho Family G Proteins Play a Critical Role in Muscle Differentiation.
H. Takano, I. Komuro, T. Oka, I. Shiojima, Y. Hiroi, T. Mizuno, and Y. Yazaki (1998)
Mol. Cell. Biol. 18, 1580-1589
   Abstract »    Full Text »
The myogenic regulatory gene Mef2 is a direct target for transcriptional activation by Twist during Drosophila myogenesis.
R. M. Cripps, B. L. Black, B. Zhao, C.-L. Lien, R. A. Schulz, and E. N. Olson (1998)
Genes & Dev. 12, 422-434
   Abstract »    Full Text »
MEF2B Is a Component of a Smooth Muscle-specific Complex That Binds an A/T-rich Element Important for Smooth Muscle Myosin Heavy Chain Gene Expression.
Y. Katoh, J. D. Molkentin, V. Dave, E. N. Olson, and M. Periasamy (1998)
J. Biol. Chem. 273, 1511-1518
   Abstract »    Full Text »    PDF »
Heartbroken is a specific downstream mediator of FGF receptor signalling in Drosophila.
A. Michelson, S Gisselbrecht, E Buff, and J. Skeath (1998)
Development 125, 4379-4389
   Abstract »    PDF »
Requirement of the MADS-box transcription factor MEF2C for vascular development.
Q Lin, J Lu, H Yanagisawa, R Webb, G. Lyons, J. Richardson, and E. Olson (1998)
Development 125, 4565-4574
   Abstract »    PDF »
Divergent roles for NK-2 class homeobox genes in cardiogenesis in flies and mice.
G Ranganayakulu, D. Elliott, R. Harvey, and E. Olson (1998)
Development 125, 3037-3048
   Abstract »    PDF »
Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors.
E Buff, A Carmena, S Gisselbrecht, F Jimenez, and A. Michelson (1998)
Development 125, 2075-2086
   Abstract »    PDF »
Multiple Roles for the MyoD Basic Region in Transmission of Transcriptional Activation Signals and Interaction with MEF2.
B. L. Black, J. D. Molkentin, and E. N. Olson (1998)
Mol. Cell. Biol. 18, 69-77
   Abstract »    Full Text »
A Dominant-Negative Form of Transcription Factor MEF2 Inhibits Myogenesis.
O. I. Ornatsky, J. J. Andreucci, and J. C. McDermott (1997)
J. Biol. Chem. 272, 33271-33278
   Abstract »    Full Text »    PDF »
Elements Regulating Cardiomyocyte Expression of the Human Sarcomeric Mitochondrial Creatine Kinase Gene in Transgenic Mice.
W. Qin, Z. Khuchua, S. C. Klein, and A. W. Strauss (1997)
J. Biol. Chem. 272, 25210-25216
   Abstract »    Full Text »    PDF »
The Mesodermal Expression of rolling stone (rost) Is Essential for Myoblast Fusion in Drosophila and Encodes a Potential Transmembrane Protein.
A. Paululat, A. Goubeaud, C. Damm, S. Knirr, S. Burchard, and R. Renkawitz-Pohl (1997)
J. Cell Biol. 138, 337-348
   Abstract »    Full Text »    PDF »
Twist-mediated Activation of the NK-4 Homeobox Gene in the Visceral Mesoderm of Drosophila Requires Two Distinct Clusters of E-box Regulatory Elements.
Y. M. Lee, T. Park, R. A. Schulz, and Y. Kim (1997)
J. Biol. Chem. 272, 17531-17541
   Abstract »    Full Text »    PDF »
Identification of a Novel Marker for Primordial Smooth Muscle and Its Differential Expression Pattern in Contractile vs Noncontractile Cells.
J. E. Hungerford, J. P. Hoeffler, C. W. Bowers, L. M. Dahm, R. Falchetto, J. Shabanowitz, D. F. Hunt, and C. D. Little (1997)
J. Cell Biol. 137, 925-937
   Abstract »    Full Text »    PDF »
Fashioning the vertebrate heart: earliest embryonic decisions.
M. Fishman and K. Chien (1997)
Development 124, 2099-2117
   Abstract »    PDF »
The single MyoD family gene of Ciona intestinalis encodes two differentially expressed proteins: implications for the evolution of chordate muscle gene regulation.
T. Meedel, S. Farmer, and J. Lee (1997)
Development 124, 1711-1721
   Abstract »    PDF »
CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway.
Y Zou, S Evans, J Chen, H. Kuo, R. Harvey, and K. Chien (1997)
Development 124, 793-804
   Abstract »    PDF »
The Specification of Muscle in Drosophila.
M.K. Baylies, M. Bate, and M. Ruiz Gomez (1997)
Cold Spring Harb Symp Quant Biol 62, 385-393
   Abstract »    PDF »
A Transcriptional Pathway for Cardiac Development.
Q. Lin, D. Srivastava, and E.N. Olson (1997)
Cold Spring Harb Symp Quant Biol 62, 405-411
   Abstract »    PDF »
heartless encodes a fibroblast growth factor receptor (DFR1/DFGF-R2) involved in the directional migration of early mesodermal cells in the Drosophila embryo..
S Gisselbrecht, J B Skeath, C Q Doe, and A M Michelson (1996)
Genes & Dev. 10, 3003-3017
   Abstract »    PDF »
Distinct Domains of Myocyte Enhancer Binding Factor-2A Determining Nuclear Localization and Cell Type-specific Transcriptional Activity.
Y.-T. Yu and Y. T. Yu (1996)
J. Biol. Chem. 271, 24675-24683
   Abstract »    Full Text »    PDF »



To Advertise     Find Products


Science. ISSN 0036-8075 (print), 1095-9203 (online)