Science 3 February 1995: Vol. 267. no. 5198, pp. 682 - 685 DOI: 10.1126/science.7839144

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Articles

Quercetin Prevents LPS-Induced High-Mobility Group Box 1 Release and Proinflammatory Function.

D. Tang, R. Kang, W. Xiao, H. Zhang, M. T. Lotze, H. Wang, and X. Xiao (2009)
Am. J. Respir. Cell Mol. Biol. 41, 651-660
 |  Abstract »  |  Full Text »  |  PDF »

MEK4 Function, Genistein Treatment, and Invasion of Human Prostate Cancer Cells.

L. Xu, Y. Ding, W. J. Catalona, X. J. Yang, W. F. Anderson, B. Jovanovic, K. Wellman, J. Killmer, X. Huang, K. A. Scheidt, et al. (2009)
J Natl Cancer Inst 101, 1141-1155
 |  Abstract »  |  Full Text »  |  PDF »

Increased c-Jun Expression and Reduced GATA2 Expression Promote Aberrant Monocytic Differentiation Induced by Activating PTPN11 Mutants.

Z. Yang, T. Kondo, C. S. Voorhorst, S. C. Nabinger, L. Ndong, F. Yin, E. M. Chan, M. Yu, O. Wurstlin, C. P. Kratz, et al. (2009)
Mol. Cell. Biol. 29, 4376-4393
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Wip1 Sensitizes Cells to Stress- and DNA Damage-induced Apoptosis.

Y. Xia, P. Ongusaha, S. W. Lee, and Y.-C. Liou (2009)
J. Biol. Chem. 284, 17428-17437
 |  Abstract »  |  Full Text »  |  PDF »

Thrombin-Induced Connective Tissue Growth Factor Expression in Human Lung Fibroblasts Requires the ASK1/JNK/AP-1 Pathway.

C.-C. Yu, M.-J. Hsu, M.-L. Kuo, R. F.-C. Chen, M.-C. Chen, K.-J. Bai, M.-C. Yu, B.-C. Chen, and C.-H. Lin (2009)
J. Immunol. 182, 7916-7927
 |  Abstract »  |  Full Text »  |  PDF »

Selectivity of Docking Sites in MAPK Kinases.

A. J. Bardwell, E. Frankson, and L. Bardwell (2009)
J. Biol. Chem. 284, 13165-13173
 |  Abstract »  |  Full Text »  |  PDF »

Brx Mediates the Response of Lymphocytes to Osmotic Stress Through the Activation of NFAT5.

T. Kino, H. Takatori, I. Manoli, Y. Wang, A. Tiulpakov, M. R. Blackman, Y. A. Su, G. P. Chrousos, A. H. DeCherney, and J. H. Segars (2009)
Science Signaling 2, ra5
 |  Abstract »  |  Full Text »  |  PDF »

Elevating Calcium in Th2 Cells Activates Multiple Pathways to Induce IL-4 Transcription and mRNA Stabilization.

L. Guo, J. F. Urban, J. Zhu, and W. E. Paul (2008)
J. Immunol. 181, 3984-3993
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of Bad at Thr-201 by JNK1 Promotes Glycolysis through Activation of Phosphofructokinase-1.

H. Deng, F. Yu, J. Chen, Y. Zhao, J. Xiang, and A. Lin (2008)
J. Biol. Chem. 283, 20754-20760
 |  Abstract »  |  Full Text »  |  PDF »

Oxidative Inactivation of the Proteasome in Retinal Pigment Epithelial Cells: A POTENTIAL LINK BETWEEN OXIDATIVE STRESS AND UP-REGULATION OF INTERLEUKIN-8.

A. F. Fernandes, J. Zhou, X. Zhang, Q. Bian, J. Sparrow, A. Taylor, P. Pereira, and F. Shang (2008)
J. Biol. Chem. 283, 20745-20753
 |  Abstract »  |  Full Text »  |  PDF »

Disruption of Signaling through SEK1 and MKK7 Yields Differential Responses in Hypoxic Colon Cancer Cells Treated with Oxaliplatin.

I. A. Vasilevskaya, M. Selvakumaran, and P. J. O'Dwyer (2008)
Mol. Pharmacol. 74, 246-254
 |  Abstract »  |  Full Text »  |  PDF »

AMP-activated Protein Kinase and p38 MAPK Activate O-GlcNAcylation of Neuronal Proteins during Glucose Deprivation.

W. D. Cheung and G. W. Hart (2008)
J. Biol. Chem. 283, 13009-13020
 |  Abstract »  |  Full Text »  |  PDF »

Vitamin E succinate induces NAG-1 expression in a p38 kinase-dependent mechanism.

M. Shim and T. E. Eling (2008)
Mol. Cancer Ther. 7, 961-971
 |  Abstract »  |  Full Text »  |  PDF »

Mitogen-Activated Protein Kinase Kinase 4/c-Jun NH2-Terminal Kinase Kinase 1 Protein Expression Is Subject to Translational Regulation in Prostate Cancer Cell Lines.

V. L. Robinson, O. Shalhav, K. Otto, T. Kawai, M. Gorospe, and C. W. Rinker-Schaeffer (2008)
Mol. Cancer Res. 6, 501-508
 |  Abstract »  |  Full Text »  |  PDF »

MLH1- and ATM-dependent MAPK Signaling Is Activated through c-Abl in Response to the Alkylator N-Methyl-N'-nitro-N'-nitrosoguanidine.

W.-J. Kim, B. Rajasekaran, and K. D. Brown (2007)
J. Biol. Chem. 282, 32021-32031
 |  Abstract »  |  Full Text »  |  PDF »

MKK3-p38 signaling promotes apoptosis and the early inflammatory response in the obstructed mouse kidney.

F. Y. Ma, G. H. Tesch, R. A. Flavell, R. J. Davis, and D. J. Nikolic-Paterson (2007)
Am J Physiol Renal Physiol 293, F1556-F1563
 |  Abstract »  |  Full Text »  |  PDF »

Retinoic Acid Receptor beta Silences Human Papillomavirus-18 Oncogene Expression by Induction of de Novo Methylation and Heterochromatinization of the Viral Control Region.

J. De-Castro Arce, E. Gockel-Krzikalla, and F. Rosl (2007)
J. Biol. Chem. 282, 28520-28529
 |  Abstract »  |  Full Text »  |  PDF »

Phosphatidylinositol Ether Lipid Analogues That Inhibit AKT Also Independently Activate the Stress Kinase, p38{alpha}, through MKK3/6-independent and -dependent Mechanisms.

J. J. Gills, S. S. Castillo, C. Zhang, P. A. Petukhov, R. M. Memmott, M. Hollingshead, N. Warfel, J. Han, A. P. Kozikowski, and P. A. Dennis (2007)
J. Biol. Chem. 282, 27020-27029
 |  Abstract »  |  Full Text »  |  PDF »

p38 Pathway Kinases as Anti-inflammatory Drug Targets.

J.F. Schindler, J.B. Monahan, and W.G. Smith (2007)
Journal of Dental Research 86, 800-811
 |  Abstract »  |  Full Text »  |  PDF »

Feedback regulation of p38 activity via ATF2 is essential for survival of embryonic liver cells.

W. Breitwieser, S. Lyons, A. M. Flenniken, G. Ashton, G. Bruder, M. Willington, G. Lacaud, V. Kouskoff, and N. Jones (2007)
Genes & Dev. 21, 2069-2082
 |  Abstract »  |  Full Text »  |  PDF »

Targeted Deletion of MKK4 Gene Potentiates TNF-Induced Apoptosis through the Down-Regulation of NF-{kappa}B Activation and NF-{kappa}B-Regulated Antiapoptotic Gene Products.

G. Sethi, K. S. Ahn, D. Xia, J. M. Kurie, and B. B. Aggarwal (2007)
J. Immunol. 179, 1926-1933
 |  Abstract »  |  Full Text »  |  PDF »

Hypotonicity stimulates renal epithelial sodium transport by activating JNK via receptor tyrosine kinases.

A. Taruno, N. Niisato, and Y. Marunaka (2007)
Am J Physiol Renal Physiol 293, F128-F138
 |  Abstract »  |  Full Text »  |  PDF »

Heat Shock Protein 27 Functions in Inflammatory Gene Expression and Transforming Growth Factor-beta-activated Kinase-1 (TAK1)-mediated Signaling.

K. A. Alford, S. Glennie, B. R. Turrell, L. Rawlinson, J. Saklatvala, and J. L. E. Dean (2007)
J. Biol. Chem. 282, 6232-6241
 |  Abstract »  |  Full Text »  |  PDF »

p38-MAPK Induced Dephosphorylation of {alpha}-Tropomyosin Is Associated With Depression of Myocardial Sarcomeric Tension and ATPase Activity.

S. Vahebi, A. Ota, M. Li, C. M. Warren, P. P. de Tombe, Y. Wang, and R. J. Solaro (2007)
Circ. Res. 100, 408-415
 |  Abstract »  |  Full Text »  |  PDF »

Distinctive Epidermal Growth Factor Receptor/Extracellular Regulated Kinase-Independent and -Dependent Signaling Pathways in the Induction of Airway Mucin 5B and Mucin 5AC Expression by Phorbol 12-Myristate 13-Acetate.

D. Yuan-chen Wu, R. Wu, S. P. Reddy, Y. C. Lee, and M. M.-J. Chang (2007)
Am. J. Pathol. 170, 20-32
 |  Abstract »  |  Full Text »  |  PDF »

Palytoxin: exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis.

E. V. Wattenberg (2007)
Am J Physiol Cell Physiol 292, C24-C32
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of IL-1 and TNF Receptor Expression and Function by Endogenous Macrophage Migration Inhibitory Factor.

M.-L. Toh, D. Aeberli, D. Lacey, Y. Yang, L. L. Santos, M. Clarkson, L. Sharma, C. Clyne, and E. F. Morand (2006)
J. Immunol. 177, 4818-4825
 |  Abstract »  |  Full Text »  |  PDF »

MEKK3-mediated signaling to p38 kinase and TonE in hypertonically stressed kidney cells.

R. Padda, A. Wamsley-Davis, M. C. Gustin, R. Ross, C. Yu, and D. Sheikh-Hamad (2006)
Am J Physiol Renal Physiol 291, F874-F881
 |  Abstract »  |  Full Text »  |  PDF »

Multiple Activation Mechanisms of p38{alpha} Mitogen-activated Protein Kinase.

Y. J. Kang, A. Seit-Nebi, R. J. Davis, and J. Han (2006)
J. Biol. Chem. 281, 26225-26234
 |  Abstract »  |  Full Text »  |  PDF »

The calcineurin pathway links hyperpolarization (Kir2.1)-induced Ca2+ signals to human myoblast differentiation and fusion.

S. Konig, A. Beguet, C. R. Bader, and L. Bernheim (2006)
Development 133, 3107-3114
 |  Abstract »  |  Full Text »  |  PDF »

Transforming growth factor-beta1-induced endothelial barrier dysfunction involves Smad2-dependent p38 activation and subsequent RhoA activation.

Q. Lu, E. O. Harrington, H. Jackson, N. Morin, C. Shannon, and S. Rounds (2006)
J Appl Physiol 101, 375-384
 |  Abstract »  |  Full Text »  |  PDF »

Effects of adenylyl cyclase and protein kinase A inhibition on signaling enzymes in natural killer cells: comparison to tributyltin.

M M Whalen and S O Odman-Ghazi (2006)
Human and Experimental Toxicology 25, 333-340
 |  Abstract »  |  PDF »

Heme Oxygenase-1/Carbon Monoxide: From Basic Science to Therapeutic Applications.

S. W. Ryter, J. Alam, and A. M. K. Choi (2006)
Physiol Rev 86, 583-650
 |  Abstract »  |  Full Text »  |  PDF »

Caveolin-1 Confers Antiinflammatory Effects in Murine Macrophages via the MKK3/p38 MAPK Pathway.

X. M. Wang, H. P. Kim, R. Song, and A. M. K. Choi (2006)
Am. J. Respir. Cell Mol. Biol. 34, 434-442
 |  Abstract »  |  Full Text »  |  PDF »

Stress Kinase Signaling Regulates Androgen Receptor Phosphorylation, Transcription, and Localization.

D. Gioeli, B. E. Black, V. Gordon, A. Spencer, C. T. Kesler, S. T. Eblen, B. M. Paschal, and M. J. Weber (2006)
Mol. Endocrinol. 20, 503-515
 |  Abstract »  |  Full Text »  |  PDF »

Metformin Inhibits Proinflammatory Responses and Nuclear Factor-{kappa}B in Human Vascular Wall Cells.

K. Isoda, J. L. Young, A. Zirlik, L. A. MacFarlane, N. Tsuboi, N. Gerdes, U. Schonbeck, and P. Libby (2006)
Arterioscler Thromb Vasc Biol 26, 611-617
 |  Abstract »  |  Full Text »  |  PDF »

Cyclic AMP Inhibits p38 Activation via CREB-Induced Dynein Light Chain.

J. Zhang, T. N. Bui, J. Xiang, and A. Lin (2006)
Mol. Cell. Biol. 26, 1223-1234
 |  Abstract »  |  Full Text »  |  PDF »

The p38 Kinases MKK4 and MKK6 Suppress Metastatic Colonization in Human Ovarian Carcinoma.

J. A. Hickson, D. Huo, D. J. Vander Griend, A. Lin, C. W. Rinker-Schaeffer, and S. D. Yamada (2006)
Cancer Res. 66, 2264-2270
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear protein NP60 regulates p38 MAPK activity.

J. Fu, Z. Yang, J. Wei, J. Han, and J. Gu (2006)
J. Cell Sci. 119, 115-123
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Metastatic Colonization by the Context-Dependent Activation of the c-Jun NH2-Terminal Kinase Kinases JNKK1/MKK4 and MKK7.

D. J. Vander Griend, M. Kocherginsky, J. A. Hickson, W. M. Stadler, A. Lin, and C. W. Rinker-Schaeffer (2005)
Cancer Res. 65, 10984-10991
 |  Abstract »  |  Full Text »  |  PDF »

A Novel Mechanism of G Protein-dependent Phosphorylation of Vasodilator-stimulated Phosphoprotein.

J. Profirovic, M. Gorovoy, J. Niu, S. Pavlovic, and T. Voyno-Yasenetskaya{paragraph} (2005)
J. Biol. Chem. 280, 32866-32876
 |  Abstract »  |  Full Text »  |  PDF »

Raf: A Strategic Target for Therapeutic Development Against Cancer.

M. Beeram, A. Patnaik, and E. K. Rowinsky (2005)
J. Clin. Oncol. 23, 6771-6790
 |  Abstract »  |  Full Text »  |  PDF »

Pellino3 Is a Novel Upstream Regulator of p38 MAPK and Activates CREB in a p38-dependent Manner.

M. P. Butler, J. A. Hanly, and P. N. Moynagh (2005)
J. Biol. Chem. 280, 27759-27768
 |  Abstract »  |  Full Text »  |  PDF »

Selective Activation of Mitogen-Activated Protein (MAP) Kinase Kinase 3 and p38{alpha} MAP Kinase Is Essential for Cyclic AMP-Dependent UCP1 Expression in Adipocytes.

J. Robidoux, W. Cao, H. Quan, K. W. Daniel, F. Moukdar, X. Bai, L. M. Floering, and S. Collins (2005)
Mol. Cell. Biol. 25, 5466-5479
 |  Abstract »  |  Full Text »  |  PDF »

Induction of Human NF-IL6{beta} by Epidermal Growth Factor Is Mediated through the p38 Signaling Pathway and cAMP Response Element-binding Protein Activation in A431 Cells.

J.-M. Wang, J. T. Tseng, and W.-C. Chang (2005)
Mol. Biol. Cell 16, 3365-3376
 |  Abstract »  |  Full Text »  |  PDF »

Mitochondrial Reactive Oxygen Species Activation of p38 Mitogen-Activated Protein Kinase Is Required for Hypoxia Signaling.

B. M. Emerling, L. C. Platanias, E. Black, A. R. Nebreda, R. J. Davis, and N. S. Chandel (2005)
Mol. Cell. Biol. 25, 4853-4862
 |  Abstract »  |  Full Text »  |  PDF »

Cross-interactions of Two p38 Mitogen-activated Protein (MAP) Kinase Inhibitors and Two Cholecystokinin (CCK) Receptor Antagonists with the CCK1 Receptor and P38 MAP Kinase.

C. Morel, G. Ibarz, C. Oiry, E. Carnazzi, G. Berge, D. Gagne, J.-C. Galleyrand, and J. Martinez (2005)
J. Biol. Chem. 280, 21384-21393
 |  Abstract »  |  Full Text »  |  PDF »

c-Jun N-terminal Kinase (JNK) Positively Regulates NFATc2 Transactivation through Phosphorylation within the N-terminal Regulatory Domain.

I. Ortega-Perez, E. Cano, F. Were, M. Villar, J. Vazquez, and J. M. Redondo (2005)
J. Biol. Chem. 280, 20867-20878
 |  Abstract »  |  Full Text »  |  PDF »

Genistein Inhibits p38 Map Kinase Activation, Matrix Metalloproteinase Type 2, and Cell Invasion in Human Prostate Epithelial Cells.

X. Huang, S. Chen, L. Xu, Y. Liu, D. K. Deb, L. C. Platanias, and R. C. Bergan (2005)
Cancer Res. 65, 3470-3478
 |  Abstract »  |  Full Text »  |  PDF »

H-Ras-specific Activation of Rac-MKK3/6-p38 Pathway: ITS CRITICAL ROLE IN INVASION AND MIGRATION OF BREAST EPITHELIAL CELLS.

I. Shin, S. Kim, H. Song, H.-R. C. Kim, and A. Moon (2005)
J. Biol. Chem. 280, 14675-14683
 |  Abstract »  |  Full Text »  |  PDF »

The nucleolus as a stress sensor: JNK2 inactivates the transcription factor TIF-IA and down-regulates rRNA synthesis.

C. Mayer, H. Bierhoff, and I. Grummt (2005)
Genes & Dev. 19, 933-941
 |  Abstract »  |  Full Text »  |  PDF »

p38 MAPK Autophosphorylation Drives Macrophage IL-12 Production during Intracellular Infection.

L. Kim, L. D. Rio, B. A. Butcher, T. H. Mogensen, S. R. Paludan, R. A. Flavell, and E. Y. Denkers (2005)
J. Immunol. 174, 4178-4184
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Mitogen-activated Protein Kinase Kinase (MKK) 3 and MKK6 by Type I Interferons.

Y. Li, S. Batra, A. Sassano, B. Majchrzak, D. E. Levy, M. Gaestel, E. N. Fish, R. J. Davis, and L. C. Platanias (2005)
J. Biol. Chem. 280, 10001-10010
 |  Abstract »  |  Full Text »  |  PDF »

Peroxisome Proliferator-activated Receptor {gamma}-independent Activation of p38 MAPK by Thiazolidinediones Involves Calcium/Calmodulin-dependent Protein Kinase II and Protein Kinase R: CORRELATION WITH ENDOPLASMIC RETICULUM STRESS.

O. S. Gardner, C.-W. Shiau, C.-S. Chen, and L. M. Graves (2005)
J. Biol. Chem. 280, 10109-10118
 |  Abstract »  |  Full Text »  |  PDF »

Loss of mitogen-activated protein kinase kinase kinase 4 (MEKK4) results in enhanced apoptosis and defective neural tube development.

H. Chi, M. R. Sarkisian, P. Rakic, and R. A. Flavell (2005)
PNAS 102, 3846-3851
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of p38 Phosphorylation and Topoisomerase II{alpha} Expression in the B-Cell Lymphoma Line Jiyoye by CD26/Dipeptidyl Peptidase IV Is Associated with Enhanced In vitro and In vivo Sensitivity to Doxorubicin.

T. Yamochi, T. Yamochi, U. Aytac, T. Sato, K. Sato, K. Ohnuma, K. S. McKee, C. Morimoto, and N. H. Dang (2005)
Cancer Res. 65, 1973-1983
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B- and C/EBP{beta}-driven Interleukin-1{beta} Gene Expression and PAK1-mediated Caspase-1 Activation Play Essential Roles in Interleukin-1{beta} Release from Helicobacter pylori Lipopolysaccharide-stimulated Macrophages.

C. Basak, S. K. Pathak, A. Bhattacharyya, D. Mandal, S. Pathak, and M. Kundu (2005)
J. Biol. Chem. 280, 4279-4288
 |  Abstract »  |  Full Text »  |  PDF »

MAPK p38{alpha} Is Dispensable for Lymphocyte Development and Proliferation.

J. M. Kim, J. M. White, A. S. Shaw, and B. P. Sleckman (2005)
J. Immunol. 174, 1239-1244
 |  Abstract »  |  Full Text »  |  PDF »

MKK3 and -6-dependent activation of p38{alpha} MAP kinase is required for cytoskeletal changes in pulmonary microvascular endothelial cells induced by ICAM-1 ligation.

Q. Wang, M. Yerukhimovich, W. A. Gaarde, I. J. Popoff, and C. M. Doerschuk (2005)
Am J Physiol Lung Cell Mol Physiol 288, L359-L369
 |  Abstract »  |  Full Text »  |  PDF »

Iron-mediated H2O2 Production as a Mechanism for Cell Type-specific Inhibition of Tumor Necrosis Factor {alpha}-Induced but Not Interleukin-1{beta}-induced I{kappa}B Kinase Complex/Nuclear Factor-{kappa}B Activation.

A. Panopoulos, M. Harraz, J. F. Engelhardt, and E. Zandi (2005)
J. Biol. Chem. 280, 2912-2923
 |  Abstract »  |  Full Text »  |  PDF »

c-Jun N-Terminal Protein Kinase 1 (JNK1), but Not JNK2, Is Essential for Tumor Necrosis Factor Alpha-Induced c-Jun Kinase Activation and Apoptosis.

J. Liu, Y. Minemoto, and A. Lin (2004)
Mol. Cell. Biol. 24, 10844-10856
 |  Abstract »  |  Full Text »  |  PDF »

MAP2K4/MKK4 Expression in Pancreatic Cancer: Genetic Validation of Immunohistochemistry and Relationship to Disease Course.

W. Xin, K. J. Yun, F. Ricci, M. Zahurak, W. Qiu, G. H. Su, C. J. Yeo, R. H. Hruban, S. E. Kern, and C. A. Iacobuzio-Donahue (2004)
Clin. Cancer Res. 10, 8516-8520
 |  Abstract »  |  Full Text »  |  PDF »

Replication of varicella-zoster virus is influenced by the levels of JNK/SAPK and p38/MAPK activation.

M. Rahaus, N. Desloges, and M. H. Wolff (2004)
J. Gen. Virol. 85, 3529-3540
 |  Abstract »  |  Full Text »  |  PDF »

Comparative Proteomes of the Proliferating C2C12 Myoblasts and Fully Differentiated Myotubes Reveal the Complexity of the Skeletal Muscle Differentiation Program.

N. S. Tannu, V. K. Rao, R. M. Chaudhary, F. Giorgianni, A. E. Saeed, Y. Gao, and R. Raghow (2004)
Mol. Cell. Proteomics 3, 1065-1082
 |  Abstract »  |  Full Text »  |  PDF »

Ectopic Expression of Nonliganded Retinoic Acid Receptor {beta} Abrogates AP-1 Activity by Selective Degradation of c-Jun in Cervical Carcinoma Cells.

J. D.-C. Arce, U. Soto, J. van Riggelen, E. Schwarz, H. z. Hausen, and F. Rosl (2004)
J. Biol. Chem. 279, 45408-45416
 |  Abstract »  |  Full Text »  |  PDF »

Phosphorylation of p38 MAPK Induced by Oxidative Stress Is Linked to Activation of Both Caspase-8- and -9-mediated Apoptotic Pathways in Dopaminergic Neurons.

W.-S. Choi, D.-S. Eom, B. S. Han, W. K. Kim, B. H. Han, E.-J. Choi, T. H. Oh, G. J. Markelonis, J. W. Cho, and Y. J. Oh (2004)
J. Biol. Chem. 279, 20451-20460
 |  Abstract »  |  Full Text »  |  PDF »

Lipopolysaccharide Induces CYP2E1 in Astrocytes through MAP Kinase Kinase-3 and C/EBP{beta} and -{delta}.

P. Kelicen and N. Tindberg (2004)
J. Biol. Chem. 279, 15734-15742
 |  Abstract »  |  Full Text »  |  PDF »

p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene.

W. Cao, K. W. Daniel, J. Robidoux, P. Puigserver, A. V. Medvedev, X. Bai, L. M. Floering, B. M. Spiegelman, and S. Collins (2004)
Mol. Cell. Biol. 24, 3057-3067
 |  Abstract »  |  Full Text »  |  PDF »

Docking Interactions in the c-Jun N-terminal Kinase Pathway.

L. M. Mooney and A. J. Whitmarsh (2004)
J. Biol. Chem. 279, 11843-11852
 |  Abstract »  |  Full Text »  |  PDF »

Mitotic Aberration Coupled With Centrosome Amplification Is Induced by Hepatitis B Virus X Oncoprotein via the Ras-Mitogen-Activated Protein/Extracellular Signal-Regulated Kinase-Mitogen-Activated Protein Pathway.

C. Yun, H. Cho, S.-J. Kim, J.-H. Lee, S. Y. Park, G. K. Chan, and H. Cho (2004)
Mol. Cancer Res. 2, 159-169
 |  Abstract »  |  Full Text »  |  PDF »

Toxoplasma gondii Interferes with Lipopolysaccharide-Induced Mitogen-Activated Protein Kinase Activation by Mechanisms Distinct from Endotoxin Tolerance.

L. Kim, B. A. Butcher, and E. Y. Denkers (2004)
J. Immunol. 172, 3003-3010
 |  Abstract »  |  Full Text »  |  PDF »

Altered Mitogen-Activated Protein Kinase Signal Transduction in Human Skin Fibroblasts During In Vitro Aging: Differential Expression of Low-Density Lipoprotein Receptor.

C. Bose, C. Bhuvaneswaran, and K. B. Udupa (2004)
J. Gerontol. A Biol. Sci. Med. Sci. 59, B126-135
 |  Abstract »  |  Full Text »  |  PDF »

Anthocyanidins inhibit activator protein 1 activity and cell transformation: structure-activity relationship and molecular mechanisms.

D.-X. Hou, K. Kai, J.-J. Li, S. Lin, N. Terahara, M. Wakamatsu, M. Fujii, M. R. Young, and N. Colburn (2004)
Carcinogenesis 25, 29-36
 |  Abstract »  |  Full Text »  |  PDF »

Expression and Activation of Mitogen-Activated Protein Kinase Kinases-3 and -6 in Rheumatoid Arthritis.

M. Chabaud-Riou and G. S. Firestein (2004)
Am. J. Pathol. 164, 177-184
 |  Abstract »  |  Full Text »  |  PDF »

A critical role of neural-specific JNK3 for ischemic apoptosis.

C.-Y. Kuan, A. J. Whitmarsh, D. D. Yang, G. Liao, A. J. Schloemer, C. Dong, J. Bao, K. J. Banasiak, G. G. Haddad, R. A. Flavell, et al. (2003)
PNAS 100, 15184-15189
 |  Abstract »  |  Full Text »  |  PDF »

Serine/Threonine Kinase Mirk/Dyrk1B Is an Inhibitor of Epithelial Cell Migration and Is Negatively Regulated by the Met Adaptor Ran-binding Protein M.

Y. Zou, S. Lim, K. Lee, X. Deng, and E. Friedman (2003)
J. Biol. Chem. 278, 49573-49581
 |  Abstract »  |  Full Text »  |  PDF »

Subdomain VIII Is a Specificity-determining Region in MEKK1.

Z. Tu and F. S. Lee (2003)
J. Biol. Chem. 278, 48498-48505
 |  Abstract »  |  Full Text »  |  PDF »

The Death Domain Kinase RIP1 Is Essential for Tumor Necrosis Factor Alpha Signaling to p38 Mitogen-Activated Protein Kinase.

T. H. Lee, Q. Huang, S. Oikemus, J. Shank, J.-J. Ventura, N. Cusson, R. R. Vaillancourt, B. Su, R. J. Davis, and M. A. Kelliher (2003)
Mol. Cell. Biol. 23, 8377-8385
 |  Abstract »  |  Full Text »  |  PDF »

Exploiting features of adenovirus replication to support mammalian kinase production.

M. Cotten, K. Stegmueller, J. Eickhoff, M. Hanke, K. Herzberger, T. Herget, A. Choidas, H. Daub, and K. Godl (2003)
Nucleic Acids Res. 31, e128
 |  Abstract »  |  Full Text »  |  PDF »

Mirk/dyrk1B Is a Rho-induced Kinase Active in Skeletal Muscle Differentiation.

X. Deng, D. Z. Ewton, B. Pawlikowski, M. Maimone, and E. Friedman (2003)
J. Biol. Chem. 278, 41347-41354
 |  Abstract »  |  Full Text »  |  PDF »

Speed kills: cellular and molecular bases of methamphetamine-induced nerve terminal degeneration and neuronal apoptosis.

J. L. CADET, S. JAYANTHI, and X. DENG (2003)
FASEB J 17, 1775-1788
 |  Abstract »  |  Full Text »  |  PDF »

Viral Induction of Inflammatory Cytokines in Human Epithelial Cells Follows a p38 Mitogen-Activated Protein Kinase-Dependent but NF-{kappa}B-Independent Pathway.

T. R. Meusel and F. Imani (2003)
J. Immunol. 171, 3768-3774
 |  Abstract »  |  Full Text »  |  PDF »

PEA3 Transactivates the Muc4/Sialomucin Complex Promoter in Mammary Epithelial and Tumor Cells.

A. Perez, R. Barco, I. Fernandez, S. A. Price-Schiavi, and K. L. Carraway (2003)
J. Biol. Chem. 278, 36942-36952
 |  Abstract »  |  Full Text »  |  PDF »

A Regulatory Role for p38{delta} MAPK in Keratinocyte Differentiation: EVIDENCE FOR p38{delta}-ERK1/2 COMPLEX FORMATION.

T. Efimova, A.-M. Broome, and R. L. Eckert (2003)
J. Biol. Chem. 278, 34277-34285
 |  Abstract »  |  Full Text »  |  PDF »

p38 Kinase Is a Key Signaling Molecule for H-Ras-induced Cell Motility and Invasive Phenotype in Human Breast Epithelial Cells.

M.-S. Kim, E.-J. Lee, H.-R. C. Kim, and A. Moon (2003)
Cancer Res. 63, 5454-5461
 |  Abstract »  |  Full Text »  |  PDF »

Synergistic antileukemic interactions between 17-AAG and UCN-01 involve interruption of RAF/MEK- and AKT-related pathways.

W. Jia, C. Yu, M. Rahmani, G. Krystal, E. A. Sausville, P. Dent, and S. Grant (2003)
Blood 102, 1824-1832
 |  Abstract »  |  Full Text »  |  PDF »

Hepatitis C Virus NS5A Protein Modulates c-Jun N-terminal Kinase through Interaction with Tumor Necrosis Factor Receptor-associated Factor 2.

K.-J. Park, S.-H. Choi, D.-H. Choi, J.-M. Park, S. W. Yie, S. Y. Lee, and S. B. Hwang (2003)
J. Biol. Chem. 278, 30711-30718
 |  Abstract »  |  Full Text »  |  PDF »

Mechanism of p38 MAP kinase activation in vivo.

D. Brancho, N. Tanaka, A. Jaeschke, J.-J. Ventura, N. Kelkar, Y. Tanaka, M. Kyuuma, T. Takeshita, R. A. Flavell, and R. J. Davis (2003)
Genes & Dev. 17, 1969-1978
 |  Abstract »  |  Full Text »  |  PDF »

cFLIP-L Inhibits p38 MAPK Activation: AN ADDITIONAL ANTI-APOPTOTIC MECHANISM IN BILE ACID-MEDIATED APOPTOSIS.

A. Grambihler, H. Higuchi, S. F. Bronk, and G. J. Gores (2003)
J. Biol. Chem. 278, 26831-26837
 |  Abstract »  |  Full Text »  |  PDF »

The Osmoregulatory and the Amino Acid-regulated Responses of System A Are Mediated by Different Signal Transduction Pathways.

M. Lopez-Fontanals, S. Rodriguez-Mulero, F. J. Casado, B. Derijard, and M. Pastor-Anglada (2003)
J. Gen. Physiol. 122, 5-16
 |  Abstract »  |  Full Text »  |  PDF »

c-Jun NH2-Terminal Kinase-Mediated Signaling Is Essential for Pseudomonas aeruginosa ExoS-Induced Apoptosis.

J. Jia, M. Alaoui-El-Azher, M. Chow, T. C. Chambers, H. Baker, and S. Jin (2003)
Infect. Immun. 71, 3361-3370
 |  Abstract »  |  Full Text »  |  PDF »

TNF-induced death of adult human oligodendrocytes is mediated by c-jun NH2-terminal kinase-3.

A. Jurewicz, M. Matysiak, K. Tybor, and K. Selmaj (2003)
Brain 126, 1358-1370
 |  Abstract »  |  Full Text »  |  PDF »

p38{alpha} Isoform Mxi2 Binds to Extracellular Signal-Regulated Kinase 1 and 2 Mitogen-Activated Protein Kinase and Regulates Its Nuclear Activity by Sustaining Its Phosphorylation Levels.

V. Sanz-Moreno, B. Casar, and P. Crespo (2003)
Mol. Cell. Biol. 23, 3079-3090
 |  Abstract »  |  Full Text »  |  PDF »

The lectin jacalin induces phosphorylation of ERK and JNK in CD4+ T cells.

S. M. L. Tamma, V. S. Kalyanaraman, S. Pahwa, P. Dominguez, and R. R. Modesto (2003)
J. Leukoc. Biol. 73, 682-688
 |  Abstract »  |  Full Text »  |  PDF »

Convergence of CpG DNA- and BCR-mediated signals at the c-Jun N-terminal kinase and NF-{kappa}B activation pathways: regulation by mitogen-activated protein kinases.

A.-K. Yi, J.-G. Yoon, and A. M. Krieg (2003)
Int. Immunol. 15, 577-591
 |  Abstract »  |  Full Text »  |  PDF »

Hypertonicity-induced Aquaporin-1 (AQP1) Expression Is Mediated by the Activation of MAPK Pathways and Hypertonicity-responsive Element in the AQP1 Gene.

F. Umenishi and R. W. Schrier (2003)
J. Biol. Chem. 278, 15765-15770
 |  Abstract »  |  Full Text »  |  PDF »

Connective Tissue Growth Factor Gene Regulation. REQUIREMENTS FOR ITS INDUCTION BY TRANSFORMING GROWTH FACTOR-beta 2 IN FIBROBLASTS.

A. Leask, A. Holmes, C. M. Black, and D. J. Abraham (2003)
J. Biol. Chem. 278, 13008-13015
 |  Abstract »  |  Full Text »  |  PDF »

Complex Regulation of the Fibroblast Growth Factor-binding Protein in MDA- MB-468 Breast Cancer Cells by CCAAT/Enhancer-binding Protein {beta}.

B. L. Kagan, R. T. Henke, R. Cabal-Manzano, G. E. Stoica, Q. Nguyen, A. Wellstein, and A. T. Riegel (2003)
Cancer Res. 63, 1696-1705
 |  Abstract »  |  Full Text »  |  PDF »

Three Mitogen-Activated Protein Kinases Inhibit Insulin Signaling by Different Mechanisms in 3T3-L1 Adipocytes.

M. Fujishiro, Y. Gotoh, H. Katagiri, H. Sakoda, T. Ogihara, M. Anai, Y. Onishi, H. Ono, M. Abe, N. Shojima, et al. (2003)
Mol. Endocrinol. 17, 487-497
 |  Abstract »  |  Full Text »  |  PDF »

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