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Science 23 December 1994:
Vol. 266. no. 5193, pp. 1999 - 2002
DOI: 10.1126/science.266.5193.1999
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Articles

Trans-Acting Dosage Effects on the Expression of Model Gene Systems in Maize Aneuploids

Mei Guo 1 and James A. Birchler 1

1 Division of Biological Sciences, University of Missouri, Columbia, MO 6521 1, USA.

The reduction in vigor of aneuploids was classically thought to be due to the imbalance of gene products expressed from the varied chromosome relative to those from the remainder of the genome. In this study, the dosage of chromosomal segments was varied, but the transcript level of most genes encoded therein showed compensation for the number of copies of the gene. Genes whose dosage was not altered were affected by aneuploidy of unlinked chromosomal segments. The phenotypic effects of aneuploidy and of a substantial fraction of quantitative variation are hypothesized to be the consequence of an altered dosage-sensitive regulatory system.

Submitted on April 19, 1994
Accepted on October 3, 1994


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