Science 16 December 1994: Vol. 266. no. 5192, pp. 1821 - 1828 DOI: 10.1126/science.7997877

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Articles

Safeguarding Entry into Mitosis: the Antephase Checkpoint.

C. F. Chin and F. M. Yeong (2010)
Mol. Cell. Biol. 30, 22-32
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced DNA binding capacity on up-regulated epidermal wild-type p53 in vitiligo by H2O2-mediated oxidation: a possible repair mechanism for DNA damage.

M. M. A. E. L. Salem, M. Shalbaf, N. C. J. Gibbons, B. Chavan, J. M. Thornton, and K. U. Schallreuter (2009)
FASEB J 23, 3790-3807
 |  Abstract »  |  Full Text »  |  PDF »

The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks.

C. E. Bansbach, R. Betous, C. A. Lovejoy, G. G. Glick, and D. Cortez (2009)
Genes & Dev. 23, 2405-2414
 |  Abstract »  |  Full Text »  |  PDF »

Reduced p16 and Increased Cyclin D1 and pRb Expression Are Correlated With Progression in Cutaneous Melanocytic Tumors.

R. Z. Karim, W. Li, A. Sanki, M. H. Colman, Y. H. Yang, J. F. Thompson, and R. A. Scolyer (2009)
International Journal of Surgical Pathology 17, 361-367
 |  Abstract »  |  PDF »

Are nicotine replacement therapy, varenicline or bupropion options for pregnant mothers to quit smoking? Effects on the respiratory system of the offspring.

G. S. Maritz (2009)
Therapeutic Advances in Respiratory Disease 3, 193-210
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Reconstitution of Rad53 Activation by Mec1 through Adaptor Protein Mrc1.

S.-h. Chen and H. Zhou (2009)
J. Biol. Chem. 284, 18593-18604
 |  Abstract »  |  Full Text »  |  PDF »

Cancer Preventive Isothiocyanates Induce Selective Degradation of Cellular {alpha}- and {beta}-Tubulins by Proteasomes.

L. Mi, N. Gan, A. Cheema, S. Dakshanamurthy, X. Wang, D. C. H. Yang, and F.-L. Chung (2009)
J. Biol. Chem. 284, 17039-17051
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Cdk2 and Cdk4 Activities Are Dispensable for Tumorigenesis Caused by the Loss of p53.

V. C. Padmakumar, E. Aleem, C. Berthet, M. B. Hilton, and P. Kaldis (2009)
Mol. Cell. Biol. 29, 2582-2593
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Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate.

J. D. Orth, Y. Tang, J. Shi, C. T. Loy, C. Amendt, C. Wilm, F. T. Zenke, and T. J. Mitchison (2008)
Mol. Cancer Ther. 7, 3480-3489
 |  Abstract »  |  Full Text »  |  PDF »

CDK Inhibitor p21 Is Degraded by a Proliferating Cell Nuclear Antigen-coupled Cul4-DDB1Cdt2 Pathway during S Phase and after UV Irradiation.

H. Nishitani, Y. Shiomi, H. Iida, M. Michishita, T. Takami, and T. Tsurimoto (2008)
J. Biol. Chem. 283, 29045-29052
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A Dietary Anthocyanidin Delphinidin Induces Apoptosis of Human Prostate Cancer PC3 Cells In vitro and In vivo: Involvement of Nuclear Factor-{kappa}B Signaling.

B. B. Hafeez, I. A. Siddiqui, M. Asim, A. Malik, F. Afaq, V. M. Adhami, M. Saleem, M. Din, and H. Mukhtar (2008)
Cancer Res. 68, 8564-8572
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Chk2 Ubiquitination and Signaling through Autophosphorylation of Serine 379.

C. M. Lovly, L. Yan, C. E. Ryan, S. Takada, and H. Piwnica-Worms (2008)
Mol. Cell. Biol. 28, 5874-5885
 |  Abstract »  |  Full Text »  |  PDF »

Separate roles for the DNA damage checkpoint protein kinases in stabilizing DNA replication forks.

M. Segurado and J. F.X. Diffley (2008)
Genes & Dev. 22, 1816-1827
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Phosphatases Mediate the Deactivation of the DNA Damage Checkpoint Kinase Rad53.

A. Travesa, A. Duch, and D. G. Quintana (2008)
J. Biol. Chem. 283, 17123-17130
 |  Abstract »  |  Full Text »  |  PDF »

Cdk5-mediated Phosphorylation of c-Myc on Ser-62 Is Essential in Transcriptional Activation of Cyclin B1 by Cyclin G1.

H. R. Seo, J. Kim, S. Bae, J.-W. Soh, and Y.-S. Lee (2008)
J. Biol. Chem. 283, 15601-15610
 |  Abstract »  |  Full Text »  |  PDF »

An Oncogene-Induced DNA Damage Model for Cancer Development.

T. D. Halazonetis, V. G. Gorgoulis, and J. Bartek (2008)
Science 319, 1352-1355
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Pathogenesis of Oral Squamous Cell Carcinoma: Implications for Therapy.

S. Choi and J.N. Myers (2008)
Journal of Dental Research 87, 14-32
 |  Abstract »  |  Full Text »  |  PDF »

ECRG1, a novel esophageal gene, cloned and identified from human esophagus and its inhibition effect on tumors.

W. Yueying, W. Jianbo, L. Hailin, T. Huaijing, G. Liping, and L. Shih-Hsin (2008)
Carcinogenesis 29, 157-160
 |  Abstract »  |  Full Text »  |  PDF »

p53 Gene and Protein Status: The Role of p53 Alterations in Predicting Outcome in Patients With Bladder Cancer.

B. George, R. H. Datar, L. Wu, J. Cai, N. Patten, S. J. Beil, S. Groshen, J. Stein, D. Skinner, P. A. Jones, et al. (2007)
J. Clin. Oncol. 25, 5352-5358
 |  Abstract »  |  Full Text »  |  PDF »

Msc1 Acts Through Histone H2A.Z to Promote Chromosome Stability in Schizosaccharomyces pombe.

S. Ahmed, B. Dul, X. Qiu, and N. C. Walworth (2007)
Genetics 177, 1487-1497
 |  Abstract »  |  Full Text »  |  PDF »

TAp73 Is a Downstream Target of p53 in Controlling the Cellular Defense against Stress.

J. Wang, Y.-X. Liu, M. P. Hande, A. C. Wong, Y. J. Jin, and Y. Yin (2007)
J. Biol. Chem. 282, 29152-29162
 |  Abstract »  |  Full Text »  |  PDF »

Phase I Dose-Finding Study of Weekly Docetaxel Followed by Flavopiridol for Patients with Advanced Solid Tumors.

M.N. Fornier, D. Rathkopf, M. Shah, S. Patil, E. O'Reilly, A.N. Tse, C. Hudis, R. Lefkowitz, D.P. Kelsen, and G.K. Schwartz (2007)
Clin. Cancer Res. 13, 5841-5846
 |  Abstract »  |  Full Text »  |  PDF »

The human checkpoint sensor Rad9 Rad1 Hus1 interacts with and stimulates DNA repair enzyme TDG glycosylase.

X. Guan, A. Madabushi, D.-Y. Chang, M. E. Fitzgerald, G. Shi, A. C. Drohat, and A-L. Lu (2007)
Nucleic Acids Res. 35, 6207-6218
 |  Abstract »  |  Full Text »  |  PDF »

BubR1 and APC/EB1 cooperate to maintain metaphase chromosome alignment.

J. Zhang, S. Ahmad, and Y. Mao (2007)
J. Cell Biol. 178, 773-784
 |  Abstract »  |  Full Text »  |  PDF »

Cdc18/CDC6 activates the Rad3-dependent checkpoint in the fission yeast.

N. Fersht, D. Hermand, J. Hayles, and P. Nurse (2007)
Nucleic Acids Res. 35, 5323-5337
 |  Abstract »  |  Full Text »  |  PDF »

A Molecular Link between E2F-1 and the MAPK Cascade.

J. Wang, W. H. Shen, Y. J. Jin, P. W. Brandt-Rauf, and Y. Yin (2007)
J. Biol. Chem. 282, 18521-18531
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Factor-{kappa}B and Manganese Superoxide Dismutase Mediate Adaptive Radioresistance in Low-Dose Irradiated Mouse Skin Epithelial Cells.

M. Fan, K. M. Ahmed, M. C. Coleman, D. R. Spitz, and J. J. Li (2007)
Cancer Res. 67, 3220-3228
 |  Abstract »  |  Full Text »  |  PDF »

Endoreduplication of human smooth muscle cells induced by 2-methoxyestradiol: a role for cyclin-dependent kinase 2.

Y. Gui, H. Yin, J.-Y. He, S.-H. Yang, M. P. Walsh, and X.-L. Zheng (2007)
Am J Physiol Heart Circ Physiol 292, H1313-H1320
 |  Abstract »  |  Full Text »  |  PDF »

Pathway-Specific Effect of Caffeine on Protection against UV Irradiation-Induced Apoptosis in Corneal Epithelial Cells.

L. Wang and L. Lu (2007)
Invest. Ophthalmol. Vis. Sci. 48, 652-660
 |  Abstract »  |  Full Text »  |  PDF »

Cell cycle phenotype-based optimization of G2-abrogating peptides yields CBP501 with a unique mechanism of action at the G2 checkpoint.

S.-K. Sha, T. Sato, H. Kobayashi, M. Ishigaki, S. Yamamoto, H. Sato, A. Takada, S. Nakajyo, Y. Mochizuki, J. M. Friedman, et al. (2007)
Mol. Cancer Ther. 6, 147-153
 |  Abstract »  |  Full Text »  |  PDF »

Hydrogen sulfide-induces DNA damage and changes in apoptotic gene expression in human lung fibroblast cells.

R. Baskar, L. Li, and P. K. Moore (2007)
FASEB J 21, 247-255
 |  Abstract »  |  Full Text »  |  PDF »

Cannabinoid Receptor Agonist-induced Apoptosis of Human Prostate Cancer Cells LNCaP Proceeds through Sustained Activation of ERK1/2 Leading to G1 Cell Cycle Arrest.

S. Sarfaraz, F. Afaq, V. M. Adhami, A. Malik, and H. Mukhtar (2006)
J. Biol. Chem. 281, 39480-39491
 |  Abstract »  |  Full Text »  |  PDF »

Nuclear Factor-{kappa}B p65 Inhibits Mitogen-Activated Protein Kinase Signaling Pathway in Radioresistant Breast Cancer Cells.

K. M. Ahmed, S. Dong, M. Fan, and J. J. Li (2006)
Mol. Cancer Res. 4, 945-955
 |  Abstract »  |  Full Text »  |  PDF »

Radiation clastogenesis and cell cycle checkpoint function as functional markers of breast cancer risk.

W. K. Kaufmann, L. Filatov, S. E. Oglesbee, D. A. Simpson, M. A. Lotano, H. D. McKeen, L. R. Sawyer, D. T. Moore, R. C. Millikan, M. Cordeiro-Stone, et al. (2006)
Carcinogenesis 27, 2519-2527
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Cell Cycle Progression in Human Tumors: A Pharmacokinetic and Tumor Molecular Pharmacodynamic Study of Cisplatin Plus the Chk1 Inhibitor UCN-01 (NSC 638850).

R. P. Perez, L. D. Lewis, A. P. Beelen, A. J. Olszanski, N. Johnston, C. H. Rhodes, B. Beaulieu, M. S. Ernstoff, and A. Eastman (2006)
Clin. Cancer Res. 12, 7079-7085
 |  Abstract »  |  Full Text »  |  PDF »

Limiting amounts of budding yeast Rad53 S-phase checkpoint activity results in increased resistance to DNA alkylation damage.

V. Cordon-Preciado, S. Ufano, and A. Bueno (2006)
Nucleic Acids Res. 34, 5852-5862
 |  Abstract »  |  Full Text »  |  PDF »

Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak..

D. Xiao, V. Vogel, and S. V. Singh (2006)
Mol. Cancer Ther. 5, 2931-2945
 |  Abstract »  |  Full Text »  |  PDF »

Chk1- and Claspin-Dependent but ATR/ATM- and Rad17-Independent DNA Replication Checkpoint Response in HeLa Cells..

V. Rodriguez-Bravo, S. Guaita-Esteruelas, R. Florensa, O. Bachs, and N. Agell (2006)
Cancer Res. 66, 8672-8679
 |  Abstract »  |  Full Text »  |  PDF »

Differential roles of checkpoint kinase 1, checkpoint kinase 2, and mitogen-activated protein kinase-activated protein kinase 2 in mediating DNA damage-induced cell cycle arrest: implications for cancer therapy..

Z. Xiao, J. Xue, T. J. Sowin, and H. Zhang (2006)
Mol. Cancer Ther. 5, 1935-1943
 |  Abstract »  |  Full Text »  |  PDF »

p53 Transgenic Mice Are Highly Susceptible to 4-Nitroquinoline-1-Oxide-Induced Oral Cancer.

Z. Zhang, Y. Wang, R. Yao, R. A. Lubet, and M. You (2006)
Mol. Cancer Res. 4, 401-410
 |  Abstract »  |  Full Text »  |  PDF »

Loss of p53 impedes the antileukemic response to BCR-ABL inhibition.

H.-G. Wendel, E. de Stanchina, E. Cepero, S. Ray, M. Emig, J. S. Fridman, D. R. Veach, W. G. Bornmann, B. Clarkson, W. R. McCombie, et al. (2006)
PNAS 103, 7444-7449
 |  Abstract »  |  Full Text »  |  PDF »

Mammalian rad9 plays a role in telomere stability, s- and g2-phase-specific cell survival, and homologous recombinational repair..

R. K. Pandita, G. G. Sharma, A. Laszlo, K. M. Hopkins, S. Davey, M. Chakhparonian, A. Gupta, R. J. Wellinger, J. Zhang, S. N. Powell, et al. (2006)
Mol. Cell. Biol. 26, 1850-1864
 |  Abstract »  |  Full Text »  |  PDF »

Targeting the Cell Cycle: A New Approach to Cancer Therapy.

G. K. Schwartz and M. A. Shah (2005)
J. Clin. Oncol. 23, 9408-9421
 |  Abstract »  |  Full Text »  |  PDF »

Glutathione S-Transferase {pi}1 Promotes Tumorigenicity in HCT116 Human Colon Cancer Cells.

D. T. Dang, F. Chen, M. Kohli, C. Rago, J. M. Cummins, and L. H. Dang (2005)
Cancer Res. 65, 9485-9494
 |  Abstract »  |  Full Text »  |  PDF »

Less Efficient G2-M Checkpoint Is Associated with an Increased Risk of Lung Cancer in African Americans.

Y.-L. Zheng, C. A. Loffredo, A. J. Alberg, Z. Yu, R. T. Jones, D. Perlmutter, L. Enewold, M. J. Krasna, R. Yung, P. G. Shields, et al. (2005)
Cancer Res. 65, 9566-9573
 |  Abstract »  |  Full Text »  |  PDF »

Recombination Regulation by Transcription-Induced Cohesin Dissociation in rDNA Repeats.

T. Kobayashi and A. R. D. Ganley (2005)
Science 309, 1581-1584
 |  Abstract »  |  Full Text »  |  PDF »

Pituitary Hypoplasia in Pttg-/- Mice Is Protective for Rb+/- Pituitary Tumorigenesis.

V. Chesnokova, K. Kovacs, A.-V. Castro, S. Zonis, and S. Melmed (2005)
Mol. Endocrinol. 19, 2371-2379
 |  Abstract »  |  Full Text »  |  PDF »

Persistent Nicotine Treatment Potentiates Amplification of the Dihydrofolate Reductase Gene in Rat Lung Epithelial Cells as a Consequence of Ras Activation.

J. Guo, M. Chu, T. Abbeyquaye, and C.-Y. Chen (2005)
J. Biol. Chem. 280, 30422-30431
 |  Abstract »  |  Full Text »  |  PDF »

Gamma Interferon-Inducible Protein 10 Induces HeLa Cell Apoptosis through a p53-Dependent Pathway Initiated by Suppression of Human Papillomavirus Type 18 E6 and E7 Expression.

H. M. Zhang, J. Yuan, P. Cheung, D. Chau, B. W. Wong, B. M. McManus, and D. Yang (2005)
Mol. Cell. Biol. 25, 6247-6258
 |  Abstract »  |  Full Text »  |  PDF »

ER{beta} is a potent inhibitor of cell proliferation in the HCT8 human colon cancer cell line through regulation of cell cycle components.

V. Martineti, L. Picariello, I. Tognarini, S. C. Sala, A. Gozzini, C. Azzari, C. Mavilia, A. Tanini, A. Falchetti, G. Fiorelli, et al. (2005)
Endocr. Relat. Cancer 12, 455-469
 |  Abstract »  |  Full Text »  |  PDF »

Curcumin Selectively Induces Apoptosis in Deregulated Cyclin D1-expressed Cells at G2 Phase of Cell Cycle in a p53-dependent Manner.

T. Choudhuri, S. Pal, T. Das, and G. Sa (2005)
J. Biol. Chem. 280, 20059-20068
 |  Abstract »  |  Full Text »  |  PDF »

A Phase I Clinical Trial of the Sequential Combination of Irinotecan Followed by Flavopiridol.

M. A. Shah, J. Kortmansky, M. Motwani, M. Drobnjak, M. Gonen, S. Yi, A. Weyerbacher, C. Cordon-Cardo, R. Lefkowitz, B. Brenner, et al. (2005)
Clin. Cancer Res. 11, 3836-3845
 |  Abstract »  |  Full Text »  |  PDF »

Acacetin inhibits cell growth and cell cycle progression, and induces apoptosis in human prostate cancer cells: structure-activity relationship with linarin and linarin acetate.

R. P. Singh, P. Agrawal, D. Yim, C. Agarwal, and R. Agarwal (2005)
Carcinogenesis 26, 845-854
 |  Abstract »  |  Full Text »  |  PDF »

Co-activation of ERK, NF-{kappa}B, and GADD45{beta} in Response to Ionizing Radiation.

T. Wang, Y.-C. Hu, S. Dong, M. Fan, D. Tamae, M. Ozeki, Q. Gao, D. Gius, and J. J. Li (2005)
J. Biol. Chem. 280, 12593-12601
 |  Abstract »  |  Full Text »  |  PDF »

Tirapazamine Cytotoxicity for Neuroblastoma Is p53 Dependent.

B. Yang and C. P. Reynolds (2005)
Clin. Cancer Res. 11, 2774-2780
 |  Abstract »  |  Full Text »  |  PDF »

B23 Regulates GADD45a Nuclear Translocation and Contributes to GADD45a-induced Cell Cycle G2-M Arrest.

H. Gao, S. Jin, Y. Song, M. Fu, M. Wang, Z. Liu, M. Wu, and Q. Zhan (2005)
J. Biol. Chem. 280, 10988-10996
 |  Abstract »  |  Full Text »  |  PDF »

TTK/hMps1 Participates in the Regulation of DNA Damage Checkpoint Response by Phosphorylating CHK2 on Threonine 68.

J.-H. Wei, Y.-F. Chou, Y.-H. Ou, Y.-H. Yeh, S.-W. Tyan, T.-P. Sun, C.-Y. Shen, and S.-Y. Shieh (2005)
J. Biol. Chem. 280, 7748-7757
 |  Abstract »  |  Full Text »  |  PDF »

Bax and Bak Are Required for Apoptosis Induction by Sulforaphane, a Cruciferous Vegetable-Derived Cancer Chemopreventive Agent.

S. Choi and S. V. Singh (2005)
Cancer Res. 65, 2035-2043
 |  Abstract »  |  Full Text »  |  PDF »

A Spindle Checkpoint Functions during Mitosis in the Early Caenorhabditis elegans Embryo.

S. E. Encalada, J. Willis, R. Lyczak, and B. Bowerman (2005)
Mol. Biol. Cell 16, 1056-1070
 |  Abstract »  |  Full Text »  |  PDF »

Methylator-induced, Mismatch Repair-dependent G2 Arrest Is Activated through Chk1 and Chk2.

A. W. Adamson, D. I. Beardsley, W.-J. Kim, Y. Gao, R. Baskaran, and K. D. Brown (2005)
Mol. Biol. Cell 16, 1513-1526
 |  Abstract »  |  Full Text »  |  PDF »

Calcium Sensing Receptor in Human Colon Carcinoma: Interaction with Ca2+ and 1,25-Dihydroxyvitamin D3.

S. Chakrabarty, H. Wang, L. Canaff, G. N. Hendy, H. Appelman, and J. Varani (2005)
Cancer Res. 65, 493-498
 |  Abstract »  |  Full Text »  |  PDF »

Prognostic Implications of Molecular and Immunohistochemical Profiles of the Rb and p53 Cell Cycle Regulatory Pathways in Primary Non-Small Cell Lung Carcinoma.

L. Burke, D. B. Flieder, D. G. Guinee, E. Brambilla, A. N. Freedman, W. P. Bennett, R. T. Jones, A. Borkowski, N. A. Caporaso, M. Fleming, et al. (2005)
Clin. Cancer Res. 11, 232-241
 |  Abstract »  |  Full Text »  |  PDF »

Hsp90 Regulates the Activity of Wild Type p53 under Physiological and Elevated Temperatures.

L. Muller, A. Schaupp, D. Walerych, H. Wegele, and J. Buchner (2004)
J. Biol. Chem. 279, 48846-48854
 |  Abstract »  |  Full Text »  |  PDF »

DNA Replication Checkpoint Control Mediated by the Spindle Checkpoint Protein Mad2p in Fission Yeast.

I. Sugimoto, H. Murakami, Y. Tonami, A. Moriyama, and M. Nakanishi (2004)
J. Biol. Chem. 279, 47372-47378
 |  Abstract »  |  Full Text »  |  PDF »

PTEN Gene Targeting Reveals a Radiation-Induced Size Checkpoint in Human Cancer Cells.

C. Lee, J.-S. Kim, and T. Waldman (2004)
Cancer Res. 64, 6906-6914
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Chk1 by the G2 DNA damage checkpoint inhibitor isogranulatimide.

X. Jiang, B. Zhao, R. Britton, L. Y. Lim, D. Leong, J. S. Sanghera, B.-B. S. Zhou, E. Piers, R. J. Andersen, and M. Roberge (2004)
Mol. Cancer Ther. 3, 1221-1227
 |  Abstract »  |  Full Text »  |  PDF »

Potentiation of Cytotoxicity of Topoisomerase I Poison by Concurrent and Sequential Treatment with the Checkpoint Inhibitor UCN-01 Involves Disparate Mechanisms Resulting in Either p53-Independent Clonogenic Suppression or p53-Dependent Mitotic Catastrophe.

A. N. Tse and G. K. Schwartz (2004)
Cancer Res. 64, 6635-6644
 |  Abstract »  |  Full Text »  |  PDF »

Cytokines in recurrent miscarriage.

H Carp (2004)
Lupus 13, 630-634
 |  Abstract »  |  PDF »

Enhanced expression of 14-3-3sigma in pancreatic cancer and its role in cell cycle regulation and apoptosis.

A. Guweidhi, J. Kleeff, N. Giese, J. E. Fitori, K. Ketterer, T. Giese, M. W. Buchler, M. Korc, and H. Friess (2004)
Carcinogenesis 25, 1575-1585
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Ras-Ral Pathway Attenuates p53-independent DNA Damage G2 Checkpoint.

L. S. Agapova, J. L. Volodina, P. M. Chumakov, and B. P. Kopnin (2004)
J. Biol. Chem. 279, 36382-36389
 |  Abstract »  |  Full Text »  |  PDF »

NPDC-1, a Novel Regulator of Neuronal Proliferation, Is Degraded by the Ubiquitin/Proteasome System through a PEST Degradation Motif.

M. L. Spencer, M. Theodosiou, and D. J. Noonan (2004)
J. Biol. Chem. 279, 37069-37078
 |  Abstract »  |  Full Text »  |  PDF »

Phase I and Pharmacokinetic Study of the Novel Oral Cell-Cycle Inhibitor Ro 31-7453 in Patients With Advanced Solid Tumors.

J. Dupont, B. Bienvenu, C. Aghajanian, S. Pezzulli, P. Sabbatini, P. Vongphrachanh, C. Chang, C. Perkell, K. Ng, S. Passe, et al. (2004)
J. Clin. Oncol. 22, 3366-3374
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of Mouse Rad9 Causes Abnormal Cellular Responses to DNA Damage, Genomic Instability, and Embryonic Lethality.

K. M. Hopkins, W. Auerbach, X. Y. Wang, M. P. Hande, H. Hang, D. J. Wolgemuth, A. L. Joyner, and H. B. Lieberman (2004)
Mol. Cell. Biol. 24, 7235-7248
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Interaction Partners and Substrates of the Cyclin A1-CDK2 Complex.

S. Diederichs, N. Baumer, P. Ji, S. K. Metzelder, G. E. Idos, T. Cauvet, W. Wang, M. Moller, S. Pierschalski, J. Gromoll, et al. (2004)
J. Biol. Chem. 279, 33727-33741
 |  Abstract »  |  Full Text »  |  PDF »

Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery.

V. M. Adhami, M. H. Aziz, S. R. Reagan-Shaw, M. Nihal, H. Mukhtar, and N. Ahmad (2004)
Mol. Cancer Ther. 3, 933-940
 |  Abstract »  |  Full Text »  |  PDF »

Sulforaphane-induced G2/M Phase Cell Cycle Arrest Involves Checkpoint Kinase 2-mediated Phosphorylation of Cell Division Cycle 25C.

S. V. Singh, A. Herman-Antosiewicz, A. V. Singh, K. L. Lew, S. K. Srivastava, R. Kamath, K. D. Brown, L. Zhang, and R. Baskaran (2004)
J. Biol. Chem. 279, 25813-25822
 |  Abstract »  |  Full Text »  |  PDF »

Chromatin Association of Rad17 Is Required for an Ataxia Telangiectasia and Rad-Related Kinase-Mediated S-Phase Checkpoint in Response to Low-Dose Ultraviolet Radiation.

R. Garg, S. Callens, D.-S. Lim, C. E. Canman, M. B. Kastan, and B. Xu (2004)
Mol. Cancer Res. 2, 362-369
 |  Abstract »  |  Full Text »  |  PDF »

p53 protein interacts specifically with the meiosis-specific mammalian RecA-like protein DMC1 in meiosis.

T. Habu, N. Wakabayashi, K. Yoshida, K. Yomogida, Y. Nishimune, and T. Morita (2004)
Carcinogenesis 25, 889-893
 |  Abstract »  |  Full Text »  |  PDF »

An Essential Role for the Saccharomyces cerevisiae DEAD-Box Helicase DHH1 in G1/S DNA-Damage Checkpoint Recovery.

M. Bergkessel and J. C. Reese (2004)
Genetics 167, 21-33
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Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells.

D. Xiao, C. S. Johnson, D. L. Trump, and S. V. Singh (2004)
Mol. Cancer Ther. 3, 567-576
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Reduced oocyte activation and first cleavage rate after ICSI with spermatozoa from a sterile mouse chromosome mutant.

E.B. Baart, G.W. van der Heijden, F.A. van der Hoeven, R. Bakker, T.G. Cooper, and P. de Boer (2004)
Hum. Reprod. 19, 1140-1147
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Recruitment of the Cell Cycle Checkpoint Kinase ATR to Chromatin during S-phase.

D. A. Dart, K. E. Adams, I. Akerman, and N. D. Lakin (2004)
J. Biol. Chem. 279, 16433-16440
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Double Strand Break Repair by Homologous Recombination Is Regulated by Cell Cycle-independent Signaling via ATM in Human Glioma Cells.

S. E. Golding, E. Rosenberg, A. Khalil, A. McEwen, M. Holmes, S. Neill, L. F. Povirk, and K. Valerie (2004)
J. Biol. Chem. 279, 15402-15410
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Human Checkpoint Protein hRad9 Functions as a Negative Coregulator To Repress Androgen Receptor Transactivation in Prostate Cancer Cells.

L. Wang, C.-L. Hsu, J. Ni, P.-H. Wang, S. Yeh, P. Keng, and C. Chang (2004)
Mol. Cell. Biol. 24, 2202-2213
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Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition.

Y. Arima, T. Hirota, C. Bronner, M. Mousli, T. Fujiwara, S.-i. Niwa, H. Ishikawa, and H. Saya (2004)
Genes Cells 9, 131-142
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Molecular Mechanisms of Toxic Chemicals.

W. E. Criss (2003)
Indoor and Built Environment 12, 395-399
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Expression of the cell cycle regulatory proteins p34cdc2, p21waf1, and p53 in node negative invasive ductal breast carcinoma.

H P Kourea, A K Koutras, C D Scopa, M N Marangos, E Tzoracoeleftherakis, D Koukouras, and H P Kalofonos (2003)
Mol. Pathol. 56, 328-335
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Inverse correlation between high level expression of cyclin E and proliferation index in transitional cell carcinoma of the bladder.

A A Khan, P D Abel, K S Chaudhary, Z Gulzar, G W H Stamp, and E-N Lalani (2003)
Mol. Pathol. 56, 353-361
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Alterations in p53 predict response to preoperative high dose chemotherapy in patients with gastric cancer.

F Bataille, P Rummele, W Dietmaier, D Gaag, F Klebl, A Reichle, P Wild, F Hofstadter, and A Hartmann (2003)
Mol. Pathol. 56, 286-292
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Caffeine Inhibits Checkpoint Responses without Inhibiting the Ataxia-Telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) Protein Kinases.

D. Cortez (2003)
J. Biol. Chem. 278, 37139-37145
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The Fission Yeast Rad32 (Mre11)-Rad50-Nbs1 Complex Is Required for the S-Phase DNA Damage Checkpoint.

C. Chahwan, T. M. Nakamura, S. Sivakumar, P. Russell, and N. Rhind (2003)
Mol. Cell. Biol. 23, 6564-6573
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Expression of Mammalian Paralogues of HRAD9 and Mrad9 Checkpoint Control Genes in Normal and Cancerous Testicular Tissue.

K. M. Hopkins, X. Wang, A. Berlin, H. Hang, H. M. Thaker, and H. B. Lieberman (2003)
Cancer Res. 63, 5291-5298
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Delineating the position of rad4+/cut5+ within the DNA-structure checkpoint pathways in Schizosaccharomyces pombe.

S. Harris, C. Kemplen, T. Caspari, C. Chan, H. D. Lindsay, M. Poitelea, A. M. Carr, and C. Price (2003)
J. Cell Sci. 116, 3519-3529
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ELG1, a yeast gene required for genome stability, forms a complex related to replication factor C.

S. Ben-Aroya, A. Koren, B. Liefshitz, R. Steinlauf, and M. Kupiec (2003)
PNAS 100, 9906-9911
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Induction of Apoptosis by Caffeine Is Mediated by the p53, Bax, and Caspase 3 Pathways.

Z. He, W.-Y. Ma, T. Hashimoto, A. M. Bode, C. S. Yang, and Z. Dong (2003)
Cancer Res. 63, 4396-4401
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CR6-interacting Factor 1 Interacts with Gadd45 Family Proteins and Modulates the Cell Cycle.

H. K. Chung, Y.-W. Yi, N.-C. Jung, D. Kim, J. M. Suh, H. Kim, K. C. Park, J. H. Song, D. W. Kim, E. S. Hwang, et al. (2003)
J. Biol. Chem. 278, 28079-28088
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