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Science 9 December 1994:
Vol. 266. no. 5191, pp. 1697 - 1702
DOI: 10.1126/science.7992053
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Articles

Science, Vol 266, Issue 5191, 1697-1702
Copyright © 1994 by American Association for the Advancement of Science

articles

Naturally occurring variation in bristle number and DNA polymorphisms at the scabrous locus of Drosophila melanogaster

C Lai, RF Lyman, AD Long, CH Langley, and TF Mackay

Center for Population Biology, University of California at Davis 95616.

The association between quantitative genetic variation in bristle number and molecular variation at a candidate neurogenic locus, scabrous, was examined in Drosophila melanogaster. Approximately 32 percent of the genetic variation in abdominal bristle number (21 percent for sternopleural bristle number) among 47 second chromosomes from a natural population was correlated with DNA sequence polymorphisms at this locus. Several polymorphic sites associated with large phenotypic effects occurred at intermediate frequency. Quantitative genetic variation in natural populations caused by alleles that have large effects at a few loci and that segregate at intermediate frequencies conflicts with the classical infinitesimal model of the genetic basis of quantitative variation.


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