Science 2 December 1994: Vol. 266. no. 5190, pp. 1576 - 1578 DOI: 10.1126/science.7527156

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Articles

The Phosphotyrosine Interactome of the Insulin Receptor Family and Its Substrates IRS-1 and IRS-2.

S. Hanke and M. Mann (2009)
Mol. Cell. Proteomics 8, 519-534
 |  Abstract »  |  Full Text »  |  PDF »

Macrophage 3 Integrin Suppresses Hyperlipidemia-Induced Inflammation by Modulating TNF{alpha} Expression.

J. G. Schneider, Y. Zhu, T. Coleman, and C. F. Semenkovich (2007)
Arterioscler Thromb Vasc Biol 27, 2699-2706
 |  Abstract »  |  Full Text »  |  PDF »

Substrate Matters: Reciprocally Stimulatory Integrin and VEGF Signaling in Endothelial Cells.

E. Brakenhielm (2007)
Circ. Res. 101, 536-538
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The Role of the IGF System in Cancer Growth and Metastasis: Overview and Recent Insights.

A. A. Samani, S. Yakar, D. LeRoith, and P. Brodt (2007)
Endocr. Rev. 28, 20-47
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Insulin Receptor Substrate 1 (IRS-1) Promotes Mammary Tumor Metastasis.

Z. Ma, S. L. Gibson, M. A. Byrne, J. Zhang, M. F. White, and L. M. Shaw (2006)
Mol. Cell. Biol. 26, 9338-9351
 |  Abstract »  |  Full Text »  |  PDF »

Inductive mechanisms limiting response to anti-epidermal growth factor receptor therapy.

I. R Hutcheson, J. M Knowlden, H. E Jones, R. S Burmi, R. A McClelland, D. Barrow, J. M W Gee, and R. I Nicholson (2006)
Endocr. Relat. Cancer 13, S89-S97
 |  Abstract »  |  Full Text »  |  PDF »

Epidermal Growth Factor Induces Insulin Receptor Substrate-2 in Breast Cancer Cells via c-Jun NH2-Terminal Kinase/Activator Protein-1 Signaling to Regulate Cell Migration..

X. Cui, H.-J. Kim, I. Kuiatse, H. Kim, P. H. Brown, and A. V. Lee (2006)
Cancer Res. 66, 5304-5313
 |  Abstract »  |  Full Text »  |  PDF »

The Heparin Binding Domain of Vitronectin Is the Region that Is Required to Enhance Insulin-Like Growth Factor-I Signaling.

L. A. Maile, W. H. Busby, K. Sitko, B. E. Capps, T. Sergent, J. Badley-Clarke, Y. Ling, and D. R. Clemmons (2006)
Mol. Endocrinol. 20, 881-892
 |  Abstract »  |  Full Text »  |  PDF »

Downregulation of IRS-1 Expression Causes Inhibition of Corneal Angiogenesis.

M. Berdugo, C. Andrieu-Soler, M. Doat, Y. Courtois, D. BenEzra, and F. Behar-Cohen (2005)
Invest. Ophthalmol. Vis. Sci. 46, 4072-4078
 |  Abstract »  |  Full Text »  |  PDF »

{beta}1A Integrin Expression Is Required for Type 1 Insulin-Like Growth Factor Receptor Mitogenic and Transforming Activities and Localization to Focal Contacts.

H. L. Goel, M. Breen, J. Zhang, I. Das, S. Aznavoorian-Cheshire, N. M. Greenberg, A. Elgavish, and L. R. Languino (2005)
Cancer Res. 65, 6692-6700
 |  Abstract »  |  Full Text »  |  PDF »

Integrin Activates Receptor-Like Protein Tyrosine Phosphatase {alpha}, Src, and Rho to Increase Prolactin Gene Expression through a Final Phosphatidylinositol 3-Kinase/Cytoskeletal Pathway that Is Additive with Insulin.

A. I. Vulin, K. K. Jacob, and F. M. Stanley (2005)
Endocrinology 146, 3535-3546
 |  Abstract »  |  Full Text »  |  PDF »

{beta}1 integrin and IL-3R coordinately regulate STAT5 activation and anchorage-dependent proliferation.

P. Defilippi, A. Rosso, P. Dentelli, C. Calvi, G. Garbarino, G. Tarone, L. Pegoraro, and M. F. Brizzi (2005)
J. Cell Biol. 168, 1099-1108
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Mechanisms Underlying the Proangiogenic Effect of Factor XIII.

R. Dardik, J. Loscalzo, R. Eskaraev, and A. Inbal (2005)
Arterioscler Thromb Vasc Biol 25, 526-532
 |  Abstract »  |  Full Text »  |  PDF »

DOK1 Mediates SHP-2 Binding to the {alpha}V{beta}3 Integrin and Thereby Regulates Insulin-like Growth Factor I Signaling in Cultured Vascular Smooth Muscle Cells.

Y. Ling, L. A. Maile, J. Badley-Clarke, and D. R. Clemmons (2005)
J. Biol. Chem. 280, 3151-3158
 |  Abstract »  |  Full Text »  |  PDF »

Identification and modulation of a caveolae-dependent signal pathway that regulates plasminogen activator inhibitor-1 in insulin-resistant adipocytes.

J. Venugopal, K. Hanashiro, Z.-Z. Yang, and Y. Nagamine (2004)
PNAS 101, 17120-17125
 |  Abstract »  |  Full Text »  |  PDF »

{alpha}v{beta}3 Integrin Interacts with the Transforming Growth Factor {beta} (TGF{beta}) Type II Receptor to Potentiate the Proliferative Effects of TGF{beta}1 in Living Human Lung Fibroblasts.

A. K. Scaffidi, N. Petrovic, Y. P. Moodley, M. Fogel-Petrovic, K. M. Kroeger, R. M. Seeber, K. A. Eidne, P. J. Thompson, and D. A. Knight (2004)
J. Biol. Chem. 279, 37726-37733
 |  Abstract »  |  Full Text »  |  PDF »

p130Cas-associated Protein (p140Cap) as a New Tyrosine-phosphorylated Protein Involved in Cell Spreading.

P. Di Stefano, S. Cabodi, E. B. Erba, V. Margaria, E. Bergatto, M. G. Giuffrida, L. Silengo, G. Tarone, E. Turco, and P. Defilippi (2004)
Mol. Biol. Cell 15, 787-800
 |  Abstract »  |  Full Text »  |  PDF »

The Pattern of Enhancement of Src Kinase Activity on Platelet-derived Growth Factor Stimulation of Glioblastoma Cells Is Affected by the Integrin Engaged.

Q. Ding, J. Stewart Jr., M. A. Olman, M. R. Klobe, and C. L. Gladson (2003)
J. Biol. Chem. 278, 39882-39891
 |  Abstract »  |  Full Text »  |  PDF »

Tyrosine Phosphorylation of the {beta}3-Subunit of the {alpha}V{beta}3 Integrin Is Required for Membrane Association of the Tyrosine Phosphatase SHP-2 and Its Further Recruitment to the Insulin-Like Growth Factor I Receptor.

Y. Ling, L. A. Maile, and D. R. Clemmons (2003)
Mol. Endocrinol. 17, 1824-1833
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-Like Growth Factor-II Bound to Vitronectin Enhances MCF-7 Breast Cancer Cell Migration.

A. Noble, C. Towne, L. Chopin, D. Leavesley, and Z. Upton (2003)
Endocrinology 144, 2417-2424
 |  Abstract »  |  Full Text »  |  PDF »

Minireview: Integral Membrane Proteins that Function Coordinately with the Insulin-Like Growth Factor I Receptor to Regulate Intracellular Signaling.

D. R. Clemmons and L. A. Maile (2003)
Endocrinology 144, 1664-1670
 |  Abstract »  |  Full Text »  |  PDF »

MEK Kinase 1 Interacts with Focal Adhesion Kinase and Regulates Insulin Receptor Substrate-1 Expression.

T. Yujiri, R. Nawata, T. Takahashi, Y. Sato, Y. Tanizawa, T. Kitamura, and Y. Oka (2003)
J. Biol. Chem. 278, 3846-3851
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Matrix Enhances Heregulin-Dependent BRCA1 Phosphorylation and Suppresses BRCA1 Expression through Its C Terminus.

T. Miralem and H. K. Avraham (2003)
Mol. Cell. Biol. 23, 579-593
 |  Abstract »  |  Full Text »  |  PDF »

New Mechanisms of Signal Transduction Inhibitor Action: Receptor Tyrosine Kinase Down-Regulation and Blockade of Signal Transactivation.

A. V. Lee, R. Schiff, X. Cui, D. Sachdev, D. Yee, A. P. Gilmore, C. H. Streuli, S. Oesterreich, and D. L. Hadsell (2003)
Clin. Cancer Res. 9, 516s-523s
 |  Abstract »  |  Full Text »

Focal Adhesion Kinase (FAK) Regulates Insulin-stimulated Glycogen Synthesis in Hepatocytes.

D. Huang, A. T. Cheung, J. T. Parsons, and M. Bryer-Ash (2002)
J. Biol. Chem. 277, 18151-18160
 |  Abstract »  |  Full Text »  |  PDF »

Insulin Receptor Substrate 1 Translocation to the Nucleus by the Human JC Virus T-antigen.

A. Lassak, L. Del Valle, F. Peruzzi, J. Y. Wang, S. Enam, S. Croul, K. Khalili, and K. Reiss (2002)
J. Biol. Chem. 277, 17231-17238
 |  Abstract »  |  Full Text »  |  PDF »

Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways.

M. A. Schwartz and R. K. Assoian (2002)
J. Cell Sci. 114, 2553-2560
 |  Abstract »  |  Full Text »  |  PDF »

Differences in Sensitivity of Biological Functions Mediated by Epidermal Growth Factor Receptor Activation with Respect to Endogenous and Exogenous Ligands.

R. S. Sawhney, G.-H. K. Zhou, L. E. Humphrey, P. Ghosh, J. I. Kreisberg, and M. G. Brattain (2002)
J. Biol. Chem. 277, 75-86
 |  Abstract »  |  Full Text »

Effect of basal lamina of ovarian follicle on T- and L-type Ca2+ currents in differentiated granulosa cells.

E. K. Asem, W. Qin, and S. G. Rane (2002)
Am J Physiol Endocrinol Metab 282, E184-E196
 |  Abstract »  |  Full Text »  |  PDF »

Integrin and Growth Factor Receptor Crosstalk.

B. P. Eliceiri (2001)
Circ. Res. 89, 1104-1110
 |  Abstract »  |  Full Text »  |  PDF »

E2-Induced Degradation of Uterine Insulin Receptor Substrate-2: Requirement for an IGF-I-Stimulated, Proteasome-Dependent Pathway.

R. G. Richards, D. M. Klotz, M. R. Bush, D. K. Walmer, and R. P. DiAugustine (2001)
Endocrinology 142, 3842-3849
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Insulin Receptor Substrate 1 (IRS-1) and IRS-2 as Signaling Intermediates in the {alpha}6{beta}4 Integrin-Dependent Activation of Phosphoinositide 3-OH Kinase and Promotion of Invasion.

L. M. Shaw (2001)
Mol. Cell. Biol. 21, 5082-5093
 |  Abstract »  |  Full Text »  |  PDF »

Synthesis of Extracellular Matrix and Adhesion Through {beta}1 Integrins Are Critical for Fetal Ventricular Myocyte Proliferation.

L. K. Hornberger, S. Singhroy, T. Cavalle-Garrido, W. Tsang, F. Keeley, and M. Rabinovitch (2000)
Circ. Res. 87, 508-515
 |  Abstract »  |  Full Text »  |  PDF »

PECAM-1/CD31 Trans-homophilic Binding at the Intercellular Junctions Is Independent of Its Cytoplasmic Domain; Evidence for Heterophilic Interaction with Integrin alpha vbeta 3 in Cis.

C. W.Y. Wong, G. Wiedle, C. Ballestrem, B. Wehrle-Haller, S. Etteldorf, M. Bruckner, B. Engelhardt, R. H. Gisler, and B. A. Imhof (2000)
Mol. Biol. Cell 11, 3109-3121
 |  Abstract »  |  Full Text »

Cross Talk of pp125FAK and pp59Lyn Non-Receptor Tyrosine Kinases to Insulin-Mimetic Signaling in Adipocytes.

G. Müller, S. Wied, and W. Frick (2000)
Mol. Cell. Biol. 20, 4708-4723
 |  Abstract »  |  Full Text »

Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis.

D. MacKenna, S. R. Summerour, and F. J. Villarreal (2000)
Cardiovasc Res 46, 257-263
 |  Abstract »  |  Full Text »  |  PDF »

Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat.

P. M. D'Cruz, D. Yasumura, J. Weir, M. T. Matthes, H. Abderrahim, M. M. LaVail, and D. Vollrath (2000)
Hum. Mol. Genet. 9, 645-651
 |  Abstract »  |  Full Text »  |  PDF »

Insulin-Like Growth Factor I-Induced Degradation of Insulin Receptor Substrate 1 Is Mediated by the 26S Proteasome and Blocked by Phosphatidylinositol 3'-Kinase Inhibition.

A. V. Lee, J. L. Gooch, S. Oesterreich, R. L. Guler, and D. Yee (2000)
Mol. Cell. Biol. 20, 1489-1496
 |  Abstract »  |  Full Text »

Functional Genomic Analysis in Arthritis-Affected Cartilage: Yin-Yang Regulation of Inflammatory Mediators by {alpha}5{beta}1 and {alpha}V{beta}3 Integrins.

M. G. Attur, M. N. Dave, R. M. Clancy, I. R. Patel, S. B. Abramson, and A. R. Amin (2000)
J. Immunol. 164, 2684-2691
 |  Abstract »  |  Full Text »  |  PDF »

The role of transient ERK2 signals in fibronectin- and insulin-mediated DNA synthesis.

A. Asthagiri, C. Reinhart, A. Horwitz, and D. Lauffenburger (2000)
J. Cell Sci. 113, 4499-4510
 |  Abstract »  |  PDF »

The regulation of proliferation and differentiation in oligodendrocyte progenitor cells by alphaV integrins.

K. Blaschuk, E. Frost, and C ffrench-Constant (2000)
Development 127, 1961-1969
 |  Abstract »  |  PDF »

Vinexin Forms a Signaling Complex with Sos and Modulates Epidermal Growth Factor-induced c-Jun N-terminal Kinase/Stress-activated Protein Kinase Activities.

M. Akamatsu, S.-i. Aota, A. Suwa, K. Ueda, T. Amachi, K. M. Yamada, S. K. Akiyama, and N. Kioka (1999)
J. Biol. Chem. 274, 35933-35937
 |  Abstract »  |  Full Text »  |  PDF »

PTEN Gene and Integrin Signaling in Cancer.

M. Tamura, J. Gu, H. Tran, and K. M. Yamada (1999)
J Natl Cancer Inst 91, 1820-1828
 |  Abstract »  |  Full Text »  |  PDF »

Integrin Signaling.

F. G. Giancotti and E. Ruoslahti (1999)
Science 285, 1028-1033
 |  Abstract »  |  Full Text »

Extracellular Matrix Selectively Modulates the Response of Mammary Epithelial Cells to Different Soluble Signaling Ligands.

Y.-J. Lee and C. H. Streuli (1999)
J. Biol. Chem. 274, 22401-22408
 |  Abstract »  |  Full Text »  |  PDF »

Arcadlin Is a Neural Activity-regulated Cadherin Involved in Long Term Potentiation.

K. Yamagata, K. I. Andreasson, H. Sugiura, E. Maru, M. Dominique, Y. Irie, N. Miki, Y. Hayashi, M. Yoshioka, K. Kaneko, et al. (1999)
J. Biol. Chem. 274, 19473-19479
 |  Abstract »  |  Full Text »  |  PDF »

Pro-adhesive and Chemotactic Activities of Thrombospondin-1 for Breast Carcinoma Cells Are Mediated by alpha 3beta 1 Integrin and Regulated by Insulin-like Growth Factor-1 and CD98.

S. Chandrasekaran, N.-h. Guo, R. G. Rodrigues, J. Kaiser, and D. D. Roberts (1999)
J. Biol. Chem. 274, 11408-11416
 |  Abstract »  |  Full Text »  |  PDF »

Concerted Activity of Tyrosine Phosphatase SHP-2 and Focal Adhesion Kinase in Regulation of Cell Motility.

S. Manes, E. Mira, C. Gomez-Mouton, Z. J. Zhao, R. A. Lacalle, and C. Martinez-A. (1999)
Mol. Cell. Biol. 19, 3125-3135
 |  Abstract »  |  Full Text »  |  PDF »

Prostatic Carcinoma Cell Migration via {{alpha}}v{beta}3Integrin Is Modulated by a Focal Adhesion Kinase Pathway.

D.-Q. Zheng, A. S. Woodard, M. Fornaro, G. Tallini, and L. R. Languino (1999)
Cancer Res. 59, 1655-1664
 |  Abstract »  |  Full Text »  |  PDF »

Extracellular Matrix Regulates Apoptosis in Mammary Epithelium through a Control on Insulin Signaling.

N. Farrelly, Y.-J. Lee, J. Oliver, C. Dive, and C. H. Streuli (1999)
J. Cell Biol. 144, 1337-1348
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative Changes in Integrin and Focal Adhesion Signaling Regulate Myoblast Cell Cycle Withdrawal.

S. K. Sastry, M. Lakonishok, S. Wu, T. Q. Truong, A. Huttenlocher, C. E. Turner, and A. F. Horwitz (1999)
J. Cell Biol. 144, 1295-1309
 |  Abstract »  |  Full Text »  |  PDF »

The LIM-Only Protein PINCH Directly Interacts with Integrin-Linked Kinase and Is Recruited to Integrin-Rich Sites in Spreading Cells.

Y. Tu, F. Li, S. Goicoechea, and C. Wu (1999)
Mol. Cell. Biol. 19, 2425-2434
 |  Abstract »  |  Full Text »  |  PDF »

Nck-2, a Novel Src Homology2/3-containing Adaptor Protein That Interacts with the LIM-only Protein PINCH and Components of Growth Factor Receptor Kinase-signaling Pathways.

Y. Tu, F. Li, and C. Wu (1998)
Mol. Biol. Cell 9, 3367-3382
 |  Abstract »  |  Full Text »

Insulin Receptor Substrate-1 as a Signaling Molecule for Focal Adhesion Kinase pp125FAK and pp60src.

P. Lebrun, I. Mothe-Satney, L. Delahaye, E. Van Obberghen, and V. Baron (1998)
J. Biol. Chem. 273, 32244-32253
 |  Abstract »  |  Full Text »  |  PDF »

Adenoviral Gene Transfer of ฿3 Integrin Subunit Induces Conversion from Radial to Vertical Growth Phase in Primary Human Melanoma.

M.-Y. Hsu, D.-T. Shih, F. E. Meier, P. Van Belle, J.-Y. Hsu, D. E. Elder, C. A. Buck, and M. Herlyn (1998)
Am. J. Pathol. 153, 1435-1442
 |  Abstract »  |  Full Text »  |  PDF »

Highly Stoichiometric, Stable, and Specific Association of Integrin alpha 3beta 1 with CD151 Provides a Major Link to Phosphatidylinositol 4-Kinase, and May Regulate Cell Migration.

R. L. Yauch, F. Berditchevski, M. B. Harler, J. Reichner, and M. E. Hemler (1998)
Mol. Biol. Cell 9, 2751-2765
 |  Abstract »  |  Full Text »

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase.

M. Delcommenne, C. Tan, V. Gray, L. Rue, J. Woodgett, and S. Dedhar (1998)
PNAS 95, 11211-11216
 |  Abstract »  |  Full Text »  |  PDF »

Blocking ligand occupancy of the alpha Vbeta 3 integrin inhibits insulin-like growth factor I signaling in vascular smooth muscle cells.

B. Zheng and D. R. Clemmons (1998)
PNAS 95, 11217-11222
 |  Abstract »  |  Full Text »  |  PDF »

Cross-talk between Insulin Receptor and Integrin alpha 5beta 1 Signaling Pathways.

A. Guilherme, K. Torres, and M. P. Czech (1998)
J. Biol. Chem. 273, 22899-22903
 |  Abstract »  |  Full Text »  |  PDF »

Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins.

A. E. Aplin, A. Howe, S. K. Alahari, and R. L. Juliano (1998)
Pharmacol. Rev. 50, 197-264
 |  Abstract »  |  Full Text »  |  PDF »

Integrin-mediated Tyrosine Phosphorylation of SHPS-1 and Its Association with SHP-2. ROLES OF Fak AND Src FAMILY KINASES.

M. Tsuda, T. Matozaki, K. Fukunaga, Y. Fujioka, A. Imamoto, T. Noguchi, T. Takada, T. Yamao, H. Takeda, F. Ochi, et al. (1998)
J. Biol. Chem. 273, 13223-13229
 |  Abstract »  |  Full Text »  |  PDF »

The Effect of alpha 4beta 1-Integrin Binding Sequences of Fibronectin on Growth of Cells From Human Hematopoietic Progenitors.

K. P. Schofield, M. J. Humphries, E. de Wynter, N. Testa, and J. T. Gallagher (1998)
Blood 91, 3230-3238
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Mammary Differentiation by Extracellular Matrix Involves Protein-tyrosine Phosphatases.

G. M. Edwards, F. H. Wilford, X. Liu, L. Hennighausen, J. Djiane, and C. H. Streuli (1998)
J. Biol. Chem. 273, 9495-9500
 |  Abstract »  |  Full Text »  |  PDF »

The Effect of Extracellular Matrix Proteins on Porcine Smooth Muscle Cell Insulin-like Growth Factor (IGF) Binding Protein-5 Synthesis and Responsiveness to IGF-I.

B. Zheng, C. Duan, and D. R. Clemmons (1998)
J. Biol. Chem. 273, 8994-9000
 |  Abstract »  |  Full Text »  |  PDF »

p125Fak Focal Adhesion Kinase Is a Substrate for the Insulin and Insulin-like Growth Factor-I Tyrosine Kinase Receptors.

V. Baron, V. Calleja, P. Ferrari, F. Alengrin, and E. Van Obberghen (1998)
J. Biol. Chem. 273, 7162-7168
 |  Abstract »  |  Full Text »  |  PDF »

Adhesion of Human Umbilical Vein Endothelial Cells to the Immediate-Early Gene Product Cyr61 Is Mediated through Integrin alpha vbeta 3.

M. L. Kireeva, S. C.-T. Lam, and L. F. Lau (1998)
J. Biol. Chem. 273, 3090-3096
 |  Abstract »  |  Full Text »  |  PDF »

Fibronectin matrix assembly enhances adhesion-dependent cell growth.

J Sottile, D. Hocking, and P. Swiatek (1998)
J. Cell Sci. 111, 2933-2943
 |  Abstract »  |  PDF »

Integrins, Adhesion, and Cardiac Remodeling.

W. A. Hsueh, R. E. Law, and Y. S. Do (1998)
Hypertension 31, 176-180
 |  Abstract »  |  Full Text »  |  PDF »

Defining Extracellular Integrin alpha -Chain Sites That Affect Cell Adhesion and Adhesion Strengthening without Altering Soluble Ligand Binding.

C. Pujades, R. Alon, R. L. Yauch, A. Masumoto, L. C. Burkly, C. Chen, T. A. Springer, R. R. Lobb, and M. E. Hemler (1997)
Mol. Biol. Cell 8, 2647-2657
 |  Abstract »  |  Full Text »

Integrins, Oncogenes, and Anchorage Independence.

M. A. Schwartz (1997)
J. Cell Biol. 139, 575-578
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Epidermal Growth Factor Modulates Tyrosine Phosphorylation of p130Cas. INVOLVEMENT OF PHOSPHATIDYLINOSITOL 3'-KINASE AND ACTIN CYTOSKELETON.

M. Ojaniemi and K. Vuori (1997)
J. Biol. Chem. 272, 25993-25998
 |  Abstract »  |  Full Text »  |  PDF »

Cell Anchorage Permits Efficient Signal Transduction Between Ras and Its Downstream Kinases.

T. H. Lin, Q. Chen, A. Howe, and R. L. Juliano (1997)
J. Biol. Chem. 272, 8849-8852
 |  Abstract »  |  Full Text »  |  PDF »

The Proto-oncogene Product p120cbl Links c-Src and Phosphatidylinositol 3'-Kinase to the Integrin Signaling Pathway.

M. Ojaniemi, S. S. Martin, F. Dolfi, J. M. Olefsky, and K. Vuori (1997)
J. Biol. Chem. 272, 3780-3787
 |  Abstract »  |  Full Text »  |  PDF »

The IRS-2 Gene on Murine Chromosome 8 Encodes a Unique Signaling Adapter for Insulin and Cytokine Action.

X. J. Sun, S. Pons, L.-M. Wang, Y. Zhang, L. Yenush, D. Burks, M. G. Myers Jr., E. Glasheen, N. G. Copeland, N. A. Jenkins, et al. (1997)
Mol. Endocrinol. 11, 251-262
 |  Abstract »  |  Full Text »

Ligation of Integrin alpha 5beta 1 Is Required for Internalization of Vitronectin by Integrin alpha vbeta 3.

V. Pijuan-Thompson and C. L. Gladson (1997)
J. Biol. Chem. 272, 2736-2743
 |  Abstract »  |  Full Text »  |  PDF »

Insulin stimulates haptotactic migration of human epidermal keratinocytes through activation of NF-kappa B transcription factor.

A. Benoliel, B Kahn-Peries, J Imbert, and P Verrando (1997)
J. Cell Sci. 110, 2089-2097
 |  Abstract »  |  PDF »

NPXY motifs control the recruitment of the alpha5beta1 integrin in focal adhesions independently of the association of talin with the beta1 chain.

L Vignoud, C Albiges-Rizo, P Frachet, and M. Block (1997)
J. Cell Sci. 110, 1421-1430
 |  Abstract »  |  PDF »

Inducible Tyrosine Phosphorylation of the beta 3 Integrin Requires the alpha v Integrin Cytoplasmic Tail.

S. D. Blystone, F. P. Lindberg, M. P. Williams, K. P. McHugh, and E. J. Brown (1996)
J. Biol. Chem. 271, 31458-31462
 |  Abstract »  |  Full Text »  |  PDF »

The Fyn Tyrosine Kinase Binds Irs-1 and Forms a Distinct Signaling Complex during Insulin Stimulation.

X. J. Sun, S. Pons, T. Asano, M. G. Myers Jr., E. Glasheen, and M. F. White (1996)
J. Biol. Chem. 271, 10583-10587
 |  Abstract »  |  Full Text »  |  PDF »

The Roles of Integrins and Extracellular Matrix Proteins in the Insulin-like Growth Factor I-stimulated Chemotaxis of Human Breast Cancer Cells.

M. E. Doerr and J. I. Jones (1996)
J. Biol. Chem. 271, 2443-2447
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of cell migration by the integrin beta subunit ectodomain.

E. Filardo, S. Deming, and D. Cheresh (1996)
J. Cell Sci. 109, 1615-1622
 |  Abstract »  |  PDF »

The Type I Interferon Receptor Mediates Tyrosine Phosphorylation of Insulin Receptor Substrate 2.

L. C. Platanias, S. Uddin, A. Yetter, X.-J. Sun, and M. F. White (1996)
J. Biol. Chem. 271, 278-282
 |  Abstract »  |  Full Text »  |  PDF »

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Stat5 as a Target for Regulation by Extracellular Matrix.

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Specific Association Of CD63 with the VLA-3 and VLA-6 Integrins.

F. Berditchevski, G. Bazzoni, and M. E. Hemler (1995)
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Soluble Ligands of the [IMAGE][IMAGE][IMAGE][IMAGE] Integrin Mediate Enhanced Tyrosine Phosphorylation of Multiple Proteins in Adherent Bovine Pulmonary Artery Endothelial Cells.

S. Bhattacharya, C. Fu, J. Bhattacharya, and S. Greenberg (1995)
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Integrins and signal transduction pathways: the road taken.

E. Clark and J. Brugge (1995)
Science 268, 233-239
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Cell Adhesion and Focal Adhesion Kinase Regulate Insulin Receptor Substrate-1 Expression.

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Platelet-derived Growth Factor Receptor beta and Vascular Endothelial Growth Factor Receptor 2 Bind to the beta 3 Integrin through Its Extracellular Domain.

E. Borges, Y. Jan, and E. Ruoslahti (2000)
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