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Science 25 November 1994:
Vol. 266. no. 5189, pp. 1395 - 1399
DOI: 10.1126/science.7973732

Articles

Science, Vol 266, Issue 5189, 1395-1399
Copyright © 1994 by American Association for the Advancement of Science


articles

Lymphotactin: a cytokine that represents a new class of chemokine

GS Kelner, J Kennedy, KB Bacon, S Kleyensteuber, DA Largaespada, NA Jenkins, NG Copeland, JF Bazan, KW Moore, TJ Schall, and al. et

Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304.

In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both the Cys-Cys and Cys-X-Cys chemokine families but lacks two of the four cysteine residues that are characteristic of the chemokines. Lymphotactin is also expressed in activated CD8+ T cells and CD4-CD8- T cell receptor alpha beta + thymocytes. It has chemotactic activity for lymphocytes but not for monocytes or neutrophils. The gene encoding lymphotactin maps to chromosome one. Taken together, these observations suggest that lymphotactin represents a novel addition to the chemokine superfamily.


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   Abstract »    Full Text »    PDF »
C10 Is a Novel Chemokine Expressed in Experimental Inflammatory Demyelinating Disorders that Promotes Recruitment of Macrophages to the Central Nervous System.
V. C. Asensio, S. Lassmann, A. Pagenstecher, S. C. Steffensen, S. J. Henriksen, and I. L. Campbell (1999)
Am. J. Pathol. 154, 1181-1191
   Abstract »    Full Text »    PDF »
Islet-Specific Th1, But Not Th2, Cells Secrete Multiple Chemokines and Promote Rapid Induction of Autoimmune Diabetes.
L. M. Bradley, V. C. Asensio, L.-K. Schioetz, J. Harbertson, T. Krahl, G. Patstone, N. Woolf, I. L. Campbell, and N. Sarvetnick (1999)
J. Immunol. 162, 2511-2520
   Abstract »    Full Text »    PDF »
Similarities and Differences in RANTES- and (AOP)-RANTES-triggered Signals: Implications for Chemotaxis.
J. M. Rodriguez-Frade, A. J. Vila-Coro, A. Martin, M. Nieto, F. Sanchez-Madrid, A. E.I. Proudfoot, T. N.C. Wells, C. Martinez-A, and M. Mellado (1999)
J. Cell Biol. 144, 755-765
   Abstract »    Full Text »    PDF »
Lymphotactin Acts as an Innate Mucosal Adjuvant.
J. W. Lillard Jr., P. N. Boyaka, J. A. Hedrick, A. Zlotnik, and J. R. McGhee (1999)
J. Immunol. 162, 1959-1965
   Abstract »    Full Text »    PDF »
CC Chemokine Receptors, CCR-1 and CCR-3, Are Potentially Involved in Antigen-Presenting Cell Function of Human Peripheral Blood Monocyte-Derived Dendritic Cells.
K. Sato, H. Kawasaki, H. Nagayama, R. Serizawa, J. Ikeda, C. Morimoto, K. Yasunaga, N. Yamaji, K. Tadokoro, T. Juji, et al. (1999)
Blood 93, 34-42
   Abstract »    Full Text »    PDF »
Inflammatory Mediators of Asthma: An Update.
P. J. Barnes, K. F. Chung, and C. P. Page (1998)
Pharmacol. Rev. 50, 515-596
   Abstract »    Full Text »    PDF »
Lymphotactin Gene-Modified Bone Marrow Dendritic Cells Act as More Potent Adjuvants for Peptide Delivery to Induce Specific Antitumor Immunity.
X. Cao, W. Zhang, L. He, Z. Xie, S. Ma, Q. Tao, Y. Yu, H. Hamada, and J. Wang (1998)
J. Immunol. 161, 6238-6244
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Identification of a Truncated Form of the CC Chemokine CK{beta}-8 Demonstrating Greatly Enhanced Biological Activity.
C. H. Macphee, E. R. Appelbaum, K. Johanson, K. E. Moores, C. S. Imburgia, J. Fornwald, T. Berkhout, M. Brawner, P. H. E. Groot, K. O'Donnell, et al. (1998)
J. Immunol. 161, 6273-6279
   Abstract »    Full Text »    PDF »
Antigen-Induced Eosinophilic Lung Inflammation Develops in Mice Deficient in Chemokine Eotaxin.
Y. Yang, J. Loy, R.-P. Ryseck, D. Carrasco, and R. Bravo (1998)
Blood 92, 3912-3923
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Excitotoxic Brain Injury Stimulates Expression of the Chemokine Receptor CCR5 in Neonatal Rats.
J. M. Galasso, J. K. Harrison, and F. S. Silverstein (1998)
Am. J. Pathol. 153, 1631-1640
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Divergent Effects of Interleukin-4 and Interferon-gamma on Macrophage-Derived Chemokine Production: An Amplification Circuit of Polarized T Helper 2 Responses.
R. Bonecchi, S. Sozzani, J. T. Stine, W. Luini, G. D'Amico, P. Allavena, D. Chantry, and A. Mantovani (1998)
Blood 92, 2668-2671
   Abstract »    Full Text »    PDF »
Identification of CX3CR1. A CHEMOTACTIC RECEPTOR FOR THE HUMAN CX3C CHEMOKINE FRACTALKINE AND A FUSION CORECEPTOR FOR HIV-1.
C. Combadiere, K. Salzwedel, E. D. Smith, H. L. Tiffany, E. A. Berger, and P. M. Murphy (1998)
J. Biol. Chem. 273, 23799-23804
   Abstract »    Full Text »    PDF »
Activated Murine B Lymphocytes and Dendritic Cells Produce a Novel CC Chemokine which Acts Selectively on Activated T Cells.
C. Schaniel, E. Pardali, F. Sallusto, M. Speletas, C. Ruedl, T. Shimizu, T. Seidl, J. Andersson, F. Melchers, A. G. Rolink, et al. (1998)
J. Exp. Med. 188, 451-463
   Abstract »    Full Text »    PDF »
The Chemokine Monocyte Chemotactic Protein 1 Triggers Janus Kinase 2 Activation and Tyrosine Phosphorylation of the CCR2B Receptor.
M. Mellado, J. M. Rodriguez-Frade, A. Aragay, G. del Real, A. M. Martin, A. J. Vila-Coro, A. Serrano, F. Mayor Jr., and C. Martinez-A. (1998)
J. Immunol. 161, 805-813
   Abstract »    Full Text »    PDF »
The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3.
H. Soto, W. Wang, R. M. Strieter, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, J. Hedrick, and A. Zlotnik (1998)
PNAS 95, 8205-8210
   Abstract »    Full Text »    PDF »
Human Herpesvirus 6 Open Reading Frame U12 Encodes a Functional beta -Chemokine Receptor.
Y. Isegawa, Z. Ping, K. Nakano, N. Sugimoto, and K. Yamanishi (1998)
J. Virol. 72, 6104-6112
   Abstract »    Full Text »    PDF »
Identification of Single C Motif-1/Lymphotactin Receptor XCR1.
T. Yoshida, T. Imai, M. Kakizaki, M. Nishimura, S. Takagi, and O. Yoshie (1998)
J. Biol. Chem. 273, 16551-16554
   Abstract »    Full Text »    PDF »
Interferon-inducible T Cell Alpha Chemoattractant (I-TAC): A Novel Non-ELR CXC Chemokine with Potent Activity on Activated T Cells through Selective High Affinity Binding to CXCR3.
K. E. Cole, C. A. Strick, T. J. Paradis, K. T. Ogborne, M. Loetscher, R. P. Gladue, W. Lin, J. G. Boyd, B. Moser, D. E. Wood, et al. (1998)
J. Exp. Med. 187, 2009-2021
   Abstract »    Full Text »    PDF »
Characterization of CKbeta 8 and CKbeta 8-1: Two Alternatively Spliced Forms of Human beta -Chemokine, Chemoattractants for Neutrophils, Monocytes, and Lymphocytes, and Potent Agonists at CC Chemokine Receptor 1 .
B.-S. Youn, S. M. Zhang, H. E. Broxmeyer, S. Cooper, K. Antol, M. Fraser Jr, and B. S. Kwon (1998)
Blood 91, 3118-3126
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Selective Inhibition of Expression of the Chemokine Receptor CCR2 in Human Monocytes by IFN-{gamma}.
G. Penton-Rol, N. Polentarutti, W. Luini, A. Borsatti, R. Mancinelli, A. Sica, S. Sozzani, and A. Mantovani (1998)
J. Immunol. 160, 3869-3873
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Macrophage Inflammatory Protein-1beta Induces Migration and Activation of Human Thymocytes.
D. J. Dairaghi, K. Franz-Bacon, E. Callas, J. Cupp, T. J. Schall, S. A. Tamraz, S. A. Boehme, N. Taylor, and K. B. Bacon (1998)
Blood 91, 2905-2913
   Abstract »    Full Text »    PDF »
Noncompetitive, Chemokine-mediated Inhibition of Basic Fibroblast Growth Factor-induced Endothelial Cell Proliferation.
M. Presta, M. Belleri, A. Vecchi, J. Hesselgesser, A. Mantovani, and R. Horuk (1998)
J. Biol. Chem. 273, 7911-7919
   Abstract »    Full Text »    PDF »



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