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Science 25 November 1994: Vol. 266. no. 5189, pp. 1395 - 1399 DOI: 10.1126/science.7973732
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Articles
Science, Vol 266, Issue 5189, 1395-1399
Copyright © 1994 by American Association for the Advancement of Science
Lymphotactin: a cytokine that represents a new class of chemokine
GS Kelner,
J Kennedy,
KB Bacon,
S Kleyensteuber,
DA Largaespada,
NA Jenkins,
NG Copeland,
JF Bazan,
KW Moore,
TJ Schall,
and
al. et
Department of Immunology, DNAX Research Institute of Cellular and Molecular Biology, Palo Alto, CA 94304.
In this study, the cytokine-producing profile of progenitor T cells (pro-T cells) was determined. During screening of a complementary DNA library generated from activated mouse pro-T cells, a cytokine designated lymphotactin was discovered. Lymphotactin is similar to members of both the Cys-Cys and Cys-X-Cys chemokine families but lacks two of the four cysteine residues that are characteristic of the chemokines. Lymphotactin is also expressed in activated CD8+ T cells and CD4-CD8- T cell receptor alpha beta + thymocytes. It has chemotactic activity for lymphocytes but not for monocytes or neutrophils. The gene encoding lymphotactin maps to chromosome one. Taken together, these observations suggest that lymphotactin represents a novel addition to the chemokine superfamily.
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Infect. Immun.
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- Differential Effects of Leukotactin-1 and Macrophage Inflammatory Protein-1{alpha} on Neutrophils Mediated by CCR1.
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J. Immunol.
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- Eotaxin Activates T Cells to Chemotaxis and Adhesion Only if Induced to Express CCR3 by IL-2 Together with IL-4.
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J. Immunol.
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- C10 Is a Novel Chemokine Expressed in Experimental Inflammatory Demyelinating Disorders that Promotes Recruitment of Macrophages to the Central Nervous System.
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- Islet-Specific Th1, But Not Th2, Cells Secrete Multiple Chemokines and Promote Rapid Induction of Autoimmune Diabetes.
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- Similarities and Differences in RANTES- and (AOP)-RANTES-triggered Signals: Implications for Chemotaxis.
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J. Immunol.
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- CC Chemokine Receptors, CCR-1 and CCR-3, Are Potentially Involved in Antigen-Presenting Cell Function of Human Peripheral Blood Monocyte-Derived Dendritic Cells.
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- Inflammatory Mediators of Asthma: An Update.
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- Lymphotactin Gene-Modified Bone Marrow Dendritic Cells Act as More Potent Adjuvants for Peptide Delivery to Induce Specific Antitumor Immunity.
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J. Immunol.
161, 6238-6244
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- Identification of a Truncated Form of the CC Chemokine CK{beta}-8 Demonstrating Greatly Enhanced Biological Activity.
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Blood
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- Excitotoxic Brain Injury Stimulates Expression of the Chemokine Receptor CCR5 in Neonatal Rats.
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153, 1631-1640
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- Divergent Effects of Interleukin-4 and Interferon-gamma on Macrophage-Derived Chemokine Production: An Amplification Circuit of Polarized T Helper 2 Responses.
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Blood
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- Identification of CX3CR1. A CHEMOTACTIC RECEPTOR FOR THE HUMAN CX3C CHEMOKINE FRACTALKINE AND A FUSION CORECEPTOR FOR HIV-1.
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- Activated Murine B Lymphocytes and Dendritic Cells Produce a Novel CC Chemokine which Acts Selectively on Activated T Cells.
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- The Chemokine Monocyte Chemotactic Protein 1 Triggers Janus Kinase 2 Activation and Tyrosine Phosphorylation of the CCR2B Receptor.
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- The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3.
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PNAS
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- Characterization of CKbeta 8 and CKbeta 8-1: Two Alternatively Spliced Forms of Human beta -Chemokine, Chemoattractants for Neutrophils, Monocytes, and Lymphocytes, and Potent Agonists at CC Chemokine Receptor 1 .
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Blood
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- Selective Inhibition of Expression of the Chemokine Receptor CCR2 in Human Monocytes by IFN-{gamma}.
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- Macrophage Inflammatory Protein-1beta Induces Migration and Activation of Human Thymocytes.
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Blood
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- Noncompetitive, Chemokine-mediated Inhibition of Basic Fibroblast Growth Factor-induced Endothelial Cell Proliferation.
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