Science 25 November 1994: Vol. 266. no. 5189, pp. 1376 - 1380 DOI: 10.1126/science.7973727

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Articles

Repair of Nitric Oxide-damaged DNA in {beta}-Cells Requires JNK-dependent GADD45{alpha} Expression.

K. J. Hughes, G. P. Meares, K. T. Chambers, and J. A. Corbett (2009)
J. Biol. Chem. 284, 27402-27408
 |  Abstract »  |  Full Text »  |  PDF »

Podophyllum hexandrum Fraction (REC-2006) Shows Higher Radioprotective Efficacy in the p53-Carrying Hepatoma Cell Line: A Role of Cell Cycle Regulatory Proteins.

P. K. Singh, R. Kumar, A. Sharma, R. Arora, R. Chawla, S. K. Jain, and R. K. Sharma (2009)
Integr Cancer Ther 8, 261-272
 |  Abstract »  |  PDF »

Heat shock factor-1 modulates p53 activity in the transcriptional response to DNA damage.

I. R. Logan, H. V. McNeill, S. Cook, X. Lu, D. W. Meek, F. V. Fuller-Pace, J. Lunec, and C. N. Robson (2009)
Nucleic Acids Res. 37, 2962-2973
 |  Abstract »  |  Full Text »  |  PDF »

A BTB/POZ Gene, NAC-1, a Tumor Recurrence-Associated Gene, as a Potential Target for Taxol Resistance in Ovarian Cancer.

M. Ishibashi, K. Nakayama, S. Yeasmin, A. Katagiri, K. Iida, N. Nakayama, M. Fukumoto, and K. Miyazaki (2008)
Clin. Cancer Res. 14, 3149-3155
 |  Abstract »  |  Full Text »  |  PDF »

The crystal structure and dimerization interface of GADD45{gamma}.

J. D. Schrag, S. Jiralerspong, M. Banville, M. L. Jaramillo, and M. D. O'Connor-McCourt (2008)
PNAS 105, 6566-6571
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of Gadd45 Alleviates the G2/M Blockage and the Enhanced Phosphorylation of p53 and p38 in Zinc Supplemented Normal Human Bronchial Epithelial Cells.

R. S. M. Shih, S. H. K. Wong, N. W. Schoene, and K. Y. Lei (2008)
Experimental Biology and Medicine 233, 317-327
 |  Abstract »  |  Full Text »  |  PDF »

NAC-1 Controls Cell Growth and Survival by Repressing Transcription of Gadd45GIP1, a Candidate Tumor Suppressor.

K. Nakayama, N. Nakayama, T.-L. Wang, and I.-M. Shih (2007)
Cancer Res. 67, 8058-8064
 |  Abstract »  |  Full Text »  |  PDF »

Incorporation of an Internal Ribosome Entry Site-Dependent Mechanism in Arsenic-Induced GADD45{alpha} Expression.

Q. Chang, D. Bhatia, Y. Zhang, T. Meighan, V. Castranova, X. Shi, and F. Chen (2007)
Cancer Res. 67, 6146-6154
 |  Abstract »  |  Full Text »  |  PDF »

Coordination of JNK1 and JNK2 Is Critical for GADD45{alpha} Induction and Its Mediated Cell Apoptosis in Arsenite Responses.

D. Zhang, L. Song, J. Li, K. Wu, and C. Huang (2006)
J. Biol. Chem. 281, 34113-34123
 |  Abstract »  |  Full Text »  |  PDF »

Experimental glaucoma and optic nerve transection induce simultaneous upregulation of proapoptotic and prosurvival genes..

H. Levkovitch-Verbin, R. Dardik, S. Vander, Y. Nisgav, M. Kalev-Landoy, and S. Melamed (2006)
Invest. Ophthalmol. Vis. Sci. 47, 2491-2497
 |  Abstract »  |  Full Text »  |  PDF »

Inducible activation of CEBPB, a gene negatively regulated by BCR/ABL, inhibits proliferation and promotes differentiation of BCR/ABL-expressing cells.

C. Guerzoni, M. Bardini, S. A. Mariani, G. Ferrari-Amorotti, P. Neviani, M. L. Panno, Y. Zhang, R. Martinez, D. Perrotti, and B. Calabretta (2006)
Blood 107, 4080-4089
 |  Abstract »  |  Full Text »  |  PDF »

Nucleolin links to arsenic-induced stabilization of GADD45{alpha} mRNA.

Y. Zhang, D. Bhatia, H. Xia, V. Castranova, X. Shi, and F. Chen (2006)
Nucleic Acids Res. 34, 485-495
 |  Abstract »  |  Full Text »  |  PDF »

Loss of p21WAF1/Cip1 in Gadd45-deficient keratinocytes restores DNA repair capacity.

T. Maeda, R. A. Espino, E. G. Chomey, L. Luong, A. Bano, D. Meakins, and V. A. Tron (2005)
Carcinogenesis 26, 1804-1810
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Single Minded 2 gene expression mediates tumor-selective apoptosis and differentiation in human colon cancer cells.

M. J. Aleman, M. P. DeYoung, M. Tress, P. Keating, G. W. Perry, and R. Narayanan (2005)
PNAS 102, 12765-12770
 |  Abstract »  |  Full Text »  |  PDF »

NF-{kappa}B and Not the MAPK Signaling Pathway Regulates GADD45{beta} Expression during Acute Inflammation.

N. Zhang, M. H. Ahsan, L. Zhu, L. C. Sambucetti, A. F. Purchio, and D. B. West (2005)
J. Biol. Chem. 280, 21400-21408
 |  Abstract »  |  Full Text »  |  PDF »

Combined GADD45A and Thymidine Phosphorylase Expression Levels Predict Response and Survival of Neoadjuvant-Treated Gastric Cancer Patients.

R. Napieralski, K. Ott, M. Kremer, K. Specht, H. Vogelsang, K. Becker, M. Muller, F. Lordick, U. Fink, J. Rudiger Siewert, et al. (2005)
Clin. Cancer Res. 11, 3025-3031
 |  Abstract »  |  Full Text »  |  PDF »

B23 Regulates GADD45a Nuclear Translocation and Contributes to GADD45a-induced Cell Cycle G2-M Arrest.

H. Gao, S. Jin, Y. Song, M. Fu, M. Wang, Z. Liu, M. Wu, and Q. Zhan (2005)
J. Biol. Chem. 280, 10988-10996
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of dRFX2, a novel RFX family protein in Drosophila.

K. Otsuki, Y. Hayashi, M. Kato, H. Yoshida, and M. Yamaguchi (2004)
Nucleic Acids Res. 32, 5636-5648
 |  Abstract »  |  Full Text »  |  PDF »

Gadd45 Proteins Induce G2/M Arrest and Modulate Apoptosis in Kidney Cells Exposed to Hyperosmotic Stress.

S. K. Mak and D. Kultz (2004)
J. Biol. Chem. 279, 39075-39084
 |  Abstract »  |  Full Text »  |  PDF »

TAFII70 Isoform-Specific Growth Suppression Correlates With Its Ability to Complex With the GADD45a Protein.

W. Wang, R. Nahta, G. Huper, and J. R. Marks (2004)
Mol. Cancer Res. 2, 442-452
 |  Abstract »  |  Full Text »  |  PDF »

Organization of mammary epithelial cells into 3D acinar structures requires glucocorticoid and JNK signaling.

J. Murtagh, E. McArdle, E. Gilligan, L. Thornton, F. Furlong, and F. Martin (2004)
J. Cell Biol. 166, 133-143
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacogenomic Identification of Targets for Adjuvant Therapy with the Topoisomerase Poison Camptothecin.

J. P. Carson, N. Zhang, G. M. Frampton, N. P. Gerry, M. E. Lenburg, and M. F. Christman (2004)
Cancer Res. 64, 2096-2104
 |  Abstract »  |  Full Text »  |  PDF »

Phase I clinical trial of a human idiotypic p53 vaccine in patients with advanced malignancy.

M. Lomas, W. Liauw, D. Packham, K. Williams, A. Kelleher, J. Zaunders, and R. Ward (2004)
Ann. Onc. 15, 324-329
 |  Abstract »  |  Full Text »  |  PDF »

DQ 65-79, A Peptide Derived from HLA Class II, Mimics p21 to Block T Cell Proliferation.

C. Dong, S.-C. Lyu, A. M. Krensky, and C. Clayberger (2003)
J. Immunol. 171, 5064-5070
 |  Abstract »  |  Full Text »  |  PDF »

Functional p53 Increases Prostate Cancer Cell Survival After Exposure to Fractionated Doses of Ionizing Radiation.

S. L. Scott, J. D. Earle, and P. H. Gumerlock (2003)
Cancer Res. 63, 7190-7196
 |  Abstract »  |  Full Text »  |  PDF »

Degradation of Transcription Repressor ZBRK1 through the Ubiquitin-Proteasome Pathway Relieves Repression of Gadd45a upon DNA Damage.

J. Yun and W.-H. Lee (2003)
Mol. Cell. Biol. 23, 7305-7314
 |  Abstract »  |  Full Text »  |  PDF »

Strategic Attack on Host Cell Gene Expression during Adenovirus Infection.

H. Zhao, F. Granberg, L. Elfineh, U. Pettersson, and C. Svensson (2003)
J. Virol. 77, 11006-11015
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of the Growth Arrest and DNA Damage-Inducible Gene 45 (GADD45) by Peroxisome Proliferator-Activated Receptor {gamma} in Vascular Smooth Muscle Cells.

D. Bruemmer, F. Yin, J. Liu, J. P. Berger, T. Sakai, F. Blaschke, E. Fleck, A. J. Van Herle, B. M. Forman, and R. E. Law (2003)
Circ. Res. 93 , e38-e47
 |  Abstract »  |  Full Text »  |  PDF »

Gadd45{gamma} Expression Is Reduced in Anaplastic Thyroid Cancer and Its Reexpression Results in Apoptosis.

H. K. Chung, Y.-W. Yi, N.-C. Jung, D. Kim, J. M. Suh, H. Kim, K. C. Park, D. W. Kim, E. S. Hwang, J. H. Song, et al. (2003)
J. Clin. Endocrinol. Metab. 88, 3913-3920
 |  Abstract »  |  Full Text »  |  PDF »

Paradoxical Upregulation of Tumor Suppressor Protein p53 in Serum-Stimulated Vascular Smooth Muscle Cells: A Novel Negative-Feedback Regulatory Mechanism.

Z. H. Mnjoyan, R. Dutta, D. Zhang, B.-B. Teng, and K. Fujise (2003)
Circulation 108, 464-471
 |  Abstract »  |  Full Text »  |  PDF »

CR6-interacting Factor 1 Interacts with Gadd45 Family Proteins and Modulates the Cell Cycle.

H. K. Chung, Y.-W. Yi, N.-C. Jung, D. Kim, J. M. Suh, H. Kim, K. C. Park, J. H. Song, D. W. Kim, E. S. Hwang, et al. (2003)
J. Biol. Chem. 278, 28079-28088
 |  Abstract »  |  Full Text »  |  PDF »

Effects of Minimally Toxic Levels of Carbonyl Cyanide P-(Trifluoromethoxy) Phenylhydrazone (FCCP), Elucidated through Differential Gene Expression with Biochemical and Morphological Correlations.

S. Kuruvilla, C. W. Qualls Jr., R. D. Tyler, S. M. Witherspoon, G. R. Benavides, L. W. Yoon, K. Dold, R. H. Brown, S. Sangiah, and K. T. Morgan (2003)
Toxicol. Sci. 73, 348-361
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Ehp53, an Entamoeba histolytica protein, ancestor of the mammalian tumour suppressor p53.

L. Mendoza, E. Orozco, M. A. Rodriguez, G. Garcia-Rivera, T. Sanchez, E. Garcia, and P. Gariglio (2003)
Microbiology 149, 885-893
 |  Abstract »  |  Full Text »  |  PDF »

Gadd45a Protects against UV Irradiation-induced Skin Tumors, and Promotes Apoptosis and Stress Signaling via MAPK and p53.

J. Hildesheim, D. V. Bulavin, M. R. Anver, W. G. Alvord, M. C. Hollander, L. Vardanian, and A. J. Fornace Jr. (2002)
Cancer Res. 62, 7305-7315
 |  Abstract »  |  Full Text »  |  PDF »

A Proteomics Approach to Identify Proliferating Cell Nuclear Antigen (PCNA)-binding Proteins in Human Cell Lysates. IDENTIFICATION OF THE HUMAN CHL12/RFCs2-5 COMPLEX AS A NOVEL PCNA-BINDING PROTEIN.

S. Ohta, Y. Shiomi, K. Sugimoto, C. Obuse, and T. Tsurimoto (2002)
J. Biol. Chem. 277, 40362-40367
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Bleomycin Sensitivity of Mice Expressing Dominant-Negative p53 in the Lung Epithelium.

S. Ghosh, T. Mendoza, L. A. Ortiz, G. W. Hoyle, C. D. Fermin, A. R. Brody, M. Friedman, and G. F. Morris (2002)
Am. J. Respir. Crit. Care Med. 166, 890-897
 |  Abstract »  |  Full Text »

Stress-Dependent Nucleolin Mobilization Mediated by p53-Nucleolin Complex Formation.

Y. Daniely, D. D. Dimitrova, and J. A. Borowiec (2002)
Mol. Cell. Biol. 22, 6014-6022
 |  Abstract »  |  Full Text »  |  PDF »

Gadd45a: An Elusive Yet Attractive Candidate Gene in Pancreatic Cancer : Commentary re: K. Yamasawa et al., Clinicopathological Significance of Abnormalities in Gadd45 Expression and Its Relationship to p53 in Human Pancreatic Cancer. Clin. Cancer Res., 8: 2563-2569, 2002.

J. Hildesheim and A. J. Fornace Jr. (2002)
Clin. Cancer Res. 8, 2475-2479
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Clinicopathological Significance of Abnormalities in Gadd45 Expression and Its Relationship to p53 in Human Pancreatic Cancer.

K. Yamasawa, Y. Nio, M. Dong, K. Yamaguchi, and M. Itakura (2002)
Clin. Cancer Res. 8, 2563-2569
 |  Abstract »  |  Full Text »  |  PDF »

mda-7 (IL-24) mediates selective apoptosis in human melanoma cells by inducing the coordinated overexpression of the GADD family of genes by means of p38 MAPK.

D. Sarkar, Z.-Z. Su, I. V. Lebedeva, M. Sauane, R. V. Gopalkrishnan, K. Valerie, P. Dent, and P. B. Fisher (2002)
PNAS 99, 10054-10059
 |  Abstract »  |  Full Text »  |  PDF »

FOXO Forkhead Transcription Factors Induce G2-M Checkpoint in Response to Oxidative Stress.

Y. Furukawa-Hibi, K. Yoshida-Araki, T. Ohta, K. Ikeda, and N. Motoyama (2002)
J. Biol. Chem. 277, 26729-26732
 |  Abstract »  |  Full Text »  |  PDF »

Direct Interaction of Proliferating Cell Nuclear Antigen with the Small Subunit of DNA Polymerase delta.

X. Lu, C.-K. Tan, J.-Q. Zhou, M. You, L. M. Carastro, K. M. Downey, and A. G. So (2002)
J. Biol. Chem. 277, 24340-24345
 |  Abstract »  |  Full Text »  |  PDF »

Identification of differentially expressed genes in subcutaneous adipose tissue from subjects with familial combined hyperlipidemia.

P. M. H. Eurlings, C. J. H. van der Kallen, J. M. W. Geurts, P. Kouwenberg, W. D. Boeckx, and T. W. A. de Bruin (2002)
J. Lipid Res. 43, 930-935
 |  Abstract »  |  Full Text »  |  PDF »

cDNA Microarray Analysis of Gene Expression in Rat Alveolar Macrophages in Response to Organic Extract of Diesel Exhaust Particles.

E. Koike, S. Hirano, N. Shimojo, and T. Kobayashi (2002)
Toxicol. Sci. 67, 241-246
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenic H-Ras Enhances DNA Repair through the Ras/Phosphatidylinositol 3-Kinase/Rac1 Pathway in NIH3T3 Cells. EVIDENCE FOR ASSOCIATION WITH REACTIVE OXYGEN SPECIES.

H.-J. Cho, H. G. Jeong, J.-S. Lee, E.-R. Woo, J.-W. Hyun, M.-H. Chung, and H. J. You (2002)
J. Biol. Chem. 277, 19358-19366
 |  Abstract »  |  Full Text »  |  PDF »

p53 Binds and Activates the Xeroderma Pigmentosum DDB2 Gene in Humans but Not Mice.

T. Tan and G. Chu (2002)
Mol. Cell. Biol. 22, 3247-3254
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Expression of GADD45{gamma}, a Growth Inhibitory Gene, in Human Pituitary Adenomas: Implications for Tumorigenesis.

X. Zhang, H. Sun, D. C. Danila, S. R. Johnson, Y. Zhou, B. Swearingen, and A. Klibanski (2002)
J. Clin. Endocrinol. Metab. 87, 1262-1267
 |  Abstract »  |  Full Text »  |  PDF »

BRCA1 Regulates GADD45 through Its Interactions with the OCT-1 and CAAT Motifs.

W. Fan, S. Jin, T. Tong, H. Zhao, F. Fan, M. J. Antinore, B. Rajasekaran, M. Wu, and Q. Zhan (2002)
J. Biol. Chem. 277, 8061-8067
 |  Abstract »  |  Full Text »  |  PDF »

Oligomerization of Human Gadd45a Protein.

O. Kovalsky, F.-D. T. Lung, P. P. Roller, and A. J. Fornace Jr. (2001)
J. Biol. Chem. 276, 39330-39339
 |  Abstract »  |  Full Text »  |  PDF »

Zinc status affects p53, gadd45, and c-fos expression and caspase-3 activity in human bronchial epithelial cells.

J. C. Fanzo, S. K. Reaves, L. Cui, L. Zhu, J. Y. J. Wu, Y. R. Wang, and K. Y. Lei (2001)
Am J Physiol Cell Physiol 281, C751-C757
 |  Abstract »  |  Full Text »  |  PDF »

Isolation of Human Antibodies against the Central DNA Binding Domain of p53 from an Individual with Colorectal Cancer Using Antibody Phage Display.

D. W. J. Coomber and R. L. Ward (2001)
Clin. Cancer Res. 7, 2802-2808
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Gene Expression by 1{{alpha}},25-Dihydroxyvitamin D3 and Its Analog EB1089 under Growth-Inhibitory Conditions in Squamous Carcinoma Cells.

N. Akutsu, R. Lin, Y. Bastien, A. Bestawros, D. J. Enepekides, M. J. Black, and J. H. White (2001)
Mol. Endocrinol. 15, 1127-1139
 |  Abstract »  |  Full Text »  |  PDF »

Functional Analysis of Cyclin-Dependent Kinase Inhibitors of Arabidopsis.

L. De Veylder, T. Beeckman, G. T.S. Beemster, L. Krols, F. Terras, I. Landrieu, E. Van Der Schueren, S. Maes, M. Naudts, and D. Inze (2001)
PLANT CELL 13, 1653-1668
 |  Abstract »  |  Full Text »  |  PDF »

Ablation of p21waf1cip1 Expression Enhances the Capacity of p53-deficient Human Tumor Cells to Repair UVB-induced DNA Damage.

J.-P. Therrien, M. Loignon, R. Drouin, and E. A. Drobetsky (2001)
Cancer Res. 61, 3781-3786
 |  Abstract »  |  Full Text »

p53/p21CIP1 Cooperate in Enforcing Rapamycin-induced G1 Arrest and Determine the Cellular Response to Rapamycin.

S. Huang, L. N. Liu, H. Hosoi, M. B. Dilling, T. Shikata, and P. J. Houghton (2001)
Cancer Res. 61, 3373-3381
 |  Abstract »  |  Full Text »

Translational control of human p53 expression in yeast mediated by 5'-UTR-ORF structural interaction.

R. Mokdad-Gargouri, K. Belhadj, and A. Gargouri (2001)
Nucleic Acids Res. 29, 1222-1227
 |  Abstract »  |  Full Text »  |  PDF »

Dimethylbenzanthracene Carcinogenesis in Gadd45a-null Mice Is Associated with Decreased DNA Repair and Increased Mutation Frequency.

M. C. Hollander, O. Kovalsky, J. M. Salvador, K. E. Kim, A. D. Patterson, D. C. Haines, and A. J. Fornace Jr. (2001)
Cancer Res. 61, 2487-2491
 |  Abstract »  |  Full Text »

Involvement of the Oct-1 Regulatory Element of the gadd45 Promoter in the p53-independent Response to Ultraviolet Irradiation.

S. Takahashi, S. Saito, N. Ohtani, and T. Sakai (2001)
Cancer Res. 61, 1187-1195
 |  Abstract »  |  Full Text »

Activation of the Transcription Factor Oct-1 in Response to DNA Damage.

H. Zhao, S. Jin, F. Fan, W. Fan, T. Tong, and Q. Zhan (2000)
Cancer Res. 60, 6276-6280
 |  Abstract »  |  Full Text »

p53 Dependence of Topoisomerase I Recruitment in Vivo.

Y. Mao, S. Okada, L.-S. Chang, and M. T. Muller (2000)
Cancer Res. 60, 4538-4543
 |  Abstract »  |  Full Text »

Mechanisms and implications of the age-associated decrease in DNA repair capacity.

D. GOUKASSIAN, F. GAD, M. YAAR, M. S. ELLER, U. S. NEHAL, and B. A. GILCHREST (2000)
FASEB J 14, 1325-1334
 |  Abstract »  |  Full Text »

Characterization of MyD118, Gadd45, and Proliferating Cell Nuclear Antigen (PCNA) Interacting Domains. PCNA IMPEDES MyD118 AND Gadd45-MEDIATED NEGATIVE GROWTH CONTROL.

M. Vairapandi, N. Azam, A. G. Balliet, B. Hoffman, and D. A. Liebermann (2000)
J. Biol. Chem. 275, 16810-16819
 |  Abstract »  |  Full Text »  |  PDF »

p53-Mediated DNA Repair Responses to UV Radiation: Studies of Mouse Cells Lacking p53, p21, and/or gadd45 Genes.

M. L. Smith, J. M. Ford, M. C. Hollander, R. A. Bortnick, S. A. Amundson, Y. R. Seo, C.-X. Deng, P. C. Hanawalt, and A. J. Fornace Jr. (2000)
Mol. Cell. Biol. 20, 3705-3714
 |  Abstract »  |  Full Text »

Cytoplasmic Sequestration and Functional Repression of p53 in the Mammary Epithelium Is Reversed by Hormonal Treatment.

C. Kuperwasser, J. Pinkas, G. D. Hurlbut, S. P. Naber, and D. J. Jerry (2000)
Cancer Res. 60, 2723-2729
 |  Abstract »  |  Full Text »

Decreased DNA Repair Efficiency by Loss or Disruption of p53 Function Preferentially Affects Removal of Cyclobutane Pyrimidine Dimers from Non-transcribed Strand and Slow Repair Sites in Transcribed Strand.

Q. Zhu, M. A. Wani, M. El-mahdy, and A. A. Wani (2000)
J. Biol. Chem. 275, 11492-11497
 |  Abstract »  |  Full Text »  |  PDF »

Enhanced Sensitivity to anti-Benzo(a)pyrene-diol-epoxide DNA Damage Correlates with Decreased Global Genomic Repair Attributable to Abrogated p53 Function in Human Cells.

M. A. Wani, Q. Zhu, M. El-Mahdy, S. Venkatachalam, and A. A. Wani (2000)
Cancer Res. 60, 2273-2280
 |  Abstract »  |  Full Text »

Molecular and Genetic Aspects of Lung Cancer.

W. N. ROM, J. G. HAY, T. C. LEE, Y. JIANG, and K.-M. TCHOU-WONG (2000)
Am. J. Respir. Crit. Care Med. 161, 1355-1367
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p53-independent induction of GADD45 and GADD153 in mouse lungs exposed to hyperoxia.

M. A. O'Reilly, R. J. Staversky, R. H. Watkins, W. M. Maniscalco, and P. C. Keng (2000)
Am J Physiol Lung Cell Mol Physiol 278, L552-L559
 |  Abstract »  |  Full Text »  |  PDF »

Human cells compromised for p53 function exhibit defective global and transcription-coupled nucleotide excision repair, whereas cells compromised for pRb function are defective only in global repair.

J.-P. Therrien, R. Drouin, C. Baril, and E. A. Drobetsky (1999)
PNAS 96, 15038-15043
 |  Abstract »  |  Full Text »  |  PDF »

A Binding Site for the Transcription Factor Grainyhead/Nuclear Transcription Factor-1 Contributes to Regulation of the Drosophila Proliferating Cell Nuclear Antigen Gene Promoter.

Y. Hayashi, M. Yamagishi, Y. Nishimoto, O. Taguchi, A. Matsukage, and M. Yamaguchi (1999)
J. Biol. Chem. 274, 35080-35088
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of DNA-dependent Protein Kinase in UV-induced Replication Arrest.

J.-S. Park, S.-J. Park, X. Peng, M. Wang, M.-A. Yu, and S.-H. Lee (1999)
J. Biol. Chem. 274, 32520-32527
 |  Abstract »  |  Full Text »  |  PDF »

Stress-induced JNK Activation Is Independent of Gadd45 Induction.

E. Shaulian and M. Karin (1999)
J. Biol. Chem. 274, 29595-29598
 |  Abstract »  |  Full Text »  |  PDF »

gadd45 Is Not Required for Activation of c-Jun N-terminal Kinase or p38 during Acute Stress.

X. Wang, M. Gorospe, and N. J. Holbrook (1999)
J. Biol. Chem. 274, 29599-29602
 |  Abstract »  |  Full Text »  |  PDF »

p53 Negatively Regulates cdc2 Transcription via the CCAAT-binding NF-Y Transcription Factor.

J. Yun, H.-D. Chae, H. E. Choy, J. Chung, H.-S. Yoo, M.-H. Han, and D. Y. Shin (1999)
J. Biol. Chem. 274, 29677-29682
 |  Abstract »  |  Full Text »  |  PDF »

Toxicity Screening of a Combinatorial Library: Correlation of Cytotoxicity and Gene Induction to Compound Structure.

M. D. Todd, X. Lin, L. F. Stankowski Jr., M. Desai, and G. H.I. Wolfgang (1999)
J Biomol Screen 4, 259-268
 |  Abstract »  |  PDF »

Glutamine Deprivation Induces the Expression of GADD45 and GADD153 Primarily by mRNA Stabilization.

S. F. Abcouwer, C. Schwarz, and R. A. Meguid (1999)
J. Biol. Chem. 274, 28645-28651
 |  Abstract »  |  Full Text »  |  PDF »

The Presence of Human Immunodeficiency Virus Type 1 Vpr Correlates with a Decrease in the Frequency of Mutations in a Plasmid Shuttle Vector.

J. B. Jowett, Y.-m. Xie, and I. S. Y. Chen (1999)
J. Virol. 73, 7132-7137
 |  Abstract »  |  Full Text »

A Novel Oncostatin M-inducible Gene OIG37 Forms a Gene Family with MyD118 and GADD45 and Negatively Regulates Cell Growth.

K. Nakayama, T. Hara, M. Hibi, T. Hirano, and A. Miyajima (1999)
J. Biol. Chem. 274, 24766-24772
 |  Abstract »  |  Full Text »  |  PDF »

Potential roles for p53 in nucleotide excision repair.

B. C. McKay, M. Ljungman, and A. J. Rainbow1 (1999)
Carcinogenesis 20, 1389-1396
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Expression of the Growth Arrest Genes (GAS and GADD) Changes during Organogenesis in the Rat Fetus.

W. D. Rees, S. M. Hay, N. C. Fontanier-Razzaq, C. Antipatis, and D. N. Harries (1999)
J. Nutr. 129, 1532-1536
 |  Abstract »  |  Full Text »

Molecular Interaction Map of the Mammalian Cell Cycle Control and DNA Repair Systems.

K. W. Kohn (1999)
Mol. Biol. Cell 10, 2703-2734
 |  Abstract »  |  Full Text »

Human Cytomegalovirus and Human Herpesvirus 6 Genes That Transform and Transactivate.

J. Doniger, S. Muralidhar, and L. J. Rosenthal (1999)
Clin. Microbiol. Rev. 12, 367-382
 |  Abstract »  |  Full Text »  |  PDF »

Post-Transcriptional Regulation of MyD118 and GADD45 in Human Lung Carcinoma Cells During 6-[3-(1-Adamantyl)-4-hydroxyphenyl]-2-naphthalene Carboxylic Acid-Induced Apoptosis.

M. Sakaue, H. Adachi, and A. M. Jetten (1999)
Mol. Pharmacol. 55, 668-676
 |  Abstract »  |  Full Text »

GADD45 induction of a G2/M cell cycle checkpoint.

X. W. Wang, Q. Zhan, J. D. Coursen, M. A. Khan, H. U. Kontny, L. Yu, M. C. Hollander, P. M. O'Connor, A. J. Fornace Jr., and C. C. Harris (1999)
PNAS 96, 3706-3711
 |  Abstract »  |  Full Text »  |  PDF »

Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair.

B. J. Hwang, J. M. Ford, P. C. Hanawalt, and G. Chu (1999)
PNAS 96, 424-428
 |  Abstract »  |  Full Text »  |  PDF »

Sequestration of Mammalian Rad51-Recombination Protein into Micronuclei.

T. Haaf, E. Raderschall, G. Reddy, D. C. Ward, C. M. Radding, and E. I. Golub (1999)
J. Cell Biol. 144, 11-20
 |  Abstract »  |  Full Text »  |  PDF »

p53-Mediated Regulation of Proliferating Cell Nuclear Antigen Expression in Cells Exposed to Ionizing Radiation.

J. Xu and G. F. Morris (1999)
Mol. Cell. Biol. 19, 12-20
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UV-enhanced reactivation of a UV-damaged reporter gene suggests transcription-coupled repair is UV-inducible in human cells.

M. A. Francis and A. J. Rainbow (1999)
Carcinogenesis 20, 19-26
 |  Abstract »  |  Full Text »  |  PDF »

p53 Activates the CD95 (APO-1/Fas) Gene in Response to DNA Damage by Anticancer Drugs.

M. Muller, S. Wilder, D. Bannasch, D. Israeli, K. Lehlbach, M. Li-Weber, S. L. Friedman, P. R. Galle, W. Stremmel, M. Oren, et al. (1998)
J. Exp. Med. 188, 2033-2045
 |  Abstract »  |  Full Text »  |  PDF »

Alveolar macrophage apoptosis and TNF-alpha , but not p53, expression correlate with murine response to bleomycin.

L. A. Ortiz, K. Moroz, J.-Y. Liu, G. W. Hoyle, T. Hammond, R. F. Hamilton, A. Holian, W. Banks, A. R. Brody, and M. Friedman (1998)
Am J Physiol Lung Cell Mol Physiol 275, L1208-L1218
 |  Abstract »  |  Full Text »  |  PDF »

Identification of rCop-1, a New Member of the CCN Protein Family, as a Negative Regulator for Cell Transformation.

R. Zhang, L. Averboukh, W. Zhu, H. Zhang, H. Jo, P. J. Dempsey, R. J. Coffey, A. B. Pardee, and P. Liang (1998)
Mol. Cell. Biol. 18, 6131-6141
 |  Abstract »  |  Full Text »

Review : p53 in the pathogenesis, diagnosis, and treatment of cancer.

E. Perz and J. G. Kuhn (1998)
Journal of Oncology Pharmacy Practice 4, 75-102
 |  Abstract »  |  PDF »

Hyperosmolality Causes Growth Arrest of Murine Kidney Cells. INDUCTION OF GADD45 AND GADD153 BY OSMOSENSING VIA STRESS-ACTIVATED PROTEIN KINASE 2.

D. Kultz, S. Madhany, and M. B. Burg (1998)
J. Biol. Chem. 273, 13645-13651
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Identification of a Novel p53 Functional Domain That Is Necessary for Mediating Apoptosis.

J. Zhu, W. Zhou, J. Jiang, and X. Chen (1998)
J. Biol. Chem. 273, 13030-13036
 |  Abstract »  |  Full Text »  |  PDF »

Tumor Suppressor p53 Can Participate in Transcriptional Induction of the GADD45 Promoter in the Absence of Direct DNA Binding.

Q. Zhan, I-T. Chen, M. J. Antinore, and A. J. Fornace Jr. (1998)
Mol. Cell. Biol. 18, 2768-2778
 |  Abstract »  |  Full Text »

Cooperative Interactions Between RB and p53 Regulate Cell Proliferation, Cell Senescence, and Apoptosis in Human Vascular Smooth Muscle Cells From Atherosclerotic Plaques.

M. R. Bennett, K. Macdonald, S.-W. Chan, J. J. Boyle, and P. L. Weissberg (1998)
Circ. Res. 82, 704-712
 |  Abstract »  |  Full Text »  |  PDF »

Pacing-Induced Heart Failure in Dogs Enhances the Expression of p53 and p53-Dependent Genes in Ventricular Myocytes.

A. Leri, Y. Liu, A. Malhotra, Q. Li, P. Stiegler, P. P. Claudio, A. Giordano, J. Kajstura, T. H. Hintze, and P. Anversa (1998)
Circulation 97, 194-203
 |  Abstract »  |  Full Text »  |  PDF »

MYC Abrogates p53-Mediated Cell Cycle Arrest in N-(Phosphonacetyl)-L-Aspartate-Treated Cells, Permitting CAD Gene Amplification.

O. B. Chernova, M. V. Chernov, Y. Ishizaka, M. L. Agarwal, and G. R. Stark (1998)
Mol. Cell. Biol. 18, 536-545
 |  Abstract »  |  Full Text »

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