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Science 11 November 1994:
Vol. 266. no. 5187, pp. 1047 - 1050
DOI: 10.1126/science.7526464
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Articles

Science, Vol 266, Issue 5187, 1047-1050
Copyright © 1994 by American Association for the Advancement of Science

articles

Role of TCR zeta chain in T cell development and selection

EW Shores, K Huang, T Tran, E Lee, A Grinberg, and PE Love

Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892.

Signals mediated by the T cell receptor (TCR) are required for thymocyte maturation and selection. To examine the role of TCR zeta chain signals in development, TCR expression was restored in zeta-deficient mice with transgenic zeta chains that partially or completely lacked sequences required for signal transduction. The zeta chain played a role in thymic development by promoting TCR surface expression, but zeta-mediated signals were not essential because TCRs that contained signaling-deficient zeta chains promoted T cell maturation and transduced signals associated with thymic selection.


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