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Science 4 November 1994: Vol. 266. no. 5186, pp. 819 - 822 DOI: 10.1126/science.7973639
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Articles
Science, Vol 266, Issue 5186, 819-822
Copyright © 1994 by American Association for the Advancement of Science
The function of KGF in morphogenesis of epithelium and reepithelialization of wounds
S Werner,
H Smola,
X Liao,
MT Longaker,
T Krieg,
PH Hofschneider,
and
LT Williams
Cardiovascular Research Institute, University of California at San Francisco (UCSF) 94143-0130.
The function of keratinocyte growth factor (KGF) in normal and wounded skin was assessed by expression of a dominant-negative KGF receptor transgene in basal keratinocytes. The skin of transgenic mice was characterized by epidermal atrophy, abnormalities in the hair follicles, and dermal hyperthickening. Upon skin injury, inhibition of KGF receptor signaling reduced the proliferation rate of epidermal keratinocytes at the wound edge, resulting in substantially delayed reepithelialization of the wound.
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- Keratinocyte Growth Factor Induces Granulation Tissue in Ischemic Dermal Wounds: Importance of Epithelial-Mesenchymal Cell Interactions.
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Arch Surg
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- Keratinocyte Growth Factor Inhibits Cross-linked Envelope Formation and Nucleosomal Fragmentation in Cultured Human Keratinocytes.
- M. D. Hines and B. L. Allen-Hoffmann (1996)
J. Biol. Chem.
271, 6245-6251
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- Keratinocyte growth factor is required for hair development but not for wound healing..
- L Guo, L Degenstein, and E Fuchs (1996)
Genes & Dev.
10, 165-175
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- Impaired Insulin Signaling in Skeletal Muscles from Transgenic Mice Expressing Kinase-deficient Insulin Receptors.
- P.-Y. Chang, L. J. Goodyear, H. Benecke, J. S. Markuns, and D. E. Moller (1995)
J. Biol. Chem.
270, 12593-12600
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- Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.
- S. Frank, G. Hübner, G. Breier, M. T. Longaker, D. G. Greenhalgh, and S. Werner (1995)
J. Biol. Chem.
270, 12607-12613
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