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Science 4 November 1994:
Vol. 266. no. 5186, pp. 816 - 819
DOI: 10.1126/science.7973638

Articles

Science, Vol 266, Issue 5186, 816-819
Copyright © 1994 by American Association for the Advancement of Science


articles

Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity

S Davis, NW Gale, TH Aldrich, PC Maisonpierre, V Lhotak, T Pawson, M Goldfarb, and GD Yancopoulos

Regeneron Pharmaceuticals, Tarrytown, NY 10591.

The EPH-related transmembrane tyrosine kinases constitute the largest known family of receptor-like tyrosine kinases, with many members displaying specific patterns of expression in the developing and adult nervous system. A family of cell surface-bound ligands exhibiting distinct, but overlapping, specificities for these EPH-related kinases was identified. These ligands were unable to act as conventional soluble factors. However, they did function when presented in membrane-bound form, suggesting that they require direct cell-to-cell contact to activate their receptors. Membrane attachment may serve to facilitate ligand dimerization or aggregation, because antibody-mediated clustering activated previously inactive soluble forms of these ligands.


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Development 127, 1397-1410
   Abstract »    PDF »
A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.
H.-C. Aasheim, E. Munthe, S. Funderud, E. B. Smeland, K. Beiske, and T. Logtenberg (2000)
Blood 95, 221-230
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Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion.
A. Davy, N. W. Gale, E. W. Murray, R. A. Klinghoffer, P. Soriano, C. Feuerstein, and S. M. Robbins (1999)
Genes & Dev. 13, 3125-3135
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Selective Inhibition of Spinal Cord Neurite Outgrowth and Cell Survival by the Eph Family Ligand Ephrin-A5.
Y. Yue, J. Su, D. P. Cerretti, G. M. Fox, S. Jing, and R. Zhou (1999)
J. Neurosci. 19, 10026-10035
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Angiopoietin-1 and -2 Coiled Coil Domains Mediate Distinct Homo-oligomerization Patterns, but Fibrinogen-like Domains Mediate Ligand Activity.
W. N. Procopio, P. I. Pelavin, W. M. F. Lee, and N. M. Yeilding (1999)
J. Biol. Chem. 274, 30196-30201
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Contact-dependent Growth Inhibition and Apoptosis of Epidermal Growth Factor (EGF) Receptor-expressing Cells by the Membrane-anchored Form of Heparin-binding EGF-like Growth Factor.
R. Iwamoto, K. Handa, and E. Mekada (1999)
J. Biol. Chem. 274, 25906-25912
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Immunohistochemical Localization of EphA5 in the Adult Human Central Nervous System.
G. Olivieri and G. C. Miescher (1999)
J. Histochem. Cytochem. 47, 855-862
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Ephrin-A Binding and EphA Receptor Expression Delineate the Matrix Compartment of the Striatum.
L. S. Janis, R. M. Cassidy, and L. F. Kromer (1999)
J. Neurosci. 19, 4962-4971
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A PDZ Protein Regulates the Distribution of the Transmembrane Semaphorin, M-SemF.
L.-H. Wang, R. G. Kalb, and S. M. Strittmatter (1999)
J. Biol. Chem. 274, 14137-14146
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Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development.
N. W. Gale and G. D. Yancopoulos (1999)
Genes & Dev. 13, 1055-1066
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Specification of Distinct Dopaminergic Neural Pathways: Roles of the Eph Family Receptor EphB1 and Ligand Ephrin-B2.
Y. Yue, D. A. J. Widmer, A. K. Halladay, D. P. Cerretti, G. C. Wagner, J.-L. Dreyer, and R. Zhou (1999)
J. Neurosci. 19, 2090-2101
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Selective Inhibition of Kindling Development by Intraventricular Administration of TrkB Receptor Body.
D. K. Binder, M. J. Routbort, T. E. Ryan, G. D. Yancopoulos, and J. O. McNamara (1999)
J. Neurosci. 19, 1424-1436
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The Carboxyl Terminus of B Class Ephrins Constitutes a PDZ Domain Binding Motif.
D. Lin, G. D. Gish, Z. Songyang, and T. Pawson (1999)
J. Biol. Chem. 274, 3726-3733
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Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.
R. H. Adams, G. A. Wilkinson, C. Weiss, F. Diella, N. W. Gale, U. Deutsch, W. Risau, and R. Klein (1999)
Genes & Dev. 13, 295-306
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Eph receptors and ephrins: effectors of morphogenesis.
N Holder and R Klein (1999)
Development 126, 2033-2044
   Abstract »    PDF »
Promotion of Dendritic Growth by CPG15, an Activity-Induced Signaling Molecule.
E. Nedivi, G. Wu, and H. T. Cline (1998)
Science 281, 1863-1866
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