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Science 4 November 1994: Vol. 266. no. 5186, pp. 816 - 819 DOI: 10.1126/science.7973638
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Articles
Science, Vol 266, Issue 5186, 816-819
Copyright © 1994 by American Association for the Advancement of Science
Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity
S Davis,
NW Gale,
TH Aldrich,
PC Maisonpierre,
V Lhotak,
T Pawson,
M Goldfarb,
and
GD Yancopoulos
Regeneron Pharmaceuticals, Tarrytown, NY 10591.
The EPH-related transmembrane tyrosine kinases constitute the largest known family of receptor-like tyrosine kinases, with many members displaying specific patterns of expression in the developing and adult nervous system. A family of cell surface-bound ligands exhibiting distinct, but overlapping, specificities for these EPH-related kinases was identified. These ligands were unable to act as conventional soluble factors. However, they did function when presented in membrane-bound form, suggesting that they require direct cell-to-cell contact to activate their receptors. Membrane attachment may serve to facilitate ligand dimerization or aggregation, because antibody-mediated clustering activated previously inactive soluble forms of these ligands.
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41, 2164-2169
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- Phosphorylation of Tyrosine Residues in the Kinase Domain and Juxtamembrane Region Regulates the Biological and Catalytic Activities of Eph Receptors.
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Mol. Cell. Biol.
20, 4791-4805
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- The Interaction between the Drosophila Secreted Protein Argos and the Epidermal Growth Factor Receptor Inhibits Dimerization of the Receptor and Binding of Secreted Spitz to the Receptor.
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Mol. Cell. Biol.
20, 2098-2107
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- Nck-Interacting Ste20 Kinase Couples Eph Receptors to c-Jun N-Terminal Kinase and Integrin Activation.
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Mol. Cell. Biol.
20, 1537-1545
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- Fibroblast Growth Factor Receptor-Mediated Rescue of x-Ephrin B1-Induced Cell Dissociation in Xenopus Embryos.
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Mol. Cell. Biol.
20, 724-734
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- Expression of Eph receptors and ephrins is differentially regulated by E-cadherin.
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J. Cell Sci.
113, 1793-1802
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- Complementary expression of transmembrane ephrins and their receptors in the mouse spinal cord: a possible role in constraining the orientation of longitudinally projecting axons.
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Development
127, 1397-1410
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- A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes.
- H.-C. Aasheim, E. Munthe, S. Funderud, E. B. Smeland, K. Beiske, and T. Logtenberg (2000)
Blood
95, 221-230
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- Compartmentalized signaling by GPI-anchored ephrin-A5 requires the Fyn tyrosine kinase to regulate cellular adhesion.
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Genes & Dev.
13, 3125-3135
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- Selective Inhibition of Spinal Cord Neurite Outgrowth and Cell Survival by the Eph Family Ligand Ephrin-A5.
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J. Neurosci.
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- Angiopoietin-1 and -2 Coiled Coil Domains Mediate Distinct Homo-oligomerization Patterns, but Fibrinogen-like Domains Mediate Ligand Activity.
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274, 30196-30201
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- Contact-dependent Growth Inhibition and Apoptosis of Epidermal Growth Factor (EGF) Receptor-expressing Cells by the Membrane-anchored Form of Heparin-binding EGF-like Growth Factor.
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J. Histochem. Cytochem.
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- A PDZ Protein Regulates the Distribution of the Transmembrane Semaphorin, M-SemF.
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- Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular development.
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Genes & Dev.
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- Specification of Distinct Dopaminergic Neural Pathways: Roles of the Eph Family Receptor EphB1 and Ligand Ephrin-B2.
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J. Neurosci.
19, 2090-2101
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- Selective Inhibition of Kindling Development by Intraventricular Administration of TrkB Receptor Body.
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J. Neurosci.
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- The Carboxyl Terminus of B Class Ephrins Constitutes a PDZ Domain Binding Motif.
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274, 3726-3733
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- Roles of ephrinB ligands and EphB receptors in cardiovascular development: demarcation of arterial/venous domains, vascular morphogenesis, and sprouting angiogenesis.
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Genes & Dev.
13, 295-306
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- Eph receptors and ephrins: effectors of morphogenesis.
- N Holder and R Klein (1999)
Development
126, 2033-2044
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- Promotion of Dendritic Growth by CPG15, an Activity-Induced Signaling Molecule.
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Science
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