Science 14 October 1994: Vol. 266. no. 5183, pp. 288 - 291 DOI: 10.1126/science.7939667

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Articles

Prevalence and clinical associations of anti-Ku antibodies in patients with systemic sclerosis: a European EUSTAR-initiated multi-centre case-control study.

B Rozman, S Cucnik, S Sodin-Semrl, L Czirjak, C Varju, O Distler, D Huscher, M Aringer, G Steiner, M Matucci-Cerinic, et al. (2008)
Ann Rheum Dis 67, 1282-1286
 |  Abstract »  |  Full Text »  |  PDF »

Deletion of Ku70, Ku80, or Both Causes Early Aging without Substantially Increased Cancer.

H. Li, H. Vogel, V. B. Holcomb, Y. Gu, and P. Hasty (2007)
Mol. Cell. Biol. 27, 8205-8214
 |  Abstract »  |  Full Text »  |  PDF »

Ku80 Participates in the Targeting of Retroviral Transgenes to the Chromatin of CHO Cells.

C. Masson, S. Bury-Mone, E. Guiot, A. Saez-Cirion, D. Schoevaert-Brossault, C. Brachet-Ducos, O. Delelis, F. Subra, L. Jeanson-Leh, and J.-F. Mouscadet (2007)
J. Virol. 81, 7924-7932
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Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends.

C. J. Tsai, S. A. Kim, and G. Chu (2007)
PNAS 104, 7851-7856
 |  Abstract »  |  Full Text »  |  PDF »

Loading of the Nonhomologous End Joining Factor, Ku, on Protein-occluded DNA Ends.

S. A. Roberts and D. A. Ramsden (2007)
J. Biol. Chem. 282, 10605-10613
 |  Abstract »  |  Full Text »  |  PDF »

Structural biology and bioinformatics in drug design: opportunities and challenges for target identification and lead discovery.

T. L Blundell, B. L Sibanda, R. W. Montalvao, S. Brewerton, V. Chelliah, C. L Worth, N. J Harmer, O. Davies, and D. Burke (2006)
Phil Trans R Soc B 361, 413-423
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Ku86 Modulates DNA Topoisomerase I-Mediated Radiosensitization, but not Cytotoxicity, in Mammalian Cells.

S.-J. Shih, T. Erbele, and A. Y. Chen (2005)
Cancer Res. 65, 9194-9199
 |  Abstract »  |  Full Text »  |  PDF »

Ku86 preserves chromatin integrity in cells adapted to high NaCl.

N. I. Dmitrieva, A. Celeste, A. Nussenzweig, and M. B. Burg (2005)
PNAS 102, 10730-10735
 |  Abstract »  |  Full Text »  |  PDF »

DNA damage response and Ku80 function in the vertebrate embryo.

C. L. Bladen, W. K. Lam, W. S. Dynan, and D. J. Kozlowski (2005)
Nucleic Acids Res. 33, 3002-3010
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Ku protein targeting by Ku70 small interfering RNA enhances human cancer cell response to topoisomerase II inhibitor and {gamma} radiation.

I. S. Ayene, L. P. Ford, and C. J. Koch (2005)
Mol. Cancer Ther. 4, 529-536
 |  Abstract »  |  Full Text »  |  PDF »

Visualization of inositol phosphate-dependent mobility of Ku: depletion of the DNA-PK cofactor InsP6 inhibits Ku mobility.

J. Byrum, S. Jordan, S. T. Safrany, and W. Rodgers (2004)
Nucleic Acids Res. 32, 2776-2784
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional Regulation of P450scc Gene Expression in the Embryonic Rodent Nervous System.

F. Hammer, N. A. Compagnone, J.-L. Vigne, S. R. Bair, and S. H. Mellon (2004)
Endocrinology 145, 901-912
 |  Abstract »  |  Full Text »  |  PDF »

Down-Regulation of Histone H2B by DNA-Dependent Protein Kinase in Response to DNA Damage through Modulation of Octamer Transcription Factor 1.

C. Schild-Poulter, A. Shih, N. C. Yarymowich, and R. J. G. Hache (2003)
Cancer Res. 63, 7197-7205
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the DNA replication competence of the xrs-5 mutant cells defective in Ku86.

D. Matheos, O. Novac, G. B. Price, and M. Zannis-Hadjopoulos (2003)
J. Cell Sci. 116, 111-124
 |  Abstract »  |  Full Text »  |  PDF »

DNA-PK-dependent binding of DNA ends to plasmids containing nuclear matrix attachment region DNA sequences: evidence for assembly of a repair complex.

S. K. Mauldin, R. C. Getts, W. Liu, and T. D. Stamato (2002)
Nucleic Acids Res. 30, 4075-4087
 |  Abstract »  |  Full Text »  |  PDF »

p53 Binds and Activates the Xeroderma Pigmentosum DDB2 Gene in Humans but Not Mice.

T. Tan and G. Chu (2002)
Mol. Cell. Biol. 22, 3247-3254
 |  Abstract »  |  Full Text »  |  PDF »

DNA double-strand breaks induce formation of RP-A/Ku foci on in vitro reconstituted Xenopus sperm nuclei.

P. Grandi, M. Eltsov, I. Nielsen, and I. Raska (2002)
J. Cell Sci. 114, 3345-3357
 |  Abstract »  |  Full Text »  |  PDF »

Restriction enzymes increase efficiencies of illegitimate DNA integration but decrease homologous integration in mammalian cells.

P. Manivasakam, J. Aubrecht, S. Sidhom, and R. H. Schiestl (2001)
Nucleic Acids Res. 29, 4826-4833
 |  Abstract »  |  Full Text »  |  PDF »

Gestational Age and Gender-specific In Utero V(D)J Recombinase-mediated Deletions.

M. Yoshioka, J. P. O’Neill, P. M. Vacek, and B. A. Finette (2001)
Cancer Res. 61, 3432-3438
 |  Abstract »  |  Full Text »

Hypoxia-activated ligand HAL-1/13 is lupus autoantigen Ku80 and mediates lymphoid cell adhesion in vitro.

E. M. Lynch, R. B. Moreland, I. Ginis, S. P. Perrine, and D. V. Faller (2001)
Am J Physiol Cell Physiol 280, C897-C911
 |  Abstract »  |  Full Text »  |  PDF »

End-joining Deficiency and Radiosensitization Induced by Gemcitabine.

J. W. G. van Putten, H. J. M. Groen, K. Smid, G. J. Peters, and H. H. Kampinga (2001)
Cancer Res. 61, 1585-1591
 |  Abstract »  |  Full Text »

Nuclear localization of Ku antigen is promoted independently by basic motifs in the Ku70 and Ku80 subunits.

J Bertinato, C Schild-Poulter, and R. Hache (2001)
J. Cell Sci. 114, 89-99
 |  Abstract »  |  PDF »

Ku86 Variant Expression and Function in Multiple Myeloma Cells Is Associated with Increased Sensitivity to DNA Damage.

Y.-T. Tai, G. Teoh, B. Lin, F. E. Davies, D. Chauhan, S. P. Treon, N. Raje, T. Hideshima, Y. Shima, K. Podar, et al. (2000)
J. Immunol. 165, 6347-6355
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of ku80-Mutant Mice and Cells with Deficient Levels of p53.

D.-S. Lim, H. Vogel, D. M. Willerford, A. T. Sands, K. A. Platt, and P. Hasty (2000)
Mol. Cell. Biol. 20, 3772-3780
 |  Abstract »  |  Full Text »

Regulated Genomic Instability and Neoplasia in the Lymphoid Lineage.

G. J. Vanasse, P. Concannon, and D. M. Willerford (1999)
Blood 94, 3997-4010
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Ku Autoantigen Affects the Susceptibility to Anticancer Drugs.

S. H. Kim, D. Kim, J. S. Han, C. S. Jeong, B. S. Chung, C. D. Kang, and G. C. Li (1999)
Cancer Res. 59, 4012-4017
 |  Abstract »  |  Full Text »  |  PDF »

Photocross-linking of an Oriented DNA Repair Complex. Ku BOUND AT A SINGLE DNA END.

S. Yoo, A. Kimzey, and W. S. Dynan (1999)
J. Biol. Chem. 274, 20034-20039
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Cross-Resistance to Ionizing Radiation in a Murine Leukemic Cell Line Resistant to cis-Dichlorodiammineplatinum(II): Role of Ku Autoantigen.

P. Frit, Y. Canitrot, C. Muller, N. Foray, P. Calsou, E. Marangoni, J. Bourhis, and B. Salles (1999)
Mol. Pharmacol. 56, 141-146
 |  Abstract »  |  Full Text »

Ku Antigen-DNA Conformation Determines the Activation of DNA-Dependent Protein Kinase and DNA Sequence-Directed Repression of Mouse Mammary Tumor Virus Transcription.

W. Giffin, W. Gong, C. Schild-Poulter, and R. J. G. Hache (1999)
Mol. Cell. Biol. 19, 4065-4078
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The Ability of p53 to Activate Downstream Genes p21WAF1/cip1 and MDM2, and Cell Cycle Arrest following DNA Damage Is Delayed and Attenuated in scid Cells Deficient in the DNA-dependent Protein Kinase.

L. A. Kachnic, B. Wu, H. Wunsch, K. L. Mekeel, J. S. DeFrank, W. Tang, and S. N. Powell (1999)
J. Biol. Chem. 274, 13111-13117
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The DNA-dependent protein kinase.

G. C.M. Smith and S. P. Jackson (1999)
Genes & Dev. 13, 916-934
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Ku-Dependent Nonhomologous DNA End Joining in Xenopus Egg Extracts.

P. Labhart (1999)
Mol. Cell. Biol. 19, 2585-2593
 |  Abstract »  |  Full Text »  |  PDF »

IL-5 Induces IgG1 Isotype Switch Recombination in Mouse CD38-Activated sIgD-Positive B Lymphocytes.

C. Mizoguchi, S. Uehara, S. Akira, and K. Takatsu (1999)
J. Immunol. 162, 2812-2819
 |  Abstract »  |  Full Text »  |  PDF »

OBA/Ku86: DNA Binding Specificity and Involvement in Mammalian DNA Replication.

M. T. Ruiz, D. Matheos, G. B. Price, and M. Zannis-Hadjopoulos (1999)
Mol. Biol. Cell 10, 567-580
 |  Abstract »  |  Full Text »

Nuclear Extracts Lacking DNA-dependent Protein Kinase Are Deficient in Multiple Round Transcription.

R. L. Woodard, M. G. Anderson, and W. S. Dynan (1999)
J. Biol. Chem. 274, 478-485
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Asbestos and DNA Double Strand Breaks.

R. Okayasu, S. Takahashi, S. Yamada, T. K. Hei, and R. L. Ullrich (1999)
Cancer Res. 59, 298-300
 |  Abstract »  |  Full Text »  |  PDF »

Failure of Hairpin-Ended and Nicked DNA To Activate DNA-Dependent Protein Kinase: Implications for V(D)J Recombination.

V. Smider, W. K. Rathmell, G. Brown, S. Lewis, and G. Chu (1998)
Mol. Cell. Biol. 18, 6853-6858
 |  Abstract »  |  Full Text »

Hypersensitivity of Ku-Deficient Cells toward the DNA Topoisomerase II Inhibitor ICRF-193 Suggests a Novel Role for Ku Antigen during the G2 and M Phases of the Cell Cycle.

P. Muñoz, M. Z. Zdzienicka, J.-M. Blanchard, and J. Piette (1998)
Mol. Cell. Biol. 18, 5797-5808
 |  Abstract »  |  Full Text »

Productive and Nonproductive Complexes of Ku and DNA-Dependent Protein Kinase at DNA Termini.

R. B. West, M. Yaneva, and M. R. Lieber (1998)
Mol. Cell. Biol. 18, 5908-5920
 |  Abstract »  |  Full Text »

Xrcc3 Is Required for Assembly of Rad51 Complexes in Vivo.

D. K. Bishop, U. Ear, A. Bhattacharyya, C. Calderone, M. Beckett, R. R. Weichselbaum, and A. Shinohara (1998)
J. Biol. Chem. 273, 21482-21488
 |  Abstract »  |  Full Text »  |  PDF »

Sequence-specific Binding of Ku Autoantigen to Single-stranded DNA.

H. Torrance, W. Giffin, D. J. Rodda, L. Pope, and R. J. G. Hache (1998)
J. Biol. Chem. 273, 20810-20819
 |  Abstract »  |  Full Text »  |  PDF »

p48 Activates a UV-Damaged-DNA Binding Factor and Is Defective in Xeroderma Pigmentosum Group E Cells That Lack Binding Activity.

B. J. Hwang, S. Toering, U. Francke, and G. Chu (1998)
Mol. Cell. Biol. 18, 4391-4399
 |  Abstract »  |  Full Text »

Ku70 Is Required for Late B Cell Development and Immunoglobulin Heavy Chain Class Switching.

J. P. Manis, Y. Gu, R. Lansford, E. Sonoda, R. Ferrini, L. Davidson, K. Rajewsky, and F. W. Alt (1998)
J. Exp. Med. 187, 2081-2089
 |  Abstract »  |  Full Text »  |  PDF »

Stimulation of the DNA-dependent Protein Kinase by Poly(ADP-Ribose) Polymerase.

T. Ruscetti, B. E. Lehnert, J. Halbrook, H. Le Trong, M. F. Hoekstra, D. J. Chen, and S. R. Peterson (1998)
J. Biol. Chem. 273, 14461-14467
 |  Abstract »  |  Full Text »  |  PDF »

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku.

O. Hammarsten and G. Chu (1998)
PNAS 95, 525-530
 |  Abstract »  |  Full Text »  |  PDF »

Identification of Two Domains of the p70 Ku Protein Mediating Dimerization with p80 and DNA Binding.

J. Wang, X. Dong, K. Myung, E. A. Hendrickson, and W. H. Reeves (1998)
J. Biol. Chem. 273, 842-848
 |  Abstract »  |  Full Text »  |  PDF »

Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development.

A. Nussenzweig, K. Sokol, P. Burgman, L. Li, and G. C. Li (1997)
PNAS 94, 13588-13593
 |  Abstract »  |  Full Text »  |  PDF »

Defining the Minimal Domain of Ku80 for Interaction with Ku70.

O. Osipovich, S. K. Durum, and K. Muegge (1997)
J. Biol. Chem. 272, 27259-27265
 |  Abstract »  |  Full Text »  |  PDF »

Double Strand Break Repair.

G. Chu (1997)
J. Biol. Chem. 272, 24097-24100
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Ku70 Is Required for DNA Repair but Not for T Cell Antigen Receptor Gene Recombination In Vivo.

H. Ouyang, A. Nussenzweig, A. Kurimasa, V. d. C. Soares, X. Li, C. Cordon-Cardo, W.-h. Li, N. Cheong, M. Nussenzweig, G. Iliakis, et al. (1997)
J. Exp. Med. 186, 921-929
 |  Abstract »  |  Full Text »  |  PDF »

The human XRCC9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40 cells.

N. Liu, J. E. Lamerdin, J. D. Tucker, Z.-Q. Zhou, C. A. Walter, J. S. Albala, D. B. Busch, and L. H. Thompson (1997)
PNAS 94, 9232-9237
 |  Abstract »  |  Full Text »  |  PDF »

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination.

Y. Gu, S. Jin, Y. Gao, D. T. Weaver, and F. W. Alt (1997)
PNAS 94, 8076-8081
 |  Abstract »  |  Full Text »  |  PDF »

Finkel-Biskis-Reilly Mouse Osteosarcoma Virus v-fos Inhibits the Cellular Response to Ionizing Radiation in a Myristoylation-dependent Manner.

D. W. Abbott and J. T. Holt (1997)
J. Biol. Chem. 272, 14005-14008
 |  Abstract »  |  Full Text »  |  PDF »

DNA looping by Ku and the DNA-dependent protein kinase.

R. B. Cary, S. R. Peterson, J. Wang, D. G. Bear, E. M. Bradbury, and D. J. Chen (1997)
PNAS 94, 4267-4272
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Two DNA Double-stranded Break Repair-deficient Cell Lines That Express Inactive DNA-dependent Protein Kinase Catalytic Subunits.

S. R. Peterson, M. Stackhouse, M. J. Waltman, F. Chen, K. Sato, and D. J. Chen (1997)
J. Biol. Chem. 272, 10227-10231
 |  Abstract »  |  Full Text »  |  PDF »

Sequence-specific DNA Binding and Transcription Factor Phosphorylation by Ku Autoantigen/DNA-dependent Protein Kinase. PHOSPHORYLATION OF Ser-527 OF THE RAT GLUCOCORTICOID RECEPTOR.

W. Giffin, J. Kwast-Welfeld, D. J. Rodda, G. G. Prefontaine, M. Traykova-Andonova, Y. Zhang, N. L. Weigel, Y. A. Lefebvre, and R. J.G. Hache (1997)
J. Biol. Chem. 272, 5647-5658
 |  Abstract »  |  Full Text »  |  PDF »

HDF2, the Second Subunit of the Ku Homologue from Saccharomyces cerevisiae.

H. Feldmann, L. Driller, B. Meier, G. Mages, J. Kellermann, and E.-L. Winnacker (1996)
J. Biol. Chem. 271, 27765-27769
 |  Abstract »  |  Full Text »  |  PDF »

End-joining of Free Radical-mediated DNA Double-strand Breaks in Vitro Is Blocked by the Kinase Inhibitor Wortmannin at a Step Preceding Removal of Damaged 3' Termini.

X.-Y. Gu, R. A.O. Bennett, and L. F. Povirk (1996)
J. Biol. Chem. 271, 19660-19663
 |  Abstract »  |  Full Text »  |  PDF »

DNA Binding Specificities of YPF1, a Drosophila Homolog to the DNA Binding Subunit of Human DNA-dependent Protein Kinase, Ku.

D. B. Jacoby and P. C. Wensink (1996)
J. Biol. Chem. 271, 16827-16832
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of a Ku86 Variant Protein That Results in Altered DNA Binding and Diminished DNA-dependent Protein Kinase Activity.

Z. Han, C. Johnston, W. H. Reeves, T. Carter, J. H. Wyche, and E. A. Hendrickson (1996)
J. Biol. Chem. 271, 14098-14104
 |  Abstract »  |  Full Text »  |  PDF »

Ku80-deficient Cells Exhibit Excess Degradation of Extrachromosomal DNA.

F. Liang and M. Jasin (1996)
J. Biol. Chem. 271, 14405-14411
 |  Abstract »  |  Full Text »  |  PDF »

Human Ku Autoantigen Binds Cisplatin-damaged DNA but Fails to Stimulate Human DNA-activated Protein Kinase.

J. J. Turchi and K. Henkels (1996)
J. Biol. Chem. 271, 13861-13867
 |  Abstract »  |  Full Text »  |  PDF »

The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit.

D. W. Chan and S. P. Lees-Miller (1996)
J. Biol. Chem. 271, 8936-8941
 |  Abstract »  |  Full Text »  |  PDF »

Involvement of the Saccharomyces cerevisiae HDF1 Gene in DNA Double-strand Break Repair and Recombination.

G. J. Mages, H. M. Feldmann, and E.-L. Winnacker (1996)
J. Biol. Chem. 271, 7910-7915
 |  Abstract »  |  Full Text »  |  PDF »

Cleavage and inactivation of DNA-dependent protein kinase catalytic subunit during apoptosis in Xenopus egg extracts.

M Le Romancer, S. Cosulich, S. Jackson, and P. Clarke (1996)
J. Cell Sci. 109, 3121-3127
 |  Abstract »  |  PDF »

Intracellular redistribution of Ku immunoreactivity in response to cell-cell contact and growth modulating components in the medium.

J. Fewell and E. Kuff (1996)
J. Cell Sci. 109, 1937-1946
 |  Abstract »  |  PDF »

Stimulation of Defective DNA Transfer Activity in Recombination Deficient SCID Cell Extracts by a 72-kDa Protein from Wild-type Thymocytes.

R. Jessberger, B. Riwar, A. Rolink, and H.-R. Rodewald (1995)
J. Biol. Chem. 270, 6788-6797
 |  Abstract »  |  Full Text »  |  PDF »

DNA-dependent kinase (p350) as a candidate gene for the murine SCID defect.

C. Kirchgessner, C. Patil, J. Evans, C. Cuomo, L. Fried, T Carter, M. Oettinger, and J. Brown (1995)
Science 267, 1178-1183
 |  Abstract »  |  PDF »

Absence of p350 subunit of DNA-activated protein kinase from a radiosensitive human cell line.

S. Lees-Miller, R Godbout, D. Chan, M Weinfeld, R. Day 3rd, G. Barron, and J Allalunis-Turner (1995)
Science 267, 1183-1185
 |  Abstract »  |  PDF »

Human Ku70 Interacts with Heterochromatin Protein 1alpha.

K. Song, Y. Jung, D. Jung, and I. Lee (2001)
J. Biol. Chem. 276, 8321-8327
 |  Abstract »  |  Full Text »  |  PDF »

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