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Science 7 October 1994:
Vol. 266. no. 5182, pp. 66 - 71
DOI: 10.1126/science.7545954
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Articles

Science, Vol 266, Issue 5182, 66-71
Copyright © 1994 by American Association for the Advancement of Science

articles

A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1

Y Miki, J Swensen, D Shattuck-Eidens, PA Futreal, K Harshman, S Tavtigian, Q Liu, C Cochran, LM Bennett, W Ding, and al. et

Department of Medical Informatics, University of Utah Medical Center, Salt Lake City 84132.

A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have been detected in five of eight kindreds presumed to segregate BRCA1 susceptibility alleles. The mutations include an 11-base pair deletion, a 1-base pair insertion, a stop codon, a missense substitution, and an inferred regulatory mutation. The BRCA1 gene is expressed in numerous tissues, including breast and ovary, and encodes a predicted protein of 1863 amino acids. This protein contains a zinc finger domain in its amino-terminal region, but is otherwise unrelated to previously described proteins. Identification of BRCA1 should facilitate early diagnosis of breast and ovarian cancer susceptibility in some individuals as well as a better understanding of breast cancer biology.


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   Abstract »    Full Text »    PDF »
Radiation clastogenesis and cell cycle checkpoint function as functional markers of breast cancer risk.
W. K. Kaufmann, L. Filatov, S. E. Oglesbee, D. A. Simpson, M. A. Lotano, H. D. McKeen, L. R. Sawyer, D. T. Moore, R. C. Millikan, M. Cordeiro-Stone, et al. (2006)
Carcinogenesis 27, 2519-2527
   Abstract »    Full Text »    PDF »
BRCA1 Negatively Regulates the Cancer-Associated Aromatase Promoters I.3 and II in Breast Adipose Fibroblasts and Malignant Epithelial Cells.
M. Lu, D. Chen, Z. Lin, S. Reierstad, A. M. Trauernicht, T. G. Boyer, and S. E. Bulun (2006)
J. Clin. Endocrinol. Metab. 91, 4514-4519
   Abstract »    Full Text »    PDF »
Ashkenazi Jews and Breast Cancer: The Consequences of Linking Ethnic Identity to Genetic Disease.
S. I. Brandt-Rauf, V. H. Raveis, N. F. Drummond, J. A. Conte, and S. M. Rothman (2006)
Am J Public Health 96, 1979-1988
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Nordic collaborative study of the BARD1 Cys557Ser allele in 3956 patients with cancer: enrichment in familial BRCA1/BRCA2 mutation-negative breast cancer but not in other malignancies.
S-M Karppinen, R B Barkardottir, K Backenhorn, T Sydenham, K Syrjakoski, J Schleutker, T Ikonen, K Pylkas, K Rapakko, H Erkko, et al. (2006)
J. Med. Genet. 43, 856-862
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ASCO/SSO Review of Current Role of Risk-Reducing Surgery in Common Hereditary Cancer Syndromes.
J. G. Guillem, W. C. Wood, J. F. Moley, A. Berchuck, B. Y. Karlan, D. G. Mutch, R. F. Gagel, J. Weitzel, M. Morrow, B. L. Weber, et al. (2006)
J. Clin. Oncol. 24, 4642-4660
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Metallothionein as a prognostic biomarker in breast cancer..
B.-H. Bay, R. Jin, J. Huang, and P.-H. Tan (2006)
Experimental Biology and Medicine 231, 1516-1521
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DExD/H box RNA helicases: multifunctional proteins with important roles in transcriptional regulation.
F. V. Fuller-Pace (2006)
Nucleic Acids Res. 34, 4206-4215
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BRCA1 Suppresses Osteopontin-mediated Breast Cancer.
M. K. El-Tanani, F. C. Campbell, P. Crowe, P. Erwin, D. P. Harkin, P. Pharoah, B. Ponder, and P. S. Rudland (2006)
J. Biol. Chem. 281, 26587-26601
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Heregulin-Dependent Delay in Mitotic Progression Requires HER4 and BRCA1..
R. S. Muraoka-Cook, L. S. Caskey, M. A. Sandahl, D. M. Hunter, C. Husted, K. E. Strunk, C. I. Sartor, W. A. Rearick Jr., W. McCall, M. K. Sgagias, et al. (2006)
Mol. Cell. Biol. 26, 6412-6424
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Hyperplasia and Spontaneous Tumor Development in the Gynecologic System in Mice Lacking the BRCA1-{Delta}11 Isoform..
S. S. Kim, L. Cao, S.-C. Lim, C. Li, R.-H. Wang, X. Xu, R. Bachelier, and C.-X. Deng (2006)
Mol. Cell. Biol. 26, 6983-6992
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Gadd45a Suppresses Ras-Driven Mammary Tumorigenesis by Activation of c-Jun NH2-Terminal Kinase and p38 Stress Signaling Resulting in Apoptosis and Senescence..
J. S. Tront, B. Hoffman, and D. A. Liebermann (2006)
Cancer Res. 66, 8448-8454
   Abstract »    Full Text »    PDF »


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