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Science 7 October 1994:
Vol. 266. no. 5182, pp. 126 - 129
DOI: 10.1126/science.7939632
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Articles

Science, Vol 266, Issue 5182, 126-129
Copyright © 1994 by American Association for the Advancement of Science

articles

Interaction of the protein kinase Raf-1 with 14-3-3 proteins

H Fu, K Xia, DC Pallas, C Cui, K Conroy, RP Narsimhan, H Mamon, RJ Collier, and TM Roberts

Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, MA 02115.

Members of a family of highly conserved proteins, termed 14-3-3 proteins, were found by several experimental approaches to associate with Raf-1, a central component of a key signal transduction pathway. Optimal complex formation required the amino-terminal regulatory domain of Raf-1. The association of 14-3-3 proteins and Raf-1 was not substantially affected by the activation state of Raf.


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14-3-3 Proteins Interact with Specific MEK Kinases.
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J. Biol. Chem. 273, 940-944
   Abstract »    Full Text »    PDF »
Serine 257 Phosphorylation Regulates Association of Polyomavirus Middle T Antigen with 14-3-3 Proteins.
X. Cullere, P. Rose, U. Thathamangalam, A. Chatterjee, K. P. Mullane, D. C. Pallas, T. L. Benjamin, T. M. Roberts, and B. S. Schaffhausen (1998)
J. Virol. 72, 558-563
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S. Y. Hsu, A. Kaipia, L. Zhu, and A. J. W. Hsueh (1997)
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Serine Phosphorylation-dependent Association of the Band 4.1-related Protein-tyrosine Phosphatase PTPH1 with 14-3-3beta Protein.
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J. Biol. Chem. 272, 27281-27287
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Interaction of Phosphorylated Tryptophan Hydroxylase with 14-3-3 Proteins.
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G. J. Clark, J. K. Drugan, K. L. Rossman, J. W. Carpenter, K. Rogers-Graham, H. Fu, C. J. Der, and S. L. Campbell (1997)
J. Biol. Chem. 272, 20990-20993
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Activity of Plasma Membrane-recruited Raf-1 Is Regulated by Ras via the Raf Zinc Finger.
S. Roy, A. Lane, J. Yan, R. McPherson, and J. F. Hancock (1997)
J. Biol. Chem. 272, 20139-20145
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Raf-1 Kinase and Exoenzyme S Interact with 14-3-3zeta through a Common Site Involving Lysine 49.
L. Zhang, H. Wang, D. Liu, R. Liddington, and H. Fu (1997)
J. Biol. Chem. 272, 13717-13724
   Abstract »    Full Text »    PDF »
14-3-3 (epsilon ) Interacts with the Insulin-like Growth Factor I Receptor and Insulin Receptor Substrate I in a Phosphoserine-dependent Manner.
A. Craparo, R. Freund, and T. A. Gustafson (1997)
J. Biol. Chem. 272, 11663-11669
   Abstract »    Full Text »    PDF »
Serine Phosphorylation of Cbl Induced by Phorbol Ester Enhances Its Association with 14-3-3Proteins in T Cells via a Novel Serine-rich 14-3-3-binding Motif.
Y.-C. Liu, Y. Liu, C. Elly, H. Yoshida, S. Lipkowitz, and A. Altman (1997)
J. Biol. Chem. 272, 9979-9985
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Negative Modulation of Membrane Localization of the Raf-1 Protein Kinase by Hyperphosphorylation.
M. Wartmann, P. Hofer, P. Turowski, A. R. Saltiel, and N. E. Hynes (1997)
J. Biol. Chem. 272, 3915-3923
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The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner.
W Li, E. Skoulakis, R. Davis, and N Perrimon (1997)
Development 124, 4163-4171
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Erythropoietin Activates Raf1 by an Shc-Independent Pathway in CTLL-EPO-R Cells.
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Blood 89, 55-64
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14-3-3 Proteins Associate with A20 in an Isoform-specific Manner and Function Both as Chaperone and Adapter Molecules.
C. Vincenz and V. M. Dixit (1996)
J. Biol. Chem. 271, 20029-20034
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Y.-C. Liu, C. Elly, H. Yoshida, N. Bonnefoy-Berard, and A. Altman (1996)
J. Biol. Chem. 271, 14591-14595
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cAMP-mediated Growth Inhibition in Fibroblasts Is Not Mediated via Mitogen-activated Protein (MAP) Kinase (ERK) Inhibition. cAMP-DEPENDENT PROTEIN KINASE INDUCES A TEMPORAL SHIFT IN GROWTH FACTOR-STIMULATED MAP KINASES.
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J. Biol. Chem. 271, 13476-13483
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J. Biol. Chem. 271, 7362-7367
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Ras Interaction with Two Distinct Binding Domains in Raf-1 May Be Required for Ras Transformation.
J. K. Drugan, R. Khosravi-Far, M. A. White, C. J. Der, Y.-J. Sung, Y.-W. Hwang, and S. L. Campbell (1996)
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Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases.
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Purification of a Ras-dependent Mitogen-activated Protein Kinase Kinase Kinase from Bovine Brain Cytosol and Its Identification as a Complex of B-Raf and 14-3-3 Proteins.
B. Yamamori, S. Kuroda, K. Shimizu, K. Fukui, T. Ohtsuka, and Y. Takai (1995)
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Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation..
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Genes & Dev. 9, 1046-1058
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Stratifin, a keratinocyte specific 14-3-3 protein, harbors a pleckstrin homology (PH) domain and enhances protein kinase C activity.
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14-3-3: modulators of signaling proteins?.
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Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family.
G. Reuther, H Fu, L. Cripe, R. Collier, and A. Pendergast (1994)
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The Recruitment of Raf-1 to Membranes Is Mediated by Direct Interaction with Phosphatidic Acid and Is Independent of Association with Ras.
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N. W. J. Schroder, D. Pfeil, B. Opitz, K. S. Michelsen, J. Amberger, U. Zahringer, U. B. Gobel, and R. R. Schumann (2001)
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