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Science 30 September 1994:
Vol. 265. no. 5181, pp. 2037 - 2048
DOI: 10.1126/science.8091226

Articles

Science, Vol 265, Issue 5181, 2037-2048
Copyright © 1994 by American Association for the Advancement of Science


articles

Genetic dissection of complex traits

ES Lander and NJ Schork

Whitehead Institute for Biomedical Research, Cambridge, MA 02142.

Medical genetics was revolutionized during the 1980s by the application of genetic mapping to locate the genes responsible for simple Mendelian diseases. Most diseases and traits, however, do not follow simple inheritance patterns. Genetics have thus begun taking up the even greater challenge of the genetic dissection of complex traits. Four major approaches have been developed: linkage analysis, allele-sharing methods, association studies, and polygenic analysis of experimental crosses. This article synthesizes the current state of the genetic dissection of complex traits--describing the methods, limitations, and recent applications to biological problems.


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Coalescent-Based Association Mapping and Fine Mapping of Complex Trait Loci.
S. Zollner and J. K. Pritchard (2005)
Genetics 169, 1071-1092
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Performance of the Log-Linear Approach to Case-Parent Triad Data for Assessing Maternal Genetic Associations with Offspring Disease: Type I Error, Power, and Bias.
J. R. Starr, L. Hsu, and S. M. Schwartz (2005)
Am. J. Epidemiol. 161, 196-204
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Haplotype-Based Localization of an Alcohol Dependence Gene to the 5q34 {gamma}-Aminobutyric Acid Type A Gene Cluster.
M. Radel, R. L. Vallejo, N. Iwata, R. Aragon, J. C. Long, M. Virkkunen, and D. Goldman (2005)
Arch Gen Psychiatry 62, 47-55
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Recombination hotspots and block structure of linkage disequilibrium in the human genome exemplified by detailed analysis of PGM1 on 1p31.
N. A. Rana, N. D. Ebenezer, A. R. Webster, A. R. Linares, D. B. Whitehouse, S. Povey, and A. J. Hardcastle (2004)
Hum. Mol. Genet. 13, 3089-3102
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Genome-Wide Scan for Japanese Familial Intracranial Aneurysms: Linkage to Several Chromosomal Regions.
S. Yamada, M. Utsunomiya, K. Inoue, K. Nozaki, S. Inoue, K. Takenaka, N. Hashimoto, and A. Koizumi (2004)
Circulation 110, 3727-3733
   Abstract »    Full Text »    PDF »
Polymorphisms of IL4, IL13, and ADRB2 Genes in COPD.
A. E. Hegab, T. Sakamoto, W. Saitoh, H. H. Massoud, H. M. Massoud, K. M. Hassanein, and K. Sekizawa (2004)
Chest 126, 1832-1839
   Abstract »    Full Text »    PDF »
Compendium of genome-wide scans of lipid-related phenotypes: adding a new genome-wide search of apolipoprotein levels.
Y. Bosse, Y. C. Chagnon, J.-P. Despres, T. Rice, D. C. Rao, C. Bouchard, L. Perusse, and M.-C. Vohl (2004)
J. Lipid Res. 45, 2174-2184
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