Science 16 September 1994: Vol. 265. no. 5179, pp. 1724 - 1728 DOI: 10.1126/science.8085162

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Articles

Novel Molecular Determinants in the Pore Region of Sodium Channels Regulate Local Anesthetic Binding.

T. Yamagishi, W. Xiong, A. Kondratiev, P. Velez, A. Mendez-Fitzwilliam, J. R. Balser, E. Marban, and G. F. Tomaselli (2009)
Mol. Pharmacol. 76, 861-871
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Human Two-Pore Domain K+ Channel TREK1 by Local Anesthetic Lidocaine: Negative Cooperativity and Half-of-Sites Saturation Kinetics.

T. K. Nayak, S. Harinath, S. Nama, K. Somasundaram, and S. K. Sikdar (2009)
Mol. Pharmacol. 76, 903-917
 |  Abstract »  |  Full Text »  |  PDF »

Using Lidocaine and Benzocaine to Link Sodium Channel Molecular Conformations to State-Dependent Antiarrhythmic Drug Affinity.

D. A. Hanck, E. Nikitina, M. M. McNulty, H. A. Fozzard, G. M. Lipkind, and M. F. Sheets (2009)
Circ. Res. 105, 492-499
 |  Abstract »  |  Full Text »  |  PDF »

The external pore loop interacts with S6 and S3-S4 linker in domain 4 to assume an essential role in gating control and anticonvulsant action in the Na+ channel.

Y.-C. Yang, J.-Y. Hsieh, and C.-C. Kuo (2009)
J. Gen. Physiol. 134, 95-113
 |  Abstract »  |  Full Text »  |  PDF »

Mutational and In Silico Analyses for Antidepressant Block of Astroglial Inward-Rectifier Kir4.1 Channel.

K. Furutani, Y. Ohno, A. Inanobe, H. Hibino, and Y. Kurachi (2009)
Mol. Pharmacol. 75, 1287-1295
 |  Abstract »  |  Full Text »  |  PDF »

The Effect of Amitriptyline on Ectopic Discharge of Primary Afferent Fibers in the L5 Dorsal Root in a Rat Model of Neuropathic Pain.

X. Su, A. H. Liang, and M. O. Urban (2009)
Anesth. Analg. 108, 1671-1679
 |  Abstract »  |  Full Text »  |  PDF »

Local Anesthetics Disrupt Energetic Coupling between the Voltage-sensing Segments of a Sodium Channel.

Y. Muroi and B. Chanda (2008)
J. Gen. Physiol. 133, 1-15
 |  Abstract »  |  Full Text »  |  PDF »

Access and Binding of Local Anesthetics in the Closed Sodium Channel.

I. Bruhova, D. B. Tikhonov, and B. S. Zhorov (2008)
Mol. Pharmacol. 74, 1033-1045
 |  Abstract »  |  Full Text »  |  PDF »

Increased Sensitivity to Local Anesthetic Drugs: Bedside to Bench.

H. A. Fozzard (2008)
Circ. Res. 103, 325-327
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Lidocaine-Induced Brugada Syndrome Phenotype Linked to a Novel Double Mutation in the Cardiac Sodium Channel.

H. M. Barajas-Martinez, D. Hu, J. M. Cordeiro, Y. Wu, R. J. Kovacs, H. Meltser, H. Kui, B. Elena, R. Brugada, C. Antzelevitch, et al. (2008)
Circ. Res. 103, 396-404
 |  Abstract »  |  Full Text »  |  PDF »

State- and Use-Dependent Block of Muscle Nav1.4 and Neuronal Nav1.7 Voltage-Gated Na+ Channel Isoforms by Ranolazine.

G. K. Wang, J. Calderon, and S.-Y. Wang (2008)
Mol. Pharmacol. 73, 940-948
 |  Abstract »  |  Full Text »  |  PDF »

Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels.

C. A. Ahern, A. L. Eastwood, D. A. Dougherty, and R. Horn (2008)
Circ. Res. 102, 86-94
 |  Abstract »  |  Full Text »  |  PDF »

Relative resistance to slow inactivation of human cardiac Na+ channel hNav1.5 is reversed by lysine or glutamine substitution at V930 in D2-S6.

J. H. Chancey, P. E. Shockett, and J. P. O'Reilly (2007)
Am J Physiol Cell Physiol 293, C1895-C1905
 |  Abstract »  |  Full Text »  |  PDF »

Isoflurane Inhibits NaChBac, a Prokaryotic Voltage-Gated Sodium Channel.

W. Ouyang, T.-Y. Jih, T.-T. Zhang, A. M. Correa, and H. C. Hemmings Jr. (2007)
J. Pharmacol. Exp. Ther. 322, 1076-1083
 |  Abstract »  |  Full Text »  |  PDF »

Contribution of the Putative Inner-Pore Region to the Gating of the Transient Receptor Potential Vanilloid Subtype 1 Channel (TRPV1).

K. Susankova, R. Ettrich, L. Vyklicky, J. Teisinger, and V. Vlachova (2007)
J. Neurosci. 27, 7578-7585
 |  Abstract »  |  Full Text »  |  PDF »

Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels.

M. F. Sheets and D. A. Hanck (2007)
J. Physiol. 582, 317-334
 |  Abstract »  |  Full Text »  |  PDF »

Charge at the lidocaine binding site residue Phe-1759 affects permeation in human cardiac voltage-gated sodium channels.

M. M. McNulty, G. B. Edgerton, R. D. Shah, D. A. Hanck, H. A. Fozzard, and G. M. Lipkind (2007)
J. Physiol. 581, 741-755
 |  Abstract »  |  Full Text »  |  PDF »

Local anaesthetic block of sodium channels: raising the barrier.

T. Scheuer (2007)
J. Physiol. 581, 423
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Hydroxyamide Analogs of Propofol Exhibit State-Dependent Block of Sodium Channels in Hippocampal Neurons: Implications for Anticonvulsant Activity.

P. J. Jones, Y. Wang, M. D. Smith, N. J. Hargus, H. S. Eidam, H. S. White, J. Kapur, M. L. Brown, and M. K. Patel (2007)
J. Pharmacol. Exp. Ther. 320, 828-836
 |  Abstract »  |  Full Text »  |  PDF »

Use-Dependent Block by Lidocaine but Not Amitriptyline Is More Pronounced in Tetrodotoxin (TTX)-Resistant Nav1.8 Than in TTX-Sensitive Na+ Channels.

A. Leffler, A. Reiprich, D. P. Mohapatra, and C. Nau (2007)
J. Pharmacol. Exp. Ther. 320, 354-364
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Nav1.7 and Nav1.4 Sodium Channels by Trifluoperazine Involves the Local Anesthetic Receptor.

P. L. Sheets, P. Gerner, C.-F. Wang, S.-Y. Wang, G. K. Wang, and T. R. Cummins (2006)
J Neurophysiol 96, 1848-1859
 |  Abstract »  |  Full Text »  |  PDF »

Pharmacology of a Slowly Inactivating Outward Current in Hippocampal CA3 Pyramidal Neurons.

R. Bianchi, S.-C. Chuang, and R. K. S. Wong (2006)
J Neurophysiol 96, 1116-1123
 |  Abstract »  |  Full Text »  |  PDF »

Time-Dependent Block and Resurgent Tail Currents Induced by Mouse {beta}4154-167 Peptide in Cardiac Na+ Channels.

G. K. Wang, T. Edrich, and S.-Y. Wang (2006)
J. Gen. Physiol. 127, 277-289
 |  Abstract »  |  Full Text »  |  PDF »

Overview of Molecular Relationships in the Voltage-Gated Ion Channel Superfamily.

F. H. Yu, V. Yarov-Yarovoy, G. A. Gutman, and W. A. Catterall (2005)
Pharmacol. Rev. 57, 387-395
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Molecular Modeling of Local Anesthetic Drug Binding by Voltage-Gated Sodium Channels.

G. M. Lipkind and H. A. Fozzard (2005)
Mol. Pharmacol. 68, 1611-1622
 |  Abstract »  |  Full Text »  |  PDF »

{omega}-3 and {omega}-6 polyunsaturated fatty acids block HERG channels.

M. Guizy, C. Arias, M. David, T. Gonzalez, and C. Valenzuela (2005)
Am J Physiol Cell Physiol 289, C1251-C1260
 |  Abstract »  |  Full Text »  |  PDF »

Sodium Channel Inactivation: Molecular Determinants and Modulation.

W. Ulbricht (2005)
Physiol Rev 85, 1271-1301
 |  Abstract »  |  Full Text »  |  PDF »

{beta}-Scorpion toxin effects suggest electrostatic interactions in domain II of voltage-dependent sodium channels.

M. Mantegazza and S. Cestele (2005)
J. Physiol. 568, 13-30
 |  Abstract »  |  Full Text »  |  PDF »

Characteristics of Ginsenoside Rg3-Mediated Brain Na+ Current Inhibition.

J.-H. Lee, S. M. Jeong, J.-H. Kim, B.-H. Lee, I.-S. Yoon, J.-H. Lee, S.-H. Choi, D.-H. Kim, H. Rhim, S. S. Kim, et al. (2005)
Mol. Pharmacol. 68, 1114-1126
 |  Abstract »  |  Full Text »  |  PDF »

An Inactivation Stabilizer of the Na+ Channel Acts as an Opportunistic Pore Blocker Modulated by External Na+.

Y.-C. Yang and C.-C. Kuo (2005)
J. Gen. Physiol. 125, 465-481
 |  Abstract »  |  Full Text »  |  PDF »

Compound-specific Na+ channel pore conformational changes induced by local anaesthetics.

K. Fukuda, T. Nakajima, P. C Viswanathan, and J. R Balser (2005)
J. Physiol. 564, 21-31
 |  Abstract »  |  Full Text »  |  PDF »

A Multifunctional Aromatic Residue in the External Pore Vestibule of Na+ Channels Contributes to the Local Anesthetic Receptor.

S. Y. Tsang, R. G. Tsushima, G. F. Tomaselli, R. A. Li, and P. H. Backx (2005)
Mol. Pharmacol. 67, 424-434
 |  Abstract »  |  Full Text »  |  PDF »

Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment.

Y. Zhao, T. Scheuer, and W. A. Catterall (2004)
PNAS 101, 17873-17878
 |  Abstract »  |  Full Text »  |  PDF »

Accessibility of mid-segment domain IV S6 residues of the voltage-gated Na+ channel to methanethiosulfonate reagents.

A. Sunami, A. Tracey, I. W Glaaser, G. M Lipkind, D. A Hanck, and H. A Fozzard (2004)
J. Physiol. 561, 403-413
 |  Abstract »  |  Full Text »  |  PDF »

Block of Inactivation-deficient Na+ Channels by Local Anesthetics in Stably Transfected Mammalian Cells: Evidence for Drug Binding Along the Activation Pathway.

S.-Y. Wang, J. Mitchell, E. Moczydlowski, and G. K. Wang (2004)
J. Gen. Physiol. 124, 691-701
 |  Abstract »  |  Full Text »  |  PDF »

A novel SCN5A mutation manifests as a malignant form of long QT syndrome with perinatal onset of tachycardia/bradycardia.

C.-C. Chang, S. Acharfi, M.-H. Wu, F.-T. Chiang, J.-K. Wang, T.-C. Sung, and M. Chahine (2004)
Cardiovasc Res 64, 268-278
 |  Abstract »  |  Full Text »  |  PDF »

The VGL-Chanome: A Protein Superfamily Specialized for Electrical Signaling and Ionic Homeostasis.

F. H. Yu and W. A. Catterall (2004)
Sci. STKE 2004, re15
 |  Abstract »  |  Full Text »  |  PDF »

State-dependent trapping of flecainide in the cardiac sodium channel.

E. Ramos and M. E O'Leary (2004)
J. Physiol. 560, 37-49
 |  Abstract »  |  Full Text »  |  PDF »

Lidocaine: A Foot in the Door of the Inner Vestibule Prevents Ultra-Slow Inactivation of a Voltage-Gated Sodium Channel.

W. Sandtner, J. Szendroedi, T. Zarrabi, E. Zebedin, K. Hilber, I. Glaaser, H. A. Fozzard, S. C. Dudley, and H. Todt (2004)
Mol. Pharmacol. 66, 648-657
 |  Abstract »  |  Full Text »  |  PDF »

Unexpected Mexiletine Responses of a Mutant Cardiac Na+ Channel Implicate the Selectivity Filter as a Structural Determinant of Antiarrhythmic Drug Access.

K. Sasaki, N. Makita, A. Sunami, H. Sakurada, N. Shirai, H. Yokoi, A. Kimura, N. Tohse, M. Hiraoka, and A. Kitabatake (2004)
Mol. Pharmacol. 66, 330-336
 |  Abstract »  |  Full Text »  |  PDF »

The Effects of Class Ic Antiarrhythmics on Tetrodotoxin-Resistant Na+ Currents in Rat Sensory Neurons.

Y. Osawa, A. Oda, H. Iida, S. Tanahashi, and S. Dohi (2004)
Anesth. Analg. 99, 464-471
 |  Abstract »  |  Full Text »  |  PDF »

Mexiletine block of wild-type and inactivation-deficient human skeletal muscle hNav1.4 Na+ channels.

G. K. Wang, C. Russell, and S.-Y. Wang (2004)
J. Physiol. 554, 621-633
 |  Abstract »  |  Full Text »  |  PDF »

Closing and Inactivation Potentiate the Cocaethylene Inhibition of Cardiac Sodium Channels by Distinct Mechanisms.

M. E. O'Leary, M. Digregorio, and M. Chahine (2003)
Mol. Pharmacol. 64, 1575-1585
 |  Abstract »  |  Full Text »  |  PDF »

Lidocaine and Octanol Have Different Modes of Action at Tetrodotoxin-Resistant Na+ Channels of Peripheral Nerves.

D. Poyraz, M. E. Brau, F. Wotka, B. Puhlmann, A. M. Scholz, Prof. G. Hempelmann, Prof. W. J. Kox, and Prof. C. D. Spies (2003)
Anesth. Analg. 97, 1317-1324
 |  Abstract »  |  Full Text »  |  PDF »

Optimal Requirements for High Affinity and Use-Dependent Block of Skeletal Muscle Sodium Channel by N-Benzyl Analogs of Tocainide-Like Compounds.

A. De Luca, S. Talon, M. De Bellis, J.-F. Desaphy, G. Lentini, F. Corbo, A. Scilimati, C. Franchini, V. Tortorella, and D. C. Camerino (2003)
Mol. Pharmacol. 64, 932-945
 |  Abstract »  |  Full Text »  |  PDF »

Altered Gating and Local Anesthetic Block Mediated by Residues in the I-S6 and II-S6 Transmembrane Segments of Voltage-Dependent Na+ Channels.

A. Kondratiev and G. F. Tomaselli (2003)
Mol. Pharmacol. 64, 741-752
 |  Abstract »  |  Full Text »  |  PDF »

Isoflurane and Propofol Inhibit Voltage-Gated Sodium Channels in Isolated Rat Neurohypophysial Nerve Terminals.

W. Ouyang, G. Wang, and H. C. Hemmings Jr (2003)
Mol. Pharmacol. 64, 373-381
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Determinants of KCNQ1 Channel Block by a Benzodiazepine.

G. Seebohm, J. Chen, N. Strutz, C. Culberson, C. Lerche, and M. C. Sanguinetti (2003)
Mol. Pharmacol. 64, 70-77
 |  Abstract »  |  Full Text »  |  PDF »

Amide Local Anesthetics Potently Inhibit the Human Tandem Pore Domain Background K+ Channel TASK-2 (KCNK5).

C. H. Kindler, M. Paul, H. Zou, C. Liu, B. D. Winegar, A. T. Gray, and C. S. Yost (2003)
J. Pharmacol. Exp. Ther. 306, 84-92
 |  Abstract »  |  Full Text »  |  PDF »

Point Mutations at L1280 in Nav1.4 Channel D3-S6 Modulate Binding Affinity and Stereoselectivity of Bupivacaine Enantiomers.

C. Nau, S.-Y. Wang, and G. K. Wang (2003)
Mol. Pharmacol. 63, 1398-1406
 |  Abstract »  |  Full Text »  |  PDF »

Local Anesthetic Block of Kv Channels: Role of the S6 Helix and the S5-S6 Linker for Bupivacaine Action.

J. Nilsson, M. Madeja, and P. Arhem (2003)
Mol. Pharmacol. 63, 1417-1429
 |  Abstract »  |  Full Text »  |  PDF »

Veratridine block of rat skeletal muscle Nav1.4 sodium channels in the inner vestibule.

G. K. Wang and S.-Y. Wang (2003)
J. Physiol. 548, 667-675
 |  Abstract »  |  Full Text »  |  PDF »

Distinct Sites Regulating Grayanotoxin Binding and Unbinding to D4S6 of Nav1.4 Sodium Channel as Revealed by Improved Estimation of Toxin Sensitivity.

H. Maejima, E. Kinoshita, I. Seyama, and K. Yamaoka (2003)
J. Biol. Chem. 278, 9464-9471
 |  Abstract »  |  Full Text »  |  PDF »

Different Ability of Clenbuterol and Salbutamol to Block Sodium Channels Predicts Their Therapeutic Use in Muscle Excitability Disorders.

J.-F. Desaphy, S. Pierno, A. De Luca, P. Didonna, and D. C. Camerino (2003)
Mol. Pharmacol. 63, 659-670
 |  Abstract »  |  Full Text »  |  PDF »

Common Molecular Determinants of Flecainide and Lidocaine Block of Heart Na+ Channels: Evidence from Experiments with Neutral and Quaternary Flecainide Analogues.

H. Liu, J. Atkins, and R. S. Kass (2003)
J. Gen. Physiol. 121, 199-214
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Action of Lidocaine on the Voltage Sensors of Sodium Channels.

M. F. Sheets and D. A. Hanck (2003)
J. Gen. Physiol. 121, 163-175
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Na+ Current by Imipramine and Related Compounds: Different Binding Kinetics as an Inactivation Stabilizer and as an Open Channel Blocker.

Y.-C. Yang and C.-C. Kuo (2002)
Mol. Pharmacol. 62, 1228-1237
 |  Abstract »  |  Full Text »  |  PDF »

Role of Amino Acid Residues in Transmembrane Segments IS6 and IIS6 of the Na+ Channel alpha Subunit in Voltage-dependent Gating and Drug Block.

V. Yarov-Yarovoy, J. C. McPhee, D. Idsvoog, C. Pate, T. Scheuer, and W. A. Catterall (2002)
J. Biol. Chem. 277, 35393-35401
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Tetrodotoxin (TTX)-Resistant and TTX-Sensitive Neuronal Na+ Channels by the Secretolytic Ambroxol.

T. Weiser and N. Wilson (2002)
Mol. Pharmacol. 62, 433-438
 |  Abstract »  |  Full Text »  |  PDF »

Prenylamine Block of Nav1.5 Channel is Mediated via a Receptor Distinct from That of Local Anesthetics.

M. G. Mujtaba, S.-Y. Wang, and G. K. Wang (2002)
Mol. Pharmacol. 62, 415-422
 |  Abstract »  |  Full Text »  |  PDF »

A novel SCN5A arrhythmia mutation, M1766L, with expression defect rescued by mexiletine.

C. R Valdivia, M. J Ackerman, D. J Tester, T. Wada, J. McCormack, B. Ye, and J. C Makielski (2002)
Cardiovasc Res 55, 279-289
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of (local) anaesthetics on voltage-gated sodium and other ion channels.

A. Scholz (2002)
Br. J. Anaesth. 89, 52-61
 |  Abstract »  |  Full Text »  |  PDF »

Channel Openings Are Necessary but not Sufficient for Use-dependent Block of Cardiac Na+ Channels by Flecainide: Evidence from the Analysis of Disease-linked Mutations.

H. Liu, M. Tateyama, C. E. Clancy, H. Abriel, and R. S. Kass (2002)
J. Gen. Physiol. 120, 39-51
 |  Abstract »  |  Full Text »  |  PDF »

Cocaine binds to a common site on open and inactivated human heart (Nav1.5) sodium channels.

M E O'Leary and M Chahine (2002)
J. Physiol. 541, 701-716
 |  Abstract »  |  Full Text »  |  PDF »

The Batrachotoxin Receptor on the Voltage-Gated Sodium Channel is Guarded by the Channel Activation Gate.

H.-L. Li, D. Hadid, and D. S. Ragsdale (2002)
Mol. Pharmacol. 61, 905-912
 |  Abstract »  |  Full Text »  |  PDF »

Inherited sodium channelopathies: models for acquired arrhythmias?.

J. R. Balser (2002)
Am J Physiol Heart Circ Physiol 282, H1175-H1180
 |  Full Text »  |  PDF »

Structural Basis of Differences in Isoform-Specific Gating and Lidocaine Block between Cardiac and Skeletal Muscle Sodium Channels.

R. A. Li, I. L. Ennis, G. F. Tomaselli, and E. Marban (2002)
Mol. Pharmacol. 61, 136-141
 |  Abstract »  |  Full Text »  |  PDF »

Mexiletine block of disease-associated mutations in S6 segments of the human skeletal muscle Na+ channel.

M. P Takahashi and S. C Cannon (2001)
J. Physiol. 537, 701-714
 |  Abstract »  |  Full Text »  |  PDF »

New Approaches to Antiarrhythmic Therapy, Part II: Emerging Therapeutic Applications of the Cell Biology of Cardiac Arrhythmias.

Members of the Sicilian Gambit (2001)
Circulation 104, 2990-2994
 |  Abstract »  |  Full Text »  |  PDF »

New approaches to antiarrhythmic therapy; emerging therapeutic applications of the cell biology of cardiac arrhythmias.

Members of the Sicilian Gambit (2001)
Eur. Heart J. 22, 2148-2163
 |  Abstract »  |  PDF »

New approaches to antiarrhythmic therapy: emerging therapeutic applications of the cell biology of cardiac arrhythmias.

Members of the Sicilian Gambit (2001)
Cardiovasc Res 52, 345-360
 |  Abstract »  |  Full Text »  |  PDF »

Gating of myotonic Na channel mutants defines the response to mexiletine and a potent derivative.

J.-F. Desaphy, A. De Luca, P. Tortorella, D. De Vito, A. L. George Jr., and D. Conte Camerino (2001)
Neurology 57, 1849-1857
 |  Abstract »  |  Full Text »  |  PDF »

Lithium Increases Potency of Lidocaine-Induced Block of Voltage-Gated Na+ Currents in Rat Sensory Neurons in Vitro.

M. S. Gold and P. D. Thut (2001)
J. Pharmacol. Exp. Ther. 299, 705-711
 |  Abstract »  |  Full Text »  |  PDF »

COX inhibition excites enteric nerves that affect motility, alkaline secretion, and permeability in rat duodenum.

O. Nylander, A. Hallgren, and M. Sababi (2001)
Am J Physiol Gastrointest Liver Physiol 281, G1169-G1178
 |  Abstract »  |  Full Text »  |  PDF »

Neutralization of Gating Charges in Domain II of the Sodium Channel {alpha} Subunit Enhances Voltage-Sensor Trapping by a {beta}-Scorpion Toxin.

S. Cestele, T. Scheuer, M. Mantegazza, H. Rochat, and W. A. Catterall (2001)
J. Gen. Physiol. 118, 291-302
 |  Abstract »  |  Full Text »  |  PDF »

Propofol Blocks Human Skeletal Muscle Sodium Channels in a Voltage-Dependent Manner.

G. Haeseler, M. Stormer, J. Bufler, R. Dengler, H. Hecker, S. Piepenbrock, and M. Leuwer (2001)
Anesth. Analg. 92, 1192-1198
 |  Abstract »  |  Full Text »  |  PDF »

Disparate Role of Na+ Channel D2-S6 Residues in Batrachotoxin and Local Anesthetic Action.

S.-Y. Wang, M. Barile, and G. K. Wang (2001)
Mol. Pharmacol. 59, 1100-1107
 |  Abstract »  |  Full Text »

Structural and Gating Changes of the Sodium Channel Induced by Mutation of a Residue in the Upper Third of IVS6, Creating an External Access Path for Local Anesthetics.

A. Sunami, I. W. Glaaser, and H. A. Fozzard (2001)
Mol. Pharmacol. 59, 684-691
 |  Abstract »  |  Full Text »

Irreversible Block of Human Heart (hH1) Sodium Channels by the Plant Alkaloid Lappaconitine.

S. N. Wright (2001)
Mol. Pharmacol. 59, 183-192
 |  Abstract »  |  Full Text »

Block of Neuronal Tetrodotoxin-Resistant Na+ Currents by Stereoisomers of Piperidine Local Anesthetics.

M. E. Brau, P. Branitzki, A. Olschewski, W. Vogel, and G. Hempelmann (2000)
Anesth. Analg. 91, 1499-1505
 |  Abstract »  |  Full Text »  |  PDF »

Quaternary ammonium block of mutant Na+ channels lacking inactivation: features of a transition-intermediate mechanism.

J T Kimbrough and K J Gingrich (2000)
J. Physiol. 529, 93-106
 |  Abstract »  |  Full Text »  |  PDF »

A Structural Rearrangement in the Sodium Channel Pore Linked to Slow Inactivation and Use Dependence.

B.-H. Ong, G. F. Tomaselli, and J. R. Balser (2000)
J. Gen. Physiol. 116, 653-662
 |  Abstract »  |  Full Text »  |  PDF »

Neuroreceptors and Ion Channels as the Basis for Drug Action: Past, Present, and Future.

T. Narahashi (2000)
J. Pharmacol. Exp. Ther. 294, 1-26
 |  Abstract »  |  Full Text »

Subtype-Selective Inhibition of Neuronal Nicotinic Acetylcholine Receptors by Cocaine Is Determined by the alpha 4 and beta 4 Subunits.

M. M. Francis, R. W. Vazquez, R. L. Papke, and R. E. Oswald (2000)
Mol. Pharmacol. 58, 109-119
 |  Abstract »  |  Full Text »

Lidocaine induces a slow inactivated state in rat skeletal muscle sodium channels.

Z. Chen, B.-H. Ong, N. G Kambouris, E. Marban, G. F Tomaselli, and J. R Balser (2000)
J. Physiol. 524, 37-49
 |  Abstract »  |  Full Text »  |  PDF »

Block of Human Heart hH1 Sodium Channels by Amitriptyline.

C. Nau, M. Seaver, S.-Y. Wang, and G. K. Wang (2000)
J. Pharmacol. Exp. Ther. 292, 1015-1023
 |  Abstract »  |  Full Text »

Activation of Drosophila Sodium Channels Promotes Modification by Deltamethrin: Reductions in Affinity Caused by Knock-down Resistance Mutations.

H. Vais, M. S. Williamson, S. J. Goodson, A. L. Devonshire, J. W. Warmke, P. N.R. Usherwood, and C. J. Cohen (2000)
J. Gen. Physiol. 115, 305-318
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Determinants of Mexiletine Structure for Potent and Use-Dependent Block of Skeletal Muscle Sodium Channels.

A. De Luca, F. Natuzzi, J.-F. Desaphy, G. Loni, G. Lentini, C. Franchini, V. Tortorella, and D. C. Camerino (2000)
Mol. Pharmacol. 57, 268-277
 |  Abstract »  |  Full Text »

Molecular Determinant of High-Affinity Dofetilide Binding to HERG1 Expressed in Xenopus Oocytes: Involvement of S6 Sites.

J. P. Lees-Miller, Y. Duan, G. Q. Teng, and H. J. Duff (2000)
Mol. Pharmacol. 57, 367-374
 |  Abstract »  |  Full Text »

Differential Interaction of R-Mexiletine with the Local Anesthetic Receptor Site on Brain and Heart Sodium Channel alpha -Subunits.

T. Weiser, Y. Qu, W. A. Catterall, and T. Scheuer (1999)
Mol. Pharmacol. 56, 1238-1244
 |  Abstract »  |  Full Text »

Voltage-Gated Ion Channels and Hereditary Disease.

F. Lehmann-Horn and K. Jurkat-Rott (1999)
Physiol Rev 79, 1317-1372
 |  Abstract »  |  Full Text »  |  PDF »

Point Mutations at N434 in D1-S6 of {micro}1 Na+ Channels Modulate Binding Affinity and Stereoselectivity of Local Anesthetic Enantiomers.

C. Nau, S.-Y. Wang, G. R. Strichartz, and G. K. Wang (1999)
Mol. Pharmacol. 56, 404-413
 |  Abstract »  |  Full Text »

Local Anesthetic Anchoring to Cardiac Sodium Channels : Implications Into Tissue-Selective Drug Targeting.

R. A. Li, R. G. Tsushima, K. Himmeldirk, D. S. Dime, and P. H. Backx (1999)
Circ. Res. 85, 88-98
 |  Abstract »  |  Full Text »  |  PDF »

Structure and function of the cardiac sodium channels.

J. R. Balser (1999)
Cardiovasc Res 42, 327-328
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Intrinsic lidocaine affinity for Na channels expressed in Xenopus oocytes depends on {alpha} (hH1 vs. rSkM1) and {beta}1 subunits.

J. C Makielski, J. Limberis, Z. Fan, and J. W Kyle (1999)
Cardiovasc Res 42, 503-509
 |  Abstract »  |  Full Text »  |  PDF »

Whether "Slip-Mode Conductance" Occurs.

H. B. Nuss, E. Marbán;, C. W. Balke, L. Goldman, R. Aggarwal, S. R. Shorofsky;, J. dos Santos Cruz, L. F. Santana, C. A. Frederick, L. L. Isom, et al. (1999)
Science 284, 711a-711
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Block of Brain Sodium Channels by Peptide Mimetics of the Isoleucine, Phenylalanine, and Methionine (IFM) Motif from the Inactivation Gate.

G. Eaholtz, A. Colvin, D. Leonard, C. Taylor, and W. A. Catterall (1999)
J. Gen. Physiol. 113, 279-294
 |  Abstract »  |  Full Text »  |  PDF »

The Position of the Fast-Inactivation Gate during Lidocaine Block of Voltage-gated Na+ Channels.

V. Vedantham and S. C. Cannon (1999)
J. Gen. Physiol. 113, 7-16
 |  Abstract »  |  Full Text »  |  PDF »

A Molecular Basis for the Different Local Anesthetic Affinities of Resting Versus Open and Inactivated States of the Sodium Channel.

H.-L. Li, A. Galue, L. Meadows, and D. S. Ragsdale (1999)
Mol. Pharmacol. 55, 134-141
 |  Abstract »  |  Full Text »

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