Related Content
Search Google Scholar for:
|
|
Science 16 September 1994: Vol. 265. no. 5179, pp. 1716 - 1719 DOI: 10.1126/science.8085159
|
|
Articles
Science, Vol 265, Issue 5179, 1716-1719
Copyright © 1994 by American Association for the Advancement of Science
Stimulatory effects of yeast and mammalian 14-3-3 proteins on the Raf protein kinase
K Irie,
Y Gotoh,
BM Yashar,
B Errede,
E Nishida,
and
K Matsumoto
Department of Molecular Biology, Faculty of Science, Nagoya University, Japan.
Intracellular signaling from receptor tyrosine kinases in mammalian cells results in activation of a signal cascade that includes the guanine nucleotide-binding protein Ras and the protein kinases Raf, MEK [mitogen-activated protein kinase (MAPK) or extracellular signal-regulated kinase (ERK) kinase], and MAPK. MAPK activation that is dependent on the coupling of Ras and Raf was reconstituted in yeast. Yeast genes were isolated that, when overexpressed, enhanced the function of Raf. One of them is identical to BMH1, which encodes a protein similar to members of the mammalian 14-3-3 family. Bacterially synthesized mammalian 14-3-3 protein stimulated the activity of Raf prepared from yeast cells expressing c-Raf-1. Thus, the 14-3-3 protein may participate in or be required for activation of Raf.
THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
- Ustilago maydis Rho1 and 14-3-3 Homologues Participate in Pathways Controlling Cell Separation and Cell Polarity.
- C. D. Pham, Z. Yu, B. Sandrock, M. Bolker, S. E. Gold, and M. H. Perlin (2009)
Eukaryot. Cell
8, 977-989
| Abstract »
| Full Text »
| PDF »
- An integrin-{alpha}4-14-3-3{zeta}-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration.
- N. O. Deakin, M. D. Bass, S. Warwood, J. Schoelermann, Z. Mostafavi-Pour, D. Knight, C. Ballestrem, and M. J. Humphries (2009)
J. Cell Sci.
122, 1654-1664
| Abstract »
| Full Text »
| PDF »
- Down-regulation of 14-3-3{zeta} suppresses anchorage-independent growth of lung cancer cells through anoikis activation.
- Z. Li, J. Zhao, Y. Du, H. R. Park, S.-Y. Sun, L. Bernal-Mizrachi, A. Aitken, F. R. Khuri, and H. Fu (2008)
PNAS
105, 162-167
| Abstract »
| Full Text »
| PDF »
- A MAP Kinase Cascade That Controls Plant Cytokinesis.
- Y. Takahashi, T. Soyano, M. Sasabe, and Y. Machida (2004)
J. Biochem.
136, 127-132
| Abstract »
| Full Text »
| PDF »
- Dynamic Changes in C-Raf Phosphorylation and 14-3-3 Protein Binding in Response to Growth Factor Stimulation: DIFFERENTIAL ROLES OF 14-3-3 PROTEIN BINDING SITES.
- M. Hekman, S. Wiese, R. Metz, S. Albert, J. Troppmair, J. Nickel, M. Sendtner, and U. R. Rapp (2004)
J. Biol. Chem.
279, 14074-14086
| Abstract »
| Full Text »
| PDF »
- Blue-Light- and Phosphorylation-Dependent Binding of a 14-3-3 Protein to Phototropins in Stomatal Guard Cells of Broad Bean.
- T. Kinoshita, T. Emi, M. Tominaga, K. Sakamoto, A. Shigenaga, M. Doi, and K.-i. Shimazaki (2003)
Plant Physiology
133, 1453-1463
| Abstract »
| Full Text »
- Identification of the Insulin-Regulated Interaction of Phosphodiesterase 3B With 14-3-3 {beta} Protein.
- H. Onuma, H. Osawa, K. Yamada, T. Ogura, F. Tanabe, D. K. Granner, and H. Makino (2002)
Diabetes
51, 3362-3367
| Abstract »
| Full Text »
| PDF »
- The 14-3-3 Proteins Rad24 and Rad25 Negatively Regulate Byr2 by Affecting Its Localization in Schizosaccharomyces pombe.
- F. Ozoe, R. Kurokawa, Y. Kobayashi, H. T. Jeong, K. Tanaka, K. Sen, T. Nakagawa, H. Matsuda, and M. Kawamukai (2002)
Mol. Cell. Biol.
22, 7105-7119
| Abstract »
| Full Text »
| PDF »
- 14-3-3 Antagonizes Ras-Mediated Raf-1 Recruitment to the Plasma Membrane To Maintain Signaling Fidelity.
- Y. Light, H. Paterson, and R. Marais (2002)
Mol. Cell. Biol.
22, 4984-4996
| Abstract »
| Full Text »
| PDF »
- Consummating Signal Transduction: The Role of 14-3-3 Proteins in the Completion of Signal-Induced Transitions in Protein Activity.
- P. C. Sehnke, J. M. DeLille, and R. J. Ferl (2002)
PLANT CELL
14, S339-354
| Full Text »
| PDF »
- MRK, a Mixed Lineage Kinase-related Molecule That Plays a Role in gamma -Radiation-induced Cell Cycle Arrest.
- E. A. Gross, M. G. Callow, L. Waldbaum, S. Thomas, and R. Ruggieri (2002)
J. Biol. Chem.
277, 13873-13882
| Abstract »
| Full Text »
| PDF »
- Interaction of the E1A Oncoprotein with Yak1p, a Novel Regulator of Yeast Pseudohyphal Differentiation, and Related Mammalian Kinases.
- Z. Zhang, M. M. Smith, and J. S. Mymryk (2001)
Mol. Biol. Cell
12, 699-710
| Abstract »
| Full Text »
- Role of the {beta} isoform of 14-3-3 proteins in cellular proliferation and oncogenic transformation.
- Y. Takihara, Y. Matsuda, and J. Hara (2000)
Carcinogenesis
21, 2073-2077
| Abstract »
| Full Text »
| PDF »
- Hepatitis C Virus Core Protein Interacts with 14-3-3 Protein and Activates the Kinase Raf-1.
- H. Aoki, J. Hayashi, M. Moriyama, Y. Arakawa, and O. Hino (2000)
J. Virol.
74, 1736-1741
| Abstract »
| Full Text »
- Disruption of the 14-3-3 Binding Site within the B-Raf Kinase Domain Uncouples Catalytic Activity from PC12 Cell Differentiation.
- M. C. MacNicol, A. J. Muslin, and A. M. MacNicol (2000)
J. Biol. Chem.
275, 3803-3809
| Abstract »
| Full Text »
| PDF »
- PDK1 Homologs Activate the Pkc1-Mitogen-Activated Protein Kinase Pathway in Yeast.
- M. Inagaki, T. Schmelzle, K. Yamaguchi, K. Irie, M. N. Hall, and K. Matsumoto (1999)
Mol. Cell. Biol.
19, 8344-8352
| Abstract »
| Full Text »
| PDF »
- Nuclear Localization of Protein Kinase U-alpha Is Regulated by 14-3-3.
- S. Zhang, H. Xing, and A. J. Muslin (1999)
J. Biol. Chem.
274, 24865-24872
| Abstract »
| Full Text »
| PDF »
- Specific Interactions with TBP and TFIIB in Vitro Suggest That 14-3-3 Proteins May Participate in the Regulation of Transcription When Part of a DNA Binding Complex.
- S. Pan, P. C. Sehnke, R. J. Ferl, and W. B. Gurley (1999)
PLANT CELL
11, 1591-1602
| Abstract »
| Full Text »
- The Drosophila p38 MAPK pathway is required during oogenesis for egg asymmetric development.
- M. Suzanne, K. Irie, B. Glise, F. Agnès, E. Mori, K. Matsumoto, and S. Noselli (1999)
Genes & Dev.
13, 1464-1474
| Abstract »
| Full Text »
- The Ankyrin Repeat-containing Adaptor Protein Tvl-1 Is a Novel Substrate and Regulator of Raf-1.
- J.-H. Lin, A. Makris, C. McMahon, S. E. Bear, C. Patriotis, V. R. Prasad, R. Brent, E. A. Golemis, and P. N. Tsichlis (1999)
J. Biol. Chem.
274, 14706-14715
| Abstract »
| Full Text »
| PDF »
- Cell Adhesion Regulates the Interaction between the Docking Protein p130Cas and the 14-3-3 Proteins.
- M. Garcia-Guzman, F. Dolfi, M. Russello, and K. Vuori (1999)
J. Biol. Chem.
274, 5762-5768
| Abstract »
| Full Text »
| PDF »
- Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human.
- C. WIDMANN, S. GIBSON, M. B. JARPE, and G. L. JOHNSON (1999)
Physiol Rev
79, 143-180
| Abstract »
| Full Text »
| PDF »
- A Novel Ligand-binding Site in the zeta -Form 14-3-3 Protein Recognizing the Platelet Glycoprotein Ibalpha and Distinct from the c-Raf-binding Site.
- M. Gu and X. Du (1998)
J. Biol. Chem.
273, 33465-33471
| Abstract »
| Full Text »
| PDF »
- Hsp90 Is Required for Pheromone Signaling in Yeast.
- J.-F. Louvion, T. Abbas-Terki, and D. Picard (1998)
Mol. Biol. Cell
9, 3071-3083
| Abstract »
| Full Text »
- Association of the TLX-2 Homeodomain and 14-3-3eta Signaling Proteins.
- S. J. Tang, T.-C. Suen, R. R. McInnes, and M. Buchwald (1998)
J. Biol. Chem.
273, 25356-25363
| Abstract »
| Full Text »
| PDF »
- Ras Isoforms Vary in Their Ability to Activate Raf-1 and Phosphoinositide 3-Kinase.
- J. Yan, S. Roy, A. Apolloni, A. Lane, and J. F. Hancock (1998)
J. Biol. Chem.
273, 24052-24056
| Abstract »
| Full Text »
| PDF »
- 14-3-3 Proteins Are Required for Maintenance of Raf-1 Phosphorylation and Kinase Activity.
- J. A. Thorson, L. W. K. Yu, A. L. Hsu, N.-Y. Shih, P. R. Graves, J. W. Tanner, P. M. Allen, H. Piwnica-Worms, and A. S. Shaw (1998)
Mol. Cell. Biol.
18, 5229-5238
| Abstract »
| Full Text »
- Identification of Residues in the Cysteine-rich Domain of Raf-1 That Control Ras Binding and Raf-1 Activity.
- D. G. Winkler, R. E. Cutler Jr., J. K. Drugan, S. Campbell, D. K. Morrison, and J. A. Cooper (1998)
J. Biol. Chem.
273, 21578-21584
| Abstract »
| Full Text »
| PDF »
- 14-3-3 Facilitates Ras-Dependent Raf-1 Activation In Vitro and In Vivo.
- S. Roy, R. A. McPherson, A. Apolloni, J. Yan, A. Lane, J. Clyde-Smith, and J. F. Hancock (1998)
Mol. Cell. Biol.
18, 3947-3955
| Abstract »
| Full Text »
- Mutations in the Hydrophobic Surface of an Amphipathic Groove of 14-3-3zeta Disrupt Its Interaction with Raf-1 Kinase.
- H. Wang, L. Zhang, R. Liddington, and H. Fu (1998)
J. Biol. Chem.
273, 16297-16304
| Abstract »
| Full Text »
| PDF »
- 14-3-3zeta Binds a Phosphorylated Raf Peptide and an Unphosphorylated Peptide via Its Conserved Amphipathic Groove.
- C. Petosa, S. C. Masters, L. A. Bankston, J. Pohl, B. Wang, H. Fu, and R. C. Liddington (1998)
J. Biol. Chem.
273, 16305-16310
| Abstract »
| Full Text »
| PDF »
- Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins.
- A. E. Aplin, A. Howe, S. K. Alahari, and R. L. Juliano (1998)
Pharmacol. Rev.
50, 197-264
| Abstract »
| Full Text »
| PDF »
- Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors.
- K. L. Clark, P. B. Larsen, X. Wang, and C. Chang (1998)
PNAS
95, 5401-5406
| Abstract »
| Full Text »
| PDF »
- Human Signaling Protein 14-3-3zeta Interacts With Platelet Glycoprotein Ib Subunits Ibalpha and Ibbeta.
- D. C. Calverley, T. J. Kavanagh, and G. J. Roth (1998)
Blood
91, 1295-1303
| Abstract »
| Full Text »
| PDF »
- 14-3-3 Proteins Interact with Specific MEK Kinases.
- G. R. Fanger, C. Widmann, A. C. Porter, S. Sather, G. L. Johnson, and R. R. Vaillancourt (1998)
J. Biol. Chem.
273, 3476-3483
| Abstract »
| Full Text »
| PDF »
- Activation of the Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Pathway by Conventional, Novel, and Atypical Protein Kinase C Isotypes.
- D. C. Schönwasser, R. M. Marais, C. J. Marshall, and P. J. Parker (1998)
Mol. Cell. Biol.
18, 790-798
| Abstract »
| Full Text »
- Feedback Regulation of Raf-1 and Mitogen-activated Protein Kinase (MAP) Kinase Kinases 1 and 2 by MAP Kinase Phosphatase-1 (MKP-1).
- P. S. Shapiro and N. G. Ahn (1998)
J. Biol. Chem.
273, 1788-1793
| Abstract »
| Full Text »
| PDF »
- Radicicol Leads to Selective Depletion of Raf Kinase and Disrupts K-Ras-activated Aberrant Signaling Pathway.
- S. Soga, T. Kozawa, H. Narumi, S. Akinaga, K. Irie, K. Matsumoto, S. V. Sharma, H. Nakano, T. Mizukami, and M. Hara (1998)
J. Biol. Chem.
273, 822-828
| Abstract »
| Full Text »
| PDF »
- 14-3-3beta Protein Associates with Insulin Receptor Substrate 1 and Decreases Insulin-stimulated Phosphatidylinositol 3'-Kinase Activity in 3T3L1 Adipocytes.
- A. Kosaki, K. Yamada, J. Suga, A. Otaka, and H. Kuzuya (1998)
J. Biol. Chem.
273, 940-944
| Abstract »
| Full Text »
| PDF »
- Interference of BAD (Bcl-xL/Bcl-2-Associated Death Promoter)-Induced Apoptosis in Mammalian Cells by 14-3-3 Isoforms and P11.
- S. Y. Hsu, A. Kaipia, L. Zhu, and A. J. W. Hsueh (1997)
Mol. Endocrinol.
11, 1858-1867
| Abstract »
| Full Text »
- Serine Phosphorylation-dependent Association of the Band 4.1-related Protein-tyrosine Phosphatase PTPH1 with 14-3-3beta Protein.
- S.-H. Zhang, R. Kobayashi, P. R. Graves, H. Piwnica-Worms, and N. K. Tonks (1997)
J. Biol. Chem.
272, 27281-27287
| Abstract »
| Full Text »
| PDF »
- Interaction of Phosphorylated Tryptophan Hydroxylase with 14-3-3 Proteins.
- U. Banik, G.-A. Wang, P. D. Wagner, and S. Kaufman (1997)
J. Biol. Chem.
272, 26219-26225
| Abstract »
| Full Text »
| PDF »
- 14-3-3 Protein Binds to Insulin Receptor Substrate-1, One of the Binding Sites of Which Is in the Phosphotyrosine Binding Domain.
- T. Ogihara, T. Isobe, T. Ichimura, M. Taoka, M. Funaki, H. Sakoda, Y. Onishi, K. Inukai, M. Anai, Y. Fukushima, et al. (1997)
J. Biol. Chem.
272, 25267-25274
| Abstract »
| Full Text »
| PDF »
- 14-3-3 zeta Negatively Regulates Raf-1 Activity by Interactions with the Raf-1 Cysteine-rich Domain.
- G. J. Clark, J. K. Drugan, K. L. Rossman, J. W. Carpenter, K. Rogers-Graham, H. Fu, C. J. Der, and S. L. Campbell (1997)
J. Biol. Chem.
272, 20990-20993
| Abstract »
| Full Text »
| PDF »
- Raf-1 Kinase and Exoenzyme S Interact with 14-3-3zeta through a Common Site Involving Lysine 49.
- L. Zhang, H. Wang, D. Liu, R. Liddington, and H. Fu (1997)
J. Biol. Chem.
272, 13717-13724
| Abstract »
| Full Text »
| PDF »
- Protein binding and signaling properties of RIN1 suggest a unique effector function.
- L. Han, D. Wong, A. Dhaka, D. Afar, M. White, W. Xie, H. Herschman, O. Witte, and J. Colicelli (1997)
PNAS
94, 4954-4959
| Abstract »
| Full Text »
| PDF »
- 14-3-3 epsilon positively regulates Ras-mediated signaling in Drosophila..
- H C Chang and G M Rubin (1997)
Genes & Dev.
11, 1132-1139
| Abstract »
| PDF »
- Requirement for Drosophila 14-3-3 zeta in Raf-dependent photoreceptor development..
- L Kockel, G Vorbruggen, H Jackle, M Mlodzik, and D Bohmann (1997)
Genes & Dev.
11, 1140-1147
| Abstract »
| PDF »
- 14-3-3 (epsilon ) Interacts with the Insulin-like Growth Factor I Receptor and Insulin Receptor Substrate I in a Phosphoserine-dependent Manner.
- A. Craparo, R. Freund, and T. A. Gustafson (1997)
J. Biol. Chem.
272, 11663-11669
| Abstract »
| Full Text »
| PDF »
- Serine Phosphorylation of Cbl Induced by Phorbol Ester Enhances Its Association with 14-3-3Proteins in T Cells via a Novel Serine-rich 14-3-3-binding Motif.
- Y.-C. Liu, Y. Liu, C. Elly, H. Yoshida, S. Lipkowitz, and A. Altman (1997)
J. Biol. Chem.
272, 9979-9985
| Abstract »
| Full Text »
| PDF »
- Negative Modulation of Membrane Localization of the Raf-1 Protein Kinase by Hyperphosphorylation.
- M. Wartmann, P. Hofer, P. Turowski, A. R. Saltiel, and N. E. Hynes (1997)
J. Biol. Chem.
272, 3915-3923
| Abstract »
| Full Text »
| PDF »
- The Drosophila 14-3-3 protein Leonardo enhances Torso signaling through D-Raf in a Ras 1-dependent manner.
- W Li, E. Skoulakis, R. Davis, and N Perrimon (1997)
Development
124, 4163-4171
| Abstract »
| PDF »
- The 14-3-3 Brain Protein in Cerebrospinal Fluid as a Marker for Transmissible Spongiform Encephalopathies.
- G. Hsich, K. Kenney, C. J. Gibbs, K. H. Lee, and M. G. Harrington (1996)
N. Engl. J. Med.
335, 924-930
| Abstract »
| Full Text »
| PDF »
- 14-3-3 Proteins Associate with A20 in an Isoform-specific Manner and Function Both as Chaperone and Adapter Molecules.
- C. Vincenz and V. M. Dixit (1996)
J. Biol. Chem.
271, 20029-20034
| Abstract »
| Full Text »
| PDF »
- Activation-modulated Association of 14-3-3Proteins with Cbl in T Cells.
- Y.-C. Liu, C. Elly, H. Yoshida, N. Bonnefoy-Berard, and A. Altman (1996)
J. Biol. Chem.
271, 14591-14595
| Abstract »
| Full Text »
| PDF »
- Neoplastic Transformation Induced by Insulin Receptor Substrate-1 Overexpression Requires an Interaction with Both Grb2 and Syp Signaling Molecules.
- S. Tanaka, T. Ito, and J. R. Wands (1996)
J. Biol. Chem.
271, 14610-14616
| Abstract »
| Full Text »
| PDF »
- cAMP-mediated Growth Inhibition in Fibroblasts Is Not Mediated via Mitogen-activated Protein (MAP) Kinase (ERK) Inhibition. cAMP-DEPENDENT PROTEIN KINASE INDUCES A TEMPORAL SHIFT IN GROWTH FACTOR-STIMULATED MAP KINASES.
- F. R. McKenzie and J. Pouyssegur (1996)
J. Biol. Chem.
271, 13476-13483
| Abstract »
| Full Text »
| PDF »
- Localization of Epidermal Growth Factor-stimulated Ras/Raf-1 Interaction to Caveolae Membrane.
- C. Mineo, G. L. James, E. J. Smart, and R. G. W. Anderson (1996)
J. Biol. Chem.
271, 11930-11935
| Abstract »
| Full Text »
| PDF »
- PKN Associates and Phosphorylates the Head-Rod Domain of Neurofilament Protein.
- H. Mukai, M. Toshimori, H. Shibata, M. Kitagawa, M. Shimakawa, M. Miyahara, H. Sunakawa, and Y. Ono (1996)
J. Biol. Chem.
271, 9816-9822
| Abstract »
| Full Text »
| PDF »
- Raf-1 Kinase Possesses Distinct Binding Domains for Phosphatidylserine and Phosphatidic Acid.
- S. Ghosh, J. C. Strum, V. A. Sciorra, L. Daniel, and R. M. Bell (1996)
J. Biol. Chem.
271, 8472-8480
| Abstract »
| Full Text »
| PDF »
- Identification of a Binding Sequence for the 14-3-3 Protein within the Cytoplasmic Domain of the Adhesion Receptor, Platelet Glycoprotein Ibalpha.
- X. Du, J. E. Fox, and S. Pei (1996)
J. Biol. Chem.
271, 7362-7367
| Abstract »
| Full Text »
| PDF »
- Ras Interaction with Two Distinct Binding Domains in Raf-1 May Be Required for Ras Transformation.
- J. K. Drugan, R. Khosravi-Far, M. A. White, C. J. Der, Y.-J. Sung, Y.-W. Hwang, and S. L. Campbell (1996)
J. Biol. Chem.
271, 233-237
| Abstract »
| Full Text »
| PDF »
- Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-beta Signal Transduction.
- K. Yamaguchi, K. Shirakabe, H. Shibuya, K. Irie, I. Oishi, N. Ueno, T. Taniguchi, E. Nishida, and K. Matsumoto (1995)
Science
270, 2008-2011
| Abstract »
| PDF »
- Identification of the 14.3.3 [IMAGE] Domains Important for Self-association and Raf Binding.
- Z.-j. Luo, X.-f. Zhang, U. Rapp, and J. Avruch (1995)
J. Biol. Chem.
270, 23681-23687
| Abstract »
| Full Text »
| PDF »
- Reversal of Raf-1 activation by purified and membrane-associated protein phosphatases.
- P Dent, T Jelinek, D. Morrison, M. Weber, and T. Sturgill (1995)
Science
268, 1902-1906
| Abstract »
| PDF »
- A Direct Interaction between G-Protein [IMAGE][IMAGE] Subunits and the Raf-1 Protein Kinase.
- K. M. Pumiglia, H. LeVine, T. Haske, T. Habib, R. Jove, and S. J. Decker (1995)
J. Biol. Chem.
270, 14251-14254
| Abstract »
| Full Text »
| PDF »
- Purification of a Ras-dependent Mitogen-activated Protein Kinase Kinase Kinase from Bovine Brain Cytosol and Its Identification as a Complex of B-Raf and 14-3-3 Proteins.
- B. Yamamori, S. Kuroda, K. Shimizu, K. Fukui, T. Ohtsuka, and Y. Takai (1995)
J. Biol. Chem.
270, 11723-11726
| Abstract »
| Full Text »
| PDF »
- Localization of protein kinases by anchoring proteins: a theme in signal transduction.
- D Mochly-Rosen (1995)
Science
268, 247-251
| Abstract »
| PDF »
- 14-3-3 alpha and [IMAGE] Are the Phosphorylated Forms of Raf-activating 14-3-3 beta and [IMAGE].
- A. Aitken, S. Howell, D. Jones, J. Madrazo, and Y. Patel (1995)
J. Biol. Chem.
270, 5706-5709
| Abstract »
| Full Text »
| PDF »
- Activation of Mitogen-activated Protein Kinase by Arachidonic Acid in Rat Liver Epithelial WB Cells by a Protein Kinase C-dependent Mechanism.
- C. S. T. Hii, A. Ferrante, Y. S. Edwards, Z. H. Huang, P. J. Hartfield, D. A. Rathjen, A. Poulos, and A. W. Murray (1995)
J. Biol. Chem.
270, 4201-4204
| Abstract »
| Full Text »
| PDF »
- A Constitutive Effector Region on the C-terminal Side of Switch I of the Ras Protein.
- J. Fujita-Yoshigaki, M. Shirouzu, Y. Ito, S. Hattori, S. Furuyama, S. Nishimura, and S. Yokoyama (1995)
J. Biol. Chem.
270, 4661-4667
| Abstract »
| Full Text »
| PDF »
- Stratifin, a keratinocyte specific 14-3-3 protein, harbors a pleckstrin homology (PH) domain and enhances protein kinase C activity.
- E Dellambra, M Patrone, B Sparatore, A Negri, F Ceciliani, S Bondanza, F Molina, F. Cancedda, and M De Luca (1995)
J. Cell Sci.
108, 3569-3579
| Abstract »
| PDF »
- 14-3-3: modulators of signaling proteins?.
- D Morrison (1994)
Science
266, 56-57
| PDF »
- Binding of 14-3-3 proteins to the protein kinase Raf and effects on its activation.
- E Freed, M Symons, S. Macdonald, F McCormick, and R Ruggieri (1994)
Science
265, 1713-1716
| Abstract »
| PDF »
- Proteins of the 14-3-3 Family Associate with Raf and Contribute to Its Activation.
- E. Freed, F. McCormick, and R. Ruggieri (1994)
Cold Spring Harb Symp Quant Biol
59, 187-193
| Abstract »
| PDF »
- The Recruitment of Raf-1 to Membranes Is Mediated by Direct Interaction with Phosphatidic Acid and Is Independent of Association with Ras.
- M. A. Rizzo, K. Shome, S. C. Watkins, and G. Romero (2000)
J. Biol. Chem.
275, 23911-23918
| Abstract »
| Full Text »
| PDF »
- Glucocorticoid Receptor Interaction with 14-3-3 and Raf-1, a Proposed Mechanism for Cross-talk of Two Signal Transduction Pathways.
- C. Widen, J. Zilliacus, J.-A. Gustafsson, and A.-C. Wikstrom (2000)
J. Biol. Chem.
275, 39296-39301
| Abstract »
| Full Text »
| PDF »
- Signal Transduction by the CEACAM1 Tumor Suppressor. PHOSPHORYLATION OF SERINE 503 IS REQUIRED FOR GROWTH-INHIBITORY ACTIVITY.
- V. T. Estrera, D.-T. Chen, W. Luo, D. C. Hixson, and S.-H. Lin (2001)
J. Biol. Chem.
276, 15547-15553
| Abstract »
| Full Text »
| PDF »
|
|