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Science 19 August 1994:
Vol. 265. no. 5175, pp. 1104 - 1107
DOI: 10.1126/science.8066450
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Articles

Science, Vol 265, Issue 5175, 1104-1107
Copyright © 1994 by American Association for the Advancement of Science

articles

Requirement of a critical period of transcription for induction of a late phase of LTP

PV Nguyen, T Abel, and ER Kandel

Howard Hughes Medical Institute, New York, NY.

Repeated high-frequency trains of stimuli induce long-term potentiation (LTP) in the CA1 region that persists for up to 8 hours in hippocampal slices and for days in intact animals. This long time course has made LTP an attractive model for certain forms of long-term memory in the mammalian brain. A hallmark of long-term memory in the intact animal is a requirement for transcription, and thus whether the late phase of LTP (L-LTP) requires transcription was investigated here. With the use of different inhibitors, it was found in rat hippocampal slices that the induction of L-LTP [produced either by tetanic stimulation or by application of the cyclic adenosine monophosphate (cAMP) analog Sp-cAMPS (Sp-cyclic adenosine 3',5'-monophosphorothioate)] was selectively prevented when transcription was blocked immediately after tetanization or during application of cAMP. As with behavioral memory, this requirement for transcription had a critical time window. Thus, the late phase of LTP in the CA1 region requires transcription during a critical period, perhaps because cAMP-inducible genes must be expressed during this period.


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Transition to Endogenous Bursting After Long-Term Decentralization Requires De Novo Transcription in a Critical Time Window.
M. Thoby-Brisson and J. Simmers (2000)
J Neurophysiol 84, 596-599
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The MAPK/ERK Cascade Targets Both Elk-1 and cAMP Response Element-Binding Protein to Control Long-Term Potentiation-Dependent Gene Expression in the Dentate Gyrus In Vivo.
S. Davis, P. Vanhoutte, C. Pages, J. Caboche, and S. Laroche (2000)
J. Neurosci. 20, 4563-4572
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Upregulation of cAMP Response Element-Mediated Gene Expression during Experience-Dependent Plasticity in Adult Neocortex.
A. L. Barth, M. McKenna, S. Glazewski, P. Hill, S. Impey, D. Storm, and K. Fox (2000)
J. Neurosci. 20, 4206-4216
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Strain-dependent Differences in LTP and Hippocampus-dependent Memory in Inbred Mice.
P. V. Nguyen, T. Abel, E. R. Kandel, and R. Bourtchouladze (2000)
Learn. Mem. 7, 170-179
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Metabotropic Glutamate Receptors Trigger Homosynaptic Protein Synthesis to Prolong Long-Term Potentiation.
C. R. Raymond, V. L. Thompson, W. P. Tate, and W. C. Abraham (2000)
J. Neurosci. 20, 969-976
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Role of Tissue Plasminogen Activator Receptor LRP in Hippocampal Long-Term Potentiation.
M. Zhuo, D. M. Holtzman, Y. Li, H. Osaka, J. DeMaro, M. Jacquin, and G. Bu (2000)
J. Neurosci. 20, 542-549
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Nitric Oxide Signaling Contributes to Late-Phase LTP and CREB Phosphorylation in the Hippocampus.
Y.-F. Lu, E. R. Kandel, and R. D. Hawkins (1999)
J. Neurosci. 19, 10250-10261
   Abstract »    Full Text »    PDF »
Coincident Induction of Long-Term Facilitation in Aplysia: Cooperativity Between Cell Bodies and Remote Synapses.
C. M. Sherff and T. J. Carew (1999)
Science 285, 1911-1914
   Abstract »    Full Text »


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