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Science 5 August 1994:
Vol. 265. no. 5173, pp. 808 - 811
DOI: 10.1126/science.7914033
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Articles

Science, Vol 265, Issue 5173, 808-811
Copyright © 1994 by American Association for the Advancement of Science

articles

A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells

J Han, JD Lee, L Bibbs, and RJ Ulevitch

Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.

Mammalian cells respond to endotoxic lipopolysaccharide (LPS) by activation of protein kinase cascades that lead to new gene expression. A protein kinase, p38, that was tyrosine phosphorylated in response to LPS, was cloned. The p38 enzyme and the product of the Saccharomyces cerevisiae HOG1 gene, which are both members of the mitogen-activated protein (MAP) kinase family, have sequences at and adjacent to critical phosphorylation sites that distinguish these proteins from most other MAP kinase family members. Both HOG1 and p38 are tyrosine phosphorylated after extracellular changes in osmolarity. These findings link a signaling pathway in mammalian cells with a pathway in yeast that is responsive to physiological stress.


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   Abstract »    Full Text »    PDF »
Essential Role of p38{gamma} in K-Ras Transformation Independent of Phosphorylation.
J. Tang, X. Qi, D. Mercola, J. Han, and G. Chen (2005)
J. Biol. Chem. 280, 23910-23917
   Abstract »    Full Text »    PDF »
Phosphorylation of c-Fos by Members of the p38 MAPK Family: ROLE IN THE AP-1 RESPONSE TO UV LIGHT.
T. Tanos, M. J. Marinissen, F. C. Leskow, D. Hochbaum, H. Martinetto, J. S. Gutkind, and O. A. Coso (2005)
J. Biol. Chem. 280, 18842-18852
   Abstract »    Full Text »    PDF »
Phosphorylation-Dependent Degradation of p300 by Doxorubicin-Activated p38 Mitogen-Activated Protein Kinase in Cardiac Cells.
C. Poizat, P. L. Puri, Y. Bai, and L. Kedes (2005)
Mol. Cell. Biol. 25, 2673-2687
   Abstract »    Full Text »    PDF »
Activation of p38 MAP kinase enhances sensitivity of muscle glucose transport to insulin.
P. C. Geiger, D. C. Wright, D.-H. Han, and J. O. Holloszy (2005)
Am J Physiol Endocrinol Metab 288, E782-E788
   Abstract »    Full Text »    PDF »
MAPK p38{alpha} Is Dispensable for Lymphocyte Development and Proliferation.
J. M. Kim, J. M. White, A. S. Shaw, and B. P. Sleckman (2005)
J. Immunol. 174, 1239-1244
   Abstract »    Full Text »    PDF »
Hypertonic shock inhibits growth factor receptor signaling, induces caspase-3 activation, and causes reversible fragmentation of the mitochondrial network.
J. Copp, S. Wiley, M. W. Ward, and P. van der Geer (2005)
Am J Physiol Cell Physiol 288, C403-C415
   Abstract »    Full Text »    PDF »
Involvement of p42/p44 MAPK, p38 MAPK, JNK, and NF-{kappa}B in IL-1{beta}-induced VCAM-1 expression in human tracheal smooth muscle cells.
C.-C. Wang, W.-N. Lin, C.-W. Lee, C.-C. Lin, S.-F. Luo, J.-S. Wang, and C.-M. Yang (2005)
Am J Physiol Lung Cell Mol Physiol 288, L227-L237
   Abstract »    Full Text »    PDF »
JNK Regulates the Release of Proapoptotic Mitochondrial Factors in Reovirus-Infected Cells.
P. Clarke, S. M. Meintzer, Y. Wang, L. A. Moffitt, S. M. Richardson-Burns, G. L. Johnson, and K. L. Tyler (2004)
J. Virol. 78, 13132-13138
   Abstract »    Full Text »    PDF »
MAP kinases and the adaptive response to hypertonicity: functional preservation from yeast to mammals.
D. Sheikh-Hamad and M. C. Gustin (2004)
Am J Physiol Renal Physiol 287, F1102-F1110
   Abstract »    Full Text »    PDF »
A Novel Mechanism for TNF-{alpha} Regulation by p38 MAPK: Involvement of NF-{kappa}B with Implications for Therapy in Rheumatoid Arthritis.
J. Campbell, C. J. Ciesielski, A. E. Hunt, N. J. Horwood, J. T. Beech, L. A. Hayes, A. Denys, M. Feldmann, F. M. Brennan, and B. M. J. Foxwell (2004)
J. Immunol. 173, 6928-6937
   Abstract »    Full Text »    PDF »
Oncogenic Raf-1 regulates epithelial to mesenchymal transition via distinct signal transduction pathways in an immortalized mouse hepatic cell line.
M. Lan, T. Kojima, M. Osanai, H. Chiba, and N. Sawada (2004)
Carcinogenesis 25, 2385-2395
   Abstract »    Full Text »    PDF »
When the Stress of Your Environment Makes You Go HOG Wild.
P. J. Westfall, D. R. Ballon, and J. Thorner (2004)
Science 306, 1511-1512
   Abstract »    Full Text »    PDF »
Active Mutants of the Human p38{alpha} Mitogen-activated Protein Kinase.
R. Diskin, N. Askari, R. Capone, D. Engelberg, and O. Livnah (2004)
J. Biol. Chem. 279, 47040-47049
   Abstract »    Full Text »    PDF »
Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs.
M Karin (2004)
Ann Rheum Dis 63, ii62-ii64
   Abstract »    Full Text »    PDF »


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