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Science 5 August 1994:
Vol. 265. no. 5173, pp. 806 - 808
DOI: 10.1126/science.8047888
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Articles

Science, Vol 265, Issue 5173, 806-808
Copyright © 1994 by American Association for the Advancement of Science

articles

An osmosensing signal transduction pathway in mammalian cells

Z Galcheva-Gargova, B Derijard, IH Wu, and RJ Davis

Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester 01605.

The osmotic balance between the cytoplasmic and extracellular compartments of cells is critical for the control of cell volume. A mammalian protein kinase, Jnk, which is a distant relative of the mitogen-activated protein kinase group, was activated by phosphorylation on threonine and tyrosine in osmotically shocked cells. The activation of Jnk may be relevant to the biological response to osmotic shock because the expression of human Jnk in the yeast Saccharomyces cerevisiae rescued a defect in growth on hyper-osmolar media. These data indicate that related protein kinases may mediate osmosensing signal transduction in yeast and mammalian cells.


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M. S. Roberson, T. Zhang, H. L. Li, and J. M. Mulvaney (1999)
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   Abstract »    Full Text »    PDF »
Activation of the Janus Kinase/Signal Transducer and Activator of Transcription Pathway by Osmotic Shock.
P. Gatsios, L. Terstegen, F. Schliess, D. Haussinger, I. M. Kerr, P. C. Heinrich, and L. Graeve (1998)
J. Biol. Chem. 273, 22962-22968
   Abstract »    Full Text »    PDF »
MEKK1/JNK signaling stabilizes and activates p53.
S. Y. Fuchs, V. Adler, M. R. Pincus, and Z.'e. Ronai (1998)
PNAS 95, 10541-10546
   Abstract »    Full Text »    PDF »
JNK targets p53 ubiquitination and degradation in nonstressed cells.
S. Y. Fuchs, V. Adler, T. Buschmann, Z. Yin, X. Wu, S. N. Jones, and Z.'e. Ronai (1998)
Genes & Dev. 12, 2658-2663
   Abstract »    Full Text »
An RNA Binding Protein Negatively Controlling Differentiation in Fission Yeast.
K. Tsukahara, H. Yamamoto, and H. Okayama (1998)
Mol. Cell. Biol. 18, 4488-4498
   Abstract »    Full Text »    PDF »
Extracellular-regulated protein kinase cascades are activated in response to injury in human skeletal muscle.
D. Aronson, J. F. P. Wojtaszewski, A. Thorell, J. Nygren, D. Zangen, E. A. Richter, O. Ljungqvist, R. A. Fielding, and L. J. Goodyear (1998)
Am J Physiol Cell Physiol 275, C555-C561
   Abstract »    Full Text »    PDF »
The Fission Yeast Mitotic Regulator win1+ Encodes an MAP Kinase Kinase Kinase That Phosphorylates and Activates Wis1 MAP Kinase Kinase in Response to High Osmolarity.
I. Samejima, S. Mackie, E. Warbrick, R. Weisman, and P. A. Fantes (1998)
Mol. Biol. Cell 9, 2325-2335
   Abstract »    Full Text »
p42/p44 MAP Kinase Module Plays a Key Role in the Transcriptional Regulation of the Vascular Endothelial Growth Factor Gene in Fibroblasts.
J. Milanini, F. Vinals, J. Pouyssegur, and G. Pages (1998)
J. Biol. Chem. 273, 18165-18172
   Abstract »    Full Text »    PDF »
Ultraviolet Radiation Triggers the Ribotoxic Stress Response in Mammalian Cells.
M. S. Iordanov, D. Pribnow, J. L. Magun, T.-H. Dinh, J. A. Pearson, and B. E. Magun (1998)
J. Biol. Chem. 273, 15794-15803
   Abstract »    Full Text »    PDF »
Bidirectional Regulation of p38 Kinase and c-Jun N-terminal Protein Kinase by Insulin-like Growth Factor-I.
H.-L. Cheng and E. L. Feldman (1998)
J. Biol. Chem. 273, 14560-14565
   Abstract »    Full Text »    PDF »
Signalling in the Yeasts: An Informational Cascade with Links to the Filamentous Fungi.
F. Banuett (1998)
Microbiol. Mol. Biol. Rev. 62, 249-274
   Abstract »    Full Text »    PDF »
A combination of NaCl and urea enhances survival of IMCD cells to hyperosmolality.
B. C. Santos, A. Chevaile, M.-J. Hebert, J. Zagajeski, and S. R. Gullans (1998)
Am J Physiol Renal Physiol 274, F1167-F1173
   Abstract »    Full Text »    PDF »
Hyperosmolality Causes Growth Arrest of Murine Kidney Cells. INDUCTION OF GADD45 AND GADD153 BY OSMOSENSING VIA STRESS-ACTIVATED PROTEIN KINASE 2.
D. Kultz, S. Madhany, and M. B. Burg (1998)
J. Biol. Chem. 273, 13645-13651
   Abstract »    Full Text »    PDF »
SAPKs and transcription factors do the nucleocytoplasmic tango.
M. G. Wilkinson and J. B.A. Millar (1998)
Genes & Dev. 12, 1391-1397
   Full Text »
Human Mitogen-activated Protein Kinase Kinase 7 (MKK7) Is a Highly Conserved c-Jun N-terminal Kinase/Stress-activated Protein Kinase (JNK/SAPK) Activated by Environmental Stresses and Physiological Stimuli.
I. N. Foltz, R. E. Gerl, J. S. Wieler, M. Luckach, R. A. Salmon, and J. W. Schrader (1998)
J. Biol. Chem. 273, 9344-9351
   Abstract »    Full Text »    PDF »
Peripheral Axotomy Induces Long-Term c-Jun Amino-Terminal Kinase-1 Activation and Activator Protein-1 Binding Activity by c-Jun and junD in Adult Rat Dorsal Root Ganglia In Vivo.
A. M. Kenney and J. D. Kocsis (1998)
J. Neurosci. 18, 1318-1328
   Abstract »    Full Text »    PDF »


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