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Science 29 July 1994:
Vol. 265. no. 5172, pp. 676 - 679
DOI: 10.1126/science.8036517
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Articles

Science, Vol 265, Issue 5172, 676-679
Copyright © 1994 by American Association for the Advancement of Science

articles

Reactivation of hippocampal ensemble memories during sleep

MA Wilson and BL McNaughton

Division of Neural Systems, Memory, and Aging, University of Arizona, Tucson 85724.

Simultaneous recordings were made from large ensembles of hippocampal "place cells" in three rats during spatial behavioral tasks and in slow-wave sleep preceding and following these behaviors. Cells that fired together when the animal occupied particular locations in the environment exhibited an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks. Cells that were inactive during behavior, or that were active but had non-overlapping spatial firing, did not show this increase. This effect, which declined gradually during each post-behavior sleep session, may result from synaptic modification during waking experience. Information acquired during active behavior is thus re-expressed in hippocampal circuits during sleep, as postulated by some theories of memory consolidation.


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