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Science 22 July 1994:
Vol. 265. no. 5171, pp. 535 - 537
DOI: 10.1126/science.8036498
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Articles

Science, Vol 265, Issue 5171, 535-537
Copyright © 1994 by American Association for the Advancement of Science

articles

Association of polyomavirus middle tumor antigen with 14-3-3 proteins

DC Pallas, H Fu, LC Haehnel, W Weller, RJ Collier, and TM Roberts

Division of Cellular and Molecular Biology, Dana-Farber Cancer Institute, Boston, MA.

To carry out its transformation function, the middle tumor antigen (MT) of murine polyomavirus associates with a number of cellular proteins involved in regulation of cell proliferation, including pp60c-Src, phosphatidylinositol 3-kinase, protein phosphatase 2A, Src homologous and collagen protein and growth factor receptor-binding protein 2. Here, two additional MT-associated proteins were identified as members of the 14-3-3 family of proteins. Yeast homologs of 14-3-3 proteins have recently been shown to play a role in the timing of mitosis. Thus, regulation of 14-3-3 protein function by MT may contribute to the development of neoplasia.


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14-3-3: modulators of signaling proteins?.
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Interaction of the protein kinase Raf-1 with 14-3-3 proteins.
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Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family.
G. Reuther, H Fu, L. Cripe, R. Collier, and A. Pendergast (1994)
Science 266, 129-133
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14-3-3 protein homologs required for the DNA damage checkpoint in fission yeast.
J. Ford, F al-Khodairy, E Fotou, K. Sheldrick, D. Griffiths, and A. Carr (1994)
Science 265, 533-535
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Proteins of the 14-3-3 Family Associate with Raf and Contribute to Its Activation.
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14-3-3zeta Is an Effector of Tau Protein Phosphorylation.
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J. Biol. Chem. 275, 25247-25254
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Association of the Cyclin-dependent Kinases and 14-3-3 Sigma Negatively Regulates Cell Cycle Progression.
C. Laronga, H.-Y. Yang, C. Neal, and M.-H. Lee (2000)
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