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Science 24 June 1994:
Vol. 264. no. 5167, pp. 1921 - 1924
DOI: 10.1126/science.8009222
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Articles

Science, Vol 264, Issue 5167, 1921-1924
Copyright © 1994 by American Association for the Advancement of Science

articles

Involvement of the IRF-1 transcription factor in antiviral responses to interferons

T Kimura, K Nakayama, J Penninger, M Kitagawa, H Harada, T Matsuyama, N Tanaka, R Kamijo, J Vilcek, TW Mak, and al. et

Institute for Molecular and Cellular Biology, Osaka University, Japan.

The mechanisms underlying interferon (IFN)-induced antiviral states are not well understood. Interferon regulatory factor-1 (IRF-1) is an IFN-inducible transcriptional activator, whereas IRF-2 suppresses IRF-1 action. The inhibition of encephalomyocarditis virus (EMCV) replication by IFN-alpha and especially by IFN-gamma was impaired in cells from mice with a null mutation in the IRF-1 gene (IRF-1-/- mice). The IRF-1-/- mice were less resistant than normal mice to EMCV infection, as revealed by accelerated mortality and a larger virus titer in target organs. The absence of IRF-1 did not clearly affect replication of two other types of viruses. Thus, IRF-1 is necessary for the antiviral action of IFNs against some viruses, but IFNs activate multiple activation pathways through diverse target genes to induce the antiviral state.


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