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Science 13 May 1994:
Vol. 264. no. 5161, pp. 965 - 968
DOI: 10.1126/science.8178155
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Articles

Science, Vol 264, Issue 5161, 965-968
Copyright © 1994 by American Association for the Advancement of Science

articles

Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor

KH Grabstein, J Eisenman, K Shanebeck, C Rauch, S Srinivasan, V Fung, C Beers, J Richardson, MA Schoenborn, M Ahdieh, and al. et

Immunex Research and Development Corporation, Seattle, WA 98101.

A cytokine was identified that stimulated the proliferation of T lymphocytes, and a complementary DNA clone encoding this new T cell growth factor was isolated. The cytokine, designated interleukin-15 (IL-15), is produced by a wide variety of cells and tissues and shares many biological properties with IL-2. Monoclonal antibodies to the beta chain of the IL-2 receptor inhibited the biological activity of IL-15, and IL-15 competed for binding with IL-2, indicating that IL-15 uses components of the IL-2 receptor.


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Interleukin-15 responses to aging and unloading-induced skeletal muscle atrophy.
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The IL-15/IL-15R{alpha} on cell surfaces enables sustained IL-15 activity and contributes to the long survival of CD8 memory T cells.
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PNAS 104, 588-593
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Immunostimulatory Effects of the Anionic Alkali Mineral Complex BARODON on Equine Lymphocytes.
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T. A. Stoklasek, K. S. Schluns, and L. Lefrancois (2006)
J. Immunol. 177, 6072-6080
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Dysregulation of IL-15-mediated T-cell homeostasis in TGF-beta dominant-negative receptor transgenic mice.
P. J. Lucas, S.-J. Kim, C. L. Mackall, W. G. Telford, Y.-W. Chu, F. T. Hakim, and R. E. Gress (2006)
Blood 108, 2789-2795
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J. Immunol. 177, 2216-2223
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IL-15 mediates immune inflammatory hypernociception by triggering a sequential release of IFN-{gamma}, endothelin, and prostaglandin.
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PNAS 103, 9721-9725
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IL-15 Is Elevated in Cerebrospinal Fluid of Patients With Alzheimer's Disease and Frontotemporal Dementia..
M. Rentzos, M. Zoga, G. P. Paraskevas, E. Kapaki, A. Rombos, C. Nikolaou, A. Tsoutsou, and D. Vassilopoulos (2006)
J Geriatr Psychiatry Neurol 19, 114-117
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MyD88-Dependent Signaling for IL-15 Production Plays an Important Role in Maintenance of CD8{alpha}{alpha} TCR{alpha}beta and TCR{gamma}{delta} Intestinal Intraepithelial Lymphocytes.
Q. Yu, C. Tang, S. Xun, T. Yajima, K. Takeda, and Y. Yoshikai (2006)
J. Immunol. 176, 6180-6185
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C. L. Combe, M. M. Moretto, J. D. Schwartzman, J. P. Gigley, D. J. Bzik, and I. A. Khan (2006)
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P. J. Staton, A. B. Carpenter, and S. H. Jackman (2006)
J. Immunol. 176, 3978-3986
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The Structure of the Interleukin-15{alpha} Receptor and Its Implications for Ligand Binding.
I. Lorenzen, A. J. Dingley, Y. Jacques, and J. Grotzinger (2006)
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Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice.
K Yoshihara, T Yajima, C Kubo, and Y Yoshikai (2006)
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IL-15-Dependent Induction of 4-1BB Promotes Antigen-Independent CD8 Memory T Cell Survival..
G. Pulle, M. Vidric, and T. H. Watts (2006)
J. Immunol. 176, 2739-2748
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C. A. Amlong, D. T. Nardelli, S. H. Peterson, T. F. Warner, S. M. Callister, and R. F. Schell (2006)
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J. Immunol. 175, 3656-3662
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N. J. Poindexter, E. T. Walch, S. Chada, and E. A. Grimm (2005)
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R. Sharma, H. Bagavant, W. N. Jarjour, S.-S. J. Sung, and S.-T. Ju (2005)
J. Immunol. 175, 1965-1973
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Engagement of specific T-cell surface molecules regulates cytoskeletal polarization in HTLV-1-infected lymphocytes.
A. L. Barnard, T. Igakura, Y. Tanaka, G. P. Taylor, and C. R.M. Bangham (2005)
Blood 106, 988-995
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J. Immunol. 175, 112-123
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Survival adjustment of mature dendritic cells by IL-15.
S. P. Dubois, T. A. Waldmann, and J. R. Muller (2005)
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Central Role of Interleukin-15 in Postovulatory Recruitment of Peripheral Blood CD16(-) Natural Killer Cells into Human Endometrium.
K. Kitaya, T. Yamaguchi, and H. Honjo (2005)
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Expression of membrane-bound IL-15 by bone marrow fibroblast-like stromal cells in aplastic anemia.
L. Wenxin, F. Jinxiang, W. Yong, L. Wenxiang, S. Wenbiao, and Z. Xueguang (2005)
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IL-7 exacerbates chronic colitis with expansion of memory IL-7Rhigh CD4+ mucosal T cells in mice.
E. Okada, M. Yamazaki, M. Tanabe, T. Takeuchi, M. Nanno, S. Oshima, R. Okamoto, K. Tsuchiya, T. Nakamura, T. Kanai, et al. (2005)
Am J Physiol Gastrointest Liver Physiol 288, G745-G754
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Interleukin-15 Administration Improves Diaphragm Muscle Pathology and Function in Dystrophic mdx Mice.
L. J. Harcourt, A. G. Holmes, P. Gregorevic, J. D. Schertzer, N. Stupka, D. R. Plant, and G. S. Lynch (2005)
Am. J. Pathol. 166, 1131-1141
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T. Yajima, H. Nishimura, S. Sad, H. Shen, H. Kuwano, and Y. Yoshikai (2005)
J. Immunol. 174, 3590-3597
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   Abstract »    Full Text »    PDF »
Enhancement of the host immune responses in cutaneous T-cell lymphoma by CpG oligodeoxynucleotides and IL-15.
M. Wysocka, B. M. Benoit, S. Newton, L. Azzoni, L. J. Montaner, and A. H. Rook (2004)
Blood 104, 4142-4149
   Abstract »    Full Text »    PDF »
Association of interleukin-15 protein and interleukin-15 receptor genetic variation with resistance exercise training responses.
S. E. Riechman, G. Balasekaran, S. M. Roth, and R. E. Ferrell (2004)
J Appl Physiol 97, 2214-2219
   Abstract »    Full Text »    PDF »
Follicular Dendritic Cells Produce IL-15 That Enhances Germinal Center B Cell Proliferation in Membrane-Bound Form.
C.-S. Park, S.-O. Yoon, R. J. Armitage, and Y. S. Choi (2004)
J. Immunol. 173, 6676-6683
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Discovery of BRL 50481 [3-(N,N-dimethylsulfonamido)-4-methyl-nitrobenzene], a Selective Inhibitor of Phosphodiesterase 7: In Vitro Studies in Human Monocytes, Lung Macrophages, and CD8+ T-Lymphocytes.
S. J. Smith, L. B. Cieslinski, R. Newton, L. E. Donnelly, P. S. Fenwick, A. G. Nicholson, P. J. Barnes, M. S. Barnette, and M. A. Giembycz (2004)
Mol. Pharmacol. 66, 1679-1689
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Evidence of a Novel IL-2/15R{beta}-Targeted Cytokine Involved in Homeostatic Proliferation of Memory CD8+ T Cells.
D. Kamimura, N. Ueda, Y. Sawa, S. Hachida, T. Atsumi, T. Nakagawa, S.-i. Sawa, G.-H. Jin, H. Suzuki, K. Ishihara, et al. (2004)
J. Immunol. 173, 6041-6049
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Failed Adoptive Immunotherapy with Tumor-Specific T Cells: Reversal with Low-Dose Interleukin 15 but not Low-Dose Interleukin 2.
S. Roychowdhury, K. F. May Jr., K. S. Tzou, T. Lin, D. Bhatt, A. G. Freud, M. Guimond, A. K. Ferketich, Y. Liu, and M. A. Caligiuri (2004)
Cancer Res. 64, 8062-8067
   Abstract »    Full Text »    PDF »
Targeting IL-15 Receptor-Bearing Cells with an Antagonist Mutant IL-15/Fc Protein Prevents Disease Development and Progression in Murine Collagen-Induced Arthritis.
S. Ferrari-Lacraz, E. Zanelli, M. Neuberg, E. Donskoy, Y. S. Kim, X. X. Zheng, W. W. Hancock, W. Maslinski, X. C. Li, T. B. Strom, et al. (2004)
J. Immunol. 173, 5818-5826
   Abstract »    Full Text »    PDF »
Cutting Edge: Murine Dendritic Cells Require IL-15R{alpha} to Prime NK Cells.
R. Koka, P. Burkett, M. Chien, S. Chai, D. L. Boone, and A. Ma (2004)
J. Immunol. 173, 3594-3598
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Interleukin-15 Enhances Cytotoxicity, Receptor Expression, and Expansion of Neonatal Natural Killer Cells in Long-Term Culture.
S. S. Choi, V. S. Chhabra, Q. H. Nguyen, B. J. Ank, E. R. Stiehm, and R. L. Roberts (2004)
Clin. Vaccine Immunol. 11, 879-888
   Abstract »    Full Text »    PDF »
Natural, Proteolytic Release of a Soluble Form of Human IL-15 Receptor {alpha}-Chain That Behaves as a Specific, High Affinity IL-15 Antagonist.
E. Mortier, J. Bernard, A. Plet, and Y. Jacques (2004)
J. Immunol. 173, 1681-1688
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IL-15 and the Initiation of Cell Contact-Dependent Synovial Fibroblast-T Lymphocyte Cross-Talk in Rheumatoid Arthritis: Effect of Methotrexate.
M.-E. Miranda-Carus, A. Balsa, M. Benito-Miguel, C. Perez de Ayala, and E. Martin-Mola (2004)
J. Immunol. 173, 1463-1476
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Identification of an Interleukin-15{alpha} Receptor-binding Site on Human Interleukin-15.
J. Bernard, C. Harb, E. Mortier, A. Quemener, R. H. Meloen, C. Vermot-Desroches, J. Wijdeness, P. van Dijken, J. Grotzinger, J. W. Slootstra, et al. (2004)
J. Biol. Chem. 279, 24313-24322
   Abstract »    Full Text »    PDF »
CD56+ Cells Induce Steroid Resistance in B Cells Exposed to IL-15.
Q. Xu, E. Goleva, L.-S. Ou, L.-B. Li, and D. Y. M. Leung (2004)
J. Immunol. 172, 7110-7115
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The Size and Phenotype of Virus-Specific T Cell Populations Is Determined by Repetitive Antigenic Stimulation and Environmental Cytokines.
L. E. Gamadia, E. M. M. van Leeuwen, E. B. M. Remmerswaal, S.-L. Yong, S. Surachno, P. M. E. Wertheim-van Dillen, I. J. M. ten Berge, and R. A. W. van Lier (2004)
J. Immunol. 172, 6107-6114
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Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines.
L. Cosmi, F. Liotta, R. Angeli, B. Mazzinghi, V. Santarlasci, R. Manetti, L. Lasagni, V. Vanini, P. Romagnani, E. Maggi, et al. (2004)
Blood 103, 3117-3121
   Abstract »    Full Text »    PDF »
Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor {alpha} expression.
K. S. Schluns, E. C. Nowak, A. Cabrera-Hernandez, L. Puddington, L. Lefrancois, and H. L. Aguila (2004)
PNAS 101, 5616-5621
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IL-15 enhances the in vivo antitumor activity of tumor-reactive CD8+ T Cells.
C. A. Klebanoff, S. E. Finkelstein, D. R. Surman, M. K. Lichtman, L. Gattinoni, M. R. Theoret, N. Grewal, P. J. Spiess, P. A. Antony, D. C. Palmer, et al. (2004)
PNAS 101, 1969-1974
   Abstract »    Full Text »    PDF »
Transregulation of memory CD8 T-cell proliferation by IL-15R{alpha}+ bone marrow-derived cells.
K. S. Schluns, K. D. Klonowski, and L. Lefrancois (2004)
Blood 103, 988-994
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IL-15 and Cognate Antigen Successfully Expand De Novo-Induced Human Antigen-Specific Regulatory CD4+ T Cells That Require Antigen-Specific Activation for Suppression.
H. J. P. M. Koenen, E. Fasse, and I. Joosten (2003)
J. Immunol. 171, 6431-6441
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Interleukin-21 inhibits dendritic cell activation and maturation.
K. Brandt, S. Bulfone-Paus, D. C. Foster, and R. Ruckert (2003)
Blood 102, 4090-4098
   Abstract »    Full Text »    PDF »
New strategies to control inflammatory synovitis: interleukin 15 and beyond.
I B McInnes, J A Gracie, M Harnett, W Harnett, and F Y Liew (2003)
Ann Rheum Dis 62, ii51-54
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IL-15 induces antigen-independent expansion and differentiation of human naive CD8+ T cells in vitro.
N. L. Alves, B. Hooibrink, F. A. Arosa, and R. A. W. van Lier (2003)
Blood 102, 2541-2546
   Abstract »    Full Text »    PDF »


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