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Science 13 May 1994:
Vol. 264. no. 5161, pp. 945 - 947
DOI: 10.1126/science.264.5161.945
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Articles

Diacetylenic Lipid Tubules: Experimental Evidence for a Chiral Molecular Architecture

J. M. Schnur 1, B. R. Ratna 1, J. V. Selinger 1, A. Singh 1, G. Jyothi 2, and K. R. K. Easwaran 2

1 Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, DC 20375, USA.
2 Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India

Molecular self-assembly is of key importance for the rational design of advanced materials. To investigate the causal relation between molecular structure and the consequent self-assembled microstructure, self-assembled tubules of diacetylenic lipids were studied. Circular-dichroism studies give experimental evidence that the formation of tubules is driven by chiral molecular packing, in agreement with recent theories of tubules. On the basis of these results, a molecular mechanism for the formation of tubules is proposed.

Submitted on December 22, 1993
Accepted on April 4, 1994


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