Science 6 May 1994: Vol. 264. no. 5160, pp. 850 - 852 DOI: 10.1126/science.8171342

Prev | Table of Contents | Next

Articles

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo.

S. B. Dumanis, J. A. Tesoriero, L. W. Babus, M. T. Nguyen, J. H. Trotter, M. J. Ladu, E. J. Weeber, R. S. Turner, B. Xu, G. W. Rebeck, et al. (2009)
J. Neurosci. 29, 15317-15322
 |  Abstract »  |  Full Text »  |  PDF »

Protection of Neurons from Apoptosis by Apolipoprotein E-containing Lipoproteins Does Not Require Lipoprotein Uptake and Involves Activation of Phospholipase C{gamma}1 and Inhibition of Calcineurin.

H. Hayashi, R. B. Campenot, D. E. Vance, and J. E. Vance (2009)
J. Biol. Chem. 284, 29605-29613
 |  Abstract »  |  Full Text »  |  PDF »

Nontraditional Signaling Mechanisms of Lipoprotein Receptors.

G. W. Rebeck (2009)
Science Signaling 2, pe28
 |  Abstract »  |  Full Text »  |  PDF »

Understanding the Association of Apolipoprotein E4 with Alzheimer Disease: Clues from Its Structure.

N. Zhong and K. H. Weisgraber (2009)
J. Biol. Chem. 284, 6027-6031
 |  Abstract »  |  Full Text »  |  PDF »

ApoE alleles, depression and positive affect in multiple sclerosis.

L. Julian, L Vella, D Frankel, S. Minden, J. Oksenberg, and D. Mohr (2009)
Multiple Sclerosis 15, 311-315
 |  Abstract »  |  PDF »

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels.

D. R. Riddell, H. Zhou, K. Atchison, H. K. Warwick, P. J. Atkinson, J. Jefferson, L. Xu, S. Aschmies, Y. Kirksey, Y. Hu, et al. (2008)
J. Neurosci. 28, 11445-11453
 |  Abstract »  |  Full Text »  |  PDF »

Cerebrospinal Fluid Apolipoprotein E, Calcium and Cerebral Vasospasm after Subarachnoid Hemorrhage.

S. A. Alexander, M. E. Kerr, J. Balzer, M. Horowitz, A. Kassam, Y. Kim, L. Hoffman, and Y. P. Conley (2008)
Biol Res Nurs 10, 102-112
 |  Abstract »  |  PDF »

Ceramide Is Responsible for the Failure of Compensatory Nerve Sprouting in Apolipoprotein E Knock-Out Mice.

D. Maysinger, M. Holmes, X. Han, R. M. Epand, E. Pertens, A. Foerster, C. Barlas, D. M. Holtzman, and J. Diamond (2008)
J. Neurosci. 28, 7891-7899
 |  Abstract »  |  Full Text »  |  PDF »

Association between apolipoprotein-{varepsilon}4 and long-term outcome after traumatic brain injury.

A H P W.-v. Son, G M Ribbers, W C J Hop, C M van Duijn, and H J Stam (2008)
J. Neurol. Neurosurg. Psychiatry 79, 426-430
 |  Abstract »  |  Full Text »  |  PDF »

Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease.

Y. Li, A. Grupe, C. Rowland, P. Holmans, R. Segurado, R. Abraham, L. Jones, J. Catanese, D. Ross, K. Mayo, et al. (2008)
Hum. Mol. Genet. 17, 759-767
 |  Abstract »  |  Full Text »  |  PDF »

Rosiglitazone increases dendritic spine density and rescues spine loss caused by apolipoprotein E4 in primary cortical neurons.

J. Brodbeck, M. E. Balestra, A. M. Saunders, A. D. Roses, R. W. Mahley, and Y. Huang (2008)
PNAS 105, 1343-1346
 |  Abstract »  |  Full Text »  |  PDF »

APOE {varepsilon}4 allele is associated with cognitive impairment in patients with multiple sclerosis.

J. Shi, C. B. Zhao, T. L. Vollmer, T. M. Tyry, and S. M. Kuniyoshi (2008)
Neurology 70, 185-190
 |  Abstract »  |  Full Text »  |  PDF »

A{beta} amyloid deposition in the language system and how the brain responds.

N. Nelissen, M. Vandenbulcke, K. Fannes, A. Verbruggen, R. Peeters, P. Dupont, K. Van Laere, G. Bormans, and R. Vandenberghe (2007)
Brain 130, 2055-2069
 |  Abstract »  |  Full Text »  |  PDF »

Activation of estrogen receptor {alpha} increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo.

J. M. Wang, R. W. Irwin, and R. D. Brinton (2006)
PNAS 103, 16983-16988
 |  Abstract »  |  Full Text »  |  PDF »

The distribution of apolipoprotein E alleles in Scottish perinatal deaths.

J-C Becher, J W Keeling, N McIntosh, B Wyatt, and J Bell (2006)
J. Med. Genet. 43, 414-418
 |  Abstract »  |  Full Text »  |  PDF »

Inaugural Article: Apolipoprotein E4: A causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

R. W. Mahley, K. H. Weisgraber, and Y. Huang (2006)
PNAS 103, 5644-5651
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E and Alzheimer disease.

Y. Huang (2006)
Neurology 66, S79-S85
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein (apo) E4 enhances amyloid {beta} peptide production in cultured neuronal cells: ApoE structure as a potential therapeutic target.

S. Ye, Y. Huang, K. Mullendorff, L. Dong, G. Giedt, E. C. Meng, F. E. Cohen, I. D. Kuntz, K. H. Weisgraber, and R. W. Mahley (2005)
PNAS 102, 18700-18705
 |  Abstract »  |  Full Text »  |  PDF »

APOE-{varepsilon}4 predisposes to cognitive dysfunction following uncomplicated carotid endarterectomy.

E. J. Heyer, D. A. Wilson, D. H. Sahlein, J. Mocco, S. C. Williams, R. Sciacca, A. Rampersad, R. J. Komotar, J. Zurica, A. Benvenisty, et al. (2005)
Neurology 65, 1759-1763
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Apolipoprotein E Structure by Domain Interaction: DIFFERENCES IN LIPID-BOUND AND LIPID-FREE FORMS.

D. M. Hatters, M. S. Budamagunta, J. C. Voss, and K. H. Weisgraber (2005)
J. Biol. Chem. 280, 34288-34295
 |  Abstract »  |  Full Text »  |  PDF »

The apoE isoform binding properties of the VLDL receptor reveal marked differences from LRP and the LDL receptor.

J. Ruiz, D. Kouiavskaia, M. Migliorini, S. Robinson, E. L. Saenko, N. Gorlatova, D. Li, D. Lawrence, B. T. Hyman, K. H. Weisgraber, et al. (2005)
J. Lipid Res. 46, 1721-1731
 |  Abstract »  |  Full Text »  |  PDF »

Engineering Conformational Destabilization into Mouse Apolipoprotein E: A MODEL FOR A UNIQUE PROPERTY OF HUMAN APOLIPOPROTEIN E4.

D. M. Hatters, C. A. Peters-Libeu, and K. H. Weisgraber (2005)
J. Biol. Chem. 280, 26477-26482
 |  Abstract »  |  Full Text »  |  PDF »

Is there a relation between APOE expression and brain amyloid load in Alzheimer's disease?.

J-C Lambert, D Mann, F Richard, J Tian, J Shi, U Thaker, S Merrot, J Harris, B Frigard, T Iwatsubo, et al. (2005)
J. Neurol. Neurosurg. Psychiatry 76, 928-933
 |  Abstract »  |  Full Text »  |  PDF »

Sex, Apolipoprotein E {varepsilon}4 Status, and Hippocampal Volume in Mild Cognitive Impairment.

A. Fleisher, M. Grundman, C. R. Jack Jr, R. C. Petersen, C. Taylor, H. T. Kim, D. H. B. Schiller, V. Bagwell, D. Sencakova, M. F. Weiner, et al. (2005)
Arch Neurol 62, 953-957
 |  Abstract »  |  Full Text »  |  PDF »

Lipid homeostasis and apolipoprotein E in the development and progression of Alzheimer's disease.

R. M. Lane and M. R. Farlow (2005)
J. Lipid Res. 46, 949-968
 |  Abstract »  |  Full Text »  |  PDF »

APOE influences vasospasm and cognition of noncomatose patients with subarachnoid hemorrhage.

L. A. Lanterna, M. Rigoldi, G. Tredici, F. Biroli, C. Cesana, S. M. Gaini, and L. Dalpra (2005)
Neurology 64, 1238-1244
 |  Abstract »  |  Full Text »  |  PDF »

Fatty acids increase presenilin-1 levels and {gamma}-secretase activity in PSwt-1 cells.

Y. Liu, L. Yang, K. Conde-Knape, D. Beher, M. S. Shearman, and N. S. Shachter (2004)
J. Lipid Res. 45, 2368-2376
 |  Abstract »  |  Full Text »  |  PDF »

Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes.

N. J. Bray, L. Jehu, V. Moskvina, J. D. Buxbaum, S. Dracheva, V. Haroutunian, J. Williams, P. R. Buckland, M. J. Owen, and M. C. O'Donovan (2004)
Hum. Mol. Genet. 13, 2885-2892
 |  Abstract »  |  Full Text »  |  PDF »

APOE {epsilon}4 and cognitive decline in older stroke patients with early cognitive impairment.

C. G. Ballard, C. M. Morris, H. Rao, J. T. O'Brien, R. Barber, S. Stephens, E. Rowan, A. Gibson, R. N. Kalaria, and R. A. Kenny (2004)
Neurology 63, 1399-1402
 |  Abstract »  |  Full Text »  |  PDF »

Increased tau Phosphorylation in Apolipoprotein E4 Transgenic Mice Is Associated with Activation of Extracellular Signal-regulated Kinase: MODULATION BY ZINC.

F. M. Harris, W. J. Brecht, Q. Xu, R. W. Mahley, and Y. Huang (2004)
J. Biol. Chem. 279, 44795-44801
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein A-I-stimulated Apolipoprotein E Secretion from Human Macrophages Is Independent of Cholesterol Efflux.

M. Kockx, K.-A. Rye, K. Gaus, C. M. Quinn, J. Wright, T. Sloane, D. Sviridov, Y. Fu, D. Sullivan, J. R. Burnett, et al. (2004)
J. Biol. Chem. 279, 25966-25977
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E4 Domain Interaction Occurs in Living Neuronal Cells as Determined by Fluorescence Resonance Energy Transfer.

Q. Xu, W. J. Brecht, K. H. Weisgraber, R. W. Mahley, and Y. Huang (2004)
J. Biol. Chem. 279, 25511-25516
 |  Abstract »  |  Full Text »  |  PDF »

No major association of A poE genotype with disease characteristics and MRI findings in multiple sclerosis.

J N. Zwemmer, T van Veen, L van Winsen, G J van Kamp, F Barkhof, C H Polman, and B M. Uitdehaag (2004)
Multiple Sclerosis 10, 272-277
 |  Abstract »  |  PDF »

Glial Lipoproteins Stimulate Axon Growth of Central Nervous System Neurons in Compartmented Cultures.

H. Hayashi, R. B. Campenot, D. E. Vance, and J. E. Vance (2004)
J. Biol. Chem. 279, 14009-14015
 |  Abstract »  |  Full Text »  |  PDF »

Androgens, ApoE, and Alzheimer's Disease.

J. Raber (2004)
Sci. Aging Knowl. Environ. 2004, re2
 |  Abstract »  |  Full Text »  |  PDF »

Neuron-Specific Apolipoprotein E4 Proteolysis Is Associated with Increased Tau Phosphorylation in Brains of Transgenic Mice.

W. J. Brecht, F. M. Harris, S. Chang, I. Tesseur, G.-Q. Yu, Q. Xu, J. Dee Fish, T. Wyss-Coray, M. Buttini, L. Mucke, et al. (2004)
J. Neurosci. 24, 2527-2534
 |  Abstract »  |  Full Text »  |  PDF »

Functions of lipoprotein receptors in neurons.

U. Beffert, P. C. Stolt, and J. Herz (2004)
J. Lipid Res. 45, 403-409
 |  Abstract »  |  Full Text »  |  PDF »

Association Between Apolipoprotein E {epsilon}4 and Neuropsychiatric Symptoms During Interferon {alpha} Treatment for Chronic Hepatitis C.

P. A. Gochee, E. E. Powell, D. M. Purdie, N. Pandeya, L. Kelemen, C. Shorthouse, J. R. Jonsson, and B. Kelly (2004)
Psychosomatics 45, 49-57
 |  Abstract »  |  Full Text »  |  PDF »

Astroglial Regulation of Apolipoprotein E Expression in Neuronal Cells: IMPLICATIONS FOR ALZHEIMER'S DISEASE.

F. M. Harris, I. Tesseur, W. J. Brecht, Q. Xu, K. Mullendorff, S. Chang, T. Wyss-Coray, R. W. Mahley, and Y. Huang (2004)
J. Biol. Chem. 279, 3862-3868
 |  Abstract »  |  Full Text »  |  PDF »

Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia.

E. M. Reiman, K. Chen, G. E. Alexander, R. J. Caselli, D. Bandy, D. Osborne, A. M. Saunders, and J. Hardy (2004)
PNAS 101, 284-289
 |  Abstract »  |  Full Text »  |  PDF »

Membrane dynamics, cholesterol homeostasis, and Alzheimer's disease.

N. B. Chauhan (2003)
J. Lipid Res. 44, 2019-2029
 |  Abstract »  |  Full Text »

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice.

F. M. Harris, W. J. Brecht, Q. Xu, I. Tesseur, L. Kekonius, T. Wyss-Coray, J. D. Fish, E. Masliah, P. C. Hopkins, K. Scearce-Levie, et al. (2003)
PNAS 100, 10966-10971
 |  Abstract »  |  Full Text »  |  PDF »

Structural and functional properties of human plasma high density-sized lipoprotein containing only apoE particles.

L. Krimbou, M. Marcil, H. Chiba, and J. Genest Jr. (2003)
J. Lipid Res. 44, 884-892
 |  Abstract »  |  Full Text »  |  PDF »

Lipoprotein Lipase Affects the Survival and Differentiation of Neural Cells Exposed to Very Low Density Lipoprotein.

E. Paradis, S. Clement, P. Julien, and M. R. Ven Murthy (2003)
J. Biol. Chem. 278, 9698-9705
 |  Abstract »  |  Full Text »  |  PDF »

Isoform-Dependent Cholesterol Efflux From Macrophages by Apolipoprotein E Is Modulated by Cell Surface Proteoglycans.

M. Hara, T. Matsushima, H. Satoh, N. Iso-o, H. Noto, M. Togo, S. Kimura, Y. Hashimoto, and K. Tsukamoto (2003)
Arterioscler Thromb Vasc Biol 23, 269-274
 |  Abstract »  |  Full Text »  |  PDF »

Endocytic Pathway Alterations in Human Hippocampus after Global Ischemia and the Influence of APOE Genotype.

B. W. McColl, D. I. Graham, C. J. Weir, F. White, and K. Horsburgh (2003)
Am. J. Pathol. 162, 273-281
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E4 Forms a Molten Globule. A POTENTIAL BASIS FOR ITS ASSOCIATION WITH DISEASE.

J. A. Morrow, D. M. Hatters, B. Lu, P. Hochtl, K. A. Oberg, B. Rupp, and K. H. Weisgraber (2002)
J. Biol. Chem. 277, 50380-50385
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Alzheimer-Like Synaptic and Cholinergic Deficits in Transgenic Mice by Human Apolipoprotein E Depends on Isoform , Aging, and Overexpression of Amyloid beta Peptides But Not on Plaque Formation.

M. Buttini, G.-Q. Yu, K. Shockley, Y. Huang, B. Jones, E. Masliah, M. Mallory, T. Yeo, F. M. Longo, and L. Mucke (2002)
J. Neurosci. 22, 10539-10548
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E, Amyloid, and Alzheimer Disease.

K.R. Bales, J.C. Dodart, R.B. DeMattos, D.M. Holtzman, and S.M. Paul (2002)
Mol. Interv. 2, 363-375
 |  Abstract »  |  Full Text »  |  PDF »

Androgens Protect against Apolipoprotein E4-Induced Cognitive Deficits.

J. Raber, G. Bongers, A. LeFevour, M. Buttini, and L. Mucke (2002)
J. Neurosci. 22, 5204-5209
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E4 Potentiates Amyloid beta Peptide-induced Lysosomal Leakage and Apoptosis in Neuronal Cells.

Z.-S. Ji, R. D. Miranda, Y. M. Newhouse, K. H. Weisgraber, Y. Huang, and R. W. Mahley (2002)
J. Biol. Chem. 277, 21821-21828
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E {epsilon}4 and short-term recovery from predominantly mild brain injury.

J. N. Liberman, W. F. Stewart, K. Wesnes, and J. Troncoso (2002)
Neurology 58, 1038-1044
 |  Abstract »  |  Full Text »  |  PDF »

Joint Effect of the APOE Gene and Midlife Systolic Blood Pressure on Late-Life Cognitive Impairment: The Honolulu-Asia Aging Study Editorial Comment: The Honolulu-Asia Aging Study.

R. Peila, L.R. White, H. Petrovich, K. Masaki, G.W. Ross, R.J. Havlik, L.J. Launer, and J. Poirier (2001)
Stroke 32, 2882-2889
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages.

U. K. Misra, C. L. Adlakha, G. Gawdi, M. K. McMillian, S. V. Pizzo, and D. T. Laskowitz (2001)
J. Leukoc. Biol. 70, 677-683
 |  Abstract »  |  Full Text »  |  PDF »

Biochemical analysis of cell-derived apoE3 particles active in stimulating neurite outgrowth.

R. B. DeMattos, L. L. Rudel, and D. L. Williams (2001)
J. Lipid Res. 42, 976-987
 |  Abstract »  |  Full Text »

Association of Apolipoprotein E Polymorphism With Outcome After Aneurysmal Subarachnoid Hemorrhage : A Preliminary Study.

T. Niskakangas, J. Ohman, M. Niemela, E. Ilveskoski, T. A. Kunnas, and P. J. Karhunen (2001)
Stroke 32, 1181-1184
 |  Abstract »  |  Full Text »  |  PDF »

Alzheimer's Disease: Genes, Proteins, and Therapy.

D. J. Selkoe (2001)
Physiol Rev 81, 741-766
 |  Abstract »  |  Full Text »  |  PDF »

Two Distal Downstream Enhancers Direct Expression of the Human Apolipoprotein E Gene to Astrocytes in the Brain.

S. Grehan, E. Tse, and J. M. Taylor (2001)
J. Neurosci. 21, 812-822
 |  Abstract »  |  Full Text »  |  PDF »

Neuronal Apoptosis by Apolipoprotein E4 through Low-Density Lipoprotein Receptor-Related Protein and Heterotrimeric GTPases.

Y. Hashimoto, H. Jiang, T. Niikura, Y. Ito, A. Hagiwara, K. Umezawa, Y. Abe, Y. Murayama, and I. Nishimoto (2000)
J. Neurosci. 20, 8401-8409
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E and Neuromuscular Disease: A Critical Review of the Literature.

R. S. Bedlack, W. J. Strittmatter, and J. C. Morgenlander (2000)
Arch Neurol 57, 1561-1565
 |  Abstract »  |  Full Text »  |  PDF »

Prominent Axonopathy and Disruption of Axonal Transport in Transgenic Mice Expressing Human Apolipoprotein E4 in Neurons of Brain and Spinal Cord.

I. Tesseur, J. Van Dorpe, K. Bruynseels, F. Bronfman, R. Sciot, A. Van Lommel, and F. Van Leuven (2000)
Am. J. Pathol. 157, 1495-1510
 |  Abstract »  |  Full Text »  |  PDF »

Transcriptional regulation of Alzheimer's disease genes: implications for susceptibility.

J. Theuns and C. Van Broeckhoven (2000)
Hum. Mol. Genet. 9, 2383-2394
 |  Abstract »  |  Full Text »  |  PDF »

Prospective Study of Apolipoprotein E Genotype and Functional Outcome Following Ischemic Stroke.

M. O. McCarron, K. W. Muir, J. A. R. Nicoll, J. Stewart, Y. Currie, K. Brown, and I. Bone (2000)
Arch Neurol 57, 1480-1484
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Polymorphism : Survival and Neurological Outcome After Cardiopulmonary Resuscitation.

M. Schiefermeier, H. Kollegger, C. Madl, C. Schwarz, M. Holzer, J. Kofler, and F. Sterz (2000)
Stroke 31, 2068-2073
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E genotype related differences in brain lesions of multiple sclerosis.

F. Fazekas, S. Strasser-Fuchs, H. Schmidt, C. Enzinger, S. Ropele, A. Lechner, E. Flooh, R. Schmidt, and H.-P. Hartung (2000)
J. Neurol. Neurosurg. Psychiatry 69, 25-28
 |  Abstract »  |  Full Text »  |  PDF »

Role of the Low-density Lipoprotein Receptor-Related Protein in {beta}-Amyloid Metabolism and Alzheimer Disease.

B. T. Hyman, D. Strickland, and G. W. Rebeck (2000)
Arch Neurol 57, 646-650
 |  Abstract »  |  Full Text »  |  PDF »

Interactions between Apolipoprotein E and Apolipoprotein(a) in Patients with Late-Onset Alzheimer Disease.

V. Mooser, N. Helbecque, J. Miklossy, S. M. Marcovina, P. Nicod, and P. Amouyel (2000)
Ann Intern Med 132, 533-537
 |  Abstract »  |  Full Text »  |  PDF »

The impact of apolipoprotein E genotypes on age at onset of symptoms and phenotypic expression in Wilson's disease.

M. Schiefermeier, H. Kollegger, C. Madl, C. Polli, W. Oder, H.-J. Kuhn, F. Berr, and P. Ferenci (2000)
Brain 123, 585-590
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice.

I. Tesseur, J. Van Dorpe, K. Spittaels, C. Van den Haute, D. Moechars, and F. Van Leuven (2000)
Am. J. Pathol. 156, 951-964
 |  Abstract »  |  Full Text »  |  PDF »

Rapid determination of apolipoprotein E genotype using a heteroduplex generator.

M. K. Bolla, N. Wood, and S. E. Humphries (1999)
J. Lipid Res. 40, 2340-2345
 |  Abstract »  |  Full Text »  |  PDF »

Preliminary Observations on APOE{epsilon}4 Allele and Progression of Disability in Multiple Sclerosis.

J. Chapman, C. Sylantiev, P. Nisipeanu, and A. D. Korczyn (1999)
Arch Neurol 56, 1484-1487
 |  Abstract »  |  Full Text »  |  PDF »

Unique Lipoproteins Secreted by Primary Astrocytes From Wild Type, apoE (-/-), and Human apoE Transgenic Mice.

A. M. Fagan, D. M. Holtzman, G. Munson, T. Mathur, D. Schneider, L. K. Chang, G. S. Getz, C. A. Reardon, J. Lukens, J. A. Shah, et al. (1999)
J. Biol. Chem. 274, 30001-30007
 |  Abstract »  |  Full Text »  |  PDF »

Rapid Regression of Atherosclerosis Induced by Liver-Directed Gene Transfer of ApoE in ApoE-Deficient Mice.

K. Tsukamoto, R. Tangirala, S. H. Chun, E. Pure, and D. J. Rader (1999)
Arterioscler Thromb Vasc Biol 19, 2162-2170
 |  Abstract »  |  Full Text »  |  PDF »

A Role for apoE in Regulating the Levels of {alpha}-1-Antichymotrypsin in the Aging Mouse Brain and in Alzheimer's Disease.

F. Licastro, I. L. Campbell, C. Kincaid, I. Veinbergs, E. Van Uden, E. Rockenstein, M. Mallory, J. R. Gilbert, and E. Masliah (1999)
Am. J. Pathol. 155, 869-875
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Human Apolipoprotein E3 or E4 in the Brains of Apoe-/- Mice: Isoform-Specific Effects on Neurodegeneration.

M. Buttini, M. Orth, S. Bellosta, H. Akeefe, R. E. Pitas, T. Wyss-Coray, L. Mucke, and R. W. Mahley (1999)
J. Neurosci. 19, 4867-4880
 |  Abstract »  |  Full Text »  |  PDF »

A Test of the Cytosolic Apolipoprotein E Hypothesis Fails to Detect the Escape of Apolipoprotein E from the Endocytic Pathway into the Cytosol and Shows that Direct Expression of Apolipoprotein E in the Cytosol is Cytotoxic.

R. B. DeMattos, F. E. Thorngate, and D. L. Williams (1999)
J. Neurosci. 19, 2464-2473
 |  Abstract »  |  Full Text »  |  PDF »

Competition of Aß amyloid peptide and apolipoprotein E for receptor-mediated endocytosis.

K. Winkler, H. Scharnagl, U. Tisljar, H. Hoschützky, I. Friedrich, M. M. Hoffmann, M. Hüttinger, H. Wieland, and W. März (1999)
J. Lipid Res. 40, 447-455
 |  Abstract »  |  Full Text »

Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.

C. Xie, S. D. Turley, P. G. Pentchev, and J. M. Dietschy (1999)
Am J Physiol Endocrinol Metab 276, E336-E344
 |  Abstract »  |  Full Text »  |  PDF »

Specific Regional Transcription of Apolipoprotein E in Human Brain Neurons.

P.-T. Xu, J. R. Gilbert, H.-L. Qiu, J. Ervin, T. R. Rothrock-Christian, C. Hulette, and D. E. Schmechel (1999)
Am. J. Pathol. 154, 601-611
 |  Abstract »  |  Full Text »  |  PDF »

Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E.

R. W. Mahley and Z.-S. Ji (1999)
J. Lipid Res. 40, 1-16
 |  Abstract »  |  Full Text »

Apolipoprotein E-{epsilon}4 genotype predicts a poor outcome in survivors of traumatic brain injury.

G. Friedman, P. Froom, L. Sazbon, I. Grinblatt, M. Shochina, J. Tsenter, S. Babaey, A. B. Yehuda, and Z. Groswasser (1999)
Neurology 52, 244
 |  Abstract »  |  Full Text »

Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein.

M. Trommsdorff, J.-P. Borg, B. Margolis, and J. Herz (1998)
J. Biol. Chem. 273, 33556-33560
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E allelic influence on human cerebrospinal fluid apolipoproteins.

K. S. Montine, C. N. Bassett, J. J. Ou, W. R. Markesbery, L. L. Swift, and T. J. Montine (1998)
J. Lipid Res. 39, 2443-2451
 |  Abstract »  |  Full Text »

The Apolipoprotein E {epsilon}4 Allele and Outcome in Cerebrovascular Disease.

M. O. McCarron, K. W. Muir, C. J. Weir, A. G. Dyker, I. Bone, J.A.R. Nicoll, and K.R. Lees (1998)
Stroke 29, 1882-1887
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Inhibits Platelet-derived Growth Factor-induced Vascular Smooth Muscle Cell Migration and Proliferation by Suppressing Signal Transduction and Preventing Cell Entry to G1 Phase.

M. Ishigami, D. K. Swertfeger, N. A. Granholm, and D. Y. Hui (1998)
J. Biol. Chem. 273, 20156-20161
 |  Abstract »  |  Full Text »  |  PDF »

Modulation of Secreted beta -Amyloid Precursor Protein and Amyloid beta -Peptide in Brain by Cholesterol.

D. S. Howland, S. P. Trusko, M. J. Savage, A. G. Reaume, D. M. Lang, J. D. Hirsch, N. Maeda, R. Siman, B. D. Greenberg, R. W. Scott, et al. (1998)
J. Biol. Chem. 273, 16576-16582
 |  Abstract »  |  Full Text »  |  PDF »

Differential Cellular Accumulation/Retention of Apolipoprotein E Mediated by Cell Surface Heparan Sulfate Proteoglycans. APOLIPOPROTEINS E3 AND E2 GREATER THAN E4.

Z.-S. Ji, R. E. Pitas, and R. W. Mahley (1998)
J. Biol. Chem. 273, 13452-13460
 |  Abstract »  |  Full Text »  |  PDF »

Nerve Growth Factor Induces Rapid Increases in Functional Cell Surface Low Density Lipoprotein Receptor-related Protein.

G. Bu, Y. Sun, A. L. Schwartz, and D. M. Holtzman (1998)
J. Biol. Chem. 273, 13359-13365
 |  Abstract »  |  Full Text »  |  PDF »

Increased Synaptic Sprouting in Response to Estrogen via an Apolipoprotein E-Dependent Mechanism: Implications for Alzheimer's Disease.

D. J. Stone, I. Rozovsky, T. E. Morgan, C. P. Anderson, and C. E. Finch (1998)
J. Neurosci. 18, 3180-3185
 |  Abstract »  |  Full Text »  |  PDF »

Glial Fibrillary Acidic Protein-Apolipoprotein E (apoE) Transgenic Mice: Astrocyte-Specific Expression and Differing Biological Effects of Astrocyte-Secreted apoE3 and apoE4 Lipoproteins.

Y. Sun, S. Wu, G. Bu, M. K. Onifade, S. N. Patel, M. J. LaDu, A. M. Fagan, and D. M. Holtzman (1998)
J. Neurosci. 18, 3261-3272
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E{epsilon}4 (Epsilon) Allele Does Not Affect the Onset or Symptom Severity in Progressive Supranuclear Palsy.

I. Litvan and A. M. Saunders (1998)
Arch Neurol 55, 752-754
 |  Full Text »  |  PDF »

A Minimally Lipidated Form of Cell-derived Apolipoprotein E Exhibits Isoform-specific Stimulation of Neurite Outgrowth in the Absence of Exogenous Lipids or Lipoproteins.

R. B. DeMattos, L. K. Curtiss, and D. L. Williams (1998)
J. Biol. Chem. 273, 4206-4212
 |  Abstract »  |  Full Text »  |  PDF »

Isoform-Specific Effect of Apolipoprotein E on Cell Survival and beta -Amyloid-Induced Toxicity in Rat Hippocampal Pyramidal Neuronal Cultures.

J. Jordan, M. F. Galindo, R. J. Miller, C. A. Reardon, G. S. Getz, and M. J. LaDu (1998)
J. Neurosci. 18, 195-204
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Binds to and Potentiates the Biological Activity of Ciliary Neurotrophic Factor.

C. R. Gutman, W. J. Strittmatter, K. H. Weisgraber, and W. D. Matthew (1997)
J. Neurosci. 17, 6114-6121
 |  Abstract »  |  Full Text »  |  PDF »

Neurotoxicity of the 22 kDa Thrombin-Cleavage Fragment of Apolipoprotein E and Related Synthetic Peptides Is Receptor-Mediated.

M. Tolar, M. A. Marques, J. A. K. Harmony, and K. A. Crutcher (1997)
J. Neurosci. 17, 5678-5686
 |  Abstract »  |  Full Text »  |  PDF »

Exploring the Etiology of Alzheimer Disease Using Molecular Genetics.

C. L. Lendon, F. Ashall, and A. M. Goate (1997)
JAMA 277, 825-831
 |  Abstract »  |  PDF »

Alzheimer Disease Research Comes of Age: The Pace Accelerates.

M. Morrison-Bogorad, C. Phelps, and N. Buckholtz (1997)
JAMA 277, 837-840
 |  Abstract »  |  PDF »

Plastic Neuronal Remodeling Is Impaired in Patients with Alzheimer's Disease Carrying Apolipoprotein epsilon 4 Allele.

T. Arendt, C. Schindler, M. K. Bruckner, K. Eschrich, V. Bigl, D. Zedlick, and L. Marcova (1997)
J. Neurosci. 17, 516-529
 |  Abstract »  |  Full Text »  |  PDF »

Apolipoprotein E Inhibits Platelet Aggregation through the L-Arginine:Nitric Oxide Pathway. IMPLICATIONS FOR VASCULAR DISEASE.

D. R. Riddell, A. Graham, and J. S. Owen (1997)
J. Biol. Chem. 272, 89-95
 |  Abstract »  |  Full Text »  |  PDF »

To Advertise   |   Find Products