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Science 6 May 1994:
Vol. 264. no. 5160, pp. 847 - 850
DOI: 10.1126/science.8171341
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Articles

Science, Vol 264, Issue 5160, 847-850
Copyright © 1994 by American Association for the Advancement of Science

articles

Neural tuning for sound duration: role of inhibitory mechanisms in the inferior colliculus

JH Casseday, D Ehrlich, and E Covey

Department of Neurobiology, Duke University Medical Center, Durham, NC 27710.

Duration is a biologically important feature of sound. Some neurons in the inferior colliculus of the big brown bat, Eptesicus fuscus, are tuned to sound duration, but it is unclear at what level the tuning originates or what neural mechanisms are responsible for it. The application of antagonists of the inhibitory neurotransmitters gamma-aminobutyric acid or glycine to neurons in the inferior colliculus eliminated duration tuning. Whole-cell patch-clamp recordings of synaptic currents suggested that inhibition produces a temporal frame within which excitation can occur. A model is proposed in which duration tuning arises when an early, sustained inhibitory input interacts with a delayed, transient excitatory input.


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